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Gastric by pass

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https://www.readbyqxmd.com/read/29758343/the-effect-of-the-composition-of-a-fixed-dose-combination-on-bioequivalence-results
#1
Šalandová Jana, Franc Aleš, Hofmann Jiří, Dumicic Aleksandra, Kukačková Lenka, Červená Tereza, Beránek Josef, Srbek Jan, Repický Andrej, Vladovičová Beata, Vetchý David
The purpose of this work was to develop a new supergeneric product Meloxicam/Omeprazole. Such a combination brings a benefit in terms of decreasing side effects for the patients using meloxicam. The new combination is composed of a meloxicam powder blend (MPB) and omeprazole gastro-resistant pellets (OAP) in hard gelatin capsules. The main tasks were to select the excipients to keep the functional layer of OAP active and to prove the bioequivalence to the original products of meloxicam tablets together with omeprazole capsules...
May 11, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29755536/preclinical-study-of-ibuprofen-loaded-transnasal-mucoadhesive-microemulsion-for-neuroprotective-effect-in-mptp-mice-model
#2
Surjyanarayan Mandal, Snigdha Das Mandal, Krishna Chuttani, Krutika K Sawant, Bharat Bhushan Subudhi
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promising neuroprotection action, but it suffers from high first pass metabolism and limited ability to cross blood brain barrier. Severe gastric toxicity following oral administration further limits its utility. Hence, the aim of this study was to investigate whether ibuprofen loaded mucoadhesive microemulsion (MMEI) could enhance the brain uptake and could also protect the dopaminergic neurons from MPTP-mediated neural inflammation. In this work, ibuprofen loaded polycarbophil based mucoadhesive microemulsion (MMEI) was developed by using response surface methodology (RSM)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29741131/on-the-distribution-and-metabolism-of-fusarium-toxins-along-the-gastrointestinal-tract-of-endotoxaemic-pigs
#3
Erik Bannert, Tanja Tesch, Jeannette Kluess, Janine Winkler, Jana Frahm, Susanne Kersten, Stefan Kahlert, Lydia Renner, Hermann-Josef Rothkötter, Sven Dänicke
The aim of this study was to investigate the potential modulatory effect of E. coli lipopolysaccharides (LPS) on residues of deoxynivalenol (DON), de-epoxy-deoxynivalenol (DOM-1), zearalenone (ZEN) and its metabolites α-zearalenol (α-ZEL), β-zearalenol (β-ZEL), zearalanone (ZAN), α-zearalanol (α-ZAL) and β-zearalanol (β-ZAL) after pre- or post-hepatic administration along the gastrointestinal axis. Fifteen barrows were exposed to a naturally mycotoxin contaminated diet (4.59 mg DON/kg feed and 0.22 mg ZEN/kg feed) and equipped with jugular (ju) and portal (po) catheters...
June 2018: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/29722576/is-by-passing-the-stomach-a-means-to-optimise-sodium-bicarbonate-supplementation-a-case-study-with-a-post-bariatric-surgery-individual
#4
Luana Farias de Oliveira, Bryan Saunders, Guilherme Giannini Artioli
Sodium bicarbonate (SB) is an ergogenic supplement shown to improve high-intensity exercise via increased blood bicarbonate buffering. Substantial amounts of the ingested bicarbonate are neutralised in the stomach. Bariatric surgery results in a small gastric pouch which dramatically reduces exposure time of any ingested food in the stomach. The aim of this study was to examine the pharmacokinetics of orally ingested SB in a post-gastric bypass individual to determine the magnitude of changes in blood bicarbonate and associated side-effects...
May 3, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29663019/-retrieval-of-a-migrated-plastic-stent-in-a-51-year-old-man
#5
A Poszler, P Klare, A Weber, M Abdelhafez, K Holzapfel, R M Schmid, S von Delius
BACKGROUND: Endosonographically guided transgastric drainage is the first-line interventional therapy of walled-off necrosis and symptomatic pancreatic pseudocysts in necrotizing pancreatitis. Plastic stents or lumen apposing metal stents are commonly used. A possible complication of endoscopic therapy is stent migration. CASE REPORT: We report upon a 51-year-old man who presented with acute necrotizing pancreatitis. Transgastric necrosectomy was performed and 5 transmural double-pigtail stents (DPS) were left in situ to drain the residual retroperitoneal cavity...
April 16, 2018: Der Internist
https://www.readbyqxmd.com/read/29614986/rapunzel-syndrome-an-infrequent-cause-of-severe-iron-deficiency-anemia-and-abdominal-pain-presenting-to-the-pediatric-emergency-department
#6
Giuseppe Cannalire, Luigi Conti, Maurizio Celoni, Carmine Grassi, Andrea Cella, Giulia Bensi, Patrizio Capelli, Giacomo Biasucci
BACKGROUND: Iron deficiency anemia (IDA) and abdominal pain are commonly seen in a pediatric emergency department (8 and 18% incidence respectively in our center). They are manifestations of a wide variety of diseases ranging from benign to immediately life-threatening. Trichobezoar is an under-diagnosed entity that has to be considered in children and adolescents, expecially female, suffering from trichotillomania (compulsion to pull hair) and trichophagy (compulsion to swallow hair)...
April 4, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29536407/alimentary-limb-ischemia-during-roux-en-y-gastric-bypass-and-its-management
#7
Tarun Mittal, Ashish Dey, Abhilash Nali, Sheikh Mohammad Taha Mustafa, Vinod K Malik
INTRODUCTION: Ischemia of the tip of the alimentary limb involving the gastrojejunostomy (GJ) is an unusual complication during Roux-en-Y gastric bypass (RYGB). Revision of the GJ may be needed to manage this complication. OBJECTIVES: We present a case of inadvertent perforation of the jejunum by a gastric calibration tube, which was recognized on the table and appropriate measures are then taken. Repair of this enterotomy however then led to ischemia of the tip of alimentary limb extending to a portion of the GJ anastomosis...
March 13, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29524906/an-inhalation-ingestion-bioaccessibility-assay-iiba-for-the-assessment-of-exposure-to-metal-loid-s-in-pm-10
#8
Farzana Kastury, E Smith, Ranju R Karna, Kirk G Scheckel, A L Juhasz
Although metal(loid) bioaccessibility of ambient particulate matter, with an aerodynamic diameter of <10μm (PM10 ), has recently received increasing attention, limited research exists into standardising in-vitro methodologies using simulated lung fluid (SLF). Contradictions exist regarding which assay parameters should be adopted. Additionally, potential continuation of metal(loid) dissolution once PM10 is cleared from the lungs and passed through the gastro-intestinal tract (GIT) has rarely been addressed...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29482080/a-case-report-of-large-gastric-diverticulum-with-literature-review
#9
Chee Marianne, Mutee Ur Rehman, Chew Min Hoe
INTRODUCTION: A gastric diverticulum is a rare form of diverticular disease due to outpouching of the gastric wall. It is equally presented within both sexes and commonly occurs in fifth and sixth decades of life. Patients mostly asymptomatic but may present with mild gastric symptoms. Surgical treatment is largely dependent on the patient's symptoms, and a laparoscopic approach is usually recommended for surgery. CASE PRESENTATION: A 77-year-old gentleman presented to the outpatient clinic with a one-month history of passing black stools...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29389636/simulated-gastrointestinal-conditions-increase-adhesion-ability-of-lactobacillus-paracasei-strains-isolated-from-kefir-to-caco-2-cells-and-mucin
#10
Ana Agustina Bengoa, Lucía Zavala, Paula Carasi, Sebastián Alejandro Trejo, Silvia Bronsoms, María de Los Ángeles Serradell, Graciela Liliana Garrote, Analía Graciela Abraham
Gastrointestinal conditions along the digestive tract are the main stress to which probiotics administrated orally are exposed because they must survive these adverse conditions and arrive alive to the intestine. Adhesion to epithelium has been considered one of the key criteria for the characterization of probiotics because it extends their residence time in the intestine and as a consequence, can influence the health of the host by modifying the local microbiota or modulating the immune response. Nevertheless, there are very few reports on the adhesion properties to epithelium and mucus of microorganisms after passing through the gastrointestinal tract...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29347980/semiprone-position-is-superior-to-supine-position-for-paediatric-endotracheal-intubation-during-massive-regurgitation-a-randomized-crossover-simulation-trial
#11
Espen Fevang, Karin Haaland, Jo Røislien, Conrad Arnfinn Bjørshol
BACKGROUND: Endotracheal intubation of patients with massive regurgitation represents a challenge in emergency airway management. Gastric contents tend to block suction catheters, and few treatment alternatives exist. Based on a technique that was successfully applied in our district, we wanted to examine if endotracheal intubation would be easier and quicker to perform when the patient is turned over to a semiprone position, as compared to the supine position. METHODS: In a randomized crossover simulation trial, a child manikin with on-going regurgitation was intubated both in the supine and semiprone positions...
January 18, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29305305/the-safety-and-efficacy-of-the-procedureless-intragastric-balloon
#12
Salman Alsabah, Eliana Al Haddad, Shehab Ekrouf, Ahmad Almulla, Saud Al-Subaie, Mubarak Al Kendari
BACKGROUND: Obesity is on a continuous rise worldwide, and with it, novel bariatric procedures have emerged. The introduction of gastric balloons has opened up a nonsurgical option for patients opting for it. However, they still require some form of sedation and endoscopy for insertion and/or removal. OBJECTIVES: The Elipse balloon is a novel creation that has managed to bypass both these procedures; therefore, the investigation into its effectiveness is of importance...
March 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29302869/lanthanum-induced-mucosal-alterations-in-the-stomach-lanthanum-gastropathy-a-comparative-study-using-an-animal-model
#13
Kei Yabuki, Joji Haratake, Yojiro Tsuda, Eisuke Shiba, Hiroshi Harada, Kenji Yorita, Kazuyoshi Uchihashi, Atsuji Matsuyama, Keiji Hirata, Masanori Hisaoka
Lanthanum (La) carbonate (LC) is one of the most potent phosphate binders that prevents the elevation of serum phosphate levels in patients with end-stage renal diseases undergoing dialysis. LC binds strongly to dietary phosphate and forms insoluble complexes that pass through the gastrointestinal tract. La deposition in patients treated with LC is a recently documented finding particularly observed in gastric mucosa. We herein describe the detailed gastric mucosal lesions in 45 LC-treated patients and address the potential underlying pathologic mechanism using oral LC administration in rats...
January 4, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29120790/digestion-under-saliva-simulated-gastric-and-small-intestinal-conditions-and-fermentation-in-vitro-by-human-intestinal-microbiota-of-polysaccharides-from-fuzhuan-brick-tea
#14
Guijie Chen, Minhao Xie, Peng Wan, Dan Chen, Hong Ye, Ligen Chen, Xiaoxiong Zeng, Zhonghua Liu
The aim of present study was to examine whether the digestivesystem (saliva, simulated gastric and small intestinal conditions) could break down and large intestinal microbiota could utilize the polysaccharides from Fuzhuan brick tea (FBTPS). The results showed that there was no change in molecular weight, monosaccharide content and content of reducing sugars before and after saliva, simulated gastric and small intestinal digestion, indicating that FBTPS could pass through the digestive system without being broken down and reach the large intestine safely...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29043696/-complete-and-inverted-esophagastric-duplicity
#15
J M Morán Penco, J Vázquez, E Forsheden Ahs, S Sanjuán Rodríguez, A Pairola, V García-Martínez
CASE REPORT: A 4-month old girl affected by gastric duplication discovered as a palpable abdominal mass displacing the spleen and left kidney. During laparotomy, a yellowish secretion is aspirated and the gastric duplication is excised together with the common muscular Wall of the greater curvature of the stomach. Also excised, a tubular structure starting from the inferior pole of the malformation, and communicating with it, passing superior to the head of the pancreas and the second portion of the duodenum, followed by a posterior course before inserting into the right cruz of the diaphragm...
July 20, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/28923569/digestive-behavior-of-dendrobium-huoshanense-polysaccharides-in-the-gastrointestinal-tracts-of-mice
#16
Song-Zi Xie, Ji-Chun Ge, Fan Li, Jun Yang, Li-Hua Pan, Xue-Qiang Zha, Qiang-Ming Li, Jun Duan, Jian-Ping Luo
With fluorescent end-labeling method, a homogenous Dendrobium huoshanense polysaccharide (GXG) that was orally administrated to mice was found to be degraded into a stable fragment (dGXG) in the stomach, where dGXG was propelled into the small intestine and absorbed into the systemic circulation. The residual GXG in the stomach could pass through the gastrointestinal tract and was excreted into faeces with a very slow fermentation in the large intestine. The simulated digestion of GXG indicated that the acidic pH condition in the gastric fluid was responsible for GXG degradation, which was supported by the oral digestion of dGXG...
February 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28894611/cigarette-lighter-fluid-induced-gastric-ulcer-a-severe-complication-of-delayed-foreign-body-removal
#17
Ciel Harris, Lauren Stemboroski, Asim Shuja
The majority of foreign bodies ingested pass uneventfully through the gastrointestinal tract without endoscopic intervention. Nevertheless, certain ingested objects pose a greater risk for complications and are more challenging to remove than others. This case report describes a 49-year-old male who swallowed a cigarette lighter causing a gastric ulcer. The lighter was successfully removed by flexible endoscopy using a polypectomy snare. Urgent removal is required due to the shape of the object and its hazardous contents...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/28876609/laparoscopic-pancreaticoduodenectomy-at-dr-george-mukhari-academic-hospital-a-case-report
#18
M Govender, C Kalenga, O Mongale, T Mosasi
BACKGROUND: The first total laparoscopic pancreaticoduodenectomy was performed in 1994 by Gagner and Pomp. Their comments coupled with the inherent technical difficulties stifled development of the technique. In the last decade there has been a renewed interest in the technique with high volume centres publishing large series. We present our experience with the first operation completed at Dr George Mukhari Academic Hospital. METHOD: Pre-operative CT confirmed a resectable head of pancreas mass...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28766267/iodine-status-after-bariatric-surgery-a-prospective-10-year-report-from-the-swedish-obese-subjects-sos-study
#19
Sofia Manousou, Lena M S Carlsson, Robert Eggertsen, Lena Hulthén, Peter Jacobson, Kerstin Landin-Wilhelmsen, Penelope Trimpou, Per-Arne Svensson, Helena Filipsson Nyström
CONTEXT: Bariatric surgery can lead to nutrient deficiencies. Gastric by-pass (GBP) entails restriction and malabsorption, whereas, vertical banded gastroplasty (VBG) is only restrictive. OBJECTIVE: The objective of this study is to study whether GBP-patients develop iodine deficiency from malabsorption, and if GBP- and VBG-patients develop lower 24-h urinary iodine excretion (24-UIE) than obese non-operated controls (OB-controls) due to lower iodine intake. DESIGN: The Swedish Obese Subjects (SOS) study is a prospective, non-randomized study of 4047 obese patients included 1987-2001, who chose bariatric surgery or non-surgical treatment...
February 2018: Obesity Surgery
https://www.readbyqxmd.com/read/28669667/transhepatic-bile-acid-kinetics-in-pigs-and-humans
#20
Hannah M Eggink, F Samuel van Nierop, Marieke G Schooneman, Anita Boelen, Andries Kalsbeek, Martijn Koehorst, Gabriella A M Ten Have, L Maurits de Brauw, Albert K Groen, Johannes A Romijn, Nicolaas E P Deutz, Maarten R Soeters
BACKGROUND & AIMS: Bile acids (BAs) play a key role in lipid uptake and metabolic signalling in different organs including gut, liver, muscle and brown adipose tissue. Portal and peripheral plasma BA concentrations increase after a meal. However, the exact kinetics of postprandial BA metabolism have never been described in great detail. We used a conscious porcine model to investigate postprandial plasma concentrations and transorgan fluxes of BAs, glucose and insulin using the para-aminohippuric acid dilution method...
June 19, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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