Zhen Qi, Gregory M Noetscher, Alton Miles, Konstantin Weise, Thomas R Knösche, Cameron R Cadman, Alina R Potashinsky, Kelu Liu, William A Wartman, Guillermo Nunez Ponasso, Marom Bikson, Hanbing Lu, Zhi-De Deng, Aapo R Nummenmaa, Sergey N Makaroff
UNLABELLED: Across all electrical stimulation (neuromodulation) domains, conventional analysis of cell polarization involves two discrete steps: i) prediction of macroscopic electric field, ignoring presence of cells and; ii) prediction of cell polarization from tissue electric fields. The first step assumes that electric current flow is not distorted by the dense tortuous network of cell structures. The deficiencies of this assumption have long been recognized, but - except for trivial geometries - ignored, because it presented intractable computation hurdles...
April 12, 2024: bioRxiv