keyword
MENU ▼
Read by QxMD icon Read
search

pyogenes toxin

keyword
https://www.readbyqxmd.com/read/29532420/detection-of-streptococcus-pyogenes-virulence-genes-in-streptococcus-dysgalactiae-subsp-equisimilis-from-vellore-india
#1
Anshu Babbar, Andreas Itzek, Dietmar H Pieper, D Patric Nitsche-Schmitz
Streptococcus dysgalactiae subsp. equisimilis (SDSE), belonging to the group C and G streptococci, are human pathogens reported to cause clinical manifestations similar to infections caused by Streptococcus pyogenes. To scrutinize the distribution of gene coding for S. pyogenes virulence factors in SDSE, 255 isolates were collected from humans infected with SDSE in Vellore, a region in southern India, with high incidence of SDSE infections. Initial evaluation indicated SDSE isolates comprising of 82.35% group G and 17...
March 12, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29530660/streptococcal-pharyngitis-and-rheumatic-heart-disease-the-superantigen-hypothesis-revisited
#2
REVIEW
Jacklyn R Hurst, Katherine J Kasper, Akshay N Sule, John K McCormick
Streptococcus pyogenes is a human-specific and globally prominent bacterial pathogen that despite causing numerous human infections, this bacterium is normally found in an asymptomatic carrier state. This review provides an overview of both bacterial and human factors that likely play an important role in nasopharyngeal colonization and pharyngitis, as well as the development of acute rheumatic fever and rheumatic heart disease. Here we highlight a recently described role for bacterial superantigens in promoting acute nasopharyngeal infection, and discuss how these immune system activating toxins could be crucial to initiate the autoimmune process in rheumatic heart disease...
July 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29519524/identification-of-arcanobacterium-phocae-isolated-from-fur-animals-by-phenotypic-properties-by-maldi-tof-ms-analysis-and-by-detection-of-phocaelysin-encoding-gene-phl-as-probable-novel-target
#3
Mazen Alssahen, Osama Sammra, Jörn-Peter Wickhorst, Abdulwahed Ahmed Hassan, Christoph Lämmler, Mirja Raunio Saarnisto, Ellen Prenger-Berninghoff, Markus Timke, Andrè Becker, Amir Abdulmawjood
In the present study 12 Arcanobacterium phocae strains isolated from fur animals in Finland, including foxes, minks and Finnraccoons, could successfully be identified phenotypically, by matrix-assisted laser desorption ionisation-time of flight mass spectrometry (MALDI-TOF MS) and genotypically by sequencing 16S rDNA and phocaelysin (PHL) encoding gene phl. The PHL of all 12 A. phocae strains in the present study and reference strains A. phocae DSM 10002T and A. phocae DSM 10003 displayed, as typical members of the cholesterol dependent cytolysin-group of toxins, the variant undecapeptide sequence EATGLAWDPWW which appeared to be most closely related to arcanolysin of Arcanobacterium haemolyticum and pyolysin of Trueperella pyogenes...
March 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29388112/use-of-streptolysin-o-induced-membrane-damage-as-a-method-of-studying-the-function-of-lipid-rafts-during-b-cell-activation
#4
Heather Miller, Wenxia Song
B-lymphocytes have the ability to repair their plasma membranes following injury, such as by bacterial cholesterol-dependent cytolysins. The repair process includes the removal of the pore from the inflicted region of the plasma membrane via lipid raft-mediated internalization. Lipid rafts are critical for B cell receptor (BCR) activation. Cholesterol-dependent pore forming bacterial toxins provide a useful tool for examining the role of lipid rafts in B cell activation and the underlying cellular mechanisms...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29378883/endopeptidase-pepo-regulates-the-speb-cysteine-protease-and-is-essential-for-the-virulence-of-invasive-m1t1-streptococcus-pyogenes
#5
Stephan Brouwer, Amanda J Cork, Cheryl-Lynn Y Ong, Timothy C Barnett, Nicholas P West, Kevin S McIver, Mark J Walker
Streptococcus pyogenes (group A Streptococcus [GAS]) causes a wide range of human infections. The pathogenesis of GAS infections is dependent on the temporal expression of numerous secreted and surface-associated virulence factors that interact with host proteins. Streptococcal pyrogenic exotoxin B (SpeB) is one of the most extensively studied toxins produced by GAS, and the coordinate growth phase-dependent regulation of speB expression is linked to disease severity phenotypes. Here, we identified the endopeptidase PepO as a novel growth phase-dependent regulator of SpeB in the invasive GAS M1 serotype strain 5448...
April 15, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29366615/the-evaluation-and-management-of-toxic-shock-syndrome-in-the-emergency-department-a-review-of-the-literature
#6
Michael Gottlieb, Brit Long, Alex Koyfman
BACKGROUND: Toxic shock syndrome (TSS) is a severe, toxin-mediated illness that can mimic several other diseases and is lethal if not recognized and treated appropriately. OBJECTIVE: This review provides an emergency medicine evidence-based summary of the current evaluation and treatment of TSS. DISCUSSION: The most common etiologic agents are Staphylococcus aureus and Streptococcus pyogenes. Sources of TSS include postsurgical wounds, postpartum, postabortion, burns, soft tissue injuries, pharyngitis, and focal infections...
June 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29342444/scarlet-fever-epidemic-in-china-caused-by-streptococcus-pyogenes-serotype-m12-epidemiologic-and-molecular-analysis
#7
Yuanhai You, Mark R Davies, Melinda Protani, Liam McIntyre, Mark J Walker, Jianzhong Zhang
From 2011, Hong Kong and mainland China have witnessed a sharp increase in reported cases, with subsequent reports of epidemic scarlet fever in North Asia and the United Kingdom. Here we examine epidemiological data and investigate the genomic context of the predominantly serotype M12 Streptococcus pyogenes scarlet fever isolates from mainland China. Incident case data was obtained from the Chinese Nationwide Notifiable Infectious Diseases Reporting Information System. The relative risk of scarlet fever in recent outbreak years 2011-2016 was calculated using the median age-standardised incidence rate, compared to years 2003-2010 prior this outbreak...
January 11, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29290232/antibiotic-treatment-of-skin-and-soft-tissue-infections
#8
Y Gillet, M Lorrot, R Cohena, I Hau, E Grimprel, C Gras-Le Guen
Bacterial skin and soft tissues infections are common in children and frequently do not require systemic antibiotics, especially if lesions are superficial. Careful washing is always indicated in superficial lesions and is often sufficient. Careful evaluation of symptoms (which may be difficult despite the accessibility of the lesions) should be performed before prescription. Therefore, the need for drainage (spontaneous or surgical) should be assessed considering that antibiotics are mostly useless if purulent lesions are drained...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29277539/skin-wound-healing-is-accelerated-by-a-lipid-mixture-representing-major-lipid-components-of-chamaecyparis-obtusa-plant-extract
#9
Byung Eui Kim, Elena Goleva, Clifton F Hall, Sang Hyun Park, Un Ha Lee, Anne M Brauweiler, Joanne E Streib, Brittany N Richers, Gwuicheol Kim, Donald Y M Leung
In chronic nonhealing wounds, the healing process is disrupted and wounds are often infected with bacteria. About 85% of lower extremity amputations in diabetes are attributed to deep infection of foot ulcers. Therefore, infection control is critical for wound care. In this study, we analyzed lipid composition of Chamaecyparis obtusa extract, and we describe the wound-healing properties of its combination of 10 major lipid components. A 10-lipid mixture up-regulated HBD-3 and LL-37 through the olfactory receptor 2AT4 and induced phosphorylation of extracellular signal-regulated kinases and p38 mitogen-activated protein kinases in primary human keratinocytes...
May 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29142545/rapid-screening-of-pyogenic-staphylococcus-aureus-for-confirmation-of-genus-and-species-methicillin-resistance-and-virulence-factors-by-using-two-novel-multiplex-pcr
#10
Abdul Haque, Asma Haque, Muhammad Saeed, Aysha Azhar, Samreen Rasool, Sidra Shan, Beenish Ehsan, Zohaib Nisar
Objectives: Emergence of methicillin resistant Staphylococcus aureus (MRSA) is a major medical problem of current era. These bacteria are resistant to most drugs and rapid diagnosis can provide a clear guideline to clinicians. They possess specific virulence factors and relevant information can be very useful. We designed this study to develop multiplex PCRs to provide rapid information. Methods: We studied 60 Staphylococcus aureus isolates and detected methicillin resistance by cefoxitin sensitivity and targeting of mecA gene...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28882851/managing-scarlet-fever
#11
(no author information available yet)
Scarlet fever, an infection caused by toxin-producing strains of Streptococcus pyogenes, was associated with high levels of morbidity and mortality when epidemics were common in the 18(th) and 19(th) centuries throughout Europe and the USA.(1) Although this disease nearly disappeared during the 20(th) century, several countries, including the UK, have recently experienced a re-emergence of scarlet fever.(1-3) However, the reason for these new outbreaks remains unclear.(1,4) Despite a general move to reduce the use of antibiotics for many mild self-limiting infections (e...
September 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28757872/production-characterization-and-antimicrobial-activity-of-mycocin-produced-by-debaryomyces-hansenii-dsmz70238
#12
Safaa A S Al-Qaysi, Halah Al-Haideri, Zaid Akram Thabit, Wijdan Hameed Abd Al-Razzaq Al-Kubaisy, Jamal Abd Al-Rahman Ibrahim
The present study was conducted to estimate the antimicrobial activity and the potential biological control of the killer toxin produced by D. hansenii DSMZ70238 against several pathogenic microorganisms. In this study, the effects of NaCl, pH, and temperature, killer toxin production, and antimicrobial activity were studied. The results showed that the optimum inhibitory effect of killer toxin was at 8% NaCl, and the diameters of clear zones were 20, 22, 22, 21, 14, and 13 mm for Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Streptococcus pyogenes, Candida albicans, and Candida neoformans, respectively...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28483238/inverse-relationship-between-toxic-shock-syndrome-toxin-1-antibodies-and-interferon-%C3%AE-and-interleukin-6-in-peripheral-blood-mononuclear-cells-from-patients-with-pediatric-tonsillitis-caused-by-staphylococcus-aureus
#13
Yinshuang Chen, Yanmei Huang, Bingshao Liang, Hui Dong, Shuwen Yao, Yongqiang Xie, Yan Long, Huamin Zhong, Yiyu Yang, Bing Zhu, Sitang Gong, Zhenwen Zhou
INTRODUCTION: Pediatric tonsillitis is frequently caused by Staphylococcus aureus, which is the most common pathogen that causes serious pyogenic infections in humans and endangers human health. S. aureus produces numerous potent virulence factors that play a critical role in the pathogenesis of the infection caused by this bacterium, and one of the most important toxins produced by S. aureus is toxic shock syndrome toxin-1 (TSST-1). The aim of this study is to investigate the first time the levels of IFN-γ and interleukin IL-6 in TSST-1-stimulated PBMCs from pediatric tonsillitis patients and the correlation of these cytokine levels with TSST-1-specific IgG in serum...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28351920/spxa1-and-spxa2-act-coordinately-to-fine-tune-stress-responses-and-virulence-in-streptococcus-pyogenes
#14
Gary C Port, Zachary T Cusumano, Paul R Tumminello, Michael G Caparon
SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood. Here, we show that the SpxA paralogs of the pathogen Streptococcus pyogenes , SpxA1 and SpxA2, act coordinately to regulate virulence by fine-tuning toxin expression and stress resistance. Construction and analysis of mutants revealed that SpxA1- mutants were defective for growth under aerobic conditions, while SpxA2- mutants had severely attenuated responses to multiple stresses, including thermal and oxidative stresses...
March 28, 2017: MBio
https://www.readbyqxmd.com/read/28034602/contribution-of-secreted-nadase-and-streptolysin-o-to-the-pathogenesis-of-epidemic-serotype-m1-streptococcus-pyogenes-infections
#15
Luchang Zhu, Randall J Olsen, Jessica D Lee, Adeline R Porter, Frank R DeLeo, James M Musser
Streptococcus pyogenes secretes many toxins that facilitate human colonization, invasion, and dissemination. NADase (SPN) and streptolysin O (SLO) are two toxins that play important roles in pathogenesis. We previously showed that increased production of SPN and SLO in epidemic serotype M1 and M89 S. pyogenes strains is associated with rapid intercontinental spread and enhanced virulence. The biological functions of SPN and SLO have been extensively studied using eukaryotic cell lines, but the relative contribution of each of these two toxins to pathogenesis of epidemic M1 or M89 strains remains unexplored...
March 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/27991848/molecular-characteristics-of-erythromycin-resistant-streptococcus-pyogenes-strains-isolated-from-children-patients-in-tunis-tunisia
#16
Sonia Ksia, Hanen Smaoui, Manel Hraoui, Aida Bouafsoun, Ihem Boutiba-Ben Boubaker, Amel Kechrid
AIM: The aims of our study were to characterize phenotypically and genotypically erythromycin-resistant Streptococcus pyogenes or group A streptococci (ERGAS) isolates, to evaluate macrolide resistance and to analyze the association between emm types and virulence factors. Included in this study were all ERGAS strains isolated from 2000 to 2013 at the Children's hospital of Tunis. Antimicrobial susceptibility was performed according to the CA-SFM guidelines. Macrolide resistance genes were revealed by polymerase chain reaction (PCR) method...
July 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27726792/selected-topics-in-anaerobic-bacteriology
#17
REVIEW
Deirdre L Church
Alteration in the host microbiome at skin and mucosal surfaces plays a role in the function of the immune system, and may predispose immunocompromised patients to infection. Because obligate anaerobes are the predominant type of bacteria present in humans at skin and mucosal surfaces, immunocompromised patients are at increased risk for serious invasive infection due to anaerobes. Laboratory approaches to the diagnosis of anaerobe infections that occur due to pyogenic, polymicrobial, or toxin-producing organisms are described...
August 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27622163/spondylodiscitis-and-bacteremia-due-to-staphylococcus-hyicus-in-an-immunocompetent-man
#18
Maud Foissac, Maria Lekaditi, Bouchra Loutfi, Agnès Ehrhart, Frédéric-Antoine Dauchy
INTRODUCTION: Staphylococcus hyicus is a coagulase-variable Staphylococcus spp. well-known by veterinarians since it is the major agent of a severe cutaneous infection in piglets called exudative epidermitis. In other species the symptoms of infection are quite different. Human cases are uncommon but seem to occur more frequently after repeated contacts with farm animals. CASE REPORT: We report the case of a 58-year-old man suffering from debilitating subacute lumbar pain, in whom diagnosis of infectious spondylodiscitis was based on spine MRI and positive microbiological results...
September 2016: Germs
https://www.readbyqxmd.com/read/27571972/activation-of-band-3-mediates-group-a-streptococcus-streptolysin-s-based-beta-haemolysis
#19
Dustin L Higashi, Nicolas Biais, Deborah L Donahue, Jeffrey A Mayfield, Charles R Tessier, Kevin Rodriguez, Brandon L Ashfeld, Jeffrey Luchetti, Victoria A Ploplis, Francis J Castellino, Shaun W Lee
Streptococcus pyogenes, or group A Streptococcus (GAS), is a human bacterial pathogen that can manifest as a range of diseases from pharyngitis and impetigo to severe outcomes such as necrotizing fasciitis and toxic shock syndrome. GAS disease remains a global health burden with cases estimated at over 700 million annually and over half a million deaths due to severe infections(1). For over 100 years, a clinical hallmark of diagnosis has been the appearance of complete (beta) haemolysis when grown in the presence of blood...
January 18, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27507970/regulatory-rnas-in-the-less-studied-streptococcal-species-from-nomenclature-to-identification
#20
REVIEW
Mohamed A Zorgani, Roland Quentin, Marie-Frédérique Lartigue
Streptococcal species are Gram-positive bacteria involved in severe and invasive diseases in humans and animals. Although, this group includes different pathogenic species involved in life-threatening infections for humans, it also includes beneficial species, such as Streptococcus thermophilus, which is used in yogurt production. In bacteria virulence factors are controlled by various regulatory networks including regulatory RNAs. For clearness and to develop logical thinking, we start this review with a revision of regulatory RNAs nomenclature...
2016: Frontiers in Microbiology
keyword
keyword
50779
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"