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https://www.readbyqxmd.com/read/28278641/a-new-azadirachta-from-the-crude-extracts-of-neem-azadirachta-indica-a-juss-seeds
#1
Quan Gao, Jia Sun, Hang Xun, Xi Yao, Jin Wang, Feng Tang
One new compound, 2H, 3H-cyclopent[b] furo [2',3':4,5] naphtho [2,4-d] heptlactone-[3,7] furan-6aceticacid, 3-(acetyloxy)-8-(3-furyl)-2a, 4a, 4b, 4c,5,5a, 6, 6a, 8, 9,9a, 10a,10b-13 hydrogen-2a,5a,6a,5-tetramethyl-3-[[(2E)-2-methyl-1-oxo-2-butenyl]oxy]-methyl ester, named azadirachta R (1), along with 10 known ones, Azadirachta A, AZ-B, AZ-D, AZ-H, AZ-I, nimbin, deacetylnimbin, salannin, deacetylsalannin and azadiradione were isolated from the crude extracts of neem (Azadirachta indica A. Juss) seeds, which were determined by UV, IR, HR-ESI-MS and NMR data analyses...
February 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28203602/hamstring-contracture-after-acl-reconstruction-is-associated-with-an-increased-risk-of-cyclops-syndrome
#2
Francisco Guerra Pinto, Mathieu Thaunat, Matt Daggett, Charles Kajetanek, Tiago Marques, Tales Guimares, Bénédicte Quelard, Bertrand Sonnery-Cottet
BACKGROUND: Cyclops syndrome is characterized by loss of terminal knee extension due to proliferative fibrous nodule formation in the intercondylar notch. This complication occurs in the early postoperative period after anterior cruciate ligament reconstruction (ACLR). The pathogenesis of Cyclops syndrome is not well understood. HYPOTHESIS: Persistent hamstring contracture after ACLR is associated with an increased risk of subsequent Cyclops syndrome. STUDY DESIGN: Case-control study; Level of evidence, 3...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28199442/phylogeographic-history-of-south-american-populations-of-the-silky-anteater-cyclopes-didactylus-pilosa-cyclopedidae
#3
Raphael Teodoro Franciscani Coimbra, Flávia Regina Miranda, Camila Clozato Lara, Marco Antônio Alves Schetino, Fabrício Rodrigues Dos Santos
Cyclopes didactylus, commonly called silky anteater, is the smallest and least studied of the anteaters. It is an arboreal species occurring in rainforests, ranging from southern Mexico to Central and South America, with an apparently disjoint distribution between Amazon and Atlantic rainforests in Brazil. Although seven subspecies are recognized, little is known about its geographical variation. Thus, to evaluate the population dynamics and evolutionary history of the South American silky anteater, we analyzed 1542 bp sequences of the mitochondrial control region (CR), COI and Cyt-b genes of 32 individuals...
February 13, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28177281/copy-number-and-gene-dependency-analysis-reveals-partial-copy-loss-of-wild-type-sf3b1-as-a-novel-cancer-vulnerability
#4
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context of particular copy-number alterations (copy-number associated gene dependencies). The most enriched class of copy-number associated gene dependencies was CYCLOPS (Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS) genes, and spliceosome components were the most prevalent...
February 8, 2017: ELife
https://www.readbyqxmd.com/read/28171683/electronic-properties-of-optically-switchable-photochromic-diarylethene-molecules-at-the-interface-with-organic-semiconductors
#5
Qiankun Wang, Johannes Frisch, Martin Herder, Stefan Hecht, Norbert Koch
Light-switching-induced changes in the electronic properties of photochromic diarylethene, i.e., 1,2-bis(2-methyl-5-p-tolylthiophen-3-yl)cyclopent-1-ene (DAE1), thin films at interfaces to a gold electrode and two polymer semiconductors are investigated by direct and inverse photoelectron spectroscopy. The photoisomerization is achieved by in situ irradiation of ultraviolet and visible light. Efficient and reversible switching between the open and closed isomers of DAE1 is evidenced at all interfaces, with profound impact on the energy-level alignment...
February 7, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28128475/cyclops-lesions-are-associated-with-altered-gait-patterns-and-medial-knee-joint-cartilage-degeneration-at-one-year-after-acl-reconstruction
#6
Michael A Samaan, Luca Facchetti, Valentina Pedoia, Matthew S Tanaka, Thomas M Link, Richard B Souza, C Benjamin Ma, Xiaojuan Li
In this exploratory study, gait analysis and quantitative MRI (QMRI) were used to assess biomechanical differences in patients that present with cyclops lesions at 12 months after ACL-reconstruction (ACLR). Thirty ACLR patients without and 10 ACLR patients with cyclops lesions underwent 3T MR T1ρ mapping of the reconstructed knee joint prior to ACLR and at 12 months after ACLR, as well as a gait assessment during a fixed walking speed at 12 months after ACLR. Both external sagittal and frontal plane knee joint moments and joint moment impulses were calculated and assessed throughout the stance phase of gait...
January 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28068194/the-erf-required-for-nodulation1-ern1-transcription-factor-is-required-for-infection-thread-formation-in-lotus-japonicus
#7
Yasuyuki Kawaharada, Euan K James, Simon Kelly, Niels Sandal, Jens Stougaard
Several hundred genes are transcriptionally regulated during infection thread formation and development of nitrogen fixing root nodules. We have characterized a set of Lotus japonicus mutants impaired in root nodule formation and found that the causative gene, Ern1, encodes a protein with a characteristic APETALA2/Ethylene Responsive Factor (AP2/ERF) transcription factor domain. Phenotypic characterisation of four ern1 alleles shows that infection pockets are formed but root hair infection threads are absent...
January 9, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28028038/function-and-evolution-of-a-lotus-japonicus-ap2-erf-family-transcription-factor-that-is-required-for-development-of-infection-threads
#8
Koji Yano, Seishiro Aoki, Meng Liu, Yosuke Umehara, Norio Suganuma, Wataru Iwasaki, Shusei Sato, Takashi Soyano, Hiroshi Kouchi, Masayoshi Kawaguchi
Legume-rhizobium symbiosis is achieved by two major events evolutionarily acquired: root hair infection and organogenesis. Infection thread (IT) development is a distinct element for rhizobial infection. Through ITs, rhizobia are efficiently transported from infection foci on root hairs to dividing meristematic cortical cells. To unveil this process, we performed genetic screening using Lotus japonicus MG-20 and isolated symbiotic mutant lines affecting nodulation, root hair morphology, and IT development. Map-based cloning identified an AP2/ERF transcription factor gene orthologous to Medicago truncatula ERN1 LjERN1 was activated in response to rhizobial infection and depended on CYCLOPS and NSP2...
December 27, 2016: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28027968/establishment-of-the-complete-life-cycle-of-spirometra-cestoda-diphyllobothriidae-in-the-laboratory-using-a-newly-isolated-triploid-clone
#9
Tetsuya Okino, Hiroshi Ushirogawa, Kumiko Matoba, Shin-Ichiro Nishimatsu, Mineki Saito
Methods to maintain the life cycle of pathogenic organisms become powerful tools for studying molecular and cellular bases of infectious diseases. Spirometra erinaceieuropaei is a parasitic tapeworm that causes sparganosis in humans. Because S. erinaceieuropaei has a complex life cycle with different stages and host species requirements, there have been no reports to establish the complete life cycle in the laboratory. In this study, using Cyclops as the first intermediate host, mouse as the experimental second intermediate host, and dog as the final host, we succeeded in maintaining S...
April 2017: Parasitology International
https://www.readbyqxmd.com/read/27986989/cyclops-lesions-detected-by-mri-are-frequent-findings-after-acl-surgical-reconstruction-but-do-not-impact-clinical-outcome-over-2%C3%A2-years
#10
Luca Facchetti, Benedikt J Schwaiger, Alexandra S Gersing, Julio Brandao Guimaraes, Lorenzo Nardo, Sharmila Majumdar, Benjamin C Ma, Thomas M Link, Xiaojuan Li
OBJECTIVES: To assess the impact of cyclops lesions with MRI in patients treated for anterior cruciate ligament (ACL) tears on clinical outcome. METHODS: In 113 patients (age 29.8 ± 10.5y; 55 females; BMI 24.8 ± 3.7 kg/m(2)) with complete ACL tear, 3 T-MRI scans were obtained before, 6-months, 1-year (n = 75) and 2-years (n = 33) after ACL reconstruction. Presence and volume of cyclops lesions were assessed. Clinical outcomes were measured using the Knee injury and Osteoarthritis Outcome Score (KOOS) and differences between time points (∆KOOS) were calculated...
December 16, 2016: European Radiology
https://www.readbyqxmd.com/read/27913181/squarate-based-carbocyclic-nucleosides-syntheses-computational-analyses-and-anticancer-antiviral-evaluation
#11
Meijun Lu, Qing-Bin Lu, John F Honek
Squaric acid and its derivatives are versatile synthons and have demonstrated applications in medicinal chemistry, notably as non-classical bioisosteric replacements for functional groups such as carboxylic acids, alpha-amino acids, urea, guanidine, peptide bonds and phosphate/pyrophosphate linkages. Surprisingly, no reports have appeared concerning its possible application as a nucleobase substitute in nucleosides. A preliminary investigation of such an application is reported herein. 3-Amino-4-((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino-cyclobut-3-ene-1,2-dione, 3-((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino-4-methoxycyclobut-3-ene-1,2-dione, and 3-hydroxy-4-((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino-cyclobut-3-ene-1,2-dione sodium salt were synthesized...
January 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27901531/diastereoselective-construction-of-cyclopent-2-enone-4-ols-from-aldehydes-and-1-2-allenones-catalyzed-by-n-heterocyclic-carbene
#12
Dengke Ma, Chunling Fu, Shengming Ma
Cyclopent-2-enone-4-ols have been prepared highly diastereoselectively from readily available aromatic aldehydes and 1,2-allenones catalyzed by N-heterocyclic carbene. Mechanistic studies showed that there are four possible pathways.
December 13, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27792333/synthesis-of-enantiopure-alicyclic-ethers-and-their-activity-on-the-chemosensory-organ-of-the-ectoparasite-of-honey-bees-varroa-destructor
#13
Govardhana R Pinnelli, Nitin K Singh, Victoria Soroker, Erika Plettner
The preparation of enantiopure conformationally restricted alicyclic ethers and their inhibitory activities on the chemosensory organ of the Varroa destructor, a parasite of honey bees, are reported in this article. We tested the effect of enantiopure ethers of cis-5-(2'-hydroxyethyl)cyclopent-2-en-1-ol on the Varroa chemosensory organ by electrophysiology, for their ability to inhibit the responses to two honey bee-produced odors that are important for the mite to locate its host: nurse bee head space odor and (E)-β-ocimene, a honey bee brood pheromone...
November 16, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27789072/long-term-results-of-arthroscopic-arthrolysis-for-arthrofibrosis-after-anterior-cruciate-ligament-reconstruction
#14
Hermann O Mayr, Christian M Brandt, Thomas Weig, Manuel Koehne, Anke Bernstein, Norbert P Suedkamp, Robert Hube, Amelie Stoehr
PURPOSE: The current study was conducted to evaluate the long-term clinical and radiological outcomes after arthroscopic arthrolysis for arthrofibrosis after anterior cruciate ligament reconstruction (ACLR). METHODS: All patients treated with arthrolysis between 1990 and 1998 were included. Indication was arthrofibrosis in at least one knee compartment or a cyclops syndrome limiting range of motion (ROM) by > 5° of extension deficit and 15° of flexion deficit...
February 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27714297/structure-activity-studies-of-non-steroid-analogues-structurally-related-to-neuroprotective-estrogens
#15
Mingxing Qian, Elizabeth B Engler-Chiurazzi, Sara E Lewis, Nigam P Rath, James W Simpkins, Douglas F Covey
Estrone and 17β-estradiol are phenolic steroids that are known to be neuroprotective in multiple models of neuronal injury. Previous studies have identified the importance of their phenolic steroid A-ring for neuroprotection and have identified ortho substituents at the C-2 and C-4 positions on the phenol ring that enhance this activity. To investigate the importance of the steroid ring system for neuroprotective activity, phenolic compounds having the cyclopent[b]anthracene, cyclopenta[b]phenanthrene, benz[f]indene, benz[e]indene, indenes linked to a phenol, and a phenolic spiro ring system were prepared...
October 18, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27686315/management-of-cyclops-syndrome-a-case-report
#16
Lorenzo Maria Di Giacomo, Muhammad Shahid Khan, Luigi Piscitelli, Michele Bisaccia, Auro Caraffa
Anterior Cruciate ligament (ACL) is a typical athletic injury. One of the most frequent complication after ACL reconstruction is reduced range of motion (ROM) due to the impingement on the inter-condylar notch of a fibrous tissue mass, defined as Cyclops Syndrome. We report the case of a 25 years old male, who underwent reconstruction of ACL with Gracilis-semitendinosus (GR-ST) tendons with delayed onset of loss of knee extension seven years after ACL reconstruction. Clinical and magnetic resonance image (MRI) findings were consistent with Cyclops syndrome...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27660599/sonographic-and-magnetic-resonance-imaging-examination-of-a-cyclops-lesion-after-anterior-cruciate-ligament-reconstruction-a-case-report
#17
Stacey M Cornelson, Alicia M Yochum, Norman W Kettner
OBJECTIVE: This case report describes magnetic resonance imaging (MRI) and diagnostic ultrasound (US) findings for a patient with arthrofibrosis related to a complication of anterior cruciate ligament (ACL) reconstruction. CLINICAL FEATURES: A 25-year old man presented with right knee pain and loss of extension 5 years after ACL reconstruction. MRI and sonographic examination revealed a soft tissue mass anterolateral to the ACL graft consistent with a cyclops lesion...
September 2016: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/27589782/the-relationship-between-phytoplankton-evenness-and-copepod-abundance-in-lake-nansihu-china
#18
Wang Tian, Huayong Zhang, Lei Zhao, Xiang Xu, Hai Huang
The relationship between biodiversity and ecosystem functioning is a central issue in ecology. Previous studies have shown that producer diversity can impact the consumer community via predator-prey interactions. However, direct observations of this relationship remain rare, in particular for aquatic ecosystems. In this research, the relationship between phytoplankton diversity (species richness and evenness) and the abundance of copepods was analyzed in Lake Nansihu, a meso-eutrophic lake in China. The results showed that copepods abundance was significantly decreased with increasing phytoplankton evenness throughout the year...
August 31, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27549214/impact-of-surgical-timing-on-the-outcome-of-anterior-cruciate-ligament-reconstruction
#19
Elmar Herbst, Christian Hoser, Peter Gföller, Caroline Hepperger, Elisabeth Abermann, Katharina Neumayer, Volker Musahl, Christian Fink
PURPOSE: The purpose of the present study is the comparison of acute ACL reconstruction with or without meniscus repair within 48 h after injury and a delayed surgery during the inflammation-free interval. It was hypothesized that acute ACL reconstruction results in inferior patient reported outcomes and higher frequency of range of motion deficits. METHODS: The effect of acute (within 48 h) and delayed (during the inflammation-free interval) ACL surgery was prospectively studied on 160 consecutive patients with ACL injury between January 2010 and December 2011...
August 22, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27491777/decatropis-bicolor-zucc-radlk-essential-oil-induces-apoptosis-of-the-mda-mb-231-breast-cancer-cell-line
#20
C C Estanislao Gómez, A Aquino Carreño, D G Pérez Ishiwara, E San Martín Martínez, J Morales López, N Pérez Hernández, M C Gómez García
BACKGROUND: Decatropis bicolor (Zucc.)Radlk is a plant that has been traditionally used for the treatment of breast cancer in some communities of Mexico. So, the aim of this study was to determine the cytotoxic and apoptotic effect of the essential oil of Decatropis bicolor against breast cancer cell line, MDA-MB-231. METHODS: The essential oil obtained from hydrodestillation of leaves of Decatropis bicolor was studied for its biological activity against breast cancer cells MDA-MB-231 by MTT assay, Hematoxylin-eosin stain, Annexin V-FITC, TUNEL and western blot assays and for its chemical composition by GC-MS...
August 5, 2016: BMC Complementary and Alternative Medicine
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