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Sheng-Xing Long, Paul B Hamilton, Yang Yang, Sai Wang, Wen-da Huang, Chuan Chen, Ran Tao
Mercury (Hg) contamination in aquatic systems remains a global concern with the biomagnification of methylmercury (MeHg) through primary consumers (zooplankton) to fish and humans. In this study, total mercury (THg) and MeHg concentrations were analyzed in zooplankton collected from Baihua reservoir (Guizhou Province, China). Our results demonstrated that THg and MeHg concentrations were strongly correlated to zooplankton community and biomass composition. The THg concentration was significantly higher in micro-zooplankton compared to meso-zooplankton and macro-zooplankton, and MeHg concentration increased significantly as body size increased...
April 10, 2018: Environmental Pollution
Julien Buendia, Zong Chang, Hendrik Eijsberg, Régis Guillot, Angelo Frongia, Francesco Secci, Juan Xie, Sylvie Robin, Thomas Boddaert, David J Aitken
We describe a photochemical reaction paradigm using two starting materials, a cyclopent-2-enone and an alkene, which are transformed in a controlled manner via the initial [2+2]-photocycloaddition adducts into cyclobutene aldehydes (conveniently trapped as stable acetals) or unprecedented angular tricyclic 4:4:4 oxetane-containing skeletons. These compounds are formed via tandem or triple cascade photochemical reaction processes, respectively. Small libraries of each compound class have been prepared, suggesting that this photochemistry paradigm opens new opportunities for fine synthesis design and for widening molecular diversity...
April 12, 2018: Angewandte Chemie
Yan Zhai, Henk J Busscher, Yong Liu, Zhenkun Zhang, Theo G van Kooten, Linzhu Su, Yumin Zhang, Jinjian Liu, Jianfeng Liu, Yingli An, Linqi Shi
Inadvertent photosensitizer-activation and singlet-oxygen generation in between photosensitizer-administration and light-activation as well as after treatment, hampers clinical application of photodynamic-therapies. Therefore, a reversible photoswitchable system was designed for incorporation in micellar nanocarriers. Zinc-tetraphenyl porphyrin (ZnTPP) was used as a photosensitizer, while 1, 2-bis (5-(4-carbonxyphenyl)-2-methylthien-3-yl) cyclopent-1-ene (BDTE) was chosen as a photoswitch. EPR spectra of TEMP-1O2 adduct formation demonstrated that singlet-oxygen generation upon irradiation at 8 mW/cm2 (405 nm) did not occur in closed-switch micelles with ZnTPP/BDTE feeding ratios >1:10...
March 27, 2018: Biomacromolecules
Tonghao Yang, Xing Fan, Xiaopeng Zhao, Wei Yu
This paper reports that tertiary α-azidyl phenyl ketones can be transformed into enamides by treatment with FeBr2 at elevated temperature in DMF. The reaction proceeds via 1,2-benzoyl migration from α-carbon to the nitrogen atom, accompanied by expulsion of a nitrogen molecule. This protocol is suitable for the synthesis of N-(cyclopent-1-en-1-yl)benzamides, N-(cyclohex-1-en-1-yl)benzamides, and N-benzoyl-α-methyl enamines and provides a convenient approach toward isoquinolones.
March 21, 2018: Organic Letters
Hervé Ouanezar, William G Blakeney, Charles Latrobe, Adnan Saithna, Levi Reina Fernandes, Jean Romain Delaloye, Mathieu Thaunat, Bertrand Sonnery-Cottet
PURPOSE: Repairs of the posterior horn of the lateral meniscus can be technically challenging. In contrast to medial meniscus repairs, the capsule around the posterior segment attachment of the lateral meniscus is quite thin. This study evaluates the clinical results of an arthroscopic all-inside repair technique for unstable, vertical, lateral meniscus tears, using a suture repair placed directly into the popliteus tendon. METHODS: A retrospective analysis of prospectively collected data from the SANTI database was performed...
March 3, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Issa Diédhiou, Diaga Diouf
Root endosymbioses are mutualistic interactions between plants and the soil microorganisms (Fungus, Frankia or Rhizobium) that lead to the formation of nitrogen-fixing root nodules and/or arbuscular mycorrhiza. These interactions enable many species to survive in different marginal lands to overcome the nitrogen-and/or phosphorus deficient environment and can potentially reduce the chemical fertilizers used in agriculture which gives them an economic, social and environmental importance. The formation and the development of these structures require the mediation of specific gene products among which the transcription factors play a key role...
February 15, 2018: World Journal of Microbiology & Biotechnology
Rafael F A Gomes, Nuno R Esteves, Jaime A S Coelho, Carlos A M Afonso
Trans-4,5-diamino-cyclopent-2-enones (CP) are usually prepared by Lewis acid-catalyzed condensation of furfural and a secondary amine in an organic solvent. The reaction proceeds through the formation of a Stenhouse salt (SS) intermediate followed by an electrocyclization reaction to afford the desired CP. Herein, we described the use of Cu(OTf)2 as a very efficient catalyst for the synthesis of CP in water at room temperature. Furthermore, the mild reaction conditions, catalyst reusability and outstanding functional group tolerance suggests that this CP platform can be further used in chemical biology...
February 5, 2018: Journal of Organic Chemistry
Hong-Xia Ren, Lin Peng, Xiang-Jia Song, Li-Guo Liao, Ying Zou, Fang Tian, Li-Xin Wang
A novel and diastereoselective [3 + 2] annulation of isoindigos and Morita-Baylis-Hillman carbonates has been developed for the highly efficient and one-step preparation of highly steric dispiro[cyclopent-3'-ene]bisoxindoles with two all-carbon quaternary spirocenters and three adjacent cycles in excellent yields (up to >99%) and diastereoselectivities (up to >20 : 1) under mild conditions within a few minutes. A series of dispiro[cyclopent-3'-ene]bisoxindoles were obtained and scale-up experiment was conducted with excellent results demonstrating the potential applications of this protocol...
February 1, 2018: Organic & Biomolecular Chemistry
Jose I Juncosa, Kenji Takaya, Hoang V Le, Matthew J Moschitto, Pathum M Weerawarna, Romila Mascarenhas, Dali Liu, Stephen L Dewey, Richard B Silverman
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. Inhibition of GABA aminotransferase (GABA-AT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, has been established as a possible strategy for the treatment of substance abuse. The raised GABA levels that occur as a consequence of this inhibition have been found to antagonize the rapid release of dopamine in the ventral striatum (nucleus accumbens) that follows an acute challenge by an addictive substance...
January 30, 2018: Journal of the American Chemical Society
Hua Wu, Qian Wang, Jieping Zhu
A copper-catalyzed enantioselective arylative desymmetrization of prochiral cyclopentenes with diaryliodonium salts was developed. In the presence of a catalytic amount of a chiral copper-bisoxazoline complex, which was generated in situ, the reaction of 4-substituted or 4,4-disubstituted cyclopent-1-enes with diaryliodonium hexafluoroarsenates afforded the chiral arylated products in good yields with excellent enantioselectivity. A cyclohexyl-containing Box ligand was essential for the high enantioselectivity...
March 1, 2018: Angewandte Chemie
Katarina Teresa Wishart, Dorrit Winterholer, Inja Bogdan, Elmar Fritsche
No abstract text is available yet for this article.
December 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Mark A Klaassen, Jerry L Aikins
The cyclops lesion is a localized anterior arthrofibrosis most commonly seen following anterior cruciate ligament reconstruction. The lesion forms at the anterior cruciate ligament insertion creating a painful extension block between femoral intercondylar notch and tibial plateau. We present 2 cases (3 knees) in which cyclops lesions appeared atypically following bicruciate-retaining total knee replacement. Two lesions occurred in a single patient following bilateral knee replacement. One lesion occurred in an active sportswoman...
December 2017: Arthroplasty Today
Valérie Dupé, Christèle Dubourg, Marie de Tayrac, Véronique David
No abstract text is available yet for this article.
November 2017: Médecine Sciences: M/S
Hervé Ouanezar, William G Blakeney, Levi Reina Fernandes, Amrut Borade, Charles Latrobe, Eduardo Frois Temponi, Bertrand Sonnery-Cottet
PURPOSE: The primary aim of this study was to evaluate the functional outcomes, knee stability, complications, and reoperations associated with anatomic anterior cruciate ligament (ACL) reconstruction using the single anteromedial bundle biological augmentation (SAMBBA) technique in a consecutive series of 128 patients with a minimum follow-up of 24 months. A secondary aim was to compare larger preserved ACL remnants with smaller preserved remnants. METHODS: Patients who underwent primary anatomic ACL reconstruction using the SAMBBA technique from July 2013 to October 2014 were analyzed...
March 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Dugald Reid, Huijun Liu, Simon Kelly, Yasuyuki Kawaharada, Terry Mun, Stig U Andersen, Guilhem Desbrosses, Jens Stougaard
Establishment of symbiotic nitrogen-fixation in legumes is regulated by the plant hormone ethylene, but it has remained unclear whether and how its biosynthesis is regulated by the symbiotic pathway. We established a sensitive ethylene detection system for Lotus japonicus and found that ethylene production increased as early as 6 hours after inoculation with Mesorhizobium loti This ethylene response was dependent on Nod factor production by compatible rhizobia. Analyses of nodulation mutants showed that perception of Nod factor was required for ethylene emission, while downstream transcription factors including CYCLOPS, NIN, and ERN1 were not required for this response...
February 2018: Plant Physiology
Georgios I Ioannou, Tamsyn Montagnon, Dimitris Kalaitzakis, Spiros A Pergantis, Georgios Vassilikogiannakis
A series of hydroxycyclopent-2-enones and methoxycyclopent-2-enones have been synthesized in a single operation from simple furan substrates using an innovative continuous flow nebulizer system (NebPhotOX). Photooxygenation of the furan substrates takes place in an aerosol within the NebPhotOX system.
December 13, 2017: Organic & Biomolecular Chemistry
Mansour S Al-Said, Nasir A Siddiqui, Mohamed Ahmed Mukhair, Mohammad K Parvez, Perwez Alam, Mohd Ali, Anzarul Haque
Suaeda monoica Forssk. ex J.F. Gmel (Chenopodiaceae), a mangrove herb, is distributed in tropical Africa, Arabian Peninsula, India, Pakistan, Palestine and Jordan. The plant parts are used to treat sore throat, hepatitis, wounds, rheumatism, paralysis, asthma, snakebites, skin disease and ulcer. Two new phytoconstituents characterized as 13,17-octahydropentalene-4,4,10,23-tetramethyl-17,21-diisopropyl-tetradecahydrocyclo-[a]-phenanthrene-(14), 20(23), 21(30)-trien-5α-ol (SMC-3) and [1,4,4-trimethyl-cyclopent-1(5)-enyl]-9,10,17,21-tetramethyl-9α-ol-16α (17α)-epoxy heptadecan-6,10-dione (SMC-4) belong to the class norsesquaterpenol and monocyclic triterpenoid, respectively, along with two known compounds 3-epi-lupeol (SMC-1) and 4-cyclopentylpyrocatechol (SMC-2) have been isolated from the ethanol extract of aerial parts of S...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Jose L Pelliccia, Granton A Jindal, Rebecca D Burdine
Vertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish; southpaw directs left-right asymmetries, while squint and cyclops function earlier to pattern mesendoderm. TGFβ member Vg1 is implicated in mesoderm formation but the role of the zebrafish ortholog, Growth differentiation factor 3 (Gdf3), has not been fully explored. We show that zygotic expression of gdf3 is dispensable for embryonic development, while maternally deposited gdf3 is required for mesendoderm formation and dorsal-ventral patterning...
November 15, 2017: ELife
Olga A Ivanova, Alexey O Chagarovskiy, Alexey N Shumsky, Vasiliy D Krasnobrov, Irina I Levina, Igor V Trushkov
We report a mild Lewis acid induced isomerization of donor-acceptor cyclopropanes, containing an alkenyl moiety and diverse electron-withdrawing group(s) at the adjacent positions, into substituted cyclopentenes. We have found that 1,1,2-trisubstituted cyclopent-3-enes were exclusively obtained in yield of 51-99% when cyclopropanes with a 2-substituted alkenyl group as a donor underwent isomerization. For cyclopropanes bearing a trisubstituted alkenyl group either the corresponding cyclopent-3-enes or isomeric cyclopent-2-enes having two acceptor groups at the C(1) atom were formed, with the reaction selectivity being determined by the applied Lewis acid...
January 19, 2018: Journal of Organic Chemistry
Nuray Uremis, Muhammed Mehdi Uremis, Fatma Inanc Tolun, Mustafa Ceylan, Adem Doganer, Akif Hakan Kurt
Pancreatic cancer is one of the deadliest malignancies characterized by strong resistance to almost all chemotherapeutic agents and radiotherapy. In this study, we aimed to investigate the anticancer effect, enzymatic antioxidant activity [superoxide dismutase (SOD), glutathione peroxidase (GPx)] and total antioxidant capacity (TAC) of synthesized benzothiazole compounds against adenocarcinoma cancer cells (PANC-1). 2-((1S,2S)-2-((E)-4-nitrostyryl)cyclopent-3-en-1-yl)benzo[d]thiazole and 2-((1S,2S)-2-((E)-4-fluorostyryl) cyclopent-3-en-1-yl)benzo[d]thiazole containing 2-substituted benzothiazole group were synthesized in two steps...
November 2017: Anticancer Research
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