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https://www.readbyqxmd.com/read/27913181/squarate-based-carbocyclic-nucleosides-syntheses-computational-analyses-and-anticancer-antiviral-evaluation
#1
Meijun Lu, Qing-Bin Lu, John F Honek
Squaric acid and its derivatives are versatile synthons and have demonstrated applications in medicinal chemistry, notably as non-classical bioisosteric replacements for functional groups such as carboxylic acids, alpha-amino acids, urea, guanidine, peptide bonds and phosphate/pyrophosphate linkages. Surprisingly, no reports have appeared concerning its possible application as a nucleobase substitute in nucleosides. A preliminary investigation of such an application is reported herein. 3-Amino-4-((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino-cyclobut-3-ene-1,2-dione, 3-((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino-4-methoxycyclobut-3-ene-1,2-dione, and 3-hydroxy-4-((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino-cyclobut-3-ene-1,2-dione sodium salt were synthesized...
November 23, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27901531/diastereoselective-construction-of-cyclopent-2-enone-4-ols-from-aldehydes-and-1-2-allenones-catalyzed-by-n-heterocyclic-carbene
#2
Dengke Ma, Chunling Fu, Shengming Ma
Cyclopent-2-enone-4-ols have been prepared highly diastereoselectively from readily available aromatic aldehydes and 1,2-allenones catalyzed by N-heterocyclic carbene. Mechanistic studies showed that there are four possible pathways.
November 30, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27792333/synthesis-of-enantiopure-alicyclic-ethers-and-their-activity-on-the-chemosensory-organ-of-the-ectoparasite-of-honey-bees-varroa-destructor
#3
Govardhana Reddy Pinnelli, Nitin Singh, Victoria Soroker, Erika Plettner
The preparation of enantiopure conformationally restricted alicyclic ethers and their inhibitory activities on the chemosensory organ of the Varroa destructor, a parasite of honey bees, are reported in this article. We tested the effect of enantiopure ethers of cis 5-(2'-hydroxyethyl)cyclopent-2-en-1-ol on the Varroa chemosensory organ by electrophysiology, for their ability to inhibit the responses to two honey bee-produced odors that are important for the mite to locate its host: nurse bee head space odor and (E)--ocimene, a honey bee brood pheromone...
October 28, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27789072/long-term-results-of-arthroscopic-arthrolysis-for-arthrofibrosis-after-anterior-cruciate-ligament-reconstruction
#4
Hermann O Mayr, Christian M Brandt, Thomas Weig, Manuel Koehne, Anke Bernstein, Norbert P Suedkamp, Robert Hube, Amelie Stoehr
PURPOSE: The current study was conducted to evaluate the long-term clinical and radiological outcomes after arthroscopic arthrolysis for arthrofibrosis after anterior cruciate ligament reconstruction (ACLR). METHODS: All patients treated with arthrolysis between 1990 and 1998 were included. Indication was arthrofibrosis in at least one knee compartment or a cyclops syndrome limiting range of motion (ROM) by > 5° of extension deficit and 15° of flexion deficit...
October 24, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27714297/structure-activity-studies-of-non-steroid-analogues-structurally-related-to-neuroprotective-estrogens
#5
Mingxing Qian, Elizabeth B Engler-Chiurazzi, Sara E Lewis, Nigam P Rath, James W Simpkins, Douglas F Covey
Estrone and 17β-estradiol are phenolic steroids that are known to be neuroprotective in multiple models of neuronal injury. Previous studies have identified the importance of their phenolic steroid A-ring for neuroprotection and have identified ortho substituents at the C-2 and C-4 positions on the phenol ring that enhance this activity. To investigate the importance of the steroid ring system for neuroprotective activity, phenolic compounds having the cyclopent[b]anthracene, cyclopenta[b]phenanthrene, benz[f]indene, benz[e]indene, indenes linked to a phenol, and a phenolic spiro ring system were prepared...
October 18, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27686315/management-of-cyclops-syndrome-a-case-report
#6
Lorenzo Maria Di Giacomo, Muhammad Shahid Khan, Luigi Piscitelli, Michele Bisaccia, Auro Caraffa
Anterior Cruciate ligament (ACL) is a typical athletic injury. One of the most frequent complication after ACL reconstruction is reduced range of motion (ROM) due to the impingement on the inter-condylar notch of a fibrous tissue mass, defined as Cyclops Syndrome. We report the case of a 25 years old male, who underwent reconstruction of ACL with Gracilis-semitendinosus (GR-ST) tendons with delayed onset of loss of knee extension seven years after ACL reconstruction. Clinical and magnetic resonance image (MRI) findings were consistent with Cyclops syndrome...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27660599/sonographic-and-magnetic-resonance-imaging-examination-of-a-cyclops-lesion-after-anterior-cruciate-ligament-reconstruction-a-case-report
#7
Stacey M Cornelson, Alicia M Yochum, Norman W Kettner
OBJECTIVE: This case report describes magnetic resonance imaging (MRI) and diagnostic ultrasound (US) findings for a patient with arthrofibrosis related to a complication of anterior cruciate ligament (ACL) reconstruction. CLINICAL FEATURES: A 25-year old man presented with right knee pain and loss of extension 5 years after ACL reconstruction. MRI and sonographic examination revealed a soft tissue mass anterolateral to the ACL graft consistent with a cyclops lesion...
September 2016: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/27589782/the-relationship-between-phytoplankton-evenness-and-copepod-abundance-in-lake-nansihu-china
#8
Wang Tian, Huayong Zhang, Lei Zhao, Xiang Xu, Hai Huang
The relationship between biodiversity and ecosystem functioning is a central issue in ecology. Previous studies have shown that producer diversity can impact the consumer community via predator-prey interactions. However, direct observations of this relationship remain rare, in particular for aquatic ecosystems. In this research, the relationship between phytoplankton diversity (species richness and evenness) and the abundance of copepods was analyzed in Lake Nansihu, a meso-eutrophic lake in China. The results showed that copepods abundance was significantly decreased with increasing phytoplankton evenness throughout the year...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27549214/impact-of-surgical-timing-on-the-outcome-of-anterior-cruciate-ligament-reconstruction
#9
Elmar Herbst, Christian Hoser, Peter Gföller, Caroline Hepperger, Elisabeth Abermann, Katharina Neumayer, Volker Musahl, Christian Fink
PURPOSE: The purpose of the present study is the comparison of acute ACL reconstruction with or without meniscus repair within 48 h after injury and a delayed surgery during the inflammation-free interval. It was hypothesized that acute ACL reconstruction results in inferior patient reported outcomes and higher frequency of range of motion deficits. METHODS: The effect of acute (within 48 h) and delayed (during the inflammation-free interval) ACL surgery was prospectively studied on 160 consecutive patients with ACL injury between January 2010 and December 2011...
August 22, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27491777/decatropis-bicolor-zucc-radlk-essential-oil-induces-apoptosis-of-the-mda-mb-231-breast-cancer-cell-line
#10
C C Estanislao Gómez, A Aquino Carreño, D G Pérez Ishiwara, E San Martín Martínez, J Morales López, N Pérez Hernández, M C Gómez García
BACKGROUND: Decatropis bicolor (Zucc.)Radlk is a plant that has been traditionally used for the treatment of breast cancer in some communities of Mexico. So, the aim of this study was to determine the cytotoxic and apoptotic effect of the essential oil of Decatropis bicolor against breast cancer cell line, MDA-MB-231. METHODS: The essential oil obtained from hydrodestillation of leaves of Decatropis bicolor was studied for its biological activity against breast cancer cells MDA-MB-231 by MTT assay, Hematoxylin-eosin stain, Annexin V-FITC, TUNEL and western blot assays and for its chemical composition by GC-MS...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27461927/a-practical-synthesis-of-chiral-tricyclic-cyclopenta-b-benzofuran-a-key-intermediate-of-beraprost
#11
Xiaoyu Liu, Chengsen Tian, Xiaozhen Jiao, Xiaoyu Li, Hongguang Yang, Yangyang Yao, Ping Xie
A novel formal synthesis of Beraprost (1) is described. The tricyclic cyclopent[b]benzofuran core is efficiently prepared from (-)-Corey lactone diol in 12 steps with an overall yield of 37.4%. Key features of the strategy include a ring-closing metathesis reaction and aromatization to form the tricyclic cyclopenta[b]benzofuran framework, and selective halogenation/formylation to install the butyrate side-chain.
August 10, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27394709/cyclopes-and-giants-from-homer-s-odyssey-to-contemporary-genetic-diagnosis
#12
Georgios K Markantes, Anastasia Theodoropoulou, Anastasia K Armeni, Vasiliki Vasileiou, Constantine A Stratakis, Neoklis A Georgopoulos
No abstract text is available yet for this article.
July 11, 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27377428/morphological-convergence-in-the-pubis-of-slow-moving-primates-and-xenarthrans
#13
Kristi L Lewton, Heather L Dingwall
OBJECTIVES: Determining the functional significance of pubic rami is important for reconstructing locomotor behavior of fossil species. The slow loris pelvis, characterized by long pubic rami, is unusual among primates. Long pubic rami may be related to increasing the moment arm of the abdominal musculature during ventroflexion after the termination of hindlimb suspension, which is a common component of slow arboreal quadrupedalism (AQ). Some extant xenarthran species are also slow AQ taxa, and provide an ideal group to test hypotheses of morphologically convergent adaptations to slow AQ...
July 5, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27198759/the-difference-in-clinical-outcome-of-single-bundle-anterior-cruciate-ligament-reconstructions-with-and-without-remnant-preservation-a-meta-analysis
#14
REVIEW
Kai Tie, Liaobin Chen, Dongcai Hu, Hua Wang
BACKGROUND: The aim of this study was to compare the clinical performance and complications between an ACL reconstruction with a remnant-preserving single-bundle technique and a standard single-bundle technique. METHODS: A search was performed of RCTs comparing the clinical outcomes and complications of ACL reconstruction with remnant-preserving and standard single-bundle techniques during October 2014. Relevant data were extracted and CONSORT was used to assess the methodological quality...
August 2016: Knee
https://www.readbyqxmd.com/read/27162746/dracunculiasis-in-oral-and-maxillofacial-surgery
#15
REVIEW
Soung Min Kim
Dracunculiasis, otherwise known as guinea worm disease (GWD), is caused by infection with the nematode Dracunculus medinensis. This nematode is transmitted to humans exclusively via contaminated drinking water. The transmitting vectors are Cyclops copepods (water fleas), which are tiny free-swimming crustaceans usually found abundantly in freshwater ponds. Humans can acquire GWD by drinking water that contains vectors infected with guinea worm larvae. This disease is prevalent in some of the most deprived areas of the world, and no vaccine or medicine is currently available...
April 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/27124652/algal-diet-of-small-bodied-crustacean-zooplankton-in-a-cyanobacteria-dominated-eutrophic-lake
#16
Ilmar Tõnno, Helen Agasild, Toomas Kõiv, Rene Freiberg, Peeter Nõges, Tiina Nõges
Small-bodied cladocerans and cyclopoid copepods are becoming increasingly dominant over large crustacean zooplankton in eutrophic waters where they often coexist with cyanobacterial blooms. However, relatively little is known about their algal diet preferences. We studied grazing selectivity of small crustaceans (the cyclopoid copepods Mesocyclops leuckarti, Thermocyclops oithonoides, Cyclops kolensis, and the cladocerans Daphnia cucullata, Chydorus sphaericus, Bosmina spp.) by liquid chromatographic analyses of phytoplankton marker pigments in the shallow, highly eutrophic Lake Võrtsjärv (Estonia) during a seasonal cycle...
2016: PloS One
https://www.readbyqxmd.com/read/27115681/a-ccamk-cyclops-della-complex-activates-transcription-of-ram1-to-regulate-arbuscule-branching
#17
Priya Pimprikar, Samy Carbonnel, Michael Paries, Katja Katzer, Verena Klingl, Monica J Bohmer, Leonhard Karl, Daniela S Floss, Maria J Harrison, Martin Parniske, Caroline Gutjahr
No abstract text is available yet for this article.
April 25, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27100902/base-free-conditions-for-rhodium-catalyzed-asymmetric-arylation-to-produce-stereochemically-labile-%C3%AE-aryl-ketones
#18
Xiaowei Dou, Yixin Lu, Tamio Hayashi
The asymmetric arylation of 2,2-dialkyl cyclopent-4-ene-1,3-diones with aryl boronic acids was found to be efficiently catalyzed by a chiral diene-rhodium μ-chloro dimer, [{RhCl((R)-diene*)}2 ], in the absence of bases in toluene/H2 O to give 2,2-dialkyl 4-aryl cyclopentane-1,3-diones in high yields with high enantioselectivity. Such compounds can not be obtained with high enantiomeric purity under the standard basic conditions used for rhodium-catalyzed asymmetric arylation because the α-aryl ketone products undergo racemization under the basic conditions...
June 1, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27077952/the-apelin-receptor-enhances-nodal-tgf%C3%AE-signaling-to-ensure-proper-cardiac-development
#19
Ashish R Deshwar, Serene C Chng, Lena Ho, Bruno Reversade, Ian C Scott
The Apelin receptor (Aplnr) is essential for heart development, controlling the early migration of cardiac progenitors. Here we demonstrate that in zebrafish Aplnr modulates Nodal/TGFβ signaling, a key pathway essential for mesendoderm induction and migration. Loss of Aplnr function leads to a reduction in Nodal target gene expression whereas activation of Aplnr by a non-peptide agonist increases the expression of these same targets. Furthermore, loss of Aplnr results in a delay in the expression of the cardiogenic transcription factors mespaa/ab...
2016: ELife
https://www.readbyqxmd.com/read/27020747/a-ccamk-cyclops-della-complex-activates-transcription-of-ram1-to-regulate-arbuscule-branching
#20
Priya Pimprikar, Samy Carbonnel, Michael Paries, Katja Katzer, Verena Klingl, Monica J Bohmer, Leonhard Karl, Daniela S Floss, Maria J Harrison, Martin Parniske, Caroline Gutjahr
Intracellular arbuscular mycorrhiza symbiosis between plants and glomeromycotan fungi leads to formation of highly branched fungal arbuscules that release mineral nutrients to the plant host. Their development is regulated in plants by a mechanistically unresolved interplay between symbiosis, nutrient, and hormone (gibberellin) signaling. Using a positional cloning strategy and a retrotransposon insertion line, we identify two novel alleles of Lotus japonicus REDUCED ARBUSCULAR MYCORRHIZA1 (RAM1) encoding a GRAS protein...
April 25, 2016: Current Biology: CB
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