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https://www.readbyqxmd.com/read/28818464/one-pot-synthesis-of-bioactive-cyclopentenones-from-%C3%AE-linolenic-acid-and-docosahexaenoic-acid
#1
Daniel Maynard, Sara Mareike Müller, Monika Hahmeier, Jana Löwe, Ivo Feussner, Harald Gröger, Andrea Viehhauser, Karl-Josef Dietz
Oxidation products of the poly-unsaturated fatty acids (PUFAs) arachidonic acid, α-linolenic acid and docosahexaenoic acid are bioactive in plants and animals as shown for the cyclopentenones prostaglandin 15d-PGJ2 and PGA2, cis-(+)-12-oxophytodienoic acid (12-OPDA), and 14-A-4 neuroprostane. In this study an inexpensive and simple enzymatic multi-step one-pot synthesis is presented for 12-OPDA, which is derived from α-linolenic acid, and the analogous docosahexaenoic acid (DHA)-derived cyclopentenone [(4Z,7Z,10Z)-12-[[-(1S,5S)-4-oxo-5-(2Z)-pent-2-en-1yl]-cyclopent-2-en-1yl] dodeca-4,7,10-trienoic acid, OCPD]...
August 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28789611/role-of-the-gras-transcription-factor-ata-ram1-in-the-transcriptional-reprogramming-of-arbuscular-mycorrhiza-in-petunia-hybrida
#2
Mélanie K Rich, Pierre-Emmanuel Courty, Christophe Roux, Didier Reinhardt
BACKGROUND: Development of arbuscular mycorrhiza (AM) requires a fundamental reprogramming of root cells for symbiosis. This involves the induction of hundreds of genes in the host. A recently identified GRAS-type transcription factor in Petunia hybrida, ATA/RAM1, is required for the induction of host genes during AM, and for morphogenesis of the fungal endosymbiont. To better understand the role of RAM1 in symbiosis, we set out to identify all genes that depend on activation by RAM1 in mycorrhizal roots...
August 8, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28690383/molecular-docking-based-screening-of-listeriolysin-o-for-improved-inhibitors
#3
Sara Ghafari, Matin Komeilian, Mohaddese Sadat Hashemi, Sareh Oushani, Garshasb Rigi, Behnam Rashidieh, Kamran Yarahmadi, Fatemeh Khoddam
Listeriolysine-O (LLO) is a 50KDa protein responsible for Listeria monocytogenes pathogenicity. The structure of LLO (PDB ID: 4CDB) with domains D1 to D4 is known. Therefore, it is of interest to identify conserved regions among LLO variants for destabilizing oligomerization (50 mer complex) of its monomers using appropriate inhibitors. Therefore, it is of interest to identify suitable inhibitors for inhibiting LLO. Previous reports suggest the use of flavanoids like compounds for inhibiting LLO. Our interest is to identify improved compounds to destabilize LLO oligomerization...
2017: Bioinformation
https://www.readbyqxmd.com/read/28670852/chemical-composition-antioxidant-properties-%C3%AE-glucosidase-inhibitory-and-antimicrobial-activity-of-essential-oils-from-acacia-mollissima-and-acacia-cyclops-cultivated-in-tunisia
#4
Amira Jelassi, Manel Hassine, Malek Besbes Hlila, Hichem Ben Jannet
The genus Acacia is quite large and can be found in the warm subarid and arid parts but little is known about its chemistry, specially the volatile parts. The volatile oils from fresh flowers of A. mollissima and A. cyclops (growing in Tunisia) obtained by hydrodistillation were analyzed by GC then GC-MS. 18 (94.7% of the total oil composition) and 23 (97.4%) compounds were identified in these oils, respectively. (E,E)-α-Farnesene (51.5%) and (E)-cinnamyl alcohol (10.7%) constituted the major compounds of the flower oil of A...
July 3, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28657903/light-induced-photoisomerization-of-a-diarylethene-molecular-switch-on-solid-surfaces
#5
Fabian Nickel, Matthias Bernien, Martin Herder, Sandro Wrzalek, Pantelis Chittas, Kai Kraffert, Lucas Machado Arruda, Lalminthang Kipgen, Dennis Krüger, Stefan Hecht, Wolfgang Kuch
Diarylethene is a molecular switch, the state of which can efficiently be controlled by illumination with ultraviolet or visible light. To use the change in the molecular properties when switching between the two states for a specific function, direct contact with solid surfaces is advantageous as they provide immobilization. Here we present a study of a diarylethene derivate (T-DAE, 1,2-bis(5-methyl-2-phenylthiazol-4-yl)cyclopent-1-ene) in direct contact with a highly ordered graphite as well as with the semimetallic Bi(111) surface by x-ray photoelectron spectroscopy, x-ray absorption spectroscopy, and simulated spectra based on density functional theory...
June 28, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28653590/guinea-worm-from-robert-leiper-to-eradication
#6
Ahmed Tayeh, Sandy Cairncross, Francis E G Cox
Guinea worm disease, dracunculiasis or dracontiasis, is an ancient disease with records going back over 4500 years, but until the beginning of the 20th century, little was known about its life cycle, particularly how humans became infected. In 1905, Robert Thomas Leiper was sent by the British colonial authorities to West Africa to investigate the spread of Guinea worm disease and to recommend measures to prevent it. While carrying out his investigations, he made important contributions to the aetiology, epidemiology and public health aspects of Guinea worm disease and provided definitive answers to many outstanding questions...
June 27, 2017: Parasitology
https://www.readbyqxmd.com/read/28643449/morphology-of-the-tongue-of-vermilingua-xenarthra-pilosa-and-evolutionary-considerations
#7
Daniel M Casali, Elisângela Martins-Santos, André L Q Santos, Flávia R Miranda, Germán A B Mahecha, Fernando A Perini
The tongue of anteaters (Xenarthra, Pilosa, Vermilingua) is a highly specialized for myrmecophagy. Here, we describe the topography and histology of the tongue, and compare it to that of other xenarthrans and other myrmecophagous eutherian mammals. The tongue of Vermilingua is long and slender, with an apical protuberance, which differs between Myrmecophagidae and Cyclopes didactylus. In the former, the rostral region is conical, and in the latter, it is dorsoventrally compressed, as observed in sloths. The tongue of Vermilingua has filiform and circumvallate papillae on the surface; foliate and fungiform papillae are absent...
June 22, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28609898/fauna-of-cladocera-and-copepoda-from-xinjiang-uyghur-autonomous-region-china
#8
Elena S Chertoprud, Artem Y Sinev, Inta Dimante-Deimantovica
This study evaluates the species composition of Cladocera and Copepoda in the five lakes of the Bogda-Shan Mountain range and in the floodplain of the Tarim and Konchedarya rivers located in the Xinjiang Uygur Autonomous Region of China (Xinjiang). We collected seven species of Cladocera and six species of Copepoda. Seven species were identified as new for Xinjiang fauna, and two species (Cyclops cf. herberti Einsle, 1996, and Eucyclops roseus Ishida, 1997) were first records for China. Herein, we characterize the distribution ranges for the detected species and provide taxonomic remarks...
May 3, 2017: Zootaxa
https://www.readbyqxmd.com/read/28592297/negative-anti-neutrophil-cytoplasm-antibody-at-switch-to-maintenance-therapy-is-associated-with-a-reduced-risk-of-relapse
#9
Matthew David Morgan, Matthew Szeto, Michael Walsh, David Jayne, Kerstin Westman, Niels Rasmussen, Thomas F Hiemstra, Oliver Flossmann, Annelies Berden, Peter Höglund, Lorraine Harper
BACKGROUND: Relapse of disease is frequent in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). It is unclear whether persistent ANCA when starting maintenance therapy increases the risk of relapse. We examined the association between ANCA status and relapse in two randomised controlled trials. METHODS: ANCA-positive patients in two trials, CYCLOPS and IMPROVE, were switched from cyclophosphamide to maintenance therapy after achieving clinical remission...
June 7, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28503742/the-ern1-transcription-factor-gene-is-a-target-of-the-ccamk-cyclops-complex-and-controls-rhizobial-infection-in%C3%A2-lotus-japonicus
#10
Marion R Cerri, Quanhui Wang, Paul Stolz, Jessica Folgmann, Lisa Frances, Katja Katzer, Xiaolin Li, Anne B Heckmann, Trevor L Wang, J Allan Downie, Andreas Klingl, Fernanda de Carvalho-Niebel, Fang Xie, Martin Parniske
Bacterial accommodation inside living plant cells is restricted to the nitrogen-fixing root nodule symbiosis. In many legumes, bacterial uptake is mediated via tubular structures called infection threads (ITs). To identify plant genes required for successful symbiotic infection, we screened an ethyl methanesulfonate mutagenized population of Lotus japonicus for mutants defective in IT formation and cloned the responsible gene, ERN1, encoding an AP2/ERF transcription factor. We performed phenotypic analysis of two independent L...
May 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/28439010/cyclops-reveals-human-transcriptional-rhythms-in-health-and-disease
#11
Ron C Anafi, Lauren J Francey, John B Hogenesch, Junhyong Kim
Circadian rhythms modulate many aspects of physiology. Knowledge of the molecular basis of these rhythms has exploded in the last 20 years. However, most of these data are from model organisms, and translation to clinical practice has been limited. Here, we present an approach to identify molecular rhythms in humans from thousands of unordered expression measurements. Our algorithm, cyclic ordering by periodic structure (CYCLOPS), uses evolutionary conservation and machine learning to identify elliptical structure in high-dimensional data...
May 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28278641/a-new-azadirachta-from-the-crude-extracts-of-neem-azadirachta-indica-a-juss-seeds
#12
Quan Gao, Jia Sun, Hang Xun, Xi Yao, Jin Wang, Feng Tang
One new compound, 2H, 3H-cyclopent[b] furo [2',3':4,5] naphtho [2,4-d] heptlactone-[3,7] furan-6aceticacid, 3-(acetyloxy)-8-(3-furyl)-2a, 4a, 4b, 4c,5,5a, 6, 6a, 8, 9,9a, 10a,10b-13 hydrogen-2a,5a,6a,5-tetramethyl-3-[[(2E)-2-methyl-1-oxo-2-butenyl]oxy]-methyl ester, named azadirachta R (1), along with 10 known ones, Azadirachta A, AZ-B, AZ-D, AZ-H, AZ-I, nimbin, deacetylnimbin, salannin, deacetylsalannin and azadiradione were isolated from the crude extracts of neem (Azadirachta indica A. Juss) seeds, which were determined by UV, IR, HR-ESI-MS and NMR data analyses...
February 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28203602/hamstring-contracture-after-acl-reconstruction-is-associated-with-an-increased-risk-of-cyclops-syndrome
#13
Francisco Guerra Pinto, Mathieu Thaunat, Matt Daggett, Charles Kajetanek, Tiago Marques, Tales Guimares, Bénédicte Quelard, Bertrand Sonnery-Cottet
BACKGROUND: Cyclops syndrome is characterized by loss of terminal knee extension due to proliferative fibrous nodule formation in the intercondylar notch. This complication occurs in the early postoperative period after anterior cruciate ligament reconstruction (ACLR). The pathogenesis of Cyclops syndrome is not well understood. HYPOTHESIS: Persistent hamstring contracture after ACLR is associated with an increased risk of subsequent Cyclops syndrome. STUDY DESIGN: Case-control study; Level of evidence, 3...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28199442/phylogeographic-history-of-south-american-populations-of-the-silky-anteater-cyclopes-didactylus-pilosa-cyclopedidae
#14
Raphael Teodoro Franciscani Coimbra, Flávia Regina Miranda, Camila Clozato Lara, Marco Antônio Alves Schetino, Fabrício Rodrigues Dos Santos
Cyclopes didactylus, commonly called silky anteater, is the smallest and least studied of the anteaters. It is an arboreal species occurring in rainforests, ranging from southern Mexico to Central and South America, with an apparently disjoint distribution between Amazon and Atlantic rainforests in Brazil. Although seven subspecies are recognized, little is known about its geographical variation. Thus, to evaluate the population dynamics and evolutionary history of the South American silky anteater, we analyzed 1542 bp sequences of the mitochondrial control region (CR), COI and Cyt-b genes of 32 individuals...
January 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28177281/copy-number-and-gene-dependency-analysis-reveals-partial-copy-loss-of-wild-type-sf3b1-as-a-novel-cancer-vulnerability
#15
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context of particular copy-number alterations (copy-number associated gene dependencies). The most enriched class of copy-number associated gene dependencies was CYCLOPS (Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS) genes, and spliceosome components were the most prevalent...
February 8, 2017: ELife
https://www.readbyqxmd.com/read/28171683/electronic-properties-of-optically-switchable-photochromic-diarylethene-molecules-at-the-interface-with-organic-semiconductors
#16
Qiankun Wang, Johannes Frisch, Martin Herder, Stefan Hecht, Norbert Koch
Light-switching-induced changes in the electronic properties of photochromic diarylethene, i.e., 1,2-bis(2-methyl-5-p-tolylthiophen-3-yl)cyclopent-1-ene (DAE1), thin films at interfaces to a gold electrode and two polymer semiconductors are investigated by direct and inverse photoelectron spectroscopy. The photoisomerization is achieved by in situ irradiation of ultraviolet and visible light. Efficient and reversible switching between the open and closed isomers of DAE1 is evidenced at all interfaces, with profound impact on the energy-level alignment...
February 7, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28128475/cyclops-lesions-are-associated-with-altered-gait-patterns-and-medial-knee-joint-cartilage-degeneration-at-1-year-after-acl-reconstruction
#17
Michael A Samaan, Luca Facchetti, Valentina Pedoia, Matthew S Tanaka, Thomas M Link, Richard B Souza, C Benjamin Ma, Xiaojuan Li
In this exploratory study, gait analysis and quantitative MRI (QMRI) were used to assess biomechanical differences in patients that present with cyclops lesions at 12 months after ACL-reconstruction (ACLR). Thirty ACLR patients without and 10 ACLR patients with cyclops lesions underwent 3T MR T1ρ mapping of the reconstructed knee joint prior to ACLR and at 12 months after ACLR, as well as a gait assessment during a fixed walking speed at 12 months after ACLR. Both external sagittal and frontal plane knee joint moments and joint moment impulses were calculated and assessed throughout the stance phase of gait...
January 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28068194/the-ethylene-responsive-factor-required-for-nodulation-1-ern1-transcription-factor-is-required-for-infection-thread-formation-in-lotus-japonicus
#18
Yasuyuki Kawaharada, Euan K James, Simon Kelly, Niels Sandal, Jens Stougaard
Several hundred genes are transcriptionally regulated during infection-thread formation and development of nitrogen-fixing root nodules. We have characterized a set of Lotus japonicus mutants impaired in root-nodule formation and found that the causative gene, Ern1, encodes a protein with a characteristic APETALA2/Ethylene Responsive Factor (AP2/ERF) transcription-factor domain. Phenotypic characterization of four ern1 alleles shows that infection pockets are formed but root-hair infection threads are absent...
March 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28028038/function-and-evolution-of-a-lotus-japonicus-ap2-erf-family-transcription-factor-that-is-required-for-development-of-infection-threads
#19
Koji Yano, Seishiro Aoki, Meng Liu, Yosuke Umehara, Norio Suganuma, Wataru Iwasaki, Shusei Sato, Takashi Soyano, Hiroshi Kouchi, Masayoshi Kawaguchi
Legume-rhizobium symbiosis is achieved by two major events evolutionarily acquired: root hair infection and organogenesis. Infection thread (IT) development is a distinct element for rhizobial infection. Through ITs, rhizobia are efficiently transported from infection foci on root hairs to dividing meristematic cortical cells. To unveil this process, we performed genetic screening using Lotus japonicus MG-20 and isolated symbiotic mutant lines affecting nodulation, root hair morphology, and IT development. Map-based cloning identified an AP2/ERF transcription factor gene orthologous to Medicago truncatula ERN1 LjERN1 was activated in response to rhizobial infection and depended on CYCLOPS and NSP2...
December 27, 2016: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28027968/establishment-of-the-complete-life-cycle-of-spirometra-cestoda-diphyllobothriidae-in-the-laboratory-using-a-newly-isolated-triploid-clone
#20
Tetsuya Okino, Hiroshi Ushirogawa, Kumiko Matoba, Shin-Ichiro Nishimatsu, Mineki Saito
Methods to maintain the life cycle of pathogenic organisms become powerful tools for studying molecular and cellular bases of infectious diseases. Spirometra erinaceieuropaei is a parasitic tapeworm that causes sparganosis in humans. Because S. erinaceieuropaei has a complex life cycle with different stages and host species requirements, there have been no reports to establish the complete life cycle in the laboratory. In this study, using Cyclops as the first intermediate host, mouse as the experimental second intermediate host, and dog as the final host, we succeeded in maintaining S...
April 2017: Parasitology International
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