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Yasuyuki Kawaharada, Euan K James, Simon Kelly, Niels Sandal, Jens Stougaard
Several hundred genes are transcriptionally regulated during infection thread formation and development of nitrogen fixing root nodules. We have characterized a set of Lotus japonicus mutants impaired in root nodule formation and found that the causative gene, Ern1, encodes a protein with a characteristic APETALA2/Ethylene Responsive Factor (AP2/ERF) transcription factor domain. Phenotypic characterisation of four ern1 alleles shows that infection pockets are formed but root hair infection threads are absent...
January 9, 2017: Molecular Plant-microbe Interactions: MPMI
Koji Yano, Seishiro Aoki, Meng Liu, Yosuke Umehara, Norio Suganuma, Wataru Iwasaki, Shusei Sato, Takashi Soyano, Hiroshi Kouchi, Masayoshi Kawaguchi
Legume-rhizobium symbiosis is achieved by two major events evolutionarily acquired: root hair infection and organogenesis. Infection thread (IT) development is a distinct element for rhizobial infection. Through ITs, rhizobia are efficiently transported from infection foci on root hairs to dividing meristematic cortical cells. To unveil this process, we performed genetic screening using Lotus japonicus MG-20 and isolated symbiotic mutant lines affecting nodulation, root hair morphology, and IT development. Map-based cloning identified an AP2/ERF transcription factor gene orthologous to Medicago truncatula ERN1 LjERN1 was activated in response to rhizobial infection and depended on CYCLOPS and NSP2...
December 27, 2016: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
Tetsuya Okino, Hiroshi Ushirogawa, Kumiko Matoba, Shin-Ichiro Nishimatsu, Mineki Saito
Methods to maintain the life cycle of pathogenic organisms become powerful tools for studying molecular and cellular bases of infectious diseases. Spirometra erinaceieuropaei is a parasitic tapeworm that causes sparganosis in humans. Because S. erinaceieuropaei has a complex life cycle with different stages and host species requirements, there have been no reports to establish the complete life cycle in the laboratory. In this study, using Cyclops as the first intermediate host, mouse as the experimental second intermediate host, and dog as the final host, we succeeded in maintaining S...
December 24, 2016: Parasitology International
Luca Facchetti, Benedikt J Schwaiger, Alexandra S Gersing, Julio Brandao Guimaraes, Lorenzo Nardo, Sharmila Majumdar, Benjamin C Ma, Thomas M Link, Xiaojuan Li
OBJECTIVES: To assess the impact of cyclops lesions with MRI in patients treated for anterior cruciate ligament (ACL) tears on clinical outcome. METHODS: In 113 patients (age 29.8 ± 10.5y; 55 females; BMI 24.8 ± 3.7 kg/m(2)) with complete ACL tear, 3 T-MRI scans were obtained before, 6-months, 1-year (n = 75) and 2-years (n = 33) after ACL reconstruction. Presence and volume of cyclops lesions were assessed. Clinical outcomes were measured using the Knee injury and Osteoarthritis Outcome Score (KOOS) and differences between time points (∆KOOS) were calculated...
December 16, 2016: European Radiology
Meijun Lu, Qing-Bin Lu, John F Honek
Squaric acid and its derivatives are versatile synthons and have demonstrated applications in medicinal chemistry, notably as non-classical bioisosteric replacements for functional groups such as carboxylic acids, alpha-amino acids, urea, guanidine, peptide bonds and phosphate/pyrophosphate linkages. Surprisingly, no reports have appeared concerning its possible application as a nucleobase substitute in nucleosides. A preliminary investigation of such an application is reported herein. 3-Amino-4-((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino-cyclobut-3-ene-1,2-dione, 3-((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino-4-methoxycyclobut-3-ene-1,2-dione, and 3-hydroxy-4-((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino-cyclobut-3-ene-1,2-dione sodium salt were synthesized...
January 15, 2017: Bioorganic & Medicinal Chemistry Letters
Dengke Ma, Chunling Fu, Shengming Ma
Cyclopent-2-enone-4-ols have been prepared highly diastereoselectively from readily available aromatic aldehydes and 1,2-allenones catalyzed by N-heterocyclic carbene. Mechanistic studies showed that there are four possible pathways.
December 13, 2016: Chemical Communications: Chem Comm
Govardhana R Pinnelli, Nitin K Singh, Victoria Soroker, Erika Plettner
The preparation of enantiopure conformationally restricted alicyclic ethers and their inhibitory activities on the chemosensory organ of the Varroa destructor, a parasite of honey bees, are reported in this article. We tested the effect of enantiopure ethers of cis-5-(2'-hydroxyethyl)cyclopent-2-en-1-ol on the Varroa chemosensory organ by electrophysiology, for their ability to inhibit the responses to two honey bee-produced odors that are important for the mite to locate its host: nurse bee head space odor and (E)-β-ocimene, a honey bee brood pheromone...
November 16, 2016: Journal of Agricultural and Food Chemistry
Hermann O Mayr, Christian M Brandt, Thomas Weig, Manuel Koehne, Anke Bernstein, Norbert P Suedkamp, Robert Hube, Amelie Stoehr
PURPOSE: The current study was conducted to evaluate the long-term clinical and radiological outcomes after arthroscopic arthrolysis for arthrofibrosis after anterior cruciate ligament reconstruction (ACLR). METHODS: All patients treated with arthrolysis between 1990 and 1998 were included. Indication was arthrofibrosis in at least one knee compartment or a cyclops syndrome limiting range of motion (ROM) by > 5° of extension deficit and 15° of flexion deficit...
October 24, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Mingxing Qian, Elizabeth B Engler-Chiurazzi, Sara E Lewis, Nigam P Rath, James W Simpkins, Douglas F Covey
Estrone and 17β-estradiol are phenolic steroids that are known to be neuroprotective in multiple models of neuronal injury. Previous studies have identified the importance of their phenolic steroid A-ring for neuroprotection and have identified ortho substituents at the C-2 and C-4 positions on the phenol ring that enhance this activity. To investigate the importance of the steroid ring system for neuroprotective activity, phenolic compounds having the cyclopent[b]anthracene, cyclopenta[b]phenanthrene, benz[f]indene, benz[e]indene, indenes linked to a phenol, and a phenolic spiro ring system were prepared...
October 18, 2016: Organic & Biomolecular Chemistry
Lorenzo Maria Di Giacomo, Muhammad Shahid Khan, Luigi Piscitelli, Michele Bisaccia, Auro Caraffa
Anterior Cruciate ligament (ACL) is a typical athletic injury. One of the most frequent complication after ACL reconstruction is reduced range of motion (ROM) due to the impingement on the inter-condylar notch of a fibrous tissue mass, defined as Cyclops Syndrome. We report the case of a 25 years old male, who underwent reconstruction of ACL with Gracilis-semitendinosus (GR-ST) tendons with delayed onset of loss of knee extension seven years after ACL reconstruction. Clinical and magnetic resonance image (MRI) findings were consistent with Cyclops syndrome...
October 2016: JPMA. the Journal of the Pakistan Medical Association
Stacey M Cornelson, Alicia M Yochum, Norman W Kettner
OBJECTIVE: This case report describes magnetic resonance imaging (MRI) and diagnostic ultrasound (US) findings for a patient with arthrofibrosis related to a complication of anterior cruciate ligament (ACL) reconstruction. CLINICAL FEATURES: A 25-year old man presented with right knee pain and loss of extension 5 years after ACL reconstruction. MRI and sonographic examination revealed a soft tissue mass anterolateral to the ACL graft consistent with a cyclops lesion...
September 2016: Journal of Chiropractic Medicine
Wang Tian, Huayong Zhang, Lei Zhao, Xiang Xu, Hai Huang
The relationship between biodiversity and ecosystem functioning is a central issue in ecology. Previous studies have shown that producer diversity can impact the consumer community via predator-prey interactions. However, direct observations of this relationship remain rare, in particular for aquatic ecosystems. In this research, the relationship between phytoplankton diversity (species richness and evenness) and the abundance of copepods was analyzed in Lake Nansihu, a meso-eutrophic lake in China. The results showed that copepods abundance was significantly decreased with increasing phytoplankton evenness throughout the year...
2016: International Journal of Environmental Research and Public Health
Elmar Herbst, Christian Hoser, Peter Gföller, Caroline Hepperger, Elisabeth Abermann, Katharina Neumayer, Volker Musahl, Christian Fink
PURPOSE: The purpose of the present study is the comparison of acute ACL reconstruction with or without meniscus repair within 48 h after injury and a delayed surgery during the inflammation-free interval. It was hypothesized that acute ACL reconstruction results in inferior patient reported outcomes and higher frequency of range of motion deficits. METHODS: The effect of acute (within 48 h) and delayed (during the inflammation-free interval) ACL surgery was prospectively studied on 160 consecutive patients with ACL injury between January 2010 and December 2011...
August 22, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
C C Estanislao Gómez, A Aquino Carreño, D G Pérez Ishiwara, E San Martín Martínez, J Morales López, N Pérez Hernández, M C Gómez García
BACKGROUND: Decatropis bicolor (Zucc.)Radlk is a plant that has been traditionally used for the treatment of breast cancer in some communities of Mexico. So, the aim of this study was to determine the cytotoxic and apoptotic effect of the essential oil of Decatropis bicolor against breast cancer cell line, MDA-MB-231. METHODS: The essential oil obtained from hydrodestillation of leaves of Decatropis bicolor was studied for its biological activity against breast cancer cells MDA-MB-231 by MTT assay, Hematoxylin-eosin stain, Annexin V-FITC, TUNEL and western blot assays and for its chemical composition by GC-MS...
August 5, 2016: BMC Complementary and Alternative Medicine
Xiaoyu Liu, Chengsen Tian, Xiaozhen Jiao, Xiaoyu Li, Hongguang Yang, Yangyang Yao, Ping Xie
A novel formal synthesis of Beraprost (1) is described. The tricyclic cyclopent[b]benzofuran core is efficiently prepared from (-)-Corey lactone diol in 12 steps with an overall yield of 37.4%. Key features of the strategy include a ring-closing metathesis reaction and aromatization to form the tricyclic cyclopenta[b]benzofuran framework, and selective halogenation/formylation to install the butyrate side-chain.
August 10, 2016: Organic & Biomolecular Chemistry
Georgios K Markantes, Anastasia Theodoropoulou, Anastasia K Armeni, Vasiliki Vasileiou, Constantine A Stratakis, Neoklis A Georgopoulos
No abstract text is available yet for this article.
July 2016: Hormones: International Journal of Endocrinology and Metabolism
Kristi L Lewton, Heather L Dingwall
OBJECTIVES: Determining the functional significance of pubic rami is important for reconstructing locomotor behavior of fossil species. The slow loris pelvis, characterized by long pubic rami, is unusual among primates. Long pubic rami may be related to increasing the moment arm of the abdominal musculature during ventroflexion after the termination of hindlimb suspension, which is a common component of slow arboreal quadrupedalism (AQ). Some extant xenarthran species are also slow AQ taxa, and provide an ideal group to test hypotheses of morphologically convergent adaptations to slow AQ...
July 5, 2016: American Journal of Physical Anthropology
Kai Tie, Liaobin Chen, Dongcai Hu, Hua Wang
BACKGROUND: The aim of this study was to compare the clinical performance and complications between an ACL reconstruction with a remnant-preserving single-bundle technique and a standard single-bundle technique. METHODS: A search was performed of RCTs comparing the clinical outcomes and complications of ACL reconstruction with remnant-preserving and standard single-bundle techniques during October 2014. Relevant data were extracted and CONSORT was used to assess the methodological quality...
August 2016: Knee
Soung Min Kim
Dracunculiasis, otherwise known as guinea worm disease (GWD), is caused by infection with the nematode Dracunculus medinensis. This nematode is transmitted to humans exclusively via contaminated drinking water. The transmitting vectors are Cyclops copepods (water fleas), which are tiny free-swimming crustaceans usually found abundantly in freshwater ponds. Humans can acquire GWD by drinking water that contains vectors infected with guinea worm larvae. This disease is prevalent in some of the most deprived areas of the world, and no vaccine or medicine is currently available...
April 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
Ilmar Tõnno, Helen Agasild, Toomas Kõiv, Rene Freiberg, Peeter Nõges, Tiina Nõges
Small-bodied cladocerans and cyclopoid copepods are becoming increasingly dominant over large crustacean zooplankton in eutrophic waters where they often coexist with cyanobacterial blooms. However, relatively little is known about their algal diet preferences. We studied grazing selectivity of small crustaceans (the cyclopoid copepods Mesocyclops leuckarti, Thermocyclops oithonoides, Cyclops kolensis, and the cladocerans Daphnia cucullata, Chydorus sphaericus, Bosmina spp.) by liquid chromatographic analyses of phytoplankton marker pigments in the shallow, highly eutrophic Lake Võrtsjärv (Estonia) during a seasonal cycle...
2016: PloS One
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