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Endometrial biopsy

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https://www.readbyqxmd.com/read/29334205/overexpression-of-endometrial-estrogen-receptor-alpha-in-the-window-of-implantation-in-women-with-unexplained-infertility
#1
Mehran Dorostghoal, Hamid-O-Allah Ghaffari, Farideh Marmazi, Narjes Keikhah
Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during implantation may be a critical event that coincides with the expression of specific genes and the formation of a receptive endometrium. The aim of the present study was to assess the expression of ER-α in the mid-secretory phase in the endometrium of women with unexplained infertility...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29332643/role-of-laparoscopy-in-diagnosing-genital-tuberculosis-in-suspected-women-a-cross-sectional-study-from-a-tertiary-care-hospital-in-northern-india
#2
Y M Mala, Ruchi Prasad, Nilanchali Singh, C P Baweja, Reva Tripathi, Niharika Yedla
This study was included 60 women with suspected genital tuberculosis, attending outpatient department of a tertiary care hospital. The aim was to evaluate the role and accuracy of laparoscopy in the diagnosis of genital tuberculosis. The patients were investigated for tuberculosis with Erythrocyte Sedimentation Rate, Montoux, chest X-ray, serum ELISA, CA125, ultrasonography, endometrial biopsy and laparoscopic biopsy. Culture or histopathology was taken as a gold standard for confirming the cases of genital tuberculosis...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29328024/endometrial-polyps-in-women-of-reproductive-age-clinical-and-pathogene-tic-variations
#3
N Kosei, N Zakharenko, D Herman
The aim of the study was to study the relationship between the morphofunctional characteristics of the endometrium, hormonal homeostasis and microbiocenosis of the reproductive system in patients with endometrial polyps. The study involved 130 patients aged 18-35 years: 34 patients with endometrial polyps, 30 patients with micropolyps, 36 patients with endometrial polyps and micropolyps, 30 healthy women of the control group. Hysteroscopy was performed for women who had been suspected for endometrial polyps and who had infertility or repeated recurrent miscarriages...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29315421/development-of-a-new-comprehensive-and-reliable-endometrial-receptivity-map-er-map-er-grade-based-on-rt-qpcr-gene-expression-analysis
#4
M Enciso, J P Carrascosa, J Sarasa, P A Martínez-Ortiz, S Munné, J A Horcajadas, J Aizpurua
STUDY QUESTION: Is it possible to determine the receptivity status of an endometrium by combined quantitative reverse transcription PCR (RT-qPCR) expression analysis of genes involved in endometrial proliferation and immunity? SUMMARY ANSWER: The new ER Map®/ER Grade® test can predict endometrial receptivity status by RT-qPCR using a new panel of genes involved in endometrial proliferation and the maternal immune response associated to embryonic implantation. WHAT IS KNOWN ALREADY: The human endometrium reaches a receptive status adequate for embryonic implantation around Days 19-21 of the menstrual cycle...
January 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29314167/comparative-histomorphological-study-of-endometrium-in-mares
#5
M Herrera, J M Herrera, S Cantatore, J Aguilar, A Felipe, E Fumuso
Uterine acute post-breeding inflammation is a physiological tissue response to the entry of exogenous elements, with persistent endometritis being the main pathology responsible for subfertility in the mare (Equus ferus caballus; Linnaeus, 1758). Mares can be classified as susceptible or resistant to endometritis according to their ability to remove intrauterine fluid within 48 hr after experimental inoculation. Endometrial biopsy is a technique that is commonly used to establish the degree of lesions that can affect the fertility of the mare...
January 3, 2018: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29306233/vanishing-endometrial-carcinoma-in-hysterectomy-specimens-probable-implications-for-fertility-sparing-management
#6
Murat Öz, Alper Karalök, Levent Şirvan, Tolga Taşçı, Reyhan Öcalan, Ahmet Taner Turan, Tayfun Güngör, Mehmet Mutlu Meydanlı
Background/aim: The vanishing cancer phenomenon was first reported in radical prostatectomy specimens in the absence of neo-adjuvant treatment. Reported cases are mostly well-differentiated and low-volume tumors. A similar entity was described for hysterectomy specimens of patients with biopsy proven endometrial cancer (EC). In this study, we discuss the probable reasons for vanishing EC and long-term follow-up results of EC patients without residual tumors in hysterectomy specimens. Materials and methods: This study was carried at two institutions in Ankara, Turkey, in a retrospective design...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29303931/prognostic-significance-of-omental-disease-and-the-role-of-omental-sampling-in-patients-with-uterine-carcinosarcoma
#7
Malcolm Strachan Ross, Esther Elishaev, Jessica Layne Berger, Joseph Leo Kelley, Sarah Elizabeth Taylor
OBJECTIVES: Uterine carcinosarcomas are an aggressive and rare form of endometrial cancer. Omentectomy is not part of routine staging, but biopsy is often done because omental disease is a known poor prognostic indicator. We sought to define the role of routine omental sampling during surgical staging. METHODS/MATERIALS: Patients who underwent staging for uterine carcinosarcoma at our institution from January 2000 to December 2013 were identified. Clinical and pathological data were abstracted...
January 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29299770/a-role-for-the-endometrial-microbiome-in-dysfunctional-menstrual-bleeding
#8
Elise S Pelzer, Dana Willner, Melissa Buttini, Flavia Huygens
This study aimed to characterise the microbial community within the endometrial cavity and endocervix in women with menorrhagia or dysmenorrhea. Paired endocervical and endometrial biopsy samples were collected from women undergoing operative hysteroscopy and/or laparoscopy. Samples were cohorted based on pathology, indications for surgery, and histological dating of the endometrium. Samples were interrogated for the presence of microbial DNA using a two-step next generation sequencing technology approach to exploit the V5-V8 regions of the 16S rRNA gene...
January 3, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29297956/hysteroscopy-after-repeated-implantation-failure-of-assisted-reproductive-technology-a-meta-analysis
#9
REVIEW
Hanyu Cao, Di You, Mingwei Yuan, Mingrong Xi
We conducted this meta-analysis to explore the prognostic value of outpatient (or office) hysteroscopy (OH) preceding in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles in women who had experienced repeated implantation failure (RIF), particularly in regard to the conflicting evidence reported by previous studies. Two reviewers independently searched Pubmed, MEDLINE, Web of Science, Cochrane Library and Embase to identify all publications of clinical trials of hysteroscopy with or without endometrial biopsy in RIF patients...
January 3, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29288227/endobronchial-metastasis-of-mixed-mullerian-tumour-of-the-uterus
#10
Vadsala Baskaran, Laura Pugh, Robert James Berg, John Anderson
Endobronchial metastasis occurs in only 2%-5% of non-pulmonary cancers. Here we report on an 84-year-old woman who presented with breathlessness and light-headedness while on holiday in Australia, 2 years post-treatment for endometrial cancer. Initial CT pulmonary angiogram identified a soft tissue mass in the left hemithorax. A chest radiograph performed after repatriation was consistent with a large left pleural effusion, but bedside ultrasound showed a lobulated mass involving the left hemidiaphragm. A pleural procedure in the traditional 'triangle of safety' would have resulted in inadvertent puncture of the underlying mass...
December 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29285481/comparing-the-frequency-of-endometritis-in-unexplained-infertility-and-anovulatory-infertility
#11
Ataollah Ghahiri, Bahare Malekzadeh, Hatav Ghassemi Tehrani
Background: Acute pelvic inflammatory disease (PID) is a common reason for infertility. This study aimed to evaluate the frequency distribution of endometritis in women with unexplained infertility and comparison with frequency distribution of endometritis in anovulatory infertility to identify the importance of endometritis due to subacute PID evaluation in the case of infertility. Materials and Methods: This case-control study was done on 100 women with unexplained infertility and ovulatory infertility who referred to Shahid Beheshti clinic in 2013 in Isfahan, Iran...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29284899/myometrium-invasion-tumour-size-and-lymphovascular-invasion-as-a-prognostic-factor-in-dissemination-of-pelvic-lymphatics-at-endometrial-carcinoma
#12
Nenad Lucic, Dragica Draganovic, Sanja Sibincic, Vesna Ecim-Zlojutro, Snjezana Milicevic
Objective: The aim of this work is to show the importance of the depth of myometrium invasion, tumour size and lymphovascular invasion as prognostic factors in dissemination of lymphatic nodes at endometrial carcinoma (CE). Materials and methods: In the period from 2010 to 2015 at the University Clinic for Gynecology and Obstetrics in Banja Luka, 221 endometrial cancer surgeries were done (laparatomy 184-83%, laparascopy 37-16,74%). Patients who had uterus bleeding in peri/postmenopause or those whose endometrium thickness was bigger than 5 mm which was established by ultrasound, or those who had in their cavum uteri pathological (PH) diagnosis, underwent fractional curettage (FC) or hysteroscopy in order to obtain pathohistological endometrium diagnosis...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29273307/sentinel-lymph-node-biopsy-in-endometrial-cancer-feasibility-safety-and-lymphatic-complications
#13
Barbara Geppert, Céline Lönnerfors, Michele Bollino, Jan Persson
OBJECTIVE: To compare the rate of lymphatic complications in women with endometrial cancer undergoing sentinel lymph node biopsy versus a full pelvic and infrarenal paraaortic lymphadenectomy, and to examine the overall feasibility and safety of the former. METHODS: A prospective study of 188 patients with endometrial cancer planned for robotic surgery. Indocyanine green was used to identify the sentinel lymph nodes. In low-risk patients the lymphadenectomy was restricted to removal of sentinel lymph nodes whereas in high-risk patients also a full lymphadenectomy was performed...
December 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29250656/immunohistochemical-reaction-of-the-glandular-epithelium-in-endometrial-hyperplasia-compared-to-endometrial-carcinoma
#14
Victor Emanuel Stoenescu, Mihaela Niculescu, Liliana Novac, Maria Magdalena Manolea, Paul Ioan Tomescu, Anda Lorena Dijmărescu, Marius Bogdan Novac, Ştefania Tudorache, Dominic Gabriel Iliescu
The histopathological and immunohistochemical diagnosis of endometrial biopsies is used for estimating the risk of progression in endometrial hyperplastic lesions in carcinoma and for guiding the clinical management. The objective of this study was to evaluate the immunohistochemical expression of the estrogen receptor (ER) and progesterone receptor (PR), p14, p53, phosphatase and tensin homolog (PTEN), Ki67, in patients with endometrial hyperplasia (EH) with/without atypia versus endometrioid endometrial carcinoma type 1...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29247086/risk-of-high-grade-lesions-after-atypical-glandular-cells-in-cervical-screening-a-population-based-cohort-study
#15
Ingrid Norman, Anders Hjerpe, Joakim Dillner
OBJECTIVES: To determine how human papillomavirus (HPV) positivity of atypical glandular cells (AGCs) affects the predictive values for the presence of high-grade cervical lesions. DESIGN: Population-based cohort study. SETTING: Stockholm-Gotland region, Sweden. PARTICIPANTS: Between 17 February 2014 and 30 June 2016, there were 562 women with AGC detected in a cervical sample. Registry linkages up to 30 June 2016 identified 392 women with an associated HPV test and a histopathological follow-up...
December 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29244071/the-glycosyltransferase-eogt-regulates-adropin-expression-in-decidualizing-human-endometrium
#16
Joanne Muter, Mohammad T Alam, Pavle Vrljicak, Flavio S V Barros, Peter T Ruane, Lauren J Ewington, John D Aplin, Melissa Westwood, Jan J Brosens
In pregnancy, resistance of endometrial decidual cells to stress signals is critical for the integrity of the feto-maternal interface and, by extension, survival of the conceptus. O-GlcNAcylation is an essential post-translational modification that links glucose sensing to cellular stress resistance. Unexpectedly, decidualization of primary endometrial stromal cells (EnSCs) was associated with a 60% reduction in O-GlcNAc modified proteins, reflecting downregulation of the enzyme that adds O-GlcNAc to substrates (O-GlcNAc transferase, OGT) but not the enzyme that removes the modification (O-GlcNAcase, OGA)...
December 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/29230975/negative-pap-tests-in-women-with-high-grade-cervical-lesions-on-follow-up-biopsies-contributing-factors-and-role-of-human-papillomavirus-genotyping
#17
Steven Goodman, Roxanne R Mody, Donna Coffey, Blythe K Gorman, Eric Luna, Donna Armylagos, Mary R Schwartz, Dina R Mody, Yimin Ge
BACKGROUND: Previous studies have indicated that negative Papanicolaou (Pap) tests can precede high-grade cervical lesions (HGCL) on biopsy. This study aims to determine the contributing factors for cytologic discrepancy and the potential role of human papilloma virus (HPV) testing in risk evaluation of women with negative Pap tests. METHODS: Of 42,797 Pap tests interpreted as negative for intraepithelial lesion or malignancy (NILM) from March 1, 2013 to December 30, 2014, 426 had available HPV testing and follow-up biopsy...
December 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29223999/two-years-follow-up-of-patients-with-abnormal-uterine-bleeding-after-insertion-of-the-levonorgestrel-releasing-intrauterine-system
#18
Numan Cim, Sunullah Soysal, Sena Sayan, Begum Yildizhan, Erbil Karaman, Orkun Cetin, Harun Egemen Tolunay, Recep Yildizhan
AIM: To evaluate the efficacy and safety of levonorgestrel-releasing intrauterine system (LNG-IUS) in the long-term treatment of heavy menstrual blood loss in women unrelated to intrauterine pathology. METHODS: One hundred and six parous women aged 33-48 years with recurrent heavy menstrual bleeding (HMB) participated in this study. The women were followed up for 24 months and were assessed for intensity of bleeding both for pre- and post-insertion periods. An LNG-IUS was inserted in each patient within 7 days of the start of menstrual flow...
December 8, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29223698/risk-factors-for-unsuccessful-office-based-endometrial-biopsy-a-comparative-study-of-office-based-endometrial-biopsy-pipelle-and-diagnostic-dilation-and-curettage-d-c
#19
Bingying Xie, Cuifeng Qian, Bingyi Yang, Chengcheng Ning, Xiaoying Yao, Yan Du, Yue Shi, Xuezhen Luo, Xiaojun Chen
STUDY OBJECTIVE: To determine the risk factors for Pipelle diagnostic failure, which might help health care providers to choose the appropriate protocol for endometrial evaluation individually. DESIGN: A single-center prospective study (Canadian Task Force II) SETTING: The Obstetrics and Gynecology Hospital of Fudan University PATIENTS: 466 patients with an indication for endometrial biopsy INTERVENTIONS: All patients received Pipelle and then diagnostic dilation and curettage (D&C)...
December 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29218411/effect-of-clinical-information-and-previous-exam-execution-on-observer-agreement-and-reliability-in-the-analysis-of-hysteroscopic-video-recordings
#20
Margarida Suzel Lopes Martinho, Cristina Maria Nogueira da Costa Santos, João Luís Mendonça Silva Carvalho, João Francisco Montenegro Andrade Lima Bernardes
INTRODUCTION: Inter-observer agreement and reliability in hysteroscopic image assessment remain uncertain and the type of factors that may influence it has only been studied in relation to the experience of hysteroscopists. We aim to assess the effect of clinical information and previous exam execution on observer agreement and reliability in the analysis of hysteroscopic video-recordings. MATERIALS AND METHODS: Ninety hysteroscopies were video-recorded and randomized into a group without (Group 1) and with clinical information (Group 2)...
December 7, 2017: Archives of Gynecology and Obstetrics
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