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https://www.readbyqxmd.com/read/28213548/effects-of-gelling-agent-and-extracellular-signaling-molecules-on-the-culturability-of-marine-bacteria
#1
Anita Mac Rygaard, Mariane Schmidt Thøgersen, Kristian Fog Nielsen, Lone Gram, Mikkel Bentzon-Tilia
Only 1 % of marine bacteria are currently culturable using standard laboratory procedures and this is a major obstacle for our understanding of the biology of marine microorganisms and for the discovery of novel microbial natural products. Therefore, the purpose of the present study was to investigate if improved cultivation conditions, including the use of an alternative gelling agent, and supplementation with signaling molecules, could improve the culturability of bacteria from seawater. Substituting agar with gellan gum improved viable counts 3 - 40-fold, depending on medium composition and incubation conditions, with a maximum of 6...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28202318/corrigendum-to-bioprospecting-of-microalgae-proper-extraction-followed-by-high-performance-liquid-chromatographic-high-resolution-mass-spectrometric-fingerprinting-as-key-tools-for-successful-metabolom-characterization-j-chromatogr-b-1015-1016-2016-22-23
#2
Milena Stranska-Zachariasova, Petr Kastanek, Zbynek Dzuman, Josep Rubert, Michal Godula, Jana Hajslova
No abstract text is available yet for this article.
February 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28191021/phylogenetic-tree-analysis-of-the-cold-hot-nature-of-traditional-chinese-marine-medicine-for-possible-anticancer-activity
#3
Xianjun Fu, Xuxia Song, Xuebo Li, Kah Keng Wong, Jiaoyang Li, Fengcong Zhang, Changyun Wang, Zhenguo Wang
Traditional Chinese Marine Medicine (TCMM) represents one of the medicinal resources for research and development of novel anticancer drugs. In this study, to investigate the presence of anticancer activity (AA) displayed by cold or hot nature of TCMM, we analyzed the association relationship and the distribution regularity of TCMMs with different nature (613 TCMMs originated from 1,091 species of marine organisms) via association rules mining and phylogenetic tree analysis. The screened association rules were collected from three taxonomy groups: (1) Bacteria superkingdom, Phaeophyceae class, Fucales order, Sargassaceae family, and Sargassum genus; (2) Viridiplantae kingdom, Streptophyta phylum, Malpighiales class, and Rhizophoraceae family; (3) Holothuroidea class, Aspidochirotida order, and Holothuria genus...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28168318/endophyte-bioprospecting-in-south-asian-medicinal-plants-an-attractive-resource-for-biopharmaceuticals
#4
REVIEW
Rabia Tanvir, Aqeel Javeed, Aamir Ghafoor Bajwa
From the last several years, there has been an increasing interest in plant-associated bacteria commonly referred to as endophytes that reside asymptomatically in the internal plant tissues. This interest peaked since the last two decades due to the recognition that endophytes within medicinal plants have the capability to mimic and produce the bioactive metabolites of the host plant. A number of medicinal plants have been used for centuries by the people of South Asia to cure various diseases and this has led to abundant usage experience...
February 6, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28164707/discovery-of-novel-antimicrobial-peptides-from-varanus-komodoensis-komodo-dragon-by-large-scale-analyses-and-de-novo-assisted-sequencing-using-electron-transfer-dissociation-mass-spectrometry
#5
Barney M Bishop, Melanie L Juba, Paul S Russo, Megan Devine, Stephanie M Barksdale, Shaylyn Scott, Robert Settlage, Pawel Michalak, Kajal Gupta, Kent Vliet, Joel M Schnur, Monique L van Hoek
Komodo dragons are the largest living lizards and are the apex predators in their environs. They endure numerous strains of pathogenic bacteria in their saliva and recover from wounds inflicted by other dragons, reflecting the inherent robustness of their innate immune defense. We have employed a custom bioprospecting approach combining partial de novo peptide sequencing with transcriptome assembly to identify cationic antimicrobial peptides from Komodo dragon plasma. Through these analyses, we identified 48 novel potential cationic antimicrobial peptides...
February 6, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28160134/bacterial-and-fungal-proteolytic-enzymes-production-catalysis-and-potential-applications
#6
REVIEW
Ronivaldo Rodrigues da Silva
Submerged and solid-state bioprocesses have been extensively explored worldwide and employed in a number of important studies dealing with microbial cultivation for the production of enzymes. The development of these production technologies has facilitated the generation of new enzyme-based products with applications in pharmaceuticals, food, bioactive peptides, and basic research studies, among others. The applicability of microorganisms in biotechnology is potentiated because of their various advantages, including large-scale production, short time of cultivation, and ease of handling...
February 3, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28154939/a-practical-guide-to-recombineering-in-photorhabdus-and-xenorhabdus
#7
Jia Yin, Hailong Wang, Ruijuan Li, Vinothkannan Ravichandran, Xiaoying Bian, Aiying Li, Qiang Tu, A Francis Stewart, Jun Fu, Youming Zhang
Fluent genetic manipulation of prokaryote genomes is still limited to only a few commonly used hosts. Ideally the advanced technologies available for cloning into recombinant Escherichia coli should also be applicable in other prokaryotes. In particular, 'recombineering' is mediated by the lambda Red operon that permits fluent and precise engineering of the E. coli genome and associated recombinant DNA. The major limitation is that host-specific phage-derived recombination systems are also required in more distant species...
February 3, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28148982/bio-prospecting-laccases-in-the-bacterial-diversity-of-activated-sludge-from-pulp-and-paper-industry
#8
Vijaya Gupta, Neena Capalash, Naveen Gupta, Prince Sharma
Activated sludge is an artificial ecosystem known to harbor complex microbial communities. Bacterial diversity in activated sludge from pulp and paper industry was studied to bioprospect for laccase, the multicopper oxidase applicable in a large number of industries due to its ability to utilize a wide range of substrates. Bacterial diversity using 454 pyrosequencing and laccase diversity using degenerate primers specific to conserved copper binding domain of laccase like multicopper oxidase (LMCO) genes were investigated...
March 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28129718/response-surface-methodology-a-non-conventional-statistical-tool-to-maximize-the-throughput-of-streptomyces-species-biomass-and-their-bioactive-metabolites
#9
Selvanathan Latha, Govindhan Sivaranjani, Dharumadurai Dhanasekaran
Among diverse actinobacteria, Streptomyces is a renowned ongoing source for the production of a large number of secondary metabolites, furnishing immeasurable pharmacological and biological activities. Hence, to meet the demand of new lead compounds for human and animal use, research is constantly targeting the bioprospecting of Streptomyces. Optimization of media components and physicochemical parameters is a plausible approach for the exploration of intensified production of novel as well as existing bioactive metabolites from various microbes, which is usually achieved by a range of classical techniques including one factor at a time (OFAT)...
January 27, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28107573/diversity-and-bioprospecting-of-actinomycete-endophytes-from-the-medicinal-plants
#10
REVIEW
Nalini Monnanda Somaiah, Harishchandra Sripathy Prakash
The endophytic actinomycetes constitute one of the fascinating group of microorganisms associated with a wide range of plant species. The diversity of actinomycetes in plants and their tissue parts is a matter of debate as no consensus are derived between individual studies. Nevertheless, their diversity correlates with the occurrence in plant species harbored in unique regions of biologically diverse areas called 'hot spots'. Recent advances in the isolation techniques have facilitated the isolation of rare taxa from these environments...
January 20, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28094064/bioprospecting-of-antimicrobial-activity-of-extracts-of-endophytic-fungi-from-bauhinia-guianensis
#11
Eduardo A A Pinheiro, Jeferson R S Pina, André O Feitosa, Josiwander M Carvalho, Fábio C Borges, Patrícia S B Marinho, Andrey M R Marinho
Antibiotic resistance results in higher medical costs, prolonged hospital stays and increased mortality and is rising to dangerously high levels in all parts of the world. Therefore, this study aims to search for new antimicrobial agents through bioprospecting of extracts of endophytic fungi from Bauhinia guianensis, a typical Amazonian plant used in combating infections. Seventeen (17) fungi were isolated and as result the methanolic extract of the fungus Exserohilum rostratum showed good activity against the bacteria tested...
January 13, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28058469/fungal-endophytes-an-alternative-source-for-production-of-volatile-compounds-from-agarwood-oil-of-aquilaria-subintegra
#12
Sakon Monggoot, Siam Popluechai, Eleni Gentekaki, Patcharee Pripdeevech
Fungal endophytes are microorganisms that are well-known for producing a diverse array of secondary metabolites. Recent studies have uncovered the bioprospecting potential of several plant endophytic fungi. Here, we demonstrate the presence of highly bioactive fungal endophytic species in Aquilaria subintegra, a fragrant wood plant collected from Thailand. Thirty-three fungal endophytic strains were isolated and further identified to genus level based on morphological characteristics. These genera included Colletotrichum, Pestalotiopsis, Fusarium, Russula, Arthrinium, Diaporthe and Cladosporium...
January 5, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28044276/antimicrobial-potential-and-taxonomic-investigation-of-piezotolerant-streptomyces-sp-niot-ch-40-isolated-from-deep-sea-sediment
#13
Vishnu Priya Padmanaban, Pankaj Verma, Srividhyalakshmi Venkatabaskaran, Thirupathi Keppayan, Dharani Gopal, Ashok Kumar Sekar, Kirubagaran Ramalingam
Microbial-derived natural products from extreme niches such as deepsea are known to possess structural and functional novelty. With this background, the present study was designed to investigate the bioprospecting potential and systematics of a deep-sea derived piezotolerant bacterial strain NIOT-Ch-40, showing affiliation to the genus Streptomyces based on 16S RNA gene similarity. Preliminary screening for the presence of biosynthetic genes like polyketide synthase I, polyketide synthase II, non ribosomal peptide synthase, 3-amino-5-hydroxybenzoic acid synthase and spiroindimicin followed by antibacterial activity testing confirmed the presence of potent bioactivity...
February 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27984002/endophytes-as-sources-of-antibiotics
#14
REVIEW
Elena Martinez-Klimova, Karol Rodríguez-Peña, Sergio Sánchez
Until a viable alternative can be accessible, the emergence of resistance to antimicrobials requires the constant development of new antibiotics. Recent scientific efforts have been aimed at the bioprospecting of microorganisms' secondary metabolites, with special emphasis on the search for antimicrobial natural products derived from endophytes. Endophytes are microorganisms that inhabit the internal tissues of plants without causing apparent harm to the plant. The present review article compiles recent (2006-2016) literature to provide an update on endophyte research aimed at finding metabolites with antibiotic activities...
October 27, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27975993/bioprospecting-of-cave-bacteria-with-antifungal-activity
#15
A C Almeida, P F Azevedo, R D Marques, Ect Mello-Peixoto, L S Matsumoto
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975387/phylogenetics-of-psychoactive-plants-in-neuro-targeted-bioprospecting-24852989
#16
M H Gramkow, M Ernst, R R Dunn, C H Saslis-Lagoudakis
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27936316/bioprospecting-of-turbinaria-macroalgae-as-a-potential-source-of-health-protective-compounds
#17
Milena Stranska-Zachariasova, Isma Kurniatanty, Helena Gbelcova, Monika Jiru, Josep Rubert, Tjokorda Gde Tirta Nindhia, Cosimo Walter D'Acunto, Sony Heru Sumarsono, Marselina Irasonia Tan, Jana Hajslova, Tomas Ruml
The present study aims to focus on the bioprospecting of marine macroalgae of Turbinaria species, plenteous biomass of the world ocean. Three types of solvents, i.e., H2 O, MeOH/H2 O (80:20, v/v) and hexane/i-PrOH (50:50, v/v), were used for extraction. Both the biological activity and the pattern of present chemicals were characterized. For the cell proliferation assay, the human embryonic kidney 293 cells, cervix/breast/pancreatic adenocarcinoma, and osteosarcoma cells were used. For the antioxidant activity determination, both intracellular assay with human embryonic kidney and cervix adenocarcinoma cells, as well as the biochemical DPPH test, were employed...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27931827/selection-of-an-endogenous-2-3-butanediol-pathway-in-escherichia-coli-by-fermentative-redox-balance
#18
Keming Liang, Claire R Shen
Fermentative redox balance has long been utilized as a metabolic evolution platform to improve efficiency of NADH-dependent pathways. However, such system relies on the complete recycling of NADH and may become limited when the target pathway results in excess NADH stoichiometrically. In this study, endogenous capability of Escherichia coli for 2,3-butanediol (2,3-BD) synthesis was explored using the anaerobic selection platform based on redox balance. To address the issue of NADH excess associated with the 2,3-BD pathway, we devised a substrate-decoupled system where a pathway intermediate is externally supplied in addition to the carbon source to decouple NADH recycling ratio from the intrinsic pathway stoichiometry...
January 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/27914891/antioxidant-capacities-of-fucoxanthin-producing-algae-as-influenced-by-their-carotenoid-and-phenolic-contents
#19
Su Chern Foo, Fatimah Md Yusoff, Maznah Ismail, Mahiran Basri, Sook Kun Yau, Nicholas M H Khong, Kim Wei Chan, Mahdi Ebrahimi
Natural antioxidants from sustainable sources are favoured to accommodate worldwide antioxidant demand. In addition to bioprospecting for natural and sustainable antioxidant sources, this study aimed to investigate the relationship between the bioactives (i.e. carotenoid and phenolic acids) and the antioxidant capacities in fucoxanthin-producing algae. Total carotenoid, phenolic acid, fucoxanthin contents and fatty acid profile of six species of algae (five microalgae and one macroalga) were quantified followed by bioactivity evaluation using four antioxidant assays...
January 10, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/27900683/constructing-and-screening-a-metagenomic-library-of-a-cold-and-alkaline-extreme-environment
#20
Mikkel A Glaring, Jan K Vester, Peter Stougaard
Natural cold or alkaline environments are common on Earth. A rare combination of these two extremes is found in the permanently cold (less than 6 °C) and alkaline (pH above 10) ikaite columns in the Ikka Fjord in Southern Greenland. Bioprospecting efforts have established the ikaite columns as a source of bacteria and enzymes adapted to these conditions. They have also highlighted the limitations of cultivation-based methods in this extreme environment and metagenomic approaches may provide access to novel extremophilic enzymes from the uncultured majority of bacteria...
2017: Methods in Molecular Biology
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