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https://www.readbyqxmd.com/read/28725529/recent-progress-on-piezoelectric-and-triboelectric-energy-harvesters-in-biomedical-systems
#1
REVIEW
Qiang Zheng, Bojing Shi, Zhou Li, Zhong Lin Wang
Implantable medical devices (IMDs) have become indispensable medical tools for improving the quality of life and prolonging the patient's lifespan. The minimization and extension of lifetime are main challenges for the development of IMDs. Current innovative research on this topic is focused on internal charging using the energy generated by the physiological environment or natural body activity. To harvest biomechanical energy efficiently, piezoelectric and triboelectric energy harvesters with sophisticated structural and material design have been developed...
July 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28720727/impact-of-paracoccin-gene-silencing-on-paracoccidioides-brasiliensis-virulence
#2
Fabrício F Fernandes, Aline F Oliveira, Taise N Landgraf, Cristina Cunha, Agostinho Carvalho, Patrícia E Vendruscolo, Relber A Gonçales, Fausto Almeida, Thiago A da Silva, Fernando Rodrigues, Maria Cristina Roque-Barreira
Among the endemic deep mycoses in Latin America, paracoccidioidomycosis (PCM), caused by thermodimorphic fungi of the Paracoccidioides genus, is a major cause of morbidity. Disease development and its manifestations are associated with both host and fungal factors. Concerning the latter, several recent studies have employed the methodology of gene modulation in P. brasiliensis using antisense RNA (AsRNA) and Agrobacterium tumefaciens-mediated transformation (ATMT) to identify proteins that influence fungus virulence...
July 18, 2017: MBio
https://www.readbyqxmd.com/read/28716969/genetic-determinants-of-susceptibility-to-silver-nanoparticle-induced-acute-lung-inflammation-in-mice
#3
David K Scoville, Dianne Botta, Karen Galdanes, Stefanie C Schmuck, Collin C White, Patricia L Stapleton, Theo K Bammler, James W MacDonald, William A Altemeier, Michelle Hernandez, Steven R Kleeberger, Lung-Chi Chen, Terry Gordon, Terrance J Kavanagh
Silver nanoparticles (AgNPs) are employed in a variety of consumer products; however, in vivo rodent studies indicate that AgNPs can cause lung inflammation and toxicity in a strain- and particle type-dependent manner, but mechanisms of susceptibility remain unclear. The aim of this study was to assess the variation in AgNP-induced lung inflammation and toxicity across multiple inbred mouse strains and to use genome-wide association (GWA) mapping to identify potential candidate susceptibility genes. Mice received doses of 0...
July 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28715707/design-synthesis-and-2d-qsar-study-of-novel-pyridine-and-quinolone-hydrazone-derivatives-as-potential-antimicrobial-and-antitubercular-agents
#4
Mohamed A Abdelrahman, Ismail Salama, Mohamed S Gomaa, Mahmoud M Elaasser, Marwa M Abdel-Aziz, Dalia H Soliman
The increased development of highly resistant bacterial strains and tuberculosis, constitute a serious public health threat, highlighting the urgent need of novel antibacterial agents. In this work, two novel series of nicotinic acid hydrazone derivatives (6a-r) and quinolone hydrazide derivatives (12a-l) were synthesized and evaluated as antimicrobial and antitubercular agents. The synthesized compounds were evaluated in vitro for their antibacterial, antifungal and antimycobacterial activities. Compounds 6f and 6p bearing the 3,4,5- (OCH3)3 and 2,5-(OCH3)2 benzylidene motifs were the most potent and as antibacterial, antifungal (MIC: 0...
July 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28714399/design-synthesis-and-antibacterial-evaluation-of-compounds-based-on-new-benzoxepine-oxime-1-2-3-triazole-hybrid
#5
Naveen Kuntala, Jhonsee Rani Telu, Venkanna Banothu, Sridhar Balasubramanian, Jaya Shree Anireddy, Sarbani Pal
A library of small molecules based on the new benzoxepine-oxime-1,2,3-triazole hybrid was initially designed as potential antibacterial agents. These compounds were synthesized using a Cu-catalyzed azide-alkyne cycloaddition (CuAAC) as a key step to construct the desired 1,2,3-triazole ring. Thus the click reaction between the appropriate alkyne containing the benzoxepine-oxime framework with aryl azides afforded the target compounds in good yields. To assess their antibacterial properties all the synthesized compounds were tested against four strains of bacterial microorganisms including one Gram-positive and three Gram-negative species...
July 17, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28714174/immunological-properties-and-protective-efficacy-of-a-single-mycobacterial-antigen-displayed-on-polyhydroxybutyrate-beads
#6
Patricia Rubio-Reyes, Natalie A Parlane, Bryce M Buddle, D Neil Wedlock, Bernd H A Rehm
In 2015, there were an estimated 10.4 million new tuberculosis (TB) cases and 1.4 million deaths worldwide. Bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, is the vaccine available against TB, but it is insufficient for global TB control. This study evaluated the immunogenicity of the Mycobacterium tuberculosis antigen Rv1626 in mice while assessing the effect of co-delivering either Cpe30 (immunostimulatory peptide), CS.T3378-395 (promiscuous T helper epitope) or flagellin (TLR5 agonist) or a combination of all three immunostimulatory agents...
July 17, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28713784/identification-of-novel-and-efficacious-chemical-compounds-that-disturb-influenza-a-virus-entry-in-vitro
#7
Hany Khalil, Tamer El Malah, Ahmed I Abd El Maksoud, Ibrahim El Halfawy, Ahmed A El Rashedy, Mahmoud El Hefnawy
Influenza A virus is a negative RNA stranded virus of the family Orthomyxoviridae, and represents a major public health threat, compounding existing disease conditions. Influenza A virus replicates rapidly within its host and the segmented nature of its genome facilitates re-assortment, whereby whole genes are exchanged between influenza virus subtypes during replication. Antiviral medications are important pharmacological tools in influenza virus prophylaxis and therapy. However, the use of currently available antiviral is impeded by sometimes high levels of resistance in circulating virus strains...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28713014/a-recombinant-type-2-porcine-reproductive-and-respiratory-syndrome-virus-between-nadc30-like-and-a-mlv-like-genetic-characterization-and-pathogenicity-for-piglets
#8
Ting Bian, Yingfeng Sun, Meng Hao, Lei Zhou, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen for swine industry worldwide. The recombination occurring among PRRSV strains has been recognized as one of important molecular mechanisms for the evolution of PRRSV. Current prevalence of PRRSV NADC30-like causing clinical disease outbreaks is highly concerned in China. In the present study, the genetic characterization of a recombinant type 2 PRRSV (designated TJnh1501) was analyzed and its pathogenicity for piglets was examined...
July 13, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28711510/serotyping-of-brunei-pneumococcal-clinical-strains-and-the-investigation-of-their-capability-to-adhere-and-invade-a-brain-endothelium-model
#9
Nurul Adhwa Rahman, Aishah Sharudin, Suwarni Diah, Siti Hanna Muharram
INTRODUCTION: Pneumococcal infections have caused morbidity and mortality globally. Streptococcus pneumoniae (pneumococci) are commensal bacteria that colonize the nasopharynx, asymptomatically. From there, pneumococci can spread in the lungs causing pneumonia and disseminate in the bloodstream causing bacteremia (sepsis) and reach the brain leading to meningitis. Endothelial cells are one of the most important components of the blood-brain barrier that separates the blood from the brain and plays the first protective role against pneumococcal entry...
July 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28710016/comparative-study-of-immunopathophysiological-responses-induced-by-b-%C3%A2-melitensis-and-its-lipopolysaccharide-in-mouse-model-infected-via-intranasal-route-of-exposure
#10
Abdinasir Yusuf Osman, Abdul Aziz Saharee, Faez Firdaus Jesse, Arifah Abdul Kadir
In this study, we developed a mouse model and characterized the effects of intranasal inoculation of virulent Brucella melitensis strain 16M and its lipopolysaccharide (LPS). The effects of the exposure were compared with respective control groups. Both Brucella melitensis-infected and LPS-infected groups showed no significant clinical presentation with minor relevance in the mortality associated with the infection. In Brucella melitensis-infected group, significant histopathological changes in comparison to the LPS infected group with increase bacterial burden in the lungs, reproductive and reticuloendothelial organs were observed...
July 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28710015/bactericidal-impact-of-ag-zno-and-mixed-agzno-colloidal-nanoparticles-on-h37rv-mycobacterium-tuberculosis-phagocytized-by-thp-1%C3%A2-cell-lines
#11
Alireza Jafari, Nader Mosavari, Farahnaz Movahedzadeh, Saeedeh Jafari Nodooshan, Roya Safarkar, Rossella Moro, Morteza Kamalzadeh, Ali Majidpour, Mina Boustanshenas, Tahereh Mosavi
The purpose of this research project was to infection of human macrophages (THP-1) cell lines by H37Rv strain of Mycobacterium tuberculosis (H37RvMTB) and find out the ratio/dilution of mixture silver (Ag NPs) and zinc oxide nanoparticles (ZnO NPs) whose ability to eliminate phagocytized bacteria compared to rifampicin. The colloidal Ag NPs and ZnO NPs were synthesized and their characteristics were evaluated. The THP-1 cell lines were infected with different concentration of H37RvMTB. Next, the infected cells were treated with different ratios/dilutions of Ag NPs, ZnO NPs and rifampicin...
July 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28707004/host-sirtuin-1-regulates-mycobacterial-immunopathogenesis-and-represents-a-therapeutic-target-against-tuberculosis
#12
Catherine Y Cheng, Nuria M Gutierrez, Mardiana B Marzuki, Xiaohua Lu, Taylor W Foreman, Bhairav Paleja, Bernett Lee, Akhila Balachander, Jinmiao Chen, Liana Tsenova, Natalia Kurepina, Karen W W Teng, Kim West, Smriti Mehra, Francesca Zolezzi, Michael Poidinger, Barry Kreiswirth, Deepak Kaushal, Hardy Kornfeld, Evan W Newell, Amit Singhal
Mycobacterium tuberculosis (Mtb) executes a plethora of immune-evasive mechanisms, which contribute to its pathogenesis, limited efficacy of current therapy, and the emergence of drug-resistant strains. This has led to resurgence in attempts to develop new therapeutic strategies/targets against tuberculosis (TB). We show that Mtb down-regulates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, in monocytes/macrophages, TB animal models, and TB patients with active disease...
March 2017: Science Immunology
https://www.readbyqxmd.com/read/28706209/mountain-gorilla-lymphocryptovirus-has-epstein-barr-virus-like-epidemiology-and-pathology-in-infants
#13
Tierra Smiley Evans, Linda J Lowenstine, Kirsten V Gilardi, Peter A Barry, Benard J Ssebide, Jean Felix Kinani, Fred Nizeyimana, Jean Bosco Noheri, Michael R Cranfield, Antoine Mudakikwa, Tracey Goldstein, Jonna A K Mazet, Christine Kreuder Johnson
Epstein-Barr virus (EBV) infects greater than 90% of humans, is recognized as a significant comorbidity with HIV/AIDS, and is an etiologic agent for some human cancers. The critically endangered mountain gorilla population was suspected of infection with an EBV-like virus based on serology and infant histopathology similar to pulmonary reactive lymphoid hyperplasia (PRLH), a condition associated with EBV in HIV-infected children. To further examine the presence of EBV or an EBV-like virus in mountain gorillas, we conducted the first population-wide survey of oral samples for an EBV-like virus in a nonhuman great ape...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705898/cellular-heterogeneity-in-the-ureteric-progenitor-niche-and-distinct-profiles-of-branching-morphogenesis-in-organ-development
#14
Elisabeth A Rutledge, Jean-Denis Benazet, Andrew P McMahon
Branching morphogenesis creates arborized epithelial networks. In the mammalian kidney, an epithelial progenitor pool at ureteric branch tips (UBT) creates the urine-transporting collecting system. Using region-specific mouse reporter strains, we performed an RNA-seq screen, identifying tip and stalk enriched gene sets in the developing collecting duct system. Detailed in situ hybridization studies of tip-enriched predictions identified UBT-enriched gene sets conserved between the mouse and human kidney. Comparative spatial analysis of their UBT niche expression highlighted distinct patterns of gene expression revealing novel molecular heterogeneity within the UBT progenitor population...
July 13, 2017: Development
https://www.readbyqxmd.com/read/28704964/myrcia-splendens-sw-dc-syn-m-fallax-rich-dc-myrtaceae-essential-oil-from-amazonian-ecuador-a-chemical-characterization-and-bioactivity-profile
#15
Laura Scalvenzi, Alessandro Grandini, Antonella Spagnoletti, Massimo Tacchini, David Neill, José Luis Ballesteros, Gianni Sacchetti, Alessandra Guerrini
In this study, we performed the chemical characterization of Myrcia splendens (Sw.) DC. (Myrtaceae) essential oil from Amazonian Ecuador and the assessment of its bioactivity in terms of cytotoxic, antibacterial, and antioxidant activity as starting point for possible applicative uses. M. splendens essential oil, obtained by hydro-distillation, was analyzed by Gas Chromatography-Mass Spectrometry (GC-MS) and Gas Chromatography-Flame Ionization Detector (GC-FID): the major components were found to be trans-nerolidol (67...
July 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28701401/evaluation-of-the-biological-properties-and-cross-reactive-antibody-response-to-h10-influenza-viruses-in-ferrets
#16
Troy C Sutton, Elaine W Lamirande, Rita Czako, Kanta Subbarao
The recent outbreak of avian origin H10N7 influenza among seals in Northern Europe, and two fatal human infections with an avian H10N8 virus in China, have demonstrated that H10 viruses can spread between mammals and cause severe disease in humans. To gain insight into the potential for H10 viruses to cross the species barrier and identify a candidate vaccine strain, we evaluated the in vitro and in vivo properties and antibody response in ferrets to 20 diverse H10 viruses. H10 virus infection of ferrets caused variable weight loss and all 20 viruses replicated throughout the respiratory tract; however, replication in the lungs was highly variable...
July 12, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28701178/the-future-of-mechanical-ventilation-lessons-from-the-present-and-the-past
#17
REVIEW
Luciano Gattinoni, John J Marini, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Tommaso Tonetti, Francesco Vasques, Michael Quintel
The adverse effects of mechanical ventilation in acute respiratory distress syndrome (ARDS) arise from two main causes: unphysiological increases of transpulmonary pressure and unphysiological increases/decreases of pleural pressure during positive or negative pressure ventilation. The transpulmonary pressure-related side effects primarily account for ventilator-induced lung injury (VILI) while the pleural pressure-related side effects primarily account for hemodynamic alterations. The changes of transpulmonary pressure and pleural pressure resulting from a given applied driving pressure depend on the relative elastances of the lung and chest wall...
July 12, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28700648/highly-diverse-and-antimicrobial-susceptible-escherichia-coli-display-a-na%C3%A3-ve-bacterial-population-in-fruit-bats-from-the-republic-of-congo
#18
Kathrin Nowak, Jakob Fahr, Natalie Weber, Antina Lübke-Becker, Torsten Semmler, Sabrina Weiss, Jean-Vivien Mombouli, Lothar H Wieler, Sebastian Guenther, Fabian H Leendertz, Christa Ewers
Bats are suspected to be a reservoir of several bacterial and viral pathogens relevant to animal and human health, but studies on Escherichia coli in these animals are sparse. We investigated the presence of E. coli in tissue samples (liver, lung and intestines) collected from 50 fruit bats of five different species (Eidolon helvum, Epomops franqueti, Hypsignathus monstrosus, Myonycteris torquata, Rousettus aegyptiacus) of two different areas in the Republic of Congo between 2009 and 2010. To assess E. coli pathotypes and phylogenetic relationships, we determined the presence of 59 virulence associated genes and multilocus sequence types (STs)...
2017: PloS One
https://www.readbyqxmd.com/read/28699258/cytotoxic-peptides-with-insulin-releasing-activities-from-skin-secretions-of-the-italian-stream-frog-rana-italica-ranidae
#19
J Michael Conlon, Vishal Musale, Samir Attoub, Maria Luisa Mangoni, Jérôme Leprince, Laurent Coquet, Thierry Jouenne, Yasser H A Abdel-Wahab, Peter R Flatt, Andrea C Rinaldi
Peptidomic analysis of norepinephrine-stimulated skin secretions from Italian stream frog Rana italica led to the purification and characterization of two host-defense peptides differing by a single amino acid residue belonging to the brevinin-1 family (brevinin-1ITa and -1ITb), a peptide belonging to the temporin family (temporin-ITa) and a component identified as prokineticin Bv8. The secretions contained relatively high concentrations of the methionine-sulphoxide forms of brevinin-1ITa and -1ITb suggesting that these peptides may have a role as antioxidants in the skin of this montane frog...
July 11, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28698737/draft-genome-sequence-of-a-virulent-strain-of-pasteurella-multocida-isolated-from-alpaca
#20
Raquel Enma Hurtado, Flavia Aburjaile, Diego Mariano, Marcus Vinicius Canário, Leandro Benevides, Daniel Antonio Fernandez, Nataly Olivia Allasi, Rocio Rimac, Julio Eduardo Juscamayta, Jorge Enrique Maximiliano, Raul Hector Rosadio, Vasco Azevedo, Lenin Maturrano
Pasteurella multocida is one of the most frequently isolated bacteria in acute pneumonia cases, being responsible for high mortality rates in Peruvian young alpacas, with consequent social and economic costs. Here we report the genome sequence of P. multocida strain UNMSM, isolated from the lung of an alpaca diagnosed with pneumonia, in Peru. The genome consists of 2,439,814 base pairs assembled into 82 contigs and 2,252 protein encoding genes, revealing the presence of known virulence-associated genes (ompH, ompA, tonB, tbpA, nanA, nanB, nanH, sodA, sodC, plpB and toxA)...
2017: Journal of Genomics
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