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https://www.readbyqxmd.com/read/29913444/stimulation-of-eryptosis-by-afatinib
#1
Abdulla Al Mamun Bhuyan, Florian Lang
BACKGROUND/AIMS: The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor afatinib is primarily utilized for the treatment of non-small cell lung carcinoma. The drug is at least partially effective by triggering suicidal tumor cell death. Side effects of afatinib treatment include anemia. At least in theory, afatinib induced anemia could be secondary to stimulation of suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913144/paraquat-toxicity-is-attenuated-by-4-phenylbutyrate-induced-phosphorylation-of-erk2-via-pi3k-in-a549-cells
#2
Chisato Hoshina, Tomohiro Omura, Katsuhiro Okuda, Hiroki Tanaka, Masaru Asari, Shotaro Isozaki, Kie Horioka, Hiromi Yamada, Hiroki Doi, Hiroshi Shiono, Kazuo Matsubara, Keiko Shimizu
Paraquat (PQ) is a widely used herbicide in the world despite being highly toxic to humans. PQ causes fatal damage to multiple organs, especially the lungs. While oxidative stress is the main toxic mechanism of PQ, there is no established standard therapy for PQ poisoning. In this study, we investigated the cytoprotective effect of 4-phenylbutyrate (4PBA) on PQ toxicity in human lung adenocarcinoma A549 cells. Phosphorylation levels of major survival signaling kinases Akt and ERK, as well as expression levels of antioxidant enzymes catalase and superoxide dismutase 2 (SOD2) were examined...
June 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29911072/inhibiting-glycine-decarboxylase-suppresses-pyruvate-to-lactate-metabolism-in-lung-cancer-cells
#3
Chern Chiuh Woo, Kavita Kaur, Wei Xin Chan, Xing Qi Teo, Teck Hock Philip Lee
Glycine decarboxylase (GLDC) gene is frequently upregulated in various types of cancer including lung, prostate and brain. It catabolizes glycine to yield 5,10-methylenetetrahydrofolate, an important substrate in one-carbon metabolism for nucleotide synthesis. In this study, we used exon splicing modulating steric hindrance antisense oligonucleotide (shAON) to suppress GLDC expression and investigated its effect on pyruvate metabolism via hyperpolarized carbon-13 magnetic resonance spectroscopy (MRS). The MRS technique allows us to study in vivo metabolic flux in tumor tissues with/without GLDC-shAON intervention...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29910176/emapii-monoclonal-antibody-ameliorates-influenza-a-virus-induced-lung-injury
#4
Hongyan Lu, Sarvesh Chelvanambi, Christophe Poirier, Jacob Saliba, Keith L March, Matthias Clauss, Natalia V Bogatcheva
Influenza A virus (IAV) remains a major worldwide health threat, especially to high-risk populations, including the young and elderly. There is an unmet clinical need for therapy that will protect the lungs from damage caused by lower respiratory infection. Here, we analyzed the role of EMAPII, a stress- and virus-induced pro-inflammatory and pro-apoptotic factor, in IAV-induced lung injury. First, we demonstrated that IAV induces EMAPII surface translocation, release, and apoptosis in cultured endothelial and epithelial cells...
June 14, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29908494/protective-effect-of-exogenous-hydrogen-sulfide-on-pulmonary-artery-endothelial-cells-by-suppressing-endoplasmic-reticulum-stress-in-a-rat-model-of-chronic-obstructive-pulmonary-disease
#5
Hai-Bo Ding, Kai-Xiong Liu, Jie-Feng Huang, Da-Wen Wu, Jun-Ying Chen, Qing-Shi Chen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a multicomponent disorder characterized by inflammation, representing a significant leading cause of chronic morbidity and mortality. Reports have implicated hydrogen sulfide (H2 S) in both the pathology and treatment of COPD. The present study aimed to explore the effects involved with exogenous H2 S on endoplasmic reticulum stress (ERS) and pulmonary artery endothelial cells (PAECs) in a rat model of COPD. METHODS: Rat models of COPD were successfully established by means of passive smoke exposure and intratracheal injection with lipopolysaccharide (LPS)...
June 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29908438/targeting-rna-polymerase-i-transcription-machinery-in-cancer-cells-by-a-novel-monofunctional-platinum-based-agent
#6
Zhen-Lei Zhang, Chun-Lai Zhao, Qian Chen, Kai Xu, Xin Qiao, Jing-Yuan Xu
Aberrant ribosome biogenesis and enlarged nucleoli have long been used by pathologists as a marker of aggressive tumors. Suppression of RNA polymerase I (Pol I) transcription machinery within the nucleolus could be a direct way to trigger the nucleolar stress and to inhibit the rapid proliferation of cancer cells. Here we modified cisplatin with an analogue of the selective inhibitor of RNA polymerase I-mediated transcription BMH-21 to develop a novel platinum-based Pol I selective inhibitor. We show that this novel monofunctional platinum-based agent, P1-B1, had enhanced antitumor activity of up to 17-fold greater than the clinical drug cisplatin in cisplatin-resistant non-small cell lung cancer cells...
June 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29907213/carbon-monoxide-attenuates-lipopolysaccharide-induced-lung-injury-by-mitofusin-proteins-via-p38-mapk-pathway
#7
Shu-An Dong, Yuan Zhang, Jian-Bo Yu, Xiang-Yun Li, Li-Rong Gong, Jia Shi, Yuan-Yuan Kang
BACKGROUND: The protective effects of carbon monoxide against the lipopolysaccharide (LPS)-induced lung injury were attributed to maintenance of mitochondrial dynamics, but the mechanisms remain unexplored. MATERIALS AND METHODS: Using a rat model of acute lung injury induced by LPS and the LPS attacking cell model, we investigated the effects of pretreatment of carbon monoxide molecule-2 (CORM-2) on the acute lung injury and expressions of mitofusin proteins that play a critical role in mitochondrial dynamics...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906737/achilles-tendon-loading-during-weight-bearing-exercises
#8
Naghmeh Gheidi, Thomas W Kernozek, John D Willson, Andrew Revak, Keith Diers
OBJECTIVE: Compare the estimated Achilles tendon (AT) loading using a musculoskeletal model during commonly performed weight bearing therapeutic exercises. DESIGN: Controlled laboratory study. SETTING: University biomechanics laboratory. PARTICIPANTS: Eighteen healthy males (Age:22.1 ± 1.8 years, height:177.7 ± 8.4 cm, weight = 74.29 ± 11.3 kg). MAIN OUTCOME MEASURE(S): AT loading was estimated during eleven exercises: tandem, Romberg, and unilateral standing, unilateral and bilateral heel raising, unilateral and bilateral jump landing, squat, lunge, walking, and running...
May 10, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29906250/oxidant-sensor-cation-channel-trpm2-regulates-neutrophil-extracellular-trap-formation-and-protects-against-pneumoseptic-bacterial-infection
#9
Jitendra Kumar Tripathi, Atul Sharma, Pramod Sukumaran, Yuyang Sun, Bibhuti Bhusan Mishra, Brij Bhan Singh, Jyotika Sharma
Neutrophil extracellular trap (NET) formation constitutes an important extracellular antimicrobial function of neutrophils that plays a protective role in bacterial pneumonia. Formation of reactive oxygen species (ROS) such as highly diffusible hydrogen peroxide (H2 O2 ) is a hallmark of oxidative stress during inflammatory lung conditions including pneumonia. However, the impact of exogenous ROS on NET formation and the signaling pathway involved in the process is not completely understood. Here we demonstrate that the ROS-sensing, nonselective, calcium-permeable channel transient receptor potential melastatin 2 (TRPM2) is required for NET formation in response to exogenous H2 O2 ...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29904353/low-level-light-therapy-protects-red-blood-cells-against-oxidative-stress-and-hemolysis-during-extracorporeal-circulation
#10
Tomasz Walski, Anna Drohomirecka, Jolanta Bujok, Albert Czerski, Grzegorz Wąż, Natalia Trochanowska-Pauk, Michał Gorczykowski, Romuald Cichoń, Małgorzata Komorowska
Aim: An activation of non-specific inflammatory response, coagulation disorder, and blood morphotic elements damage are the main side effects of the extracorporeal circulation (ECC). Red-to-near-infrared radiation (R/NIR) is thought to be capable of stabilizing red blood cell (RBC) membrane through increasing its resistance to destructive factors. We focused on the development of a method using low-level light therapy (LLLT) in the spectral range of R/NIR which could reduce blood trauma caused by the heart-lung machine during surgery...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29903169/-effects-of-vitamin-e-and-%C3%AF-3-fatty-acids-on-protecting-ambient-pm_-2-5-induced-cardiovascular-injury
#11
Xihao Du, Shuo Jiang, Liang Bo, Jie Liu, Xuejiao Zeng, Rongfang Jiang, Weimin Song, Jinzhuo Zhao
OBJECTIVE: To observe whether vitamin E( Ve) and ω-3 polyunsaturated fatty acids( ω-3 FA) could prevent the fine particulate matter( PM_(2. 5))-induced cardiovascular injury and explore the potential mechanism. METHODS: The SD rats were assigned randomly to 8 groups, those were control group, PM_(2. 5)group, Ve treatment groups( 3, 10, 30 mg/( kg·d)) and ω-3 FA treatment groups( 10, 30 and 90 mg/( kg·d)). The rats were pretreated with different concentration of Ve and ω-3 FA separately for 14 days, then were exposed to ambient PM_(2...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29901139/therapeutic-efficacy-of-hydrogen%C3%A2-rich-saline-alone-and-in-combination-with-pi3k-inhibitor-in-non%C3%A2-small-cell-lung-cancer
#12
Yu Jiang, Gang Liu, Li Zhang, Sheng Cheng, Chun Luo, Yang Liao, Shuliang Guo
The aim of the present study was to investigate the effects of combination therapy of LY294002, a specific inhibitor of phosphatidylinositol 3‑kinase (PI3K), with hydrogen‑rich saline on the proliferation and apoptosis of the non‑small cell lung cancer (NSCLC) A549 cell line and the mechanisms underpinning this. Excessive production of reactive oxygen species (ROS) may induce DNA mutations, DNA damage, genomic instability and cell proliferation, and ROS are involved in several types of cancer, particularly lung cancer...
June 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900137/the-effect-of-psychological-intervention-on-nutrient-status-of-perioperative-patients-with-lung-cancer
#13
Fen Xue, Fang Huang
Background: To investigate the effect of psychological intervention on nutrient status of perioperative patients with lung cancer. Methods: Overall, 176 lung cancer patients admitted to Shanghai Pulmonary Hospital, Shanghai China from 2015 to 2016 were divided into control group (n=88) and study group (n=88). Conventional nursing strategy was adopted for patients in control group, while psychological nursing strategy was implemented for those in the study group, and the specific nursing efficiency was compared between the two groups...
April 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29898704/acute-effects-of-combined-exercise-and-oscillatory-positive-expiratory-pressure-therapy-on-sputum-properties-and-lung-diffusing-capacity-in-cystic-fibrosis-a-randomized-controlled-crossover-trial
#14
Thomas Radtke, Lukas Böni, Peter Bohnacker, Marion Maggi-Beba, Peter Fischer, Susi Kriemler, Christian Benden, Holger Dressel
BACKGROUND: Regular airway clearance by chest physiotherapy and/or exercise is critical to lung health in cystic fibrosis (CF). Combination of cycling exercise and chest physiotherapy using the Flutter® device on sputum properties has not yet been investigated. METHODS: This prospective, randomized crossover study compared a single bout of continuous cycling exercise at moderate intensity (experiment A, control condition) vs a combination of interval cycling exercise plus Flutter® (experiment B)...
June 14, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29892162/oxidative-dna-damage-in-the-rat-lung-induced-by-intratracheal-instillation-and-inhalation-of-nanoparticles
#15
Yun-Shan Li, Yuko Ootsuyama, Yuya Kawasaki, Yasuo Morimoto, Toshiaki Higashi, Kazuaki Kawai
Nanoparticles are widely used as useful industrial materials. Therefore, their possible adverse health effects must be appraised. We assessed and compared the oxidative DNA damage caused by four different nanoparticles (TiO2 , NiO, ZnO and CeO2 ). The effects of the administration methods, intratracheal instillation and inhalation, were also evaluated. Rats were subjected to intratracheal instillations or 4 weeks of inhalation exposure to the nanoparticles, and the 8-hydroxydeoxyguanosine (8-OHdG) levels in the lung were analyzed by an HPLC-EC detector method...
May 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29892061/mutations-in-the-swi-snf-complex-induce-a-targetable-dependence-on-oxidative-phosphorylation-in-lung-cancer
#16
Yonathan Lissanu Deribe, Yuting Sun, Christopher Terranova, Fatima Khan, Juan Martinez-Ledesma, Jason Gay, Guang Gao, Robert A Mullinax, Tin Khor, Ningping Feng, Yu-Hsi Lin, Chia-Chin Wu, Claudia Reyes, Qian Peng, Frederick Robinson, Akira Inoue, Veena Kochat, Chang-Gong Liu, John M Asara, Cesar Moran, Florian Muller, Jing Wang, Bingliang Fang, Vali Papadimitrakopoulou, Ignacio I Wistuba, Kunal Rai, Joseph Marszalek, P Andrew Futreal
Lung cancer is a devastating disease that remains a top cause of cancer mortality. Despite improvements with targeted and immunotherapies, the majority of patients with lung cancer lack effective therapies, underscoring the need for additional treatment approaches. Genomic studies have identified frequent alterations in components of the SWI/SNF chromatin remodeling complex including SMARCA4 and ARID1A. To understand the mechanisms of tumorigenesis driven by mutations in this complex, we developed a genetically engineered mouse model of lung adenocarcinoma by ablating Smarca4 in the lung epithelium...
June 8, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29891737/reduced-myocardial-flow-reserve-by-positron-emission-tomography-predicts-cardiovascular-events-after-cardiac-transplantation
#17
Matthew C Konerman, John J Lazarus, Richard L Weinberg, Ravi V Shah, Michael Ghannam, Scott L Hummel, James R Corbett, Edward P Ficaro, Keith D Aaronson, Monica M Colvin, Todd M Koelling, Venkatesh L Murthy
BACKGROUND: We evaluated the diagnostic and prognostic value of quantification of myocardial flow reserve (MFR) with positron emission tomography (PET) in orthotopic heart transplant patients. METHODS AND RESULTS: We retrospectively identified orthotopic heart transplant patients who underwent rubidium-82 cardiac PET imaging. The primary outcome was the composite of cardiovascular death, acute coronary syndrome, coronary revascularization, and heart failure hospitalization...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29891368/protective-role-of-thymoquinone-against-paraquat-induced-hepatotoxicity-in-mice
#18
Hamed Zeinvand-Lorestani, Amir Nili-Ahmadabadi, Fatemeh Balak, Gholamreza Hasanzadeh, Omid Sabzevari
Paraquat is a common and effective herbicide; although its poisoning could lead to severe oxidative organ damages and its main target organs are the lungs, kidneys, heart, and liver. Thymoquinone is the active ingredient of Nigella sativa which is traditionally used in herbal medicine; recent studies have shown that thymoquinone could inhibit oxidative stress. This study explores protective effects of thymoquinone on paraquat-induced hepatotoxicity in mice. Accordingly, adult male mice were randomly divided into nine groups for three continuous days intraperitoneal injection treatment: (1) control; (2) solvent; (3) 20 mg/kg vitamin E; (4) 20 mg/kg thymoquinone; (5) 20 mg/kg paraquat and Groups 6, 7, 8, and 9 received 20 mg/kg of vitamin E and 5, 10, and 20 mg/kg of thymoquinone, respectively...
June 2018: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29890467/liver-injury-induced-in-balb-c-mice-by-pm-2-5-exposure-and-its-alleviation-by-compound-essential-oils
#19
Ping Ya, Henggui Xu, Yanmin Ma, Mengxiong Fang, Xiaomei Yan, Jie Zhou, Fasheng Li
Accumulating evidence has suggested a strong link between exposure to air pollution and public health. In particular, inhaled airborne particulate matter <2.5 μm in aerodynamic diameter (PM2.5 ) can rapidly diffuse from the lungs to the systemic blood circulation and accumulate in the liver. In this study, we used a Balb/c mouse model to investigate liver injury caused by PM2.5 inhalation and the anti-inflammatory and antioxidant effects of compound essential oils (CEOs) in alleviating the extent of this injury...
June 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29890333/identification-of-pasteurella-multocida-transcribed-genes-in-porcine-lungs-through-rnaseq
#20
Cristiane Silva Chitarra, João Xavier de Oliveira Filho, Nelson Morés, Mayara Inácio Vincenzi da Silva, Stefhano Luis Cândido, Paula Gabriela Cezarino, Luciano Nakazato, Valéria Dutra
Pasteurella multocida is one of the most important pathogen that causes pneumonia in swine. Although several virulence factors are known, the pathogenesis of this bacterium is not well-studied. Therefore, to study the pathogenesis of P. multocida infection in porcine lung, next-generation RNA sequencing was used to compare the transcriptomes of P. multocida grown in vivo and in vitro, respectively. After P. multocida infection a total of 704 genes were expressed in vitro, 1422 genes were expressed in vivo, and 237 genes were differentially expressed based on statistical analyses, padj of ≤0...
June 8, 2018: Microbial Pathogenesis
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