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https://www.readbyqxmd.com/read/27926751/ocular-perfusion-pressure-and-choroidal-thickness-in-early-age-related-macular-degeneration-patients-with-reticular-pseudodrusen
#1
Cheolmin Yun, Jaemoon Ahn, Minjung Kim, Soon-Young Hwang, Seong-Woo Kim, Jaeryung Oh
Purpose: The purpose of this study was to investigate the relationship between the ocular perfusion pressure (OPP) and subfoveal choroidal thickness (CT) in eyes with early age-related macular degeneration (AMD) with or without reticular pseudodrusen (RPD). Methods: We evaluated the clinical history, blood pressure parameters, fundus photography, and optical coherence tomography images of consecutive patients with early AMD. We calculated the mean OPP from blood pressure and intraocular pressure...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27907041/carotid-atherosclerosis-cerebrospinal-fluid-pressure-and-retinal-vessel-diameters-the-asymptomatic-polyvascular-abnormalities-in-community-study
#2
Jing Yan Yang, Xuan Yang, Yang Li, Jie Xu, Yong Zhou, An Xin Wang, Xiang Gao, Liang Xu, Shou Ling Wu, Wen Bin Wei, Xing Quan Zhao, Jost B Jonas
PURPOSE: To assess relationships between carotid artery atherosclerosis and retinal arteriolar and venular diameters. METHODS: The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) included a sub-population of the Kailuan study which consisted of 101,510 employees and retirees of a coal mining industry. Based on the Chinese National Census 2010 and excluding individuals with history of cerebrovascular ischemic events, 4004 individuals were included into the APAC...
2016: PloS One
https://www.readbyqxmd.com/read/27897005/strategies-for-equitable-pharmacogenomic-guided-warfarin-dosing-among-european-and-african-american-individuals-in-a-clinical-population
#3
Laura K Wiley, Jacob P Vanhouten, David C Samuels, Melinda C Aldrich, Dan M Roden, Josh F Peterson, Joshua C Denny
The blood thinner warfarin has a narrow therapeutic range and high inter- and intra-patient variability in therapeutic doses. Several studies have shown that pharmacogenomic variants help predict stable warfarin dosing. However, retrospective and randomized controlled trials that employ dosing algorithms incorporating pharmacogenomic variants under perform in African Americans. This study sought to determine if: 1) including additional variants associated with warfarin dose in African Americans, 2) predicting within single ancestry groups rather than a combined population, or 3) using percentage African ancestry rather than observed race, would improve warfarin dosing algorithms in African Americans...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27876349/morphological-study-on-the-pressure-ulcer-like-dermal-lesions-formed-in-the-rat-heel-skin-after-transection-of-the-sciatic-nerves
#4
Daijiro Haba, Chie Minami, Miki Miyagawa, Takamitsu Arakawa, Akinori Miki
Due to transection of bilateral sciatic nerves, pressure ulcer-like dermal lesion occurred in the hairy skin covering of the heel skin in almost all rats. In the present study, chronological changes of the rat heel skin after the transection were morphologically and immunohistochemically examined. In the heel skin, redness and swelling began by 3days after the operation, and open wound formed by 17days. At the redness and swelling stage, edema extensively occurred in the dermis. At the thickening stage, the epidermis at the pressed site became transiently thicker, and at the whitening stage, rapidly thinner...
November 19, 2016: Acta Histochemica
https://www.readbyqxmd.com/read/27861592/hyperoxia-induced-proliferative-retinopathy-early-interruption-of-retinal-vascular-development-with-severe-and-irreversible-neurovascular-disruption
#5
Michelle Lajko, Herminio J Cardona, Joann M Taylor, Ronil S Shah, Kathryn N Farrow, Amani A Fawzi
Bronchopulmonary dysplasia (BPD) is a major cause of neonatal morbidity in premature infants, occurring as a result of arrested lung development combined with multiple postnatal insults. Infants with BPD exposed to supplemental oxygen are at risk of retinopathy of prematurity as well. Thus, we studied the effects of hyperoxia on the retinal vasculature in a murine model of BPD. The retinal phenotype of this model, which we termed hyperoxia-induced proliferative retinopathy (HIPR), shows severe disruption of retinal vasculature and loss of vascular patterning, disorganized intra-retinal angiogenesis, inflammation and retinal detachment...
2016: PloS One
https://www.readbyqxmd.com/read/27847633/automated-macular-choroidal-thickness-measurement-by-swept-source-optical-coherence-tomography-in-pseudoxanthoma-elasticum
#6
Rosa Dolz-Marco, María Andreu-Fenoll, Pablo Hernández-Martínez, M Dolores Pinazo-Durán, Roberto Gallego-Pinazo
INTRODUCTION: Pseudoxanthoma elasticum (PXE) typically involves elastic fibers in blood vessels and Bruch membrane. Our purpose was to analyze retinal and choroidal macular thickness in patients with angioid streaks due PXE compared with a control group. METHODS: Best-corrected visual acuity (BCVA), axial length (AL), and macular swept-source optical coherence tomography were obtained. Automated segmentations of the retina and the choroid were used to obtain the corresponding thickness values...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27806382/evaluation-of-choroidal-thickness-in-children-with-iron-deficiency-anemia
#7
Ali Simsek, Mehmet Tekin, Abdurrahman Bilen, Ayse Sevgi Karadag, Ibrahim Hakan Bucak, Mehmet Turgut
Purpose: The purpose of this study was to determine whether there are differences in choroidal thickness in children with iron deficiency anemia (IDA). Methods: Fifty-two patients with IDA and 54 healthy children between 3 and 16 years of age were enrolled in this study. After complete eye examinations were conducted for each participant, the choroidal thickness was measured using optical coherence tomography. Correlations between the choroidal thickness and clinical and laboratory parameters were also evaluated...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27769587/deep-retinal-layer-microvasculature-dropout-detected-by-the-optical-coherence-tomography-angiography-in-glaucoma
#8
Min Hee Suh, Linda M Zangwill, Patricia Isabel C Manalastas, Akram Belghith, Adeleh Yarmohammadi, Felipe A Medeiros, Alberto Diniz-Filho, Luke J Saunders, Robert N Weinreb
PURPOSE: To investigate factors associated with dropout of the parapapillary deep retinal layer microvasculature assessed by optical coherence tomography angiography (OCTA) in glaucomatous eyes. DESIGN: Cross-sectional study. PARTICIPANTS: Seventy-one eyes from 71 primary open-angle glaucoma (POAG) patients with β-zone parapapillary atrophy (βPPA) enrolled in the Diagnostic Innovations in Glaucoma Study. METHODS: Parapapillary deep-layer microvasculature dropout was defined as a complete loss of the microvasculature located within the deep retinal layer of the βPPA from OCTA-derived optic nerve head vessel density maps by standardized qualitative assessment...
October 18, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27767056/alteration-of-blood-clot-structures-by-interleukin-1-beta-in-association-with-bone-defects-healing
#9
Xin Wang, Thor E Friis, Paul P Masci, Ross W Crawford, Wenbo Liao, Yin Xiao
The quality of hematomas are crucial for successful early bone defect healing, as the structure of fibrin clots can significantly influence the infiltration of cells, necessary for bone regeneration, from adjacent tissues into the fibrin network. This study investigated if there were structural differences between hematomas from normal and delayed healing bone defects and whether such differences were linked to changes in the expression of IL-1β. Using a bone defect model in rats, we found that the hematomas in the delayed healing model had thinner fibers and denser clot structures...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27750290/spatial-distribution-of-macular-pigment-in-an-elderly-french-population-the-montrachet-study
#10
Seydou Alassane, Christine Binquet, Louis Arnould, Olivier Fleck, Niyazi Acar, Cécile Delcourt, Lionel Bretillon, Alain M Bron, Catherine Creuzot-Garcher
Purpose: We describe the spatial distribution and cross-sectional associations with physical and lifestyle attributes. Methods: The participants of the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including optical coherence tomography, to measure retinal thickness. The spatial distribution of macular pigment optical density (MPOD) defined as a ring-like, intermediate or no-ring pattern, was assessed by means of the two-wavelength autofluorescence technique...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27722088/measurement-of-cortical-thickness-asymmetry-in-carotid-occlusive-disease
#11
Iris Asllani, Pamelia Slattery, Alexander Fafard, Marykay Pavol, Ronald M Lazar, Randolph S Marshall
Despite being considered an important anatomical parameter directly related to neuronal density, cortical thickness is not routinely assessed in studies of the human brain in vivo. This paucity has been largely due to the size and convoluted shape of the human cortex, which has made it difficult to develop automated algorithms that can measure cortical thickness efficiently and reliably. Since the development of such an algorithm by Fischl and Dale in 2000, the number of studies investigating the relationship between cortical thickness and other physiological parameters in the brain has been on the rise...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27695812/differences-in-body-condition-of-gilts-that-are-maintained-from-mating-to-the-end-of-gestation-affect-mammary-development
#12
C Farmer, M Comi, C R A Duarte, M Vignola, P Charagu, M-F Palin
The goal of this project was to determine if different body conditions in late gestation that are due to varying body conditions at mating affect mammary development and mammary gene expression of gilts. Gilts that were fed ad libitum in the growing period were selected based on their backfat depths to form 3 groups at mating, namely, low backfat (LBF; 12-15 mm; = 14), medium backfat (MBF; 17-19 mm; = 15), and high backfat (HBF; 22-26 mm; = 16). During gestation, LBF, MBF, and HBF gilts were fed approximately 1...
August 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27691987/claw-disorders-in-dairy-cattle-an-unexpected-association-between-energy-metabolism-and-sole-haemorrhages
#13
Katrin Wilhelm, Jürgen Wilhelm, Manfred Fürll
The present study investigated whether changes of energy metabolism post-partum (pp) are associated with claw health. For this purpose, back-fat-thickness (BFT) was measured and blood samples were taken from 146 cows at four examination times. The serum levels of free fatty acids (FFA), ß-hydroxybutyrate (BHB) and glucose were measured. Furthermore, in the first week postpartum (pp) and at 8 weeks pp, a claw trimming was done and the presence and extent of sole haemorrhages (SH) was recorded. Animals with high BFT at calving and therefore high fat mobilisation and whose FFA and BHB levels in the first week pp exceeded the reference values had fewer pathological changes of the claws than thinner animals whose FFA and BHB levels stayed within reference ranges...
October 3, 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27668068/blood-thinners-and-gastrointestinal-endoscopy
#14
REVIEW
Monjur Ahmed
As the number of diagnostic and therapeutic gastrointestinal endoscopies is increasing, and there is an increase in number of patients taking blood thinners, we are seeing more and more patients on blood thinners prior to endoscopic procedures. Gastrointestinal bleeding or thromboembolism can occur in this category of patients in the periendoscopic period. To better manage these patients, endoscopists should have a clear concept about the various blood thinners in the market. Patients' risk of thromboembolism off anticoagulation, and the risk of bleeding from endoscopic procedures should be assessed prior to endoscopy...
September 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27625163/association-between-outer-retinal-alterations-and-microvascular-changes-in-intermediate-stage-age-related-macular-degeneration-an-optical-coherence-tomography-angiography-study
#15
Lisa Toto, Enrico Borrelli, Rodolfo Mastropasqua, Luca Di Antonio, Emanuele Doronzo, Paolo Carpineto, Leonardo Mastropasqua
AIMS: To investigate associations between changes in retinal vessels and alterations detected by spectral domain optical coherence tomography (SD-OCT) scans in intermediate stage age-related macular degeneration (AMD). METHODS: Thirty eyes of 30 patients with intermediate dry AMD were enrolled in the study. Of the cohort study, 15 eyes (changes-AMD group) showed OCT changes preceding the development of drusen-associated atrophy. A control group of healthy subjects was selected for statistical comparisons...
September 13, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27561178/new-virtually-wall-less-cannulas-designed-for-augmented-venous-drainage-in-minimally-invasive-cardiac-surgery
#16
Ludwig Karl von Segesser, Denis Berdajs, Saad Abdel-Sayed, Piergiorgio Tozzi, Enrico Ferrari, Francesco Maisano
OBJECTIVE: Inadequate venous drainage during minimally invasive cardiac surgery becomes most evident when the blood trapped in the pulmonary circulation floods the surgical field. The present study was designed to assess the in vivo performance of new, thinner, virtually wall-less, venous cannulas designed for augmented venous drainage in comparison to traditional thin-wall cannulas. METHODS: Remote cannulation was realized in 5 bovine experiments (74.0 ± 2.4 kg) with percutaneous venous access over the wire, serial dilation up to 18 F and insertion of either traditional 19 F thin wall, wire-wound cannulas, or through the same access channel, new, thinner, virtually wall-less, braided cannulas designed for augmented venous drainage...
July 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27541926/choroidal-blood-flow-visualization-in-highly-myopia-using-a-projection-artifact-method-in-optical-coherence-tomography-angiography
#17
Ichiro Maruko, Richard F Spaide, Hideki Koizumi, Shota Sawaguchi, Takahiko Izumi, Taiji Hasegawa, Hisaya Arakawa, Tomohiro Iida
PURPOSE: To visualize choroidal blood flow in larger vessels in highly myopic eyes using a phenomenon of the projection artifact to in the sclera using optical coherence tomography angiography. METHODS: The retrospective study included 92 eyes (54 patients) with greater than 8 diopters of myopia. All eyes were examined using optical coherence tomography angiography (RTVue XR Avanti; Optovue Inc, Fremont, CA). The blood flow in choroidal vessels was evaluated by attempting to directly segment the choroid and also by placing the segmentation layer behind the choroid, within the sclera...
August 18, 2016: Retina
https://www.readbyqxmd.com/read/27514428/-analysis-of-hemoperfusion-in-the-treatment-of-thinner-poisoning-effect
#18
J R Wang, G Y Zhao
OBJECTIVE: To investigate the combination of drugs in blood perfusion-based rescue therapy of acute poisoning thinners. METHODS: Our department were retrospectively analyzed in May 2011 to October 2014, 54 cases thinners poisoning patients choose the thinner should be 44 cases of acute poisoning patients were divided into two groups. Toluene, xylene group 8 cases; Halogenated hydrocarbon group 34cases; Give blood perfusion 3 to 7 times, compared before and after the blood perfusion of toxicant concentration, results and biochemical indicators...
May 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27502589/acemg-mediated-hearing-preservation-in-cochlear-implant-patients-receiving-different-electrode-lengths-prohearing-study-protocol-for-a-randomized-controlled-trial
#19
Verena Scheper, Melanie Leifholz, Heiko von der Leyen, Miriam Keller, Ute Denkena, Armin Koch, Annika Karch, Josef Miller, Thomas Lenarz
BACKGROUND: The indications for a cochlear implant (CI) have been extended to include patients with some residual hearing. Shorter and thinner atraumatic electrodes have been designed to preserve the residual hearing in the implanted ear. However, the insertion of the electrode array into the cochlea, with potential mechanical trauma and the presence of this foreign body inside the cochlea, may lead to free radical formation and reduced blood perfusion of the cochlea which can result in the loss of residual hearing...
August 8, 2016: Trials
https://www.readbyqxmd.com/read/27462374/obesity-maternal-smoking-and-shbg-in-neonates
#20
Swapna Dharashivkar, Lawrence Wasser, Richard N Baumgartner, Jeffrey C King, Stephen J Winters
BACKGROUND: Sex hormone binding globulin (SHBG), a glycoprotein produced by hepatocytes that transports testosterone and other steroids in plasma, is a marker for developing metabolic syndrome and T2DM. SHBG is present in umbilical cord blood where it may be epigenetically regulated. This study was conducted to investigate whether the fetal environment, based on maternal pre-pregnancy weight, pregnancy weight gain or smoking during pregnancy, influence SHBG in newborns. METHODS: Maternal and newborn characteristics and SHBG levels and other variables were measured in cord and day 2 heel-stick blood samples in 60 healthy full-term singleton babies (31 F, 29 M)...
2016: Diabetology & Metabolic Syndrome
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