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https://www.readbyqxmd.com/read/29154057/far-infrared-ray-patches-relieve-pain-and-improve-skin-sensitivity-in-myofascial-pain-syndrome-a-double-blind-randomized-controlled-study
#1
Yen-Ting Lai, Hsiang-Lin Chan, Shu-Huan Lin, Chih-Ching Lin, Szu-Yuan Li, Chih-Kuang Liu, Hao-Wei Teng, Wen-Sheng Liu
OBJECTIVE: Myofascial pain syndrome (MPS) is a common disorder characterized by muscle pain if myofascial trigger points (MTrP) are stimulated. This study evaluated the effectiveness of far-infrared ray (FIR) patches in reducing the severity of pain in patients with MPS. METHODS: A double-blind, randomized controlled study involving 125 patients with MPS and 201 MTrPs located in the trapezius muscle. A FIR patch was applied to 98 MTrPs for 24h in the intervention group (61 patients) and a placebo patch was applied to 91 MTrPs in the control group (57 patients) at the end...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29130043/nonuniform-internal-structure-of-fibrin-fibers-protein-density-and-bond-density-strongly-decrease-with-increasing-diameter
#2
Wei Li, Justin Sigley, Stephen R Baker, Christine C Helms, Mary T Kinney, Marlien Pieters, Peter H Brubaker, Roger Cubcciotti, Martin Guthold
The major structural component of a blood clot is a meshwork of fibrin fibers. It has long been thought that the internal structure of fibrin fibers is homogeneous; that is, the protein density and the bond density between protofibrils are uniform and do not depend on fiber diameter. We performed experiments to investigate the internal structure of fibrin fibers. We formed fibrin fibers with fluorescently labeled fibrinogen and determined the light intensity of a fiber, I, as a function of fiber diameter, D...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29123870/characteristic-of-the-acute-drug-intoxication-conveyed-by-kanagawa-helicopter-emergency-medical-service
#3
Mariko Sugita, Shigeo Higami, Shigeaki Inoue, Seiji Morita, Yoshihide Nakagawa, Sadaki Inokuchi
Aim: Various critical cases have been transported since the use of the Kanagawa Helicopter Emergency Medical Service (HEMS) started at Tokai University Hospital (Isehara, Japan) in 2002, including cases of acute poisoning. We analyzed the characteristics of acute poisoning cases conveyed by the HEMS. Methods: Kanagawa HEMS conveyed 3,814 cases from July 2002 to March 2013, and acute drug and poison intoxication was diagnosed in 131 of these cases. We undertook a descriptive statistical study of these cases...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29043488/hair-analysis-does-not-allow-to-discriminate-between-acute-and-chronic-administrations-of-a-drug-in-young-children
#4
Jean Claude Alvarez, Laetitia Lasne, Isabelle Etting, Gérard Chéron, Véronique Abadie, Nicolas Fabresse, Islam Amine Larabi
There are many differences between the hair from children and that of adult subjects, the hair being thinner, more porous with a different growth rate from the usual 1 cm/month observed in adults. In order to determine whether hair analysis could discriminate between chronic use and acute administration of a drug in children like in adults, we analyzed hair from 18 children aged between 1 day and 15 years in whom the administration of different drugs was known (single therapeutic administration or acute intoxication)...
October 18, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28990282/use-of-oral-mucosal-cell-sheets-for-accelerated-oral-surgical-wound-healing
#5
Jong-Lyel Roh, Jaewang Lee, Hyejin Jang, Eun Hye Kim, Daiha Shin
BACKGROUND: We developed a highly efficient in vitro-engineered mucosa equivalent using completely autologous mucosa and blood and investigated its feasibility and efficacy for oral surgical wound healing. METHODS: Small oral mucosa samples were obtained from surgical patients, and keratinocytes and fibroblasts were primarily grown in media without animal products for generating 3D cell sheets. RESULTS: Morphological characteristics of the cell sheets were comparable to those of human mucosa, although p63-positive cells were more numerous in cell sheets...
October 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28985686/are-older-adults-willing-to-consider-new-strategies-to-reduce-stroke-risk
#6
Stuart W Grande, Elizabeth S O'Neill, Ariel E Sherman, Megan Coylewright
Atrial fibrillation (AF) is a common arrhythmia that increases patients' risk of stroke, and determining an optimal prevention therapy is a preference-sensitive decision appropriate for shared decision making (SDM). Utilizing community-based focus groups, we explored beliefs and values around options for stroke prevention. Interview transcripts from five independent focus groups were qualitatively assessed and organized into themes. Most participants were taking a blood thinner (93%) and more than half of participants (64%) reported having AF...
October 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28974461/bone-replaces-articular-cartilage-in-the-rat-knee-joint-after-prolonged-immobilization
#7
T M Campbell, K Reilly, O Laneuville, H Uhthoff, G Trudel
BACKGROUND: Lost joint range of motion (ROM) is common in chronic osteoarthritis, alters regional weight-bearing across the articular surfaces, and contributes to loss of cartilage and bone alterations. Limited data exist on the regional effects on joints subjected to chronic losses of ROM. OBJECTIVE: To characterize the regional replacement by bone as part of articular cartilage degeneration after prolonged immobilization. METHODS: Eleven rat knees were rigidly-immobilized in flexion for 32weeks with contralateral and sham-operated (n=6) knees as controls...
September 30, 2017: Bone
https://www.readbyqxmd.com/read/28950833/alphavbeta3-integrin-expression-within-uterine-endometrium-in-unexplained-infertility-a-prospective-cohort-study
#8
Ahmed Elnaggar, Amr H Farag, Mohamed E Gaber, Mohamed Abdel Hafeez, Mohamed S Ali, Alaa M Atef
BACKGROUND: Implantation defect is one of these contributing factors for unexplained infertility. In the mid-luteal phase, when implantation is expected to happen, Integrins expression is remarkably increased. So, Integrins could potentially serve as markers for the frame of the window of implantation. αVβ3 integrin could have a role as a potential receptor for embryonic attachment. The aim of the current study is to investigate whether the women with unexplained infertility have a pattern of expression of endometrial αvβ3 integrin that could differ from those who have normal fertility or not...
September 26, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28926988/quality-assessment-of-platelet-rich-fibrin-like-matrix-prepared-from-whole-blood-samples-after-extended-storage
#9
Hideo Kawabata, Kazushige Isobe, Taisuke Watanabe, Toshimitsu Okudera, Masayuki Nakamura, Masashi Suzuki, Jietsu Ryu, Yutaka Kitamura, Hajime Okudera, Kazuhiro Okuda, Koh Nakata, Tomoyuki Kawase
The platelet-rich fibrin-like matrix (PRFM) is usually prepared onsite and immediately used for regenerative therapy. Nonetheless, to meet the clinical necessity of preserving the PRFM without quality deterioration, we developed a method for preparation of PRFMs from short-term-stored whole blood (WB) samples. In this study, to evaluate the practical expiration date of storage, we extended the storage time of WB samples from 2 to 7 days and assessed the quality of the resulting PRFMs. WB samples collected with acid-citrate-dextrose were stored with gentle agitation at ambient temperature...
September 18, 2017: Biomedicines
https://www.readbyqxmd.com/read/28884176/morphometric-characterization-of-fibrinogen-s-%C3%AE-c-regions-and-their-role-in-fibrin-self-assembly-and-molecular-organization
#10
Anna D Protopopova, Rustem I Litvinov, Dennis K Galanakis, Chandrasekaran Nagaswami, Nikolay A Barinov, Alexander R Mukhitov, Dmitry V Klinov, John W Weisel
The flexible C-terminal parts of fibrinogen's Aα chains named the αC regions have been shown to play a role in fibrin self-assembly, although many aspects of their structure and functions remain unknown. To examine the involvement of the αC regions in the early stages of fibrin formation, we used high-resolution atomic force microscopy to image fibrinogen and oligomeric fibrin. Plasma-purified full-length human fibrinogen or des-αC fibrinogen lacking most of the αC regions, untreated or treated with thrombin, was imaged...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28867375/calcified-plaque-modification-alters-local-drug-delivery-in-the-treatment-of-peripheral-atherosclerosis
#11
Abraham R Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R Edelman
BACKGROUND: Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD). OBJECTIVES: We evaluated the effects of orbital atherectomy on intraluminal paclitaxel delivery to human peripheral arteries with substantial calcified plaque. METHODS: Diagnostic angiography and 3-D rotational imaging of five fresh human lower limbs revealed calcification in all main arteries. The proximal or distal segment of each artery was treated using an orbital atherectomy system (OAS) under simulated blood flow and fluoroscopy...
October 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28843033/hemodynamic-analysis-of-a-novel-bioresorbable-scaffold-in-porcine-coronary-artery-model
#12
Erhan Tenekecioglu, Ryo Torii, Christos V Bourantas, Rafael Cavalcante, Yohei Sotomi, Yaping Zeng, Carlos Collet, Tom Crake, Alexandre Abizaid, Yoshinobu Onuma, Solomon Su, Teguh Santoso, Patrick W Serruys
BACKGROUND: The shear stress distribution assessment can provide useful insights for the hemodynamic performance of the implanted stent/scaffold. Our aim was to investigate the effect of a novel bioresorbable scaffold, Mirage on local hemodynamics in animal models. METHOD: The main epicardial coronary arteries of 7 healthy mini-pigs were implanted with 11 Mirage Microfiber sirolimus-eluting Bioresorbable Scaffolds (MMSES). Optical coherence tomography (OCT) was performed post scaffold implantation and the obtained images were fused with angiographic data to reconstruct the coronary artery anatomy...
August 26, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28815276/determination-of-89-drugs-and-other-micropollutants-in-unfiltered-wastewater-and-freshwater-by-lc-ms-ms-an-alternative-sample-preparation-approach
#13
Alexandros G Asimakopoulos, Pranav Kannan, Sean Higgins, Kurunthachalam Kannan
A liquid chromatography-triple quadrupole-tandem mass spectrometry (LC-qQq-MS/MS) method was developed for simultaneous determination of 89 legal neuropsychiatric pharmaceuticals and illicit drugs (both parent compounds and metabolites) and other micropollutants in unfiltered wastewater and freshwater. The target chemicals fall under the classes of amphetamine-type stimulants, cocaine compounds, opiates and opioids, benzodiazepines, lysergic compounds, antipsychotics, anesthetics, antiepileptics, antidepressants, sympathomimetics, cannabinoids, blood thinners, antihistamines, β-blockers, caffeine derivatives, nicotine derivatives, z-drugs, new designer drugs, and Alzheimer medications...
October 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28780813/-delayed-effect-of-liver-injury-and-metabolism-of-dimethylformamide-after-high-exposures-in-rats
#14
Z J Wu, M Y Guan, M Zheng, M Zhang, W J Zhao, L J Shao, Y C Zhai, Y L Zhu, J Cheng
Objective: To investigate the delayed effect of liver injury and metabolism of dimethylformamide (DMF) after high exposures in rats. Methods: A total of 12 rats were randomly divided into four groups and 3 rats were in each group. Rats in 1d DMF+2 d delayed group were dosed for 1 day and rested for 2 days, and sacrificed at the 4th day. Rats in 3 d DMF group were dosed for 3 days and sacrificed at the 4th day. Rats in 3 d DMF+3 d delayed group were dosed for 3 days and rested for 3 days, and sacrificed at the 7th day...
June 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28687753/development-of-novel-mouse-model-of-ulcers-induced-by-implantation-of-magnets
#15
Yuriko Takeuchi, Koji Ueno, Takahiro Mizoguchi, Makoto Samura, Takasuke Harada, Atsunori Oga, Tomoaki Murata, Tohru Hosoyama, Noriyasu Morikage, Kimikazu Hamano
We developed a novel mouse model of human refractory cutaneous ulcers that more faithfully reflects pathology and evaluated the effects of mixed cell sheets comprising peripheral blood mononuclear cells and fibroblasts, which we previously developed for treating refractory cutaneous ulcers. Model development involved sandwiching the skin between two magnets, one of which was implanted under the skin for 7 consecutive days. This magnet-implanted ulcer model produced persistently large amounts of exudate and induced the infiltration of the ulcer with inflammatory cells...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28643042/oct-in-alzheimer-s-disease-thinning-of-the-rnfl-and-superior-hemiretina
#16
João Paulo Cunha, Rita Proença, Arnaldo Dias-Santos, Rita Almeida, Helena Águas, Marta Alves, Ana Luísa Papoila, Carlota Louro, António Castanheira-Dinis
BACKGROUND: Peripapillary retinal nerve fiber layer (pRNFL) and internal macular layer thinning have been demonstrated in Alzheimer's disease (AD) with optical coherence tomography (OCT) studies. The purpose of this study is to compare the pRNFL thickness and overall retinal thickness (RT) in AD patients with non-AD patients, using spectral domain optical coherence tomography (SD-OCT) and determine the sectors most characteristically affected in AD. METHODS: A cross-sectional study was performed to determine the pRNFL and overall macular RT thicknesses in AD and non-AD patients, attending a tertiary hospital center...
June 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28577053/regenerative-properties-of-collagenated-porcine-bone-grafts-in-human-maxilla-demonstrative-study-of-the-kinetics-by-synchrotron-radiation-microtomography-and-light-microscopy
#17
Alessandra Giuliani, Giovanna Iezzi, Serena Mazzoni, Adriano Piattelli, Vittoria Perrotti, Antonio Barone
OBJECTIVES: Recently, it has been reported that heterologous biomaterials, where the collagen matrix is preserved, seem to facilitate blood clotting and the subsequent invasion of repairing and regenerative cells. This study aimed at evaluating the healing of human extraction sockets grafted with a collagenated cortico-cancellous porcine bone (mp3®, OsteoBiol®, Tecnoss®, Giaveno, Italy) by synchrotron radiation X-ray microtomography (microCT) and histology in order to have a 3D quantitative characterization over time...
June 2, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28504989/structural-behavior-of-the-endothelial-glycocalyx-is-associated-with-pathophysiologic-status-in-septic-mice-an-integrated-approach-to-analyzing-the-behavior-and-function-of-the-glycocalyx-using-both-electron-and-fluorescence-intravital-microscopy
#18
Hanae Kataoka, Akira Ushiyama, Yoshihiro Akimoto, Sachie Matsubara, Hayato Kawakami, Takehiko Iijima
BACKGROUND: The endothelial surface layer (ESL) regulates vascular permeability to maintain fluid homeostasis. The glycocalyx (GCX), which has a complex and fragile ultrastructure, is an important component of the ESL. Abnormalities of the GCX have been hypothesized to trigger pathological hyperpermeability. Here, we report an integrated in vivo analysis of the morphological and functional properties of the GCX in a vital organ. METHODS: We examined the behavior of the ESL and GCX, using both electron microscopy (EM) and intravital microscopy (IVM)...
September 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28493982/comparison-of-spectral-domain-optical-coherence-tomography-for-intra-retinal-layers-thickness-measurements-between-healthy-and-diabetic-eyes-among-chinese-adults
#19
COMPARATIVE STUDY
Shu-Ting Li, Xiang-Ning Wang, Xin-Hua Du, Qiang Wu
PURPOSE: To compare intra-retinal layer thickness measurements between eyes with no or mild diabetic retinopathy (DR) and age-matched controls using Spectralis spectral-domain optical coherence tomography (SD-OCT). METHODS: Cross-sectional observational analysis study. High-resolution macular volume scans (30° * 25°) were obtained for 133 type 2 diabetes mellitus (T2DM) patients with no DR, 42 T2DM patients with mild DR and 115 healthy controls. The mean thickness was measured in all 9 Early Treatment Diabetic Retinopathy Study (ETDRS) sectors for 8 separate layers, inner retinal layer (IRL), outer retinal layer (ORL) and total retina (TR), after automated segmentation...
2017: PloS One
https://www.readbyqxmd.com/read/28493931/asymptomatic-carotid-artery-stenosis-and-retinal-nerve-fiber-layer-thickness-a-community-based-observational-study
#20
Dandan Wang, Yang Li, Yong Zhou, Cheng Jin, Qi Zhao, Anxin Wang, Shouling Wu, Wen Bin Wei, Xingquan Zhao, Jost B Jonas
PURPOSE: To examine whether an abnormally thin retinal nerve fiber layer (RNFL) is associated with cerebrovascular insufficiency. DESIGN: Community-based study. METHODS: The Asymptomatic Polyvascular Abnormalities in Community Study included Chinese aged 40+ years and without histories of cerebrovascular incidents or coronary heart disease. Using transcranial Doppler and carotid duplex ultrasound examination, we assessed presence and degree of an intracranial arterial stenosis (ICAS) and extracranial carotid arterial stenosis (ECAS) and we measured the RNFL thickness by spectral-domain optical coherence tomography...
2017: PloS One
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