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https://www.readbyqxmd.com/read/28212546/precursor-n-cadherin-mediates-glial-cell-line-derived-neurotrophic-factor-promoted-human-malignant-glioma
#1
Ye Xiong, Liyun Liu, Shuang Zhu, Baole Zhang, Yuxia Qin, Ruiqin Yao, Hao Zhou, Dian Shuai Gao
As the most prevalent primary brain tumor, gliomas are highly metastatic, invasive and are characteristic of high levels of glial cell-line derived neurotrophic factor (GDNF). GDNF is an important factor for invasive glioma cell growth; however, the underlying mechanism involved is unclear. In this study, we affirm a significantly higher expression of the precursor of N-cadherin (proN-cadherin) in most gliomas compared with normal brain tissues. Our findings reveal that GDNF interacts with the extracellular domain of proN-cadherin, which suggests that proN-cadherin mediates GDNF-induced glioma cell migration and invasion...
February 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28211838/work-satisfaction-burnout-and-gender-based-inequalities-among-ophthalmologists-in-india-a-survey
#2
Akshay Gopinathan Nair, Pooja Jain, Aniruddha Agarwal, Vandana Jain
BACKGROUND: Ophthalmology is a rapidly evolving branch of medicine and advancing technology has raised the bar of patient expectations and outcomes. However, studies that assess physician stress and satisfaction especially in developing countries are limited in literature. OBJECTIVE: This index study aims at looking at the levels of job satisfaction, burnout and perception of gender disparity among ophthalmologists in India. METHODS: An Internet-based survey was sent out to ophthalmologists...
February 17, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28208897/a-validation-of-an-examination-protocol-for-cerebral-visual-impairment-among-children-in-a-clinical-population-in-india
#3
Swetha Sara Philip, Sherab Tsherlinga, Maya Mary Thomas, Gordon N Dutton, Richard Bowman
INTRODUCTION: Cerebral Visual Impairment (CVI) is a leading cause of vision impairment in developed and developing countries due to and increased survival of preterm and low birth weight infants. There are few data concerning the validity of protocols available to diagnose CVI. AIM: This study aimed to document the face, content and construct validity of an assessment protocol namely, a 15-domain, Structured Clinical Question Inventory (SCQI), which is based on structured history taking and clinical examination, for the diagnosis of CVI in a clinical population of India...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28206881/loss-of-permanent-first-molars-in-the-mixed-dentition-circumstances-resulting-in-extraction-and-requiring-orthodontic-management
#4
Kavita R Mathu-Muju, David B Kennedy
Extraction of significantly compromised permanent first molars may be indicated during the mixed dentition stage of occlusal development. The purpose of this article was to review circumstances that can result in the loss of a permanent first molar-including dental caries, molar incisor hypomineralization, eruption disturbances of permanent teeth, and failure of restorative treatment to affirm that a complete dental arch is not necessary for the existence of a functional dental arch. The extraction of permanent first molar(s) with subsequent orthodontic treatment in a young patient can be considered a cost-effective alternative to placing complex restorations that require replacement over the lifespan...
October 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28206787/self-affirmation-increases-defensiveness-toward-health-risk-information-among-those-experiencing-negative-emotions-results-from-two-national-samples
#5
Rebecca A Ferrer, William M P Klein, Kaitlin A Graff
OBJECTIVE: Self-affirmation can promote health behavior change and yield long-term improvements in health via its effect on receptiveness to risk information in behavior change interventions. Across 2 studies, we examined whether the emotional state of the person presented with health risk information moderates self-affirmation effectiveness. METHOD: Data were collected from 2 U.S. national samples (n = 652, n = 448) via GfK, an Internet-based survey company. Female alcohol consumers completed an emotion induction (fear, anger, or neutral)...
February 16, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28206778/personal-and-cultural-identity-development-in-recently-immigrated-hispanic-adolescents-links-with-psychosocial-functioning
#6
Alan Meca, Raha F Sabet, Colleen M Farrelly, Cynthia G Benitez, Seth J Schwartz, Melinda Gonzales-Backen, Elma I Lorenzo-Blanco, Jennifer B Unger, Byron L Zamboanga, Lourdes Baezconde-Garbanati, Simona Picariello, Sabrina E Des Rosiers, Daniel W Soto, Monica Pattarroyo, Juan A Villamar, Karina M Lizzi
OBJECTIVES: This study examined directionality between personal (i.e., coherence and confusion) and cultural identity (i.e., ethnic and U.S.) as well as their additive effects on psychosocial functioning in a sample of recently immigrated Hispanic adolescents. METHOD: The sample consisted of 302 recent (<5 years) immigrant Hispanic adolescents (53% boys; Mage = 14.51 years at baseline; SD = .88 years) from Miami and Los Angeles who participated in a longitudinal study...
February 16, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28205334/long-non-coding-rna-tug1-promotes-migration-and-invasion-by-acting-as-a-cerna-of-mir-335-5p-in-osteosarcoma-cells
#7
Yong Wang, Tao Yang, Zhen Zhang, Ming Lu, Wei Zhao, Xiandong Zeng, Weiguo Zhang
Long non-coding RNAs (lncRNAs) have now become the new hotspots in an ocean of diseases including osteosarcoma. The function of taurine up-regulated gene 1 (TUG1) and its working mechanism in osteosarcoma remain unclear. In our research, we found that TUG1 was elevated and correlated with a poor prognosis in osteosarcoma patients. Also, the following functional experiment showed that decreased TUG1 could remarkably inhibit osteosarcoma cell migration and invasion, indicating that TUG1 functioned as an oncogene in osteosarcoma...
February 15, 2017: Cancer Science
https://www.readbyqxmd.com/read/28204949/caregiver-burden-and-the-medical-ethos
#8
Karsten Witt, Johanne Stümpel, Christiane Woopen
Are physicians sometimes morally required to ease caregiver burden? In our paper we defend an affirmative answer to this question. First, we examine the well-established principle that medical care should be centered on the patient. We argue that although this principle seems to give physicians some leeway to lessen caregivers' suffering, it is very restrictive when spelled out precisely. Based on a critical analysis of existing cases for transcending patient-centeredness we then go on to argue that the medical ethos should indeed contain a rule requiring physicians to alleviate caregiver burden under certain circumstances...
February 15, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28202502/narrative-empathy-and-illness-memoirs-arthur-frank-s-at-the-will-of-the-body-and-kathlyn-conway-s-ordinary-life
#9
Rosalia Baena
This article analyses the concept of narrative empathy in illness memoirs. These texts negotiate the narrative identity of an autobiographer as he or she recounts the disruptive experience of illness, an experience in which physical and emotional traces dramatically and definitively shape our sense of self. While narrative emotions are certainly deployed in these autobiographies in order to connect with the readers and promote social change, this empathic connection is not so much aimed at arousing compassion but rather more positive emotions on the experience of illness...
February 15, 2017: Medical Humanities
https://www.readbyqxmd.com/read/28202453/parenchymatous-cell-division-characterizes-the-fungal-cortex-of-some-common-foliose-lichens
#10
William B Sanders, Asunción de Los Ríos
PREMISE OF THE STUDY: Lichen-forming fungi produce diverse vegetative tissues, some closely resembling those of plants. Yet it has been repeatedly affirmed that none is a true parenchyma, in which cellular compartments are subdivided from all adjacent neighbors by cross walls adjoining older cross walls. METHODS: Using transmission electron microscopy (TEM), we tested this assumption by examining patterns of septum formation in the parenchyma-like cortex of three lichens of different phylogenetic affinities: Sticta canariensis, Leptogium cyanescens, and Endocarpon pusillum...
February 15, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28198156/prevalence-of-secondary-sj%C3%A3-gren-s-syndrome-in-indian-patients-with-rheumatoid-arthritis-a-single-center-study
#11
Krishna Santosh, Varun Dhir, Surjit Singh, Ashwani Sood, Amit Gupta, Aman Sharma, Shefali Sharma
AIM: To assess the prevalence of secondary Sjögren's syndrome (sSS) and its association with joint damage in patients with rheumatoid arthritis (RA) from northern India. METHODS: Patients included had RA, fulfilling the 1987 American College of Rheumatology criteria, with disease duration of more than 1 year. They were administered a sicca questionnaire that included six questions from subjective criteria of American European Consensus Group (AECG) criteria. Those who answered affirmatively to at least one question underwent Schirmer I test (ocular function) and salivary scintigraphy (salivary gland involvement)...
February 15, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28195577/hippocampus-glutamate-and-n-acetyl-aspartate-markers-of-excitotoxic-neuronal-compromise-in-posttraumatic-stress-disorder
#12
Isabelle M Rosso, David J Crowley, Marisa M Silveri, Scott L Rauch, J Eric Jensen
Hippocampus atrophy is implicated in posttraumatic stress disorder (PTSD), and may partly reflect stress-induced glutamate excitotoxicity that culminates in neuron injury and manifests as re-experiencing symptoms and other memory abnormalities. This study used high-field proton magnetic resonance spectroscopy (MRS) to determine whether PTSD is associated with lower hippocampus levels of the neuron marker N-acetyl aspartate (NAA), along with higher levels of glutamate (Glu) and Glu/NAA. We also predicted that metabolite levels would correlate with re-experiencing symptoms and lifetime trauma load...
February 13, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28194237/the-impact-of-micronutrient-status-on-health-correlation-network-analysis-to-understand-the-role-of-micronutrients-in-metabolic-inflammatory-processes-regulating-homeostasis-and-phenotypic-flexibility
#13
Tim J van den Broek, Bas H A Kremer, Marisa Marcondes Rezende, Femke P M Hoevenaars, Peter Weber, Ulrich Hoeller, Ben van Ommen, Suzan Wopereis
BACKGROUND: Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respond to a physiological challenge, is an essential indicator of health status. Therefore, health can be measured by applying a challenge test and monitoring the response of relevant phenotypic processes. In this study, we assessed the correlation of three fat-soluble vitamins, (i...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28193243/bite-size-research-bmc-research-notes-goes-back-to-its-roots
#14
EDITORIAL
Dirk Krüger, Diana M Marshall
Since it first launched in 2008, BMC Research Notes has been a place where researchers can publish short notes and observations, research outputs which are useful for the community but which can end up hidden in the lab notebook or as a footnote in a dataset. In order to re-affirm the importance of publishing these kinds of outputs, the journal is renewing its focus on publishing note articles as well as other potentially dark data such as short null results. Publishing these articles is useful for many researchers, therefore we are also expanding the scope to all scientific and clinical disciplines including health sciences, life sciences, physical sciences, mathematics and all engineering disciplines...
February 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28193182/de-novo-mutational-profile-in-rb1-clarified-using-a-mutation-rate-modeling-algorithm
#15
Varun Aggarwala, Arupa Ganguly, Benjamin F Voight
BACKGROUND: Studies of de novo mutations offer great promise to improve our understanding of human disease. After a causal gene has been identified, it is natural to hypothesize that disease relevant mutations accumulate within a sub-sequence of the gene - for example, an exon, a protein domain, or at CpG sites. These assessments are typically qualitative, because we lack methodology to assess the statistical significance of sub-gene mutational burden ultimately to infer disease-relevant biology...
February 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28193125/preparation-for-practice-a-novel-role-for-general-practice-in-pre-foundation-assistantships
#16
Peter S J Ryan, Gerard J Gormley, Nigel D Hart
BACKGROUND: Hospital-based undergraduate assistantships are now widely established in medical school curricula. They are considered to improve graduates' preparedness for practice in their role as a foundation doctor. Foundation doctors play a key team role in ensuring patient safety during complex transitions across the hospital/primary care interface, and their self-reported preparedness for practice still varies considerably. AIMS: We sought to explore what spending one week of the pre-foundation assistantship in General Practice might add...
February 13, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28192009/%C3%A3-tude-des-strat%C3%A3-gies-de-raisonnement-causal-dans-l-estimation-de-la-probabilit%C3%A3-diagnostique-%C3%A3-travers-un-paradigme-exp%C3%A3-rimental-de-production-de-r%C3%A3-gle
#17
Jean-Louis Stilgenbauer, Jean Baratgin
The objective of this research was to test for the existence of reasoning strategies in the estimation of the diagnostic probability: P(cause|effect). In two experiments, we show that estimation of this probability can be achieved by two paths that are formally distinct. The most intuitive approach (default strategy) consists in evaluating P(cause|effect) by means of retractable deduction type reasoning based on a retractable Modus Ponens (EFFECT; if EFFECT then CAUSE is probable; thus CAUSE is probable). The second strategy consists in estimating diagnostic probability using abductive reasoning corresponding to the affirmation of consequent argument (EFFECT; if CAUSE then EFFECT is probable; thus CAUSE is probable)...
February 13, 2017: Canadian Journal of Experimental Psychology, Revue Canadienne de Psychologie Expérimentale
https://www.readbyqxmd.com/read/28190536/fluctuation-microscopy-analysis-of-amorphous-silicon-models
#18
J M Gibson, M M J Treacy
Using computer-generated models we discuss the use of fluctuation electron microscopy (FEM) to identify the structure of amorphous silicon. We show that a combination of variable resolution FEM to measure the correlation length, with correlograph analysis to obtain the structural motif, can pin down structural correlations. We introduce the method of correlograph variance as a promising means of independently measuring the volume fraction of a paracrystalline composite. From comparisons with published data, we affirm that only a composite material of paracrystalline and continuous random network that is substantially paracrystalline could explain the existing experimental data, and point the way to more precise measurements on amorphous semiconductors...
January 31, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28187319/quantitative-diagnosis-of-breast-tumors-by-characterization-of-viscoelastic-behavior-of-healthy-breast-tissue
#19
N Madani, A Mojra
The main objective of the present study is to propose a model for characterizing the viscoelastic behavior of the healthy breast tissue. The study population consisted of 60 healthy regions of the breast tissue belonged to 9 female cases. To accomplish this, the attending cases were examined by a robot-assisted device and the mechanical stress resulted from an applied compressive strain was measured. Correlation between the experimental stress and the strain data identifies the breast tissue mechanical behavior...
February 3, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28185893/united-states-clergy-religious-values-and-relationships-to-end-of-life-discussions-and-care
#20
Michael J Balboni, Adam Sullivan, Andrea C Enzinger, Patrick T Smith, Christine Mitchell, John R Peteet, James Tulsky, Tyler VanderWeele, Tracy A Balboni
CONTEXT: While clergy interact with approximately half of U.S. patients facing end-of-life medical decisions, little is known about clergy-congregant interactions or clergy influence on end-of-life decisions. OBJECTIVE: To conduct a nationally representative survey of clergy beliefs and practices. METHODS: A mailed survey to a nationally representative sample of clergy completed in March 2015 with 1005 of 1665 responding (60% response rate)...
February 6, 2017: Journal of Pain and Symptom Management
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