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https://www.readbyqxmd.com/read/28429385/risk-factors-proximate-to-suicide-and-suicide-risk-assessment-in-the-context-of-denied-suicide-ideation
#1
Alan L Berman
Health care providers have significant opportunities to identify individuals at near-term risk for suicide, but lack empirical data on near-term risk factors. This study aimed to identify dynamic, state-related risk factors observed by clinical practitioners within the last 30 days of life of 157 patients who died by suicide and to compare these near-term risk factors among patients who denied versus responded positively to having suicide ideation (SI) when last asked by a clinical practitioner prior to their death...
April 21, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28427205/mns16a-tandem-repeat-minisatellite-of-human-telomerase-gene-functional-studies-in-colorectal-lung-and-prostate-cancer
#2
Philipp Hofer, Cornelia Zöchmeister, Christian Behm, Stefanie Brezina, Andreas Baierl, Angelina Doriguzzi, Vanita Vanas, Klaus Holzmann, Hedwig Sutterlüty-Fall, Andrea Gsur
MNS16A, a functional polymorphic tandem repeat minisatellite, is located in the promoter region of an antisense transcript of the human telomerase reverse transcriptase gene. MNS16A promoter activity depends on the variable number of tandem repeats (VNTR) presenting varying numbers of transcription factor binding sites for GATA binding protein 1. Although MNS16A has been investigated in multiple cancer epidemiology studies with incongruent findings, functional data of only two VNTRs (VNTR-243 and VNTR-302) were available thus far, linking the shorter VNTR to higher promoter activity...
March 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426223/over-destabilization-of-protein-protein-interaction-in-generalized-born-model-and-utility-of-energy-density-integration-cutoff
#3
Yukinobu Mizuhara, Dan Parkin, Koji Umezawa, Jun Ohnuki, Mitsunori Takano
The generalize Born (GB) model is frequently used in MD simulations of biomolecular systems in aqueous solution. The GB model is usually based on the so-called Coulomb field approximation (CFA) for the energy density integration. In this study, we report that the GB model with CFA overdestabilizes the long-range electrostatic attraction between oppositely-charged molecules (ionic bond forming two-helix system and kinesin-tubulin system) when the energy density integration cutoff, rmax, which is used to calculate the Born energy, is set to a large value...
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28425687/patient-protection-and-affordable-care-act-market-stabilization-final-rule
#4
(no author information available yet)
This rule finalizes changes that will help stabilize the individual and small group markets and affirm the traditional role of State regulators. This final rule amends standards relating to special enrollment periods, guaranteed availability, and the timing of the annual open enrollment period in the individual market for the 2018 plan year; standards related to network adequacy and essential community providers for qualified health plans; and the rules around actuarial value requirements.
April 18, 2017: Federal Register
https://www.readbyqxmd.com/read/28425311/later-adults-cultural-life-scripts-of-middle-and-later-adulthood
#5
Azriel Grysman, Sarah Dimakis
The cultural life script (CLS) refers to expected prototypical life events, often including life transitions overwhelmingly occurring at ages 11-30. This study outlined CLS events at ages after the majority of these events typically occur. Participants, age 38-76, nominated events they expected a person of their age to experience in the future. Participants rated each event's valence, importance, prevalence, and expected age of occurrence. Events were coded into three categories: the normative CLS for events listed by previous CLS studies, offspring's CLS for experiencing CLS events of offspring, and later adulthood CLS for other events nominated by at least 4% of participants...
April 20, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28421354/perceived-barriers-and-facilitators-to-integrating-hiv-prevention-and-treatment-with-cross-sex-hormone-therapy-for-transgender-women-in-lima-peru
#6
Sari L Reisner, Amaya G Perez-Brumer, Sarah A McLean, Javier R Lama, Alfonso Silva-Santisteban, Leyla Huerta, Jorge Sanchez, Jesse L Clark, Matthew J Mimiaga, Kenneth H Mayer
Transgender women (TW) represent a vulnerable population at increased risk for HIV infection in Peru. A mixed-methods study with 48 TW and 19 healthcare professionals was conducted between January and February 2015 to explore barriers and facilitators to implementing a model of care that integrates HIV services with gender-affirmative medical care (i.e., hormone therapy) in Lima, Peru. Perceived acceptability of the integrated care model was high among TW and healthcare professionals alike. Barriers included stigma, lack of provider training or Peruvian guidelines regarding optimal TW care, and service delivery obstacles (e...
April 18, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28415404/macrophage-phagocytosis-of-biomedical-mg-alloy-degradation-products-prepared-by-electrochemical-method
#7
Jian Zhang, Sachiko Hiromoto, Tomohiko Yamazaki, Hua Huang, Gaozhi Jia, Haiyan Li, Guangyin Yuan
Biomedical Mg alloy is promising for its widespread use clinically. In vitro and in vivo studies showed that the degradation products of biomedical Mg alloy were composed of O, P, Ca, Mg and other alloying elements. However, little is known about the metabolism of the degradation products. In this study, the in vitro macrophage phagocytosis of the degradation products of a biomedical Mg-Nd-Zn-Zr alloy was directly observed. This result affirms the necessity to investigate the long-term fate of Mg alloy degradation products in physiological environments...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414038/modulation-of-staphylococcus-epidermidis-rp62a-extracellular-polymeric-layer-by-marine-cyclic-dipeptide-cyclo-l-leucyl-l-prolyl-thwarts-biofilm-formation
#8
Shanmugaraj Gowrishankar, Shunmugiah Karutha Pandian
Staphylococcus epidermidis is the most frequent cause of biofilm mediated implant-associated infections. Extracellular polymeric substance (EPS) is a key component of most biofilms and in pathogens it specifically protects the entrenched-bacterial cells from antibiotics and hosts immune response, and thereby makes the infection ineradicable. Recently, the prominence of cyclic dipeptides in interfering with biofilms and the associated virulence factors of pathogens has offered an alternative to eliminate difficult-to-treat infections...
April 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28413121/characterisation-of-cell-cycle-arrest-and-terminal-differentiation-in-a-maximally-proliferative-human-epithelial-tissue-lessons-from-the-human-hair-follicle-matrix
#9
Talveen S Purba, Lars Brunken, Michael Peake, Asim Shahmalak, Asuncion Chaves, Enrique Poblet, Ralf Paus
Human hair follicle (HF) growth and hair shaft formation require terminal differentiation-associated cell cycle arrest of highly proliferative matrix keratinocytes. However, the regulation of this complex event remains unknown. CIP/KIP family member proteins (p21(CIP1), p27(KIP1) and p57(KIP2)) regulate cell cycle progression/arrest, endoreplication, differentiation and apoptosis. Since they have not yet been adequately characterized in the human HF, we asked whether and where CIP/KIP proteins localise in the human hair matrix and pre-cortex in relation to cell cycle activity and HF-specific epithelial cell differentiation that is marked by keratin 85 (K85) protein expression...
April 2, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28411271/neural-correlates-of-semantic-prediction-and-resolution-in-sentence-processing
#10
Luigi Grisoni, Tally McCormick Miller, Friedemann Pulvermüller
Most brain imaging studies of language comprehension focus on activity following upon meaningful stimuli. Testing adult human participants with high-density EEG, we show that, already before the presentation of a critical word, context-induced semantic predictions are reflected by a neurophysiological index, which we therefore call the Semantic Readiness Potential (SRP). The SRP precedes critical words if previous sentence context constrains the upcoming semantic content (High-constraint contexts), but not in unpredictable (Low-constraint) contexts...
April 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28408355/down-regulation-of-dlc1-in-endothelial-cells-compromises-the-angiogenesis-process
#11
Yi-Ping Shih, Sarah Y Yuan, Su Hao Lo
DLC1 is a RhoGAP-containing tumor suppressor that inhibits angiogenesis by repressing VEGF production in epithelial cells. Here we report the roles of DLC1 in endothelial cells. Silencing of DLC1 (siDLC1) enhances cell migration but reduces tube formation activities of human umbilical vein endothelial cells (HUVECs). Biochemically, RhoA activity and paxillin protein level are markedly increased in siDLC1 HUVECs. Although further silencing of RhoA restores the cell migration phenotype, the tube formation defect and up-regulated paxillin level remain unchanged...
April 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28405366/processing-political-misinformation-comprehending-the-trump-phenomenon
#12
Briony Swire, Adam J Berinsky, Stephan Lewandowsky, Ullrich K H Ecker
This study investigated the cognitive processing of true and false political information. Specifically, it examined the impact of source credibility on the assessment of veracity when information comes from a polarizing source (Experiment 1), and effectiveness of explanations when they come from one's own political party or an opposition party (Experiment 2). These experiments were conducted prior to the 2016 Presidential election. Participants rated their belief in factual and incorrect statements that President Trump made on the campaign trail; facts were subsequently affirmed and misinformation retracted...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28403285/spanish-version-of-the-scale-of-attitudes-toward-alcohol-alcoholism-and-alcoholics-content-validation
#13
Erika Gisseth León Ramírez, Divane de Vargas, Luz Patrícia Diaz Heredia, Alejandra Sepúlveda Corzo
ABSTACT Objective: to describe the process of translation and cultural adaptation of the scale of attitudes towards alcohol, alcoholism and alcoholics into the Spanish language. METHODS: this was a methodological study, which followed the international guidelines for translation and adaptation of measurement scales. RESULTS: During the process of translation and cultural adaptation of scale of attitudes towards alcohol, alcoholism and alcoholics to the Spanish language, the items were adjusted based on semantic, idiomatic and conceptual equivalence of the expressions contained in the scale of attitudes towards alcohol, alcoholism and alcoholics...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28403279/acoustic-analysis-of-speech-intonation-pattern-of-individuals-with-autism-spectrum-disorders
#14
Ana Gabriela Olivati, Francisco Baptista Assumpção, Andréa Regina Nunes Misquiatti
Purpose: This study aimed to analyze prosodic elements of speech segments of students with Autism Spectrum Disorders (ASD) and compare with the control group, using an acoustic analysis. Methods: Speech recordings were performed with a sample of individuals with ASD (n = 19) and with typical development (n = 19) of the male gender, age range: 8-33 years. The prosody questionnaire ALIB (Brazilian Linguistic Atlas) was used as script, which contains interrogative, affirmative and imperative sentences...
April 10, 2017: CoDAS
https://www.readbyqxmd.com/read/28402749/mental-health-concerns-and-insurance-denials-among-transgender-adolescents
#15
Leena Nahata, Gwendolyn P Quinn, Nicole M Caltabellotta, Amy C Tishelman
PURPOSE: Transgender youth are at high risk for mental health morbidities. Based on treatment guidelines, puberty blockers and gender-affirming hormone therapy should be considered to alleviate distress due to discordance between an individual's assigned sex and gender identity. The goals of this study were to examine the: (1) prevalence of mental health diagnoses, self-injurious behaviors, and school victimization and (2) rates of insurance coverage for hormone therapy, among a cohort of transgender adolescents at a large pediatric gender program, to understand access to recommended therapy...
April 12, 2017: LGBT Health
https://www.readbyqxmd.com/read/28402269/long-term-storage-in-liquid-nitrogen-leads-to-only-minor-phenotypic-and-gene-expression-changes-in-the-mammary-carcinoma-model-cell-line-bt474
#16
Judit Fazekas, Thomas W Grunt, Erika Jensen-Jarolim, Josef Singer
BACKGROUND/AIM: Cancer cell lines are indispensible surrogate models in cancer research, as they can be used off-the-shelf, expanded to the desired extent, easily modified and exchanged between research groups for affirmation, reproduction or follow-up experiments.As malignant cells are prone to genomic instability, phenotypical changes may occur after certain passages in culture. Thus, cell lines have to be regularly authenticated to ensure data quality. In between experiments these cell lines are often stored in liquid nitrogen for extended time periods...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401387/quantifying-microplastic-pollution-on-sandy-beaches-the-conundrum-of-large-sample-variability-and-spatial-heterogeneity
#17
Mara Fisner, Alessandra P Majer, Danilo Balthazar-Silva, Daniel Gorman, Alexander Turra
Despite the environmental risks posed by microplastic pollution, there are presently few standardized protocols for monitoring these materials within marine and coastal habitats. We provide a robust comparison of methods for sampling microplastics on sandy beaches using pellets as a model and attempt to define a framework for reliable standing stock estimation. We performed multiple comparisons to determine: (1) the optimal size of sampling equipment, (2) the depth to which samples should be obtained, (3) the optimal sample resolution for cross-shore transects, and (4) the number of transects required to yield reproducible along-shore estimates across the entire sections of a beach...
April 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28401345/vitamin-d-in-european-children-statement-from-the-european-academy-of-paediatrics-eap
#18
Zachi Grossman, Adamos Hadjipanayis, Tom Stiris, Stefano Del Torso, Jean-Christophe Mercier, Arunas Valiulis, Raanan Shamir
Vitamin D is synthesized in human skin upon sun exposure and is also a nutrient. It regulates calcium and phosphate metabolism and is essential for the maintenance of bone health. Vitamin D supplementation during infancy, in order to prevent rickets, is universally accepted. Many human cell types carry vitamin D receptor, this being a drive for conducting studies on the possible association between vitamin D status and other diseases. Studies have affirmed that a considerable number of healthy European children may be vitamin D deficient, especially in high-risk groups (darker pigmented skin, living in areas with reduced sun exposure and other disorders)...
April 12, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28400064/sexually-violent-predator-risk-assessments-with-the-violence-risk-appraisal-guide-revised-a-shaky-practice
#19
REVIEW
Brian R Abbott
Twenty-two jurisdictions in the United States permit the involuntary civil confinement of sexual offenders upon expiration of their criminal sentence and, if committed, these individuals face possible lifetime commitment. One of the legal requirements that psychologists must address in sexually violent predator evaluations is the likelihood that an individual will engage in dangerous sexual behavior and consideration of the probabilities for sexual recidivism contained in actuarial experience tables best address this inquiry...
April 8, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28397190/surrogate-end-points-for-overall-survival-in-metastatic-locally-advanced-or-unresectable-pancreatic-cancer-a-systematic-review-and-meta-analysis-of-24-randomized-controlled-trials
#20
Eleftherios A Makris, Regina MacBarb, Danielle J Harvey, George A Poultsides
BACKGROUND: Overall survival (OS) has traditionally been the primary end point in studies evaluating the clinical benefit of first-line chemotherapy in metastatic, locally advanced, or unresectable pancreatic cancer (MLAUPC). Given the prolonged follow-up assessment required to obtain OS and its potential to be confounded by second-line treatments, this study sought to determine whether progression-free survival (PFS), response rate (RR), or disease control rate (DCR) can serve as a reliable surrogate for OS...
April 10, 2017: Annals of Surgical Oncology
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