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https://www.readbyqxmd.com/read/28929382/serial-assessment-of-left-ventricular-morphology-and-function-in-a-rodent-model-of-ischemic-cardiomyopathy
#1
Vesselina Ferferieva, Nicholas D'Elia, Brecht Heyde, Petr Otahal, Frank Rademakers, Jan D'hooge
Left ventricular remodelling (LVr) occurs post myocardial infarction (MI), predisposing people to heart failure (HF). LV mechanics and morphology are important in this process. We hence sort to characterize LV mechanics and geometry in a post-MI rodent model. Thirty-two male Sprague-Dawley rats (150-200 g) sustained MI (n = 24) or sham (Sham; n = 8) surgery. In another six sham rats invasive blood pressure measurements were performed. Ultrasound imaging was done at baseline, and 1, 3, 7, 14, 30 and 60 days following surgery, and LV mechanics and morphology assessed...
September 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28928119/8-aminoguanosine-exerts-diuretic-natriuretic-and-glucosuric-activity-via-conversion-to-8-aminoguanine-yet-has-direct-antikaliuretic-effects
#2
Edwin K Jackson, Zaichuan Mi
8-Aminoguanosine induces diuresis, natriuresis, glucosuria, and antikaliuresis. These effects could be mediated via 8-aminoguanosine's metabolism to 8-aminoguanine. Here we tested this hypothesis in anesthetized rats. First, we demonstrated that at 85-115 min post intravenous administration, 8-aminoguanosine and 8-aminoguanine (33.5 µmol/kg) significantly increased urine volume [ml/30min: 8-aminoguanosine from 0.3±0.1 to 0.9±0.1 (mean±SEM; n=7); 8-aminoguanine from 0.3±0.1 to 1.5±0.2 (n=8)], sodium excretion (µmol/30min: 8-aminoguanosine from 12±5 to 109±21; 8-aminoguanine from 18±8 to 216±31), and glucose excretion (µg/30min: 8-aminoguanosine from 18±3 to 159±41; 8-aminoguanine from 17±3 to 298±65)...
September 19, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28927380/financial-burden-of-survivors-of-medically-managed-myocardial-infarction-and-its-association-with-selected-social-determinants-and-quality-of-life-in-a-lower-middle-income-country
#3
P K B Mahesh, M W Gunathunga, S Jayasinghe, S M Arnold, D S V Mallawarachchi, S K Perera, U A D Wijesinghe
BACKGROUND: Burden from ischemic heart disease is rising in Sri Lanka due to the demographic and epidemiological transitions. Documented literature is scarce on quality of life, financial burden and its determinants in relation to myocardial infarction (MI). This study was done to describe the financial burden among the survivors of MI managed only with drugs (i.e. those who did not undergo Percutaneous Coronary Intervention or Coronary Artery Bypass Graft) and its association with selected social determinants (SDHs) and quality of life (QOL)...
September 19, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28925017/early-treatment-with-resolvin-e1-facilitates-myocardial-recovery-from-ischemia-in-mice
#4
Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D Funk, Jian Zhang, Ying Yu
BACKGROUND AND PURPOSE: An appropriate inflammatory response is necessary for cardiac healing after acute myocardial infarction (MI). Resolvin E1 (RvE1) is an anti-inflammatory and pro-resolution lipid mediator derived from eicosapentaenoic acid. The purpose of this study was to investigate the potential effects of RvE1 on cardiac function recovery after MI in mice. EXPERIMENTAL APPROACH: Acute MI was induced by surgical ligation of the left anterior descending artery (LAD) in mice...
September 19, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28924368/the-effects-of-perioperative-anesthesia-and-analgesia-on-immune-function-in-patients-undergoing-breast-cancer-resection-a-prospective-randomized-study
#5
Jin Sun Cho, Mi-Hyang Lee, Seung Il Kim, Seho Park, Hyung Seok Park, Ein Oh, Jong Ho Lee, Bon-Nyeo Koo
Introduction: Perioperative anesthesia and analgesia exacerbate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. We compared the effects of two different anesthesia and analgesia methods on the NK cell cytotoxicity (NKCC) in patients undergoing breast cancer surgery. Methods: Fifty patients undergoing breast cancer resection were randomly assigned to receive propofol-remifentanil anesthesia with postoperative ketorolac analgesia (Propofol-ketorolac groups) or sevoflurane-remifentanil anesthesia with postoperative fentanyl analgesia (Sevoflurane-fentanyl group)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28921389/altered-structure-and-intrinsic-functional-connectivity-in-post-stroke-aphasia
#6
Mi Yang, Pu Yang, Yun-Shuang Fan, Jiao Li, Dezhong Yao, Wei Liao, Huafu Chen
Previous studies have demonstrated that alterations of gray matter exist in post-stroke aphasia (PSA) patients. However, so far, few studies combined structural alterations of gray matter volume (GMV) and intrinsic functional connectivity (iFC) imbalances of resting-state functional MRI to investigate the mechanism underlying PSA. The present study investigated specific regions with GMV abnormality in patients with PSA (n = 17) and age- and sex- matched healthy controls (HCs, n = 20) using voxel-based morphometry...
September 18, 2017: Brain Topography
https://www.readbyqxmd.com/read/28920454/investigation-of-o-glycosylation-heterogeneity-of-recombinant-coagulation-factor-ix-using-lc-ms-ms
#7
Youngsuk Seo, Gyeong Mi Park, Myung Jin Oh, Hyun Joo An
AIM: Recombinant coagulation factor IX (rFIX) has extraordinarily multiple post-translational modifications including N-glycosylation and O-glycosylation which have a drastic effect on biological functions and in vivo recovery. Unlike N-glycosylation extensively characterized, there are a few studies on O-glycosylation due to its intrinsic complexity. In-depth O-glycosylation analysis is necessary to better understand and assess pharmacological activity of rFIX. RESULTS: We determined unusual O-glycosylations including O-fucosylation and O-glucosylation which were located at Serine 53 and 61, respectively in EGF domain...
September 18, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28919891/moderate-intensity-exercise-affects-gut-microbiome-composition-and-influences-cardiac-function-in-myocardial-infarction-mice
#8
Zuheng Liu, Hai-Yue Liu, Haobin Zhou, Qiong Zhan, Wenyan Lai, Qingchun Zeng, Hao Ren, Dingli Xu
Physical exercise is commonly regarded as protective against cardiovascular disease (CVD). Recent studies have reported that exercise alters the gut microbiota and that modification of the gut microbiota can influence cardiac function. Here, we focused on the relationships among exercise, the gut microbiota and cardiac function after myocardial infarction (MI). Four-week-old C57BL/6J mice were exercised on a treadmill for 4 weeks before undergoing left coronary artery ligation. Cardiac function was assessed using echocardiography...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28918714/is-there-a-dark-side-to-mindfulness-relation-of-mindfulness-to-criminogenic-cognitions
#9
June P Tangney, Ashley E Dobbins, Jeffrey B Stuewig, Shannon W Schrader
In recent years, mindfulness-based interventions have been modified for use with inmate populations, but how this might relate to specific criminogenic cognitions has not been examined empirically. Theoretically, characteristics of mindfulness should be incompatible with distorted patterns of criminal thinking, but is this in fact the case? Among both 259 male jail inmates and 516 undergraduates, mindfulness was inversely related to the Criminogenic Cognitions Scale (CCS) through a latent variable of emotion regulation...
October 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28918410/-just-like-a-normal-pain-what-do-people-with-diabetes-mellitus-experience-when-having-a-myocardial-infarction-a-qualitative-study-recruited-from-uk-hospitals
#10
Nikita Berman, Melvyn Mark Jones, Daan A De Coster
OBJECTIVE: The objective of the study was to investigate the symptoms people with diabetes experience when having a myocardial infarction (MI), their illness narrative and how they present their symptoms to the health service. SETTING: Three London (UK) hospitals (coronary care units and medical wards). PARTICIPANTS: Patients were recruited with diabetes mellitus (DM) (types 1 and 2) with a clinical presentation of MI (ST elevated MI (STEMI), non-ST elevated MI (NSTEMI), acute MI unspecified and cardiac arrest)...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28917298/high-prevalence-of-bovine-cysticercosis-found-during-evaluation-of-different-post-mortem-detection-techniques-in-belgian-slaughterhouses
#11
Famke Jansen, Pierre Dorny, Dirk Berkvens, Anke Van Hul, Nick Van den Broeck, Caroline Makay, Nicolas Praet, Ramon Marc Eichenberger, Peter Deplazes, Sarah Gabriël
Bovine cysticercosis (BCC), caused by the helminth Taenia saginata, is currently diagnosed solely by official meat inspection (MI) based on macroscopic detection of viable cysticerci or typical lesions of degenerated larvae. MI has a known low sensitivity (<16%), leading to a large proportion of infected cattle carcasses entering the human food chain and posing a risk to public health. Prevalence in Belgium based on MI results is estimated at around 0.22%. Due to the low sensitivity of MI, alternative techniques to detect BCC should be considered...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28915689/different-long-term-oncologic-outcomes-after-radical-surgical-resection-for-neuroendocrine-carcinoma-and-adenocarcinoma-of-the-stomach
#12
Jian-Wei Xie, Jun Lu, Jian-Xian Lin, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chang-Ming Huang
PURPOSE: To explore differences in long-term outcomes between gastric neuroendocrine carcinoma (GNEC) and gastric adenocarcinoma (GAC). METHODS: One hundred GNEC patients and 3089 GAC patients were enrolled. Differences in long-term outcomes between the groups were analyzed by 1:2 propensity score matching. RESULTS: Statistically significant differences between the groups were noted in terms of gender, American Society of Anesthesiologists score, tumor size, T stage, N stage, TNM stage and surgical approach...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915538/long-term-t3-and-t4-treatment-as-an-alternative-to-aerobic-exercise-training-in-improving-cardiac-function-post-myocardial-infarction
#13
Rayane Brinck Teixeira, Alexsandra Zimmer, Alexandre Luz de Castro, Bruna Gazzi de Lima-Seolin, Patrick Türck, Rafaela Siqueira, Adriane Belló-Klein, Pawan K Singal, Alex Sander da Rosa Araujo
Here we aimed to compare the beneficial effects of T3 and T4 hormone treatment to those provided by aerobic exercise training in Wistar rats post-myocardial infarction (MI). Rats in one group were SHAM-operated and in the other group were subjected to MI surgery. One week after surgery, the MI group animals either received T3 and T4 hormones by gavage or underwent a low intensity aerobic exercise training protocol on a treadmill, and both treatments lasted until 10 weeks after MI. Untreated SHAM-operated and MI groups were also followed for the same duration...
September 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28915307/the-use-of-bone-morphogenetic-protein-in-spinal-transforaminal-lumbar-interbody-fusion-our-experience
#14
Eduardo Colom-Beauchamp, David Beaton-Comulada, Julio A Rodriguez, José C Pérez-López, José Montañez-Huertas, Enrique Escobar-Medina, José Massanet-Vollrath
OBJECTIVE: Since its introduction and FDA approval, rhBMP-2 has been adopted by spine surgeons as a substitute for ICBG in numerous spinal fusion techniques. As broad clinical use increased, reports on potential complications associated with rhBMP-2 also increased. We provide our experience with TLIF using rhBMP-2 or ICBG in an entirely Hispanic population. METHODS: This was a 2-year retrospective study of 67 patients, with 26 in the rhBMP-2 group and 41 in the ICBG group, who underwent TLIF...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28914987/diabetes-news
#15
Ann M Carracher, Payal H Marathe, Kelly L Close
More than 31,000 attendeesfrom around the world gathered in Barcelona, Spain for the 2017 European Society of Cardiology conference. In presentinga post-hoc analysis of the Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes(LEADER)(1) trial, Dr Neil Poulter (Imperial College London, UK) showedthat results are still positive, indicating cardioprotection, after adjusting for baseline history of stroke or myocardial infarction (MI), which had no mediating effect on the significant association between Novo Nordisk's (Copenhagen, Denmark) glucagon-like peptide-1 (GLP-1) agonist Victoza (liraglutide) and cardiovascular risk reduction...
September 15, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28913662/effects-of-short-term-exposure-to-sevoflurane-on-the-survival-proliferation-apoptosis-and-differentiation-of-neural-precursor-cells-derived-from-human-embryonic-stem-cells
#16
Jin-Woo Park, Mi-Sun Lim, So Yeon Ji, Myung Soo Cho, Seong-Joo Park, Sung-Hee Han, Jin-Hee Kim
PURPOSE: Data from animal experiments suggest that exposure to general anesthetics in early life inhibits neurogenesis and causes long-term memory deficit. Considering short operating times and the popularity of sevoflurane in pediatric anesthesia, it is important to verify the effects of short-period exposure to sevoflurane on the developing brain. METHODS: We measured the effects of short-term exposure (2 h) to 3%, 6%, or 8% sevoflurane, the most commonly used anesthetic, on neural precursor cells derived from human embryonic stem cells, SNUhES32...
September 14, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28913303/simultaneous-development-of-three-different-neoplasms-of-trichilemmoma-desmoplastic-trichilemmoma-and-basal-cell-carcinoma-arising-from-nevus-sebaceus
#17
Chi An Lee, Seok Joo Kang, Seong Pin Jeon, Hook Sun, Mi Seon Kang
Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneously. A 61-year-old male patient was admitted to our hospital for a 4 cm×2.5 cm growing tumor in a verrucous form arising within a periauricular nevus sebaceus in the post auricle of the left ear that had developed 30 years earlier...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28912121/cortical-bone-stem-cell-therapy-preserves-cardiac-structure-and-function-after-myocardial-infarction
#18
Thomas E Sharp, Giana J Schena, Alexander R Hoachlandr-Hobby, Timothy Starosta, Remus M Berretta, Markus Wallner, Giulia Borghetti, Polina Gross, Daohai Yu, Jaslyn Johnson, Eric A Feldsott, Danielle M Trappanese, Amir Toib, Joseph E Rabinowitz, Jon C George, Hajime Kubo, Sadia Mohsin, Steven R Houser
Rationale: Cortical bone stem cells (CBSCs) have been shown to reduce ventricular remodeling and improve cardiac function in a murine myocardial infarction (MI) model. These effects were superior to other stem cell types that have been used in recent early stage clinical trials. However, CBSC efficacy has not been tested in a preclinical large animal model using approaches that could be applied to patients. Objective: To determine if post-MI transendocardial injection of allogeneic CBSCs reduces pathological structural and functional remodeling and prevents the development of heart failure in a swine MI model...
September 14, 2017: Circulation Research
https://www.readbyqxmd.com/read/28910207/challenges-of-using-probabilistic-linkage-methodology-to-characterize-post-cardiac-arrest-care-in-michigan
#19
Robert Swor, Lihua Qu, Kevin Putman, Kelly N Sawyer, Robert Domeier, Jennifer Fowler, William Fales
BACKGROUND: To improve survival of patients resuscitated from out of hospital cardiac arrest (OCHA), data is needed to assess and improve inpatient post-resuscitation care. Our objective was to apply probabilistic linkage methodology to link EMS and inpatient databases and evaluate whether it may be used to describe post-arrest care in Michigan. METHODS: We performed a retrospective study to describe post-cardiac arrest care in adult OHCA patients who were transported to Michigan hospitals from July 1, 2010, to June 30, 2013...
September 14, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28903498/from-the-cover-lifelong-exposure-of-c57bl-6n-male-mice-to-bisphenol-a-or-bisphenol-s-reduces-recovery-from-a-myocardial-infarction
#20
Amanda Kasneci, Jun Seong Lee, Tae Jin Yun, Jijun Shang, Shaun Lampen, Tamar Gomolin, Cheolho C Cheong, Lorraine E Chalifour
Bisphenol A (BPA) leaches from plastics to contaminate foodstuffs. Analogs, such as bisphenol S (BPS), are now used increasingly in manufacturing. Greater BPA exposure has been correlated with exacerbation of cardiovascular disease, including myocardial infarction (MI). To test the hypothesis that bisphenol exposure impairs cardiac healing, we exposed C57bl/6n mice to water containing 25ng/ml BPA or BPS from conception and surgically induced an MI in adult male progeny. Increased early death and cardiac dilation, and reduced cardiac function were found post-MI in BPA- and BPS-exposed mice...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
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