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https://www.readbyqxmd.com/read/29776668/-fatal-cardiac-tamponade-that-developed-in-the-post-anesthesia-care-unit-a-rare-complication-after-lung-lobectomy
#1
Hyung Mook Lee, Young Jae Jeon, Hye Won Chung, Hyo Min Yun, Mi Hyun Kim
BACKGROUND AND OBJECTIVES: Cardiac tamponade is potentially fatal medical condition, which rarely occurs as a complication of lung lobectomy. We present the first case of cardiac tamponade to develop in a Post-Anesthesia Care Unit following a lung lobectomy. CASE REPORT: A 54-year-old man with pulmonary squamous cell carcinoma underwent an apparently uncomplicated lung lobectomy. His hemodynamics was unremarkable throughout the surgery and initially in the Post-Anesthesia Care Unit...
May 15, 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29775405/the-mouse-heart-attack-research-tool-mhart-1-0-database
#2
Kristine Y DeLeon-Pennell, Rugmani Padmanabhan Iyer, Yonggang Ma, Andriy Yabluchanskiy, Rogelio Zamilpa, Ying Ann Chiao, Presley Cannon, Courtney Cates, Elizabeth R Flynn, Ganesh V Halade, Lisandra E de Castro Bras, Merry L Lindsey
The generation of Big Data has enabled systems-level dissections into the mechanisms of cardiovascular pathology. Integration of genetic, proteomic, and pathophysiological variables across platforms and laboratories fosters discoveries through multidisciplinary investigations and minimizes unnecessary redundancy in research efforts. The Mouse Heart Attack Research Tool (mHART) consolidates a large dataset of over 10 years of experiments from a single laboratory for cardiovascular investigators to generate novel hypotheses and identify new predictive markers of progressive left ventricular remodeling following myocardial infarction (MI) in mice...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29774520/implantation-of-bioresorbable-scaffolds-under-guidance-of-optical-coherence-tomography-feasibility-and-pilot-clinical-results-of-a-systematic-protocol
#3
Juan Luis Gutiérrez-Chico, Carlos Cortés, Michele Schincariol, Ula Limon, Meric Yalcinli, María-Alexandra Durán-Cortés, Milosz Jaguszewski
BACKGROUND: We hypothesise that a comprehensive optical coherence tomography (OCT)-guided implantation protocol for bioresorbable scaffolds (BRS) might improve expansion and apposition, thus translating into better clinical outcomes, particularly reducing thrombotic events. METHODS: Patients considered suitable for BRS therapy in de novo coronary lesions underwent OCT. The predominant type of plaque was classified as lipidic, fibrous or calcific, undergoing tailored plaque preparation accordingly...
May 18, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29774073/polypyrrole-chitosan-conductive-biomaterial-synchronizes-cardiomyocyte-contraction-and-improves-myocardial-electrical-impulse-propagation
#4
Zhi Cui, Nathan C Ni, Jun Wu, Guo-Qing Du, Sheng He, Terrence M Yau, Richard D Weisel, Hsing-Wen Sung, Ren-Ke Li
Background: The post-myocardial infarction (MI) scar interrupts electrical impulse propagation and delays regional contraction, which contributes to ventricular dysfunction. We investigated the potential of an injectable conductive biomaterial to restore scar tissue conductivity and re-establish synchronous ventricular contraction. Methods: A conductive biomaterial was generated by conjugating conductive polypyrrole (PPY) onto chitosan (CHI) backbones. Trypan blue staining of neonatal rat cardiomyocytes (CMs) cultured on biomaterials was used to evaluate the biocompatibility of the conductive biomaterials...
2018: Theranostics
https://www.readbyqxmd.com/read/29774045/transposon-derived-non-coding-rnas-and-their-function-in-plants
#5
REVIEW
Jungnam Cho
Transposable elements (TEs) are often regarded as harmful genomic factors and indeed they are strongly suppressed by the epigenetic silencing mechanisms. On the other hand, the mobilization of TEs brings about variability of genome and transcriptome which are essential in the survival and evolution of the host species. The vast majority of such controlling TEs influence the neighboring genes in cis by either promoting or repressing the transcriptional activities. Although TEs are highly repetitive in the genomes and transcribed in specific stress conditions or developmental stages, the trans -acting regulatory roles of TE-derived RNAs have been rarely studied...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29773176/effects-of-zinc-magnesium-and-chromium-supplementation-on-cardiometabolic-risk-in-adults-with-metabolic-syndrome-a-double-blind-placebo-controlled-randomised-trial
#6
Ha-Na Kim, Se-Hong Kim, Young-Mi Eun, Sang-Wook Song
The prevalence of metabolic syndrome (MetS) has been increasing rapidly worldwide. The activities of zinc, magnesium and chromium have a potential association with MetS; therefore, we investigated the effects of zinc, magnesium and chromium supplements on metabolic risk factors in adults with MetS. In this double-blind, placebo controlled randomised study, 32 adults with MetS were included in the zinc, magnesium, and chromium-administered group (n = 16) or the placebo group (n = 16) and received either 300 mg magnesium, 600 μg chromium and 36 mg zinc per day or placebo over a 24-week period...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29770903/left-ventricular-restoration-devices-post-myocardial-infarction
#7
REVIEW
Tom Hendriks, Remco A J Schurer, Lawien Al Ali, Ad F M van den Heuvel, Pim van der Harst
Even in the era of percutaneous reperfusion therapy, left ventricular (LV) remodeling after myocardial infarction (MI) leading to heart failure remains a major health concern. Contractile dysfunction of the infarcted myocardium results in an increased pressure load, leading to maladaptive reshaping of the LV. Several percutaneous transcatheter procedures have been developed to deliver devices that restore LV shape and function. The purposes of this review are to discuss the spectrum of transcatheter devices that are available or in development for attenuation of adverse LV remodeling and to critically examine the available evidence for improvement of functional status and cardiovascular outcomes...
May 17, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29769800/the-therapeutic-potential-of-blocking-galectin-3-expression-in-acute-myocardial-infarction-and-mitigating-inflammation-of-infarct-region-a-clinical-outcome-based-translational-study
#8
Wassim Mosleh, Milind R Chaudhari, Swati Sonkawade, Supriya Mahajan, Charl Khalil, Kevin Frodey, Tanvi Shah, Suraj Dahal, Roshan Karki, Rujuta Katkar, W Matthijs Blankesteijn, Brian Page, Saraswati Pokharel, Minhyung Kim, Umesh C Sharma
Introduction: Increased galectin-3 is associated with ischemic cardiomyopathy, although its role in early remodeling post-myocardial infarction (MI) has not been fully elucidated. There are no data demonstrating that blocking galectin-3 expression would have an impact on the heart and that its relationship to remodeling is not simply an epiphenomenon. The direct association between galectin-3 and myocardial inflammation, dysfunction, and adverse cardiovascular outcomes post-MI was examined using clinical and translational studies...
2018: Biomarker Insights
https://www.readbyqxmd.com/read/29769510/surgical-management-of-a-critical-ischemic-mitral-regurgitation-patient
#9
S A Sunny, S Moinuddin, A B Adhikary, M A Hossain
Functional ischemic mitral regurgitation is strongly associated with poor outcomes in patient with coronary artery disease. The best management for mitral regurgitation at the time of coronary revascularization remains controversial. We report, a case of 58 years-old men admitted to GKNM hospital, Coimbatore, Tamil Nadu, India with chest pain and respiratory distress for last 6 hours during my fellowship training in that hospital. ECG showed acute antero-septal MI. The transthoracic echocardiogram revealed severe left ventricular dysfunction with moderate mitral regurgitation...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29767542/optimal-left-ventricular-lead-placement-for-cardiac-resynchronization-therapy-in-postmyocardial-infarction-patients
#10
Carmine Muto, Francesco Solimene, Vincenzo Russo, Gerardo Nigro, Anna Rago, Raffaele Chianese, Paola Chiariello, Carmine Ciardiello, Luigi Caliendo
AIM: To evaluate at a 12-month follow-up, the clinical and echocardiographic outcomes in postmyocardial infarction (MI) heart failure patients who underwent cardiac resynchronization therapy (CRT) device implantation. MATERIALS & METHODS: A total of 100 patients received a CRT device, and the study population was divided into three groups, according to the site of MI and left ventricular (LV) lead placed downstream of the ischemic area, as evaluated by echocardiography...
May 16, 2018: Future Cardiology
https://www.readbyqxmd.com/read/29767445/comparison-of-de-novo-igm-and-igg-anti-hla-dsa-between-belatacept-and-calcineurin-treated-patients-an-analysis-of-the-benefit-and-benefit-ext-trial-cohorts
#11
Matthew J Everly, Mustimbo Roberts, Robert Townsend, Robert A Bray, Howard M Gebel
Preventing conversion of donor-specific anti-HLA antibodies (DSA) from an IgM-to-IgG could a way to prevent chronic rejection. We evaluated whether belatacept-treated patients [belatacept less-intensive (LI) more-intensive (MI) regimens] have a lower rate of conversion than cyclosporine A (CsA) treated patients. We included 330 HLA mismatched patients from two phase-3 trials with either (a) complete donor/recipient HLA-A,-B,-DR, and -DQ loci typing or (b) incomplete HLA typing with IgG DSA detected pre- or post-transplant...
May 16, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29767239/time%C3%A2-dependent-and-independent-effects-of-thyroid-hormone-administration-following-myocardial-infarction-in-rats
#12
Ioanna Iliopoulou, Iordanis Mourouzis, George I Lambrou, Dimitra Iliopoulou, Dimitrios-Dionysios Koutsouris, Constantinos Pantos
Cardiac function is reduced following myocardial infarction (MI) due to myocardial injury and alterations in the viable non‑ischemic myocardium, a process known as cardiac remodeling. The current treatments available for patients with acute MI (AMI) reduce infarct size, preserve left ventricular (LV) function and improve survival; however, these treatments do not prevent remodeling, which can lead to heart failure. The aim of the present study was to investigate the effects of thyroid hormone (TH) treatment following MI in an in vivo rat model...
May 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29761379/a-therapeutic-angiogenesis-of-sustained-release-of-basic-fibroblast-growth-factor-using-biodegradable-gelatin-hydrogel-sheets-in-a-canine-chronic-myocardial-infarction-model
#13
Motoyuki Kumagai, Kenji Minakata, Hidetoshi Masumoto, Masaya Yamamoto, Atsushi Yonezawa, Takafumi Ikeda, Kyokun Uehara, Kazuhiro Yamazaki, Tadashi Ikeda, Kazuo Matsubara, Masayuki Yokode, Akira Shimizu, Yasuhiko Tabata, Ryuzo Sakata, Kenji Minatoya
This study investigated the safety and efficacy of a sustained release of basic fibroblast growth factor (bFGF) with biodegradable gelatin hydrogel sheets as therapeutic angiogenesis in canine chronic myocardial infarction (MI) models. Canine chronic MI model was induced by ligating the left anterior descending coronary artery and its diagonal branches. At 4 week post-induction, we applied either saline (Control group, n = 5) or 200 μg of bFGF (Treatment group, n = 6) soaked gelatin hydrogel sheets on the ischemic area of the left ventricular (LV) wall...
May 14, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29759535/utility-of-conventional-electrocardiographic-criteria-in-patients-with-idiopathic-ventricular-tachycardia
#14
Anil V Yadav, Babak Nazer, Barbara J Drew, John M Miller, Hicham El Masry, William J Groh, Andrea Natale, Nassir Marrouche, Nitish Badhwar, Yanfei Yang, Melvin M Scheinman
OBJECTIVES: This study sought to determine the ability of conventional electrocardiographic (ECG) criteria to correctly differentiate idiopathic ventricular tachycardia (VT) from supraventricular tachycardia (SVT) with aberrancy. BACKGROUND: Previously reported VT ECG criteria were developed from cohorts of patients with structural heart disease and have not been applied to patients with idiopathic VT. METHODS: ECGs of 115 idiopathic VTs, 101 post-myocardial infarction (MI) VTs, and 111 wide QRS SVTs were analyzed using standard criteria...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29756411/hexarelin-treatment-preserves-myocardial-function-and-reduces-cardiac-fibrosis-in-a-mouse-model-of-acute-myocardial-infarction
#15
Hayley McDonald, Jason Peart, Nyoman Kurniawan, Graham Galloway, Simon Royce, Chrishan S Samuel, Chen Chen
Ischemic heart disease (IHD) is a leading cause of morbidity and mortality worldwide. Growth hormone secretagogues (GHS) have been shown to improve cardiac function in models of IHD. This study determined whether hexarelin (HEX), a synthetic GHS, preserves cardiac function and morphology in a mouse model of myocardial infarction (MI). MI was induced by ligation of the left descending coronary artery in C57BL/6J mice followed by vehicle (VEH; n = 10) or HEX (0.3 mg/kg/day; n = 11) administration for 21 days...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29755513/motor-imagery-during-action-observation-of-locomotor-tasks-improves-rehabilitation-outcome-in-older-adults-after-total-hip-arthroplasty
#16
Uros Marusic, Sidney Grosprêtre, Armin Paravlic, Simon Kovač, Rado Pišot, Wolfgang Taube
This study aimed at determining whether the combination of action observation and motor imagery (AO + MI) of locomotor tasks could positively affect rehabilitation outcome after hip replacement surgery. Of initially 405 screened participants, 21 were randomly split into intervention group ( N = 10; mean age = 64 y; AO + MI of locomotor tasks: 30 min/day in the hospital, then 3×/week in their homes for two months) and control group ( N = 11, mean age = 63 y, active controls). The functional outcomes (Timed Up and Go, TUG; Four Step Square Test, FSST; and single- and dual-task gait and postural control) were measured before (PRE) and 2 months after surgery (POST)...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29753686/pharmacological-inhibition-of-the-mitochondrial-nadph-oxidase-4-pkc%C3%AE-gal-3-pathway-reduces-left-ventricular-fibrosis-following-myocardial-infarction
#17
Maria Del Carmen Asensio-Lopez, Antonio Lax Perez, Maria Josefa Fernandez Del Palacio, Yassine Sassi, Roger J Hajjar, Domingo A Pascual-Figal
Although the initial reparative fibrosis after myocardial infarction (MI) is crucial for preventing rupture of the ventricular wall, an exaggerated fibrotic response and reactive fibrosis outside the injured area are detrimental. Although metformin prevents adverse cardiac remodeling, as well as provides glycemic control, the underlying mechanisms remain poorly documented. This study describes the effect of mitochondrial NADPH oxidase 4 (mitoNox) and protein kinase C-alpha (PKCα) on the cardiac fibrosis and galectin 3 (Gal-3) expression...
April 23, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29750365/effect-of-coronary-revascularization-on-long-term-clinical-outcomes-in-patients-with-ischemic-cardiomyopathy-and-recurrent-ventricular-arrhythmia
#18
Ihab Elsokkari, Ratika Parkash, Chris J Gray, Martin J Gardner, Amir M AbdelWahab, Steve Doucette, Anthony S Tang, George A Wells, William G Stevenson, John L Sapp
BACKGROUND: Patients with ventricular tachycardia (VT) post myocardial infarction (MI) are a higher risk group with significant morbidity and mortality. We examined the impact of prior coronary revascularization on clinical outcomes in patients with ischemic cardiomyopathy (ICM) and VT. METHODS: The VANISH trial randomized 259 patients with prior MI and antiarrhythmic drug-refractory VT to receive escalated medical therapy or catheter ablation. Clinical outcomes were compared according to whether patients have undergone prior revascularization procedures...
May 11, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29749237/structural-assessment-of-myocardial-infarction-scars-and-left-ventricular-function-with-cardiac-magnetic-resonance-imaging-in-patients-at-high-risk-of-sudden-cardiac-death
#19
V Neuschl, Z Berecova, J Madaric, J Simkova, A Glezlova, R Hatala
OBJECTIVES: Results of qualitative and quantitative analyses of scars and LV (left ventricle) function acquired by means of cardiac magnetic resonance (CMR) were correlated with a subsequent occurrence of malignant ventricular arrhythmias in patients at high risk of sudden cardiac death (SCD). METHODS: We have prospectively followed 47 patients (mean age 60 ± 11 years) who were hospitalized for an implantable cardioverter-defibrillator (ICD) implantation to prevent SCD...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29746525/expression-of-adhesion-molecules-on-granulocytes-and-monocytes-following-myocardial-infarction-in-rats-drinking-white-wine
#20
Nikolina Režić-Mužinić, Angela Mastelić, Benjamin Benzon, Anita Markotić, Ivana Mudnić, Ivica Grković, Mia Grga, Ana Marija Milat, Nikola Ključević, Mladen Boban
Neutrophils and monocytes through their CD15s, CD11b and CD44 adhesion molecules are implicated in the initiation and resolution of cardiac inflammation as well as in healing processes after the myocardial infarction (MI). The aim of this study was to determine the effect of white wine consumption on granulocyte and monocyte CD15s, CD11b, and CD44 expression 24h after the surgically inflicted MI. Granulocytes and monocytes were analyzed by flow cytometry, using whole blood of male Sprague-Dawley rats that consumed white wine for 4 weeks...
2018: PloS One
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