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https://www.readbyqxmd.com/read/28448588/allogeneic-pasc-transplantation-in-humanized-pigs-attenuates-cardiac-remodeling-post-myocardial-infarction
#1
Rafael Dariolli, Marcus V Naghetini, Euclydes F Marques, Celso K Takimura, Leonardo S Jensen, Bianca Kiers, Jeane M Tsutsui, Wilson Mathias, Pedro A Lemos Neto, Jose E Krieger
Cell therapy repair strategies using adult mesenchymal stromal cells have shown promising evidence to prevent cardiac deterioration in rodents even in the absence of robust differentiation of the cells into cardiomyocytes. We tested whether increasing doses of porcine adipose-tissue derived mesenchymal stem cells (pASCs) increase cardiac tissue perfusion in pigs post-myocardial infarction (MI) receiving angiotensin-converting-enzyme inhibitor (ACE inhibitors) and Beta-blockers similarly to patients. Female pigs were subjected to MI induction by sponge permanent occlusion of left circumflex coronary artery (LCx) generating approximately 10% of injured LV area with minimum hemodynamic impact...
2017: PloS One
https://www.readbyqxmd.com/read/28448010/murine-left-anterior-descending-lad-coronary-artery-ligation-an-improved-and-simplified-model-for-myocardial-infarction
#2
Karla Reichert, Bonnie Colantuono, Isabella McCormack, Fernanda Rodrigues, Vasile Pavlov, M Ruhul Abid
Ischemic heart disease (IHD), or acute coronary syndrome (ACS), is one of the leading causes of death in the United States. IHD is characterized by reduced blood supply to the heart, resulting in the loss of oxygen to and the ensuing necrosis of the heart muscle. The MI model has gained popularity for its use as a short-term ischemia-reperfusion model and a long-term permanent ligation model. Below, we describe a reliable method for the permanent ligation of the LAD. With mouse genetic engineering technology becoming more advanced, and with an increasing availability of quality murine surgical instruments, the mouse has become a popular model for MI surgeries...
April 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447283/adenosine-stress-myocardial-perfusion-imaging-in-octogenarians-safety-tolerability-and-long-term-prognostic-implications-of-hemodynamic-response-and-spect-related-variables
#3
Athanasios Katsikis, Athanasios Theodorakos, Spyridon Papaioannou, Antonios Kalkinis, Genovefa Kolovou, Konstantinos Konstantinou, Maria Koutelou
BACKGROUND: Evaluation of tolerability, safety, and prognostic implications of adenosine stress myocardial perfusion imaging (MPI) in octogenarians. METHODS: 370 octogenarians (49% known coronary artery disease) were studied. Hemodynamic response, MPI-related data, and rest-left ventricular ejection fraction (LVEF) based on echocardiography were registered per patient, and prospective follow-up was performed to document all-cause death (ACD), cardiac death (CD), myocardial infarction (MI), and late revascularization...
April 26, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28446966/monocytes-and-macrophages-in-cardiac-injury-and-repair
#4
REVIEW
Hendrik B Sager, Thorsten Kessler, Heribert Schunkert
Myocardial infarction (MI) is one of the major contributors to worldwide morbidity and mortality. It is atherosclerosis' most dreadful complication and occurs after the supply of oxygenated blood to the heart is blocked. Understanding how cardiac tissue is injured and later regenerates is of crucial importance to improve the sequelae after the acute event. We now understand that the immune system substantially contributes to both the acute inflammatory response and the regenerative response that follow tissue injury after MI...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28446253/promoting-medication-adherence-among-patients-with-bipolar-disorder-a-multicenter-randomized-controlled-trial-of-a-multifaceted-intervention
#5
A H Pakpour, A Modabbernia, C-Y Lin, M Saffari, M Ahmadzad Asl, T L Webb
BACKGROUND: The present research aimed to investigate the efficacy of a multifaceted intervention that included motivational interviewing (MI) and psychoeducation in improving medication adherence (MA) among patients with bipolar disorder (BD). METHOD: A multicenter, cluster randomized, observer-blind, controlled, parallel-group trial was conducted in ten academic centers in Iran. Patients with BD were randomly assigned to the experimental group (EXP; n = 136) or the usual care group (UC; n = 134)...
April 27, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28444162/coronary-artery-disease-severity-and-long-term-cardiovascular-risk-in-patients-with-myocardial-infarction-a-danish-nationwide-register-based-cohort-study
#6
Cengiz Özcan, Anna Deleskog, Anne-Marie Schjerning Olsen, Helene Nordahl Christensen, Morten Lock Hansen, Gunnar Hilmar Gislason
Background: HASH(0x3192280) Long-term prognostic impact of coronary artery disease (CAD) severity in stable post-myocardial infarction (MI) patients is not well known. We examined the impact of CAD severity and co-morbidity on long-term (one year and beyond) risk of cardiovascular events after MI. Methods and Results: HASH(0x30f5510) From nationwide administrative and clinical registers, we identified 55,747 MI patients, during 2004 to 2010, who had not experienced subsequent MI, stroke or death within 7 day post-discharge...
April 21, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28439731/il-10-improves-cardiac-remodeling-after-myocardial-infarction-by-stimulating-m2-macrophage-polarization-and-fibroblast-activation
#7
Mira Jung, Yonggang Ma, Rugmani Padmanabhan Iyer, Kristine Y DeLeon-Pennell, Andriy Yabluchanskiy, Michael R Garrett, Merry L Lindsey
Inflammation resolution is important for scar formation following myocardial infarction (MI) and requires the coordinated actions of macrophages and fibroblasts. In this study, we hypothesized that exogenous interleukin-10 (IL-10), an anti-inflammatory cytokine, promotes post-MI repair through actions on these cardiac cell types. To test this hypothesis, C57BL/6J mice (male, 3- to 6-month old, n = 24/group) were treated with saline or IL-10 (50 μg/kg/day) by osmotic mini-pump infusion starting at day (d) 1 post-MI and sacrificed at d7 post-MI...
May 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28438659/the-nrf2-activator-dh404-attenuates-adverse-ventricular-remodelling-post-myocardial-infarction-by-modifying-redox-signalling
#8
Kristen J Bubb, Cindy Kok, Owen Tang, Nathalie B Rasko, Asa Birna Birgisdottir, Thomas Hansen, Rebecca Ritchie, Ravinay Bhindi, Scott A Reisman, Colin Meyer, Keith Ward, Keyvan Karimi Galougahi, Gemma A Figtree
BACKGROUND: The novel synthetic triterpenoid, bardoxolone methyl, has the ability to upregulate cytoprotective proteins via induction of the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway. This makes it a promising therapeutic agent in disease states characterized by dysregulated oxidative signalling. We have examined the effect of a Nrf2 activator, dihydro-CDDO-trifluoroethyl amide (DH404), a derivative of bardoxolone methyl, on post-infarct cardiac remodeling in rats. METHODS/RESULTS: DH404, administered from day 2 post myocardial infarction (MI: 30 min transient ischemia followed by reperfusion) resulted in almost complete protection against adverse ventricular remodeling as assessed at day 28 (left ventricular end-systolic area: sham 0...
April 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#9
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28437237/proteomics-in-hypothermia-as-adjunctive-therapy-in-patients-with-st-segment-elevation-myocardial-infarction-a-chill-mi-substudy
#10
Moman A Mohammad, Marco Noc, Irene Lang, Michael Holzer, Peter Clemmensen, Ulf Jensen, Bernhard Metzler, David Erlinge
Cardiovascular and inflammatory biomarkers in therapeutic hypothermia have been studied in cardiac arrest, but data on patients with ST-segment elevation myocardial infarction (STEMI) treated with therapeutic hypothermia are currently unavailable. A multiplex proximity extension assay allowed us to measure 157 cardiovascular disease (CVD) and inflammatory disease-related biomarkers in patients from the international, multicenter, and randomized trial; CHILL-myocardial infarction (MI) and to explore the associations of cardiovascular and inflammatory biomarkers...
March 2, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28435053/in-depth-analysis-of-the-synaptic-plasma-membrane-proteome-of-small-hippocampal-slices-using-an-integrated-approach
#11
Rui Qiao, Shuiming Li, Mi Zhou, Penghui Chen, Zhao Liu, Min Tang, Jian Zhou
Comprehensive knowledge of the synaptic plasma membrane (SPM) proteome of a distinct brain region in a defined pathological state would greatly advance the understanding of the underlying biology of synaptic plasticity. The development of innovative approaches for studying the SPM proteome of small brain tissues is highly desired. This study presents a suitable protocol that integrates biotinylation-based affinity capture of cell surface-exposed proteins, isolation of synaptosomes, and biochemical extraction of SPM proteins from biotinylated hippocampal slices...
April 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/28434472/tai-chi-with-mental-imagery-theory-improves-soleus-h-reflex-and-nerve-conduction-velocity-in-patients-with-type-2-diabetes
#12
Abdulrahman Alsubiheen, Jerrold Petrofsky, Noha Daher, Everett Lohman, Edward Balbas, Haneul Lee
OBJECTIVES: Diabetes is a disease that leads to damage to the peripheral nerves which may eventually cause balance instability. The purpose of this study was to determine the effect of 8 weeks of Tai Chi (TC) training combined with mental imagery (MI) on soleus H-reflex and nerve conduction velocity (NCV) of the sural and superficial peroneal nerves in people with diabetes. DESIGNS: Quasi-experimental, one group pretest-posttest design. SETTING: Human Research Laboratory...
April 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28431176/effect-of-melatonin-on-renewal-of-chicken-small-intestinal-mucosa
#13
J Li, R X Li, G Liu, C F Lv, Y L Mi, C Q Zhang
A higher concentration of melatonin (MEL) in the intestine - even more than that in the plasma and pineal gland - implies its putative important role in the gastrointestinal structural or functional regulation. However, little evidence has shown that MEL can regulate the physiological functions of the intestinal mucosa. In this study, fertilized chicken eggs were treated with MEL (0.1 to 10 μg/d) from embryonic d 12 (E12) to post-hatching d 6 (D6), and the small intestine samples were collected at D6 to determine the changes in mucosal construction and function...
April 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28431133/prediction-of-sudden-and-non-sudden-cardiac-death-in-post-infarction-patients-with-reduced-left-ventricular-ejection-fraction-by-periodic-repolarization-dynamics-madit-ii-substudy
#14
Konstantinos D Rizas, Scott McNitt, Wolfgang Hamm, Steffen Massberg, Stefan Kääb, Wojciech Zareba, Jean-Philippe Couderc, Axel Bauer
Aims: To test the value of Periodic Repolarization Dynamics (PRD), a recently validated electrocardiographic marker of sympathetic activity, as a novel approach to predict sudden cardiac death (SCD) and non-sudden cardiac death (N-SCD) and to improve identification of patients that profit from ICD-implantation. Methods and results: We included 856 post-infarction patients with left-ventricular ejection fraction (LVEF) ≤30% of the MADIT-II trial in sinus rhythm...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28428939/effects-of-sperm-insemination-on-the-final-meiotic-maturation-of-mouse-oocytes-arrested-at-metaphase-i-after-in-vitro-maturation
#15
Jeong Yoon, Kyoung-Mi Juhn, San-Hyun Yoon, Yong Ko, Jin-Ho Lim
OBJECTIVE: The aims of this study were to investigate whether fertilization could induce the resumption of meiosis in mouse oocytes arrested at metaphase I (MI) after in vitro maturation (IVM), and to investigate the effect of Ca(2)(+) chelator treatment at the time of fertilization on the transition from MI to metaphase II (MII). METHODS: MII-stage and arrested MI-stage mouse oocytes after IVM were fertilized, and then embryonic development was monitored. Blastocysts from each group were transferred into 2...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28428694/a-microarray-immunoassay-for-serum-thyrotropin-and-thyroglobulin-using-antibodies-immobilized-on-track-etched-membranes
#16
Bharti Jain, J Kumarasamy, Chandrakala Gholve, Savita Kulkarni, M G R Rajan
Serum thyroglobulin (Tg) and thyroid stimulating hormone (TSH) measurements have evolved as important analytes for monitoring the prognosis of patients with differentiated thyroid cancer, post-thyroidectomy. Individual analyte immunoassay is the current practice in clinical pathology, but the simultaneous assay for all relevant analytes for a given disease, can reduce assay costs, improve patient compliance and give the clinician more information for an unequivocal diagnosis. Microarray immunoassay (MI) can achieve this goal and, hence, we have developed and validated a immuno-radiometric MI for quantitation of serum TSH and Tg by using highly micro-porous polycarbonate (PC) track-etched membranes (TEM) to immobilize the monoclonal anti-TSH and polyclonal anti-Tg antibodies in ~1 mm diameter spots...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28424500/percutaneous-transluminal-coronary-angioplasty-for-acute-myocardial-infarction-the-impact-on-sexual-function-in-men
#17
C Goławski, M Dłużniewski, E Kostarska-Srokosz, K Nowosielski, J Syska-Sumińska, M Chmielewski, R Kowalczyk
The aim of this study was to evaluate changes in men's sexual function after percutaneous transluminal coronary angioplasty (PTCA) treatment for acute myocardial infarction (MI). Sixty men aged 18-70 years old were included in the study. All patients had acute MI and underwent PTCA. They underwent two post PCTA visits: 3 days and between 4 and 6 months after PTCA. During the first and second visit a standard medical interview was carried out and sexual function data collected using Changes in Sexual Functioning Questionnaire and International Index of Erectile Function (IIEF-15)...
April 20, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28422327/association-between-the-ulcer-status-and-the-risk-of-delayed-bleeding-after-the-endoscopic-mucosal-resection-of-colon
#18
Gwang-Un Kim, Myeongsook Seo, Eun Mi Song, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon
BACKGROUND AND AIM: Bleeding is the most common adverse event following colonoscopic endoscopic mucosal resection (EMR). We aimed to assess the clinical outcomes of a colon EMR according to the post-EMR ulcer status, and determine the risk factors of delayed postpolypectomy bleeding (DPPB) based on the post-EMR ulcer status. METHODS: We retrospectively reviewed the medical records and endoscopic images of patients who underwent EMR of colon polyps with diameters of ≥5 mm...
April 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28419792/breaking-the-code-what-is-the-best-post-pci-mi-definition
#19
EDITORIAL
Arnold H Seto, Morton J Kern
Various definitions of post-PCI MI have been recommended by different professional societies and studies. This present study suggests that the troponin-based 3rd universal definition of post-PCI MI has prognostic value for recurrent MI but not mortality alone, unlike the CK-MB based SCAI definition. Absent a consensus on the best definition, clinical trials should report outcomes based on multiple definitions of post-PCI MI.
April 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28418029/tmcactin-plays-an-important-role-in-gram-negative-and-positive-bacterial-infection-by-regulating-expression-of-7-amp-genes-in-tenebrio-molitor
#20
Yong Hun Jo, Yu Jung Kim, Ki Beom Park, Jeong Hwan Seong, Soo Gon Kim, Soyi Park, Mi Young Noh, Yong Seok Lee, Yeon Soo Han
Cactin was originally identified as an interactor of the Drosophila IκB factor Cactus and shown to play a role in controlling embryonic polarity and regulating the NF-κB signaling pathway. While subsequent studies have identified the roles for Cactin in the mammalian immune response, the immune function of Cactin in insects has not been described yet. Here, we identified a Cactin gene from the mealworm beetle, Tenebrio molitor (TmCactin) and characterized its functional role in innate immunity. TmCactin was highly expressed in prepupa to last instar stages, and its expression was high in the integument and Malpighian tubules of last instar larvae and adults...
April 18, 2017: Scientific Reports
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