Aeron M Small, Giorgio E M Melloni, Frederick K Kamanu, Brian A Bergmark, Marc P Bonaca, Michelle L O'Donoghue, Robert P Giugliano, Benjamin M Scirica, Deepak Bhatt, Elliott M Antman, Itamar Raz, Stephen D Wiviott, Buu Truong, Peter W F Wilson, Kelly Cho, Christopher J O'Donnell, Eugene Braunwald, Steve A Lubitz, Patrick Ellinor, Gina M Peloso, Christian T Ruff, Marc S Sabatine, Pradeep Natarajan, Nicholas A Marston
IMPORTANCE: Polygenic risk scores (PRSs) have proven to be as strong as or stronger than established clinical risk factors for many cardiovascular phenotypes. Whether this is true for aortic stenosis remains unknown. OBJECTIVE: To develop a novel aortic stenosis PRS and compare its aortic stenosis risk estimation to established clinical risk factors. DESIGN, SETTING, AND PARTICIPANTS: This was a longitudinal cohort study using data from the Million Veteran Program (MVP; 2011-2020), UK Biobank (2006-2010), and 6 Thrombolysis in Myocardial Infarction (TIMI) trials, including DECLARE-TIMI 58 (2013-2018), FOURIER (TIMI 59; 2013-2017), PEGASUS-TIMI 54 (2010-2014), SAVOR-TIMI 53 (2010-2013), SOLID-TIMI 52 (2009-2014), and ENGAGE AF-TIMI 58 (2008-2013), which were a mix of population-based and randomized clinical trials...
February 28, 2024: JAMA Cardiology