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https://www.readbyqxmd.com/read/29923953/ketamine-for-refractory-headache-a-retrospective-analysis
#1
Eric S Schwenk, Amir C Dayan, Ashwin Rangavajjula, Marc C Torjman, Mauricio G Hernandez, Clinton G Lauritsen, Stephen D Silberstein, William Young, Eugene R Viscusi
BACKGROUND AND OBJECTIVES: The burden of chronic headache disorders in the United States is substantial. Some patients are treatment refractory. Ketamine, an N-methyl-D-aspartate antagonist, provides potent analgesia in subanesthetic doses in chronic pain, and limited data suggest it may alleviate headache in some patients. METHODS: We performed a retrospective study of 61 patients admitted over 3 years for 5 days of intravenous therapy that included continuous ketamine to determine responder rate and patient and ketamine infusion characteristics...
June 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29923612/the-construction-and-application-of-a-population-physiologically-based-pharmacokinetic-model-for-methadone-in-beagles-and-greyhounds
#2
Trevor Elwell-Cuddy, Miao Li, Butch KuKanich, Zhoumeng Lin
Methadone is an opioid analgesic in veterinary and human medicine. To help develop appropriate pain management practices and to develop a quantitative model for predicting methadone dosimetry, a flow-limited multiroute physiologically based pharmacokinetic (PBPK) model for methadone in dogs constructed with Berkeley Madonna™ was developed. The model accounts for intravenous (IV), subcutaneous (SC), and oral administrations, and compartmentalizes the body into different components. This model was calibrated from plasma pharmacokinetic data after IV administration of methadone in Beagles and Greyhounds...
June 20, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29922742/biased-agonism-the-quest-for-the-analgesic-holy-grail
#3
M Alexander Stanczyk, Ram Kandasamy
Opioids alleviate pain, but adverse effects severely limit their usefulness. To solve this problem, biased ligands favoring 1 signaling pathway downstream of the μ-opioid receptor over another are being developed. In the target article, the authors synthesize compounds that preferentially activate G-protein or β-arrestin signaling. They find that increased bias towards G-protein signaling produces better antinociception with minimal side effects in mice models. G-protein-biased opioids may provide a safer treatment strategy...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922741/linking-opioid-induced-hyperalgesia-and-withdrawal-associated-injury-site-pain-a-case-report
#4
Launette Marie Rieb, Wendy V Norman, Ruth Elwood Martin, Jonathan Berkowitz, Evan Wood, Michael John Milloy, Ryan McNeil
Introduction and objectives: Understanding the details of one individual's experience with pain, opioid use and withdrawal may generate insights into possible relationships between opioid-induced hyperalgesia and withdrawal-associated injury site pain (WISP). Methods: This case study was extracted from a mixed methods study that characterized WISP. In 2014, the individual was recruited from a primary care clinic that prescribes opioid agonist therapy. In an interview, she completed a 35-item survey and elaborated on her own experience...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922083/ferulic-acid-dimer-as-a-non-opioid-therapeutic-for-acute-pain
#5
Alaini Priebe, Megan Hunke, Raquel Tonello, Yogesh Sonawane, Temugin Berta, Amarnath Natarajan, Nattamai Bhuvanesh, Mahesh Pattabiraman, Surabhi Chandra
Purpose: Search for alternate pain medications has gained more importance in the past few years due to adverse effects associated with currently prescribed drugs including nervous system dysfunction with opioids, gastrointestinal discomfort with nonsteroidal anti-inflammatory drugs, and cardiovascular anomalies with cyclooxygenase-2 (COX-2) inhibitors. Phytomedicine has been explored for the treatment of pain, as these have been used for generations in regional communities and tend to lack major side effects in general...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29921657/oligomerization-of-mrgc11-and-%C3%AE-opioid-receptors-in-sensory-neurons-enhances-morphine-analgesia
#6
Shao-Qiu He, Qian Xu, Vinod Tiwari, Fei Yang, Michael Anderson, Zhiyong Chen, Shaness A Grenald, Srinivasa N Raja, Xinzhong Dong, Yun Guan
The μ-opioid receptor (MOR) agonist morphine is commonly used for pain management, but it has severe adverse effects and produces analgesic tolerance. Thus, alternative ways of stimulating MOR activity are needed. We found that MrgC11, a sensory neuron-specific G protein-coupled receptor, may form heteromeric complexes with MOR. Peptide-mediated activation of MrgC11 enhanced MOR recycling by inducing coendocytosis and sorting of MOR for membrane reinsertion. MrgC11 activation also inhibited the coupling of MOR to β-arrestin-2 and enhanced the morphine-dependent inhibition of cAMP production...
June 19, 2018: Science Signaling
https://www.readbyqxmd.com/read/29921501/tapentadol-a-representative-of-a-new-class-of-mor-nri-analgesics
#7
REVIEW
Renata Zajączkowska, Barbara Przewłocka, Magdalena Kocot-Kępska, Joanna Mika, Wojciech Leppert, Jerzy Wordliczek
Tapentadol is a centrally acting analgesic with a dual mode of action as a μ-opioid receptor (MOR) agonist and a noradrenaline reuptake inhibitor (NRI). It was initially approved by the US Food and Drug Administration in November 2008 for the treatment of moderate-to-severe acute pain in adult patients, and in August 2011, for chronic pain in an prolonged release form in the same population. Due to its limited protein binding capacity, the absence of active metabolites and significant microsomal enzyme induction or inhibition, tapentadol has a limited potential for drug-drug interactions...
January 31, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29921487/mri-compatibility-of-silver-based-wound-dressings
#8
J Kevin Bailey, Steffen Sammet, Jason Overocker, Beretta Craft-Coffman, Cristina M Acevedo, Martin E Cowan, Heather M Powell
As silver dressings gain more widespread use, it is more likely that patients with silver-based dressings will also undergo magnetic resonance imaging (MRI). In current practice, these dressings are removed prior to imaging due to concerns over heating and image distortion. As dressing changes can be painful, the need to remove dressings simply for MRI may increase pain and contribute to opioid dependency. To examine the need for dressing removal, American Society for Testing and Materials International standards for assessing device deflection and torque were performed on 5 silver containing and 3 non-silver control dressings...
June 16, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29917231/itch-and-psyche-psychiatric-aspects-of-pruritus
#9
REVIEW
Mohammad Jafferany, Maryam E Davari
Itch, also referred to as pruritus, is an unpleasant cutaneous sensation provoking the desire to scratch. It is often an uncomfortable, subjective sensation responsible for decreased quality of life in a variety of psychodermatological conditions. Comorbid psychiatric conditions, including depression and anxiety, are frequently associated with itch and scratch cycle. The reciprocal and intricate relationship between the psyche and itch has been widely studied. The neurobiology of itch involves the complexity of specific mediators, itch-related neuronal pathways, and central processing of itch...
June 19, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29916050/opioid-analgesic-drugs-and-serotonin-toxicity-syndrome-mechanisms-animal-models-and-links-to-clinical-effects
#10
REVIEW
Brian A Baldo
Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic levels of serotonin, and opioid analgesic drugs are now recognized as being involved in some cases of serotonin toxicity especially if administered in conjunction with other serotonergic medications including monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants...
June 18, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29916029/correction-to-managing-concerning-behaviors-in-patients-prescribed-opioids-for-chronic-pain-a-delphi-study
#11
Jessica S Merlin, Sarah R Young, Joanna L Starrels, Soraya Azari, E Jennifer Edelman, Jamie Pomeranz, Payel Roy, Shalini Saini, William C Becker, Jane M Liebschutz
In this paper, the author degrees were presented incorrectly. The correct listing is above.
June 18, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29915947/a-pilot-study-of-a-breast-surgery-enhanced-recovery-after-surgery-eras-protocol-to-eliminate-narcotic-prescription-at-discharge
#12
Kristin E Rojas, Donna-Marie Manasseh, Peter L Flom, Solomon Agbroko, Nicole Bilbro, Charusheela Andaz, Patrick I Borgen
BACKGROUND: The evolving conceptualization of the management of surgical pain was a major contributor to the supply of narcotics that led to the opioid crisis. We designed and implemented a breast surgery-specific Enhanced Recovery After Surgery (ERAS) protocol using opioid-sparing techniques to eliminate narcotic prescription at discharge without sacrificing perioperative pain control. METHODS: A pilot observational study included patients with and without cancer undergoing lumpectomy...
June 18, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29914782/a-randomized-trial-comparing-surgeon-administered-intraoperative-transversus-abdominis-plane-block-with-anesthesiologist-administered-transcutaneous-block
#13
D M Narasimhulu, L Scharfman, H Minkoff, B George, P Homel, K Tyagaraj
BACKGROUND: Injection of local anesthetic into the transversus abdominis plane (TAP block) decreases systemic morphine requirements after abdominal surgery. We compared intraoperative surgeon-administered TAP block (surgical TAP) to anesthesiologist-administered transcutaneous ultrasound-guided TAP block (conventional TAP) for post-cesarean analgesia. We hypothesized that surgical TAP blocks would take less time to perform than conventional TAP blocks. METHODS: We performed a randomized trial, recruiting 41 women undergoing cesarean delivery under neuraxial anesthesia, assigning them to either surgical TAP block (n=20) or conventional TAP block (n=21)...
April 27, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29914061/pain-and-pain-medication-among-older-people-with-intellectual-disabilities-in-comparison-with-the-general-population
#14
Anna Axmon, Gerd Ahlström, Hans Westergren
Little is known about pain and pain treatment among people with intellectual disabilities (IDs). We aimed to describe pain and pain medications among older people with ID compared to the general population. Data on diagnoses and prescriptions were collected from national registers for the period between 2006 and 2012 for 7936 people with an ID and a referent cohort from the general population. IDs were associated with a decreased risk of being diagnosed with headaches, musculoskeletal pain, and pain related to the circulatory and respiratory systems, but they were associated with increased risk of being diagnosed with pain related to the urinary system...
June 15, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29914002/pain-sensitivity-and-experimentally-induced-sensitisation-in-red-haired-females
#15
Trine Andresen, Dagmar Lunden, Asbjørn M Drewes, Lars Arendt-Nielsen
Introduction and aim Pain sensitivity has been linked to the melanocortin-1 receptor (MC1R) gene. A mutation in MC1R can result in pale skin and red hair in humans and may modulate pain responses in general. Human studies have shown that women with non-functional MC1R's were sensitive to experimental induced cold and heat pain. A study demonstrated that females with red hair required higher dose of anesthesia than females with dark hair to experience analgesia to electrical stimulation. Moreover, women expressing non-functional MC1Rs display greater analgesia from opioid analgesia...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29914000/dispensing-of-prescribed-analgesics-in-norway-among-young-people-with-foreign-or-norwegian-born-parents
#16
Tomas Log, Svetlana Skurtveit, Aage Tverdal, Kari Furu, Ingeborg Hartz
Purpose To examine and compare dispensing of prescribed analgesics between young people with parents from countries with a Muslim majority and those with parents born in Norway. Methods Our study-population constituted 11,542 adolescents from the Norwegian Youth Health Surveys conducted in 2000-2003. Users and non-users of prescribed analgesics at baseline were analysed separately. Self-reported information on their parents' birth country was used to classify them into one of the three predefined groups: Norway, countries with a Muslim majority or others...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913985/corrigendum-to-a-6-months-randomised-placebo-controlled-evaluation-of-efficacy-and-tolerability-of-7-day-buprenorphine-transdermal-patch-in-osteoarthritis-patients-na%C3%A3-ve-to-potent-opioids-scandinavian-journal-of-pain-1-2010-122-141
#17
Harald Breivik, Tone Marte Ljosaa, Kristian Stengaard-Pedersen, Jan Persson, Hannu Aro, John Villumsen, Dorthe Tvinnemose
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913983/a-6-months-randomised-placebo-controlled-evaluation-of-efficacy-and-tolerability-of-a-low-dose-7-day-buprenorphine-transdermal-patch-in-osteoarthritis-patients-na%C3%A3-ve-to-potent-opioids
#18
Harald Breivik, Tone Marte Ljosaa, Kristian Stengaard-Pedersen, Jan Persson, Hannu Aro, John Villumsen, Dorthe Tvinnemose
Objective Patients with osteoarthritis (OA) pain often have insufficient pain relief from non-opioid analgesics. The aim of this trial was to study efficacy and tolerability of a low dose 7-day buprenorphine transdermal delivery system, added to a NSAID or coxib regimen, in opioid-naïve patients with moderate to severe OA pain. Methods A 6 months randomised, double-blind, parallel-group study at 19 centres in Denmark, Finland, Norway, and Sweden, in which OA patients (>40 years) with at least moderate radiographic OA changes and at least moderate pain in a hip and/or knee while on a NSAID or a coxib were randomised to a 7-day buprenorphine patch (n = 100) or an identical placebo patch (n = 99)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913961/girl-presenting-with-oesophageal-spasm-pain-after-fundoplication
#19
Ewa Gawecka, Oddbjørn Viken
Introduction A previously healthy 19-year-old woman, who had symptoms of gastric-oesophagela reflux disease for over one year, was transferred to our specialist hospital three weeks post fundoplication operation at a local hospital. She had several episodes with severe retrosternal pain lasting minutes to hours which was stabbing in character. She persistently experienced what was thought to be episodes of oesophageal spasm associated with food intake or movement. She required gradually escalating doses of opioids, both transdermal, intramuscular and intravenous...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913944/effects-of-perioperative-s-ketamine-infusion-added-to-multimodal-analgesia-in-patients-undergoing-ambulatory-haemorrhoidectomy
#20
Ulrich J Spreng, Vegard Dahl, Johan Ræder
Background and objective Perioperative low-dose ketamine has been useful for postoperative analgesia. In this study we wanted to assess the analgesic effect and possible side-effects of perioperative low-dose S (+) ketamine when added to a regime of non-opioid multimodal pain prophylaxis. Methods Seventy-seven patients scheduled for haemorrhoidectomy were enrolled in this randomized, double-blind, controlled study. They received oral paracetamol 1-2 g, total intravenous anaesthesia, intravenous 8 mg dexamethasone, 30 mg ketorolac and local infiltration with bupivacaine/epinephrine...
December 29, 2017: Scandinavian Journal of Pain
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