Maria Perpétuo Socorro Sampaio Carvalho, Fábio Magalhães-Gama, Bruna Pires Loiola, Juliana Costa Ferreira Neves, Nilberto Dias Araújo, Flavio Souza Silva, Claudio Lucas Santos Catão, Eliana Brasil Alves, João Paulo Diniz Pimentel, Maria Nazaré Saunier Barbosa, Nelson Abrahim Fraiji, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Allyson Guimarães Costa, Adriana Malheiro
BACKGROUND: Children with B-cell acute lymphoblastic leukemia (B-ALL) have an immune imbalance that is marked by remodeling of the hematopoietic compartment, with effects on peripheral blood (PB). Although the bone marrow (BM) is the main maintenance site of malignancy, the frequency with which immune cells and molecules can be monitored is limited, thus the identification of biomarkers in PB becomes an alternative for monitoring the evolution of the disease. METHODS: Here, we characterize the systemic immunological profile in children undergoing treatment for B-ALL, and evaluate the performance of cell populations, chemokines and cytokines as potential biomarkers during clinical follow-up...
2023: Frontiers in Oncology