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Chemerin

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https://www.readbyqxmd.com/read/29113429/endophilin-a2-a-potential-link-to-adiposity-and-beyond
#1
Assim A Alfadda, Reem M Sallam, Rukhsana Gul, Injae Hwang, Sojeong Ka
Adipose tissue plays a central role in regulating dynamic crosstalk between tissues and organs. A detailed description of molecules that are differentially expressed upon changes in adipose tissue mass is expected to increase our understanding of the molecular mechanisms that underlie obesity and related metabolic co-morbidities. Our previous studies suggest a possible link between endophilins (SH3Grb2 proteins) and changes in body weight. To explore this further, we sought to assess the distribution of endophilin A2 (EA2) in human adipose tissue and experimental animals...
November 6, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29090333/resolvin-e1-e2-ameliorate-lipopolysaccharide-induced-depression-like-behaviors-via-chemr23
#2
Satoshi Deyama, Kento Shimoda, Hiroe Suzuki, Yuka Ishikawa, Kohei Ishimura, Hayato Fukuda, Natsuko Hitora-Imamura, Soichiro Ide, Masamichi Satoh, Katsuyuki Kaneda, Satoshi Shuto, Masabumi Minami
RATIONALE: Resolvins are bioactive lipid mediators that are generated from docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). We recently demonstrated that the DHA-derived resolvins D1 and D2 exert antidepressant effects. However, whether the EPA-derived resolvins E1 (RvE1) and E2 (RvE2) produce antidepressant effects is not clear. OBJECTIVES: We examined the antidepressant effects of RvE1/RvE2 in a murine lipopolysaccharide (LPS)-induced depression model using the tail suspension and forced swim tests...
October 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29075000/association-between-chemerin-omentin-1-and-risk-of-heart-failure-in-the-population-based-epic-potsdam-study
#3
Juliane Menzel, Romina di Giuseppe, Ronald Biemann, Clemens Wittenbecher, Krasimira Aleksandrova, Fabian Eichelmann, Andreas Fritsche, Matthias B Schulze, Heiner Boeing, Berend Isermann, Cornelia Weikert
The adipokines chemerin and omentin-1 have been suggested to influence cardiovascular function. The study aimed to investigate the longitudinal association between chemerin, omentin-1 concentrations and risk of incident heart failure (HF), respectively. We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort (n = 27548) including a randomly drawn subsample and all incident HF cases during a mean follow-up of 8.2 ± 1.5 years...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29056935/the-atypical-receptor-ccrl2-c-c-chemokine-receptor-like-2-does-not-act-as-a-decoy-receptor-in-endothelial-cells
#4
Chiara Mazzotti, Vincenzo Gagliostro, Daniela Bosisio, Annalisa Del Prete, Laura Tiberio, Marcus Thelen, Silvano Sozzani
C-C chemokine receptor-like 2 (CCRL2) is a non-signaling seven-transmembrane domain (7-TMD) receptor related to the atypical chemokine receptor (ACKR) family. ACKRs bind chemokines but do not activate G protein-dependent signaling or cell functions. ACKRs were shown to regulate immune functions in vivo by their ability to scavenge chemokines from the local environment. This study was performed to investigate whether CCRL2 shares two of the main characteristics of ACKRs, namely the ability to internalize and scavenge the ligands...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29025245/hepatic-chemerin-mrna-in-morbidly-obese-patients-with-nonalcoholic-fatty-liver-disease
#5
Maciej Kajor, Michał Kukla, Marek Waluga, Łukasz Liszka, Michał Dyaczyński, Grzegorz Kowalski, Dominika Żądło, Agnieszka Berdowska, Mateusz Chapuła, Anna Kostrząb-Zdebel, Rafał J Bułdak, Tomasz Sawczyn, Marek Hartleb
The aim of this study was to investigate hepatic chemerin mRNA, serum chemerin concentration, and immunohistochemical staining for chemerin and and chemokine receptor-like 1 (CMKLR1) in hepatic tissue in 56 morbidly obese women with nonalcoholic fatty liver disease (NAFLD) and to search for a relationship with metabolic and histopathological features. Chemerin mRNA was assessed by quantitative real-time PCR, chemerin, and CMKLR1 immunohistochemical expression with specific antibodies, while serum chemerin concentration was assessed with commercially available enzyme-linked immunosorbent assays...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/28980906/serum-chemerin-in-systemic-sclerosis-a-novel-marker-of-early-diffuse-disease
#6
Cecilia Beatrice Chighizola, Elena Raschi, Daniela Privitera, Angela Flavia Luppino, Carolina Artusi, Tommaso Schioppo, Claudio Mastaglio, Francesca Ingegnoli, Maria Orietta Borghi, Pier Luigi Meroni
No abstract text is available yet for this article.
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28957639/serum-levels-of-chemerin-apelin-vaspin-and-omentin-1-in-obese-type-2-diabetic-egyptian-patients-with-coronary-artery-stenosis
#7
Tarek M K Motawi, Soliman G Mahdy, Maha M El-Sawalhi, Eman N Ali, Rania Farag A El-Telbany
Cardiovascular diseases (CVD) are the leading cause of death in the diabetic population. Obesity is a serious problem that has been linked with CVD and diabetes via a variety of adipokines. The aims of this study were to evaluate and correlate circulating chemerin, apelin, vaspin, and omentin-1 levels in obese type 2 diabetic Egyptian patients with coronary artery stenosis (CAS), and to assess their usefulness as noninvasive diagnostic biomarkers. Chemerin, apelin, vaspin, and omentin-1 levels were determined by enzyme immunoassay in coronary artery disease (CAD) I patients (45 non-obese, nondiabetic with CAS), CAD II patients (45 obese, diabetic with CAS), and 30 controls...
September 28, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28935125/maternal-circulating-adipokine-profile-and-insulin-resistance-in-women-at-high-risk-of-developing-gestational-diabetes-mellitus
#8
Kym J Guelfi, Ming Jing Ong, Shaofu Li, Karen E Wallman, Dorota A Doherty, Paul A Fournier, John P Newnham, Jeffrey A Keelan
BACKGROUND: Cytokines produced by adipose and placental tissues (adipokines) have been implicated in the development of gestational diabetes mellitus (GDM). There is, however, limited research regarding the relationship between advancing pregnancy, maternal adipokine profile, insulin resistance and the development of GDM. Furthermore, no studies have investigated these parameters in women with a history of GDM who are at the highest risk of recurrence. This study examined the circulating concentrations of a number of adipokines associated with insulin resistance at two points in pregnancy, and determined whether they were altered in women who developed GDM...
October 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28933132/effects-of-secukinumab-on-serum-adipocytokines-preliminary-data
#9
A Fassio, D Gatti, P Gisondi, G Girolomoni, O Viapiana, A Giollo, M Zamboni, M Rossini, L Idolazzi
Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects joints, connective tissues and the axial skeleton. Metabolic syndrome is an independent risk factor for psoriasis (Pso) development and is associated with more severe forms of Pso. Adipocytokines are secreted by white adipose tissue and are thought to link obesity with the development of metabolic and cardiovascular diseases. Secukinumab is a new monoclonal antibody with a different mechanism of action. This antibody selectively binds to and neutralizes interleukin-17 (IL-17) and it has shown efficacy in the treatment of PsA...
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28931177/effects-of-aldosterone-on-chemerin-expression-and-secretion-in-3t3-l1-adipocytes
#10
Junhua Ma, Fei Sun, Jingnan Wang, He Jiang, Jiancan Lu, Xing Wang, Jichen Zhang, Chao Shi, Wen You, Xiangqi Li, Hongling Zhu, Mingjun Gu
Aldosterone plays a pivotal role in the pathogenesis of metabolic syndrome and cardiovascular disease; however, the underlying mechanisms have not been clarified. Chemerin has been characterized as an adipokine with crucial roles in obesity-associated disorders and cardiovascular homeostasis. The aim of the present study was to investigate the direct effects of aldosterone on chemerin expression and secretion in 3T3-L1 adipocytes and to identify the potential signalling pathways involved. Chemerin mRNA levels were measured using real-time PCR, whereas the levels of secreted chemerin in the culture media were determined using ELISA...
September 20, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28924543/effect-of-the-pro12ala-polymorphism-of-the-peroxisome-proliferator-activated-receptor-%C3%AE-2-gene-on-lipid-profile-and-adipokines-levels-in-obese-subjects
#11
E Becer, A Çırakoğlu
Peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator of metabolism, adipokines production and secretion. The aim of this study was to investigate the association between the PPARγ2 gene Pro12Ala polymorphism in obesity in terms of body mass index (BMI), lipid parameters, homeostasis model assessment of insulin resistance (HOMA-IR), serum lipid, leptin, adiponectin, resistin and chemerin levels. The study included 160 obese and 140 non obese subjects. The Pro12Ala polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
June 30, 2017: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/28905319/pi3k-inhibition-protects-mice-from-nafld-by-down-regulating-cmklr1-and-nlrp3-in-kupffer-cells
#12
Wenfeng Zhang, Yan Liu, Mingbing Wu, Xiwen Zhu, Tao Wang, Kun He, Peizhi Li, Xiaoling Wu
Inflammation induced by high-fat diet (HFD) is of critical importance in the development of hepatic steatosis. The role of chemerin in the progress of nonalcoholic fatty liver disease (NAFLD) remains controversial. Here, we have evaluated the effects and mechanism of chemerin on insulin sensitivity and inflammation. An inhibitor (wortmannin) and agonist (insulin-like growth factor 1 (IGF-1) of phosphatidyl inositol 3-kinase (PI3K) were applied to Kupffer cells (KCs) after treatment with a concentration gradient of chemerin in vitro...
November 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28894050/compounds-of-psoriasis-with-obesity-and-overweight
#13
Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Many epidemiological studies have confirmed the relationship of obesity and psoriasis, and it is believed that obesity is an independent risk factor for its development and is associated with a worse prognosis. Furthermore, the reduction of body weight, using low-calorie diet combined with exercise, reduces the severity of psoriasis.Visceral adipose tissue is the largest endocrine organ, producing proinflammatory cytokines (TNF-α, IL-6, IL-17) and adipokines (adiponectin, omentin, chemerin). They participate in the development of dyslipidemia, insulin resistance, diabetes, and consequently of the cardiovascular diseases...
August 24, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28872087/-serum-level-of-chemerin-and-bone-mineral-density-in-patients-with-graves-disease
#14
Yu Li, Jianying Chang, Tiejian Jiang
To investigate relationships between serum chemerin and bone mineral density (BMD) in patients with newly diagnosed Graves disease (GD).
 Methods: A total of 120 newly diagnosed GD patients with a course more than 3 months were enrolled from the Department of Endocrinology between June 2013 and June 2015. Sixty age- and sex-matched healthy people served as a normal control. Serum levels of chemerin, β-crosslaps (β-CTX), and N-MID-osteocalcin (N-MID-OT) were measured by ELISA. Fat mass and BMD were evaluated by dual energy X-ray absorptiometry (DEXA)...
August 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28846666/interleukin-6-il-6-and-tumor-necrosis-factor-%C3%AE-tnf-%C3%AE-single-nucleotide-polymorphisms-snps-inflammation-and-metabolism-in-gestational-diabetes-mellitus-in-inner-mongolia
#15
Jie Zhang, Haiyi Chi, Huiying Xiao, Xiaoyan Tian, Yilin Wang, Xia Yun, Yancheng Xu
BACKGROUND Gestational diabetes mellitus (GDM) is common all over the world. GDM women are with inflammatory and metabolisms abnormalities. However, few studies have focused on the association of IL-65-72C/G and TNF-α -857C/T single nucleotide polymorphisms (SNPs), inflammatory biomarkers, and metabolic indexes in women with GDM, especially in the Inner Mongolia population. The aim of this study was to investigate the associations of IL-65-72C/G and TNF-α -857C/T SNPs, and inflammation and metabolic biomarkers in women with GDM pregnancies...
August 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28833355/serum-chemerin-levels-are-inversely-associated-with-renal-function-in-a-general-population
#16
Stephanie Zylla, Rainer Rettig, Henry Völzke, Karlhans Endlich, Matthias Nauck, Nele Friedrich
OBJECTIVE: Chemerin has been found to be highly expressed in the kidneys of rodents and has been suggested to affect metabolic syndrome (MetS)-related phenotypes which are in turn related to kidney damage. Only few clinical studies have addressed the relation between circulating chemerin and renal function in humans, and no population-based analyses have yet been performed. The potential influence of MetS-related phenotypes on the assumed association has been largely neglected. We aimed to investigate the association of serum chemerin with renal function in a general population with special regard to possible interactions between chemerin and metabolic phenotypes...
August 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28778084/inhibition-of-chemerin-cmklr1-axis-in-neuroblastoma-cells-reduces-clonogenicity-and-cell-viability-in-vitro-and-impairs-tumor-growth-in-vivo
#17
Conny Tümmler, Igor Snapkov, Malin Wickström, Ugo Moens, Linda Ljungblad, Lotta Helena Maria Elfman, Jan-Olof Winberg, Per Kogner, John Inge Johnsen, Baldur Sveinbjørnsson
Pro-inflammatory cells, cytokines, and chemokines are essential in promoting a tumor supporting microenvironment. Chemerin is a chemotactic protein and a natural ligand for the receptors CMKLR1, GPR1, and CCRL2. The chemerin/CMKLR1 axis is involved in immunity and inflammation, and it has also been implicated in obesity and cancer.In neuroblastoma, a childhood tumor of the peripheral nervous system we identified correlations between high CMKLR1 and GPR1 expression and reduced overall survival probability. CMKLR1, GPR1, and chemerin RNA and protein were detected in neuroblastoma cell lines and neuroblastoma primary tumor tissue...
July 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28771382/relationship-of-circulating-chemerin-and-omentin-levels-with-th17-and-th9-cell-immune-responses-in-patients-with-asthma
#18
Qing Zhou, Yu Fu, Liangan Hu, Qian Li, Meng Jin, E Jiang
OBJECTIVE: Adipokines are correlated with immune response in asthma, but data on the roles of chemerin and omentin in asthmaare limited. This studyexplored the relationship of chemerin and omentin levels with Th17 and Th9 cells in asthma. METHODS: Seventy-six asthmatics were divided into the intermittent to mild persistent (n = 28), moderate persistent (n = 26) and severe persistent (n = 22) and enrolled in the study. Additionally, 20 healthy subjects were enrolled as controls...
August 3, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28759013/papillary-renal-cell-carcinoma-derived-chemerin-il-8-and-cxcl16-promote-monocyte-recruitment-and-differentiation-into-foam-cell-macrophages
#19
Krzysztof M Krawczyk, Helén Nilsson, Roni Allaoui, David Lindgren, Michael Arvidsson, Karin Leandersson, Martin E Johansson
Papillary renal cell carcinoma (pRCC) is the second most common type of renal cell carcinoma. The only curative treatment available for pRCC is radical surgery. If the disease becomes widespread, neither chemo- nor radiotherapy will have therapeutic effect, hence further research on pRCC is of utmost importance. Histologically, pRCC is characterized by a papillary growth pattern with focal aggregation of macrophages of the foam cell phenotype. In other forms of cancer, a clear role for tumor-associated macrophages during cancer growth and progression has been shown...
November 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28694840/hepatic-adipocyte-enteric-and-pancreatic-hormones-response-to-dietary-macronutrient-composition-and-relationship-with-metabolism
#20
Bridget M Hron, Cara B Ebbeling, Henry A Feldman, David S Ludwig
BACKGROUND: We sought to characterize the effects of dietary macronutrient composition on various hormones implicated in the regulation of insulin sensitivity (IS) and energy expenditure (EE). METHODS: Following 10-15% weight loss, 21 overweight subjects consumed 3 weight-loss maintenance diets [low fat (LF), low glycemic index (LGI) and very low carbohydrate (VLC)] in random order, each for 4 weeks. At baseline and at the end of each treatment period, fasting samples for fibroblast growth factor (FGF)-21, heme-oxygenase-1 (HO-1), chemerin, irisin, secreted frizzle-related protein (SFRP-4), total bile acids, ghrelin, gastrin inhibitory peptide (GIP), peptide-Y, and amylin; hepatic and peripheral IS; and EE were obtained...
2017: Nutrition & Metabolism
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