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Chemerin

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https://www.readbyqxmd.com/read/28198147/intrahepatic-fat-abdominal-adipose-tissues-and-metabolic-state-magnetic-resonance-imaging-study
#1
Anat Yaskolka Meir, Lilac Tene, Noa Cohen, Ilan Shelef, Dan Schwarzfuchs, Yftach Gepner, Hila Zelicha, Michal Rein, Nitzan Bril, Dana Serfaty, Shira Kenigsbuch, Yoash Chassidim, Benjamin Sarusy, Dror Dicker, Joachim Thiery, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Meir J Stampfer, Assaf Rudich, Iris Shai
BACKGROUND: Intrahepatic-fat (IHF) is best known to associate with waist circumference (WC) and visceral-adipose-tissue (VAT), but its relation to abdominal subcutaneous-adipose tissue (SAT) is controversial. While IHF > 5% dichotomously defines fatty liver, %IHF is rarely considered as a continuous variable that includes the normal range. In this study, we aimed to evaluate %IHF association with abdominal fat sub-depots, pancreatic and renal-sinus fats. METHODS: We evaluated %IHF, abdominal fat sub-depots, %pancreatic and renal-sinus fats, among individuals with moderate abdominal obesity, using 3-T magnetic resonance imaging (MRI)...
February 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28166197/chemerin-has-a-protective-role-in-hepatocellular-carcinoma-by-inhibiting-the-expression-of-il-6-and-gm-csf-and-mdsc-accumulation
#2
Y Lin, X Yang, W Liu, B Li, W Yin, Y Shi, R He
Hepatocellular carcinoma (HCC) is linked to inflammation and immunosuppression. Chemerin is highly expressed in the liver and implicated in the regulation of inflammation. However, the role of chemerin in HCC remains unclear. In this study, we aimed to investigate whether chemerin is able to influence HCC progression by regulating tumor-associated inflammation. Here we demonstrated that chemerin significantly decreased in blood and tumor tissues of HCC patients, and tumor chemerin levels were inversely associated with the prognosis...
February 6, 2017: Oncogene
https://www.readbyqxmd.com/read/28160556/prognostic-significance-of-serum-chemerin-levels-in-patients-with-non-small-cell-lung-cancer
#3
Chun-Hua Xu, Yang Yang, Yu-Chao Wang, Jun Yan, Li-Hua Qian
Chemerin plays an important role in adipogenesis and chemotaxis of the innate immune system. The aim of this study was to explore the significance and prognostic value of serum chemerin levels in patients with non-small cell lung cancer (NSCLC). Serum specimens from 189 NSCLC patients and 120 healthy controls were collected. The levels of serum chemerin were measured by sandwich enzyme-linked immunosorbent assay (ELISA). The serum chemerin levels were significantly elevated in NSCLC patients compared with healthy controls (P < 0...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28120562/serum-chemerin-levels-are-associated-with-visceral-adiposity-independent-of-waist-circumference-in-newly-diagnosed-type-2-diabetic-subjects
#4
Dae Young Cheon, Jun Goo Kang, Seong Jin Lee, Sung Hee Ihm, Eun Jig Lee, Moon Gi Choi, Hyung Joon Yoo, Chul Sik Kim
PURPOSE: Chemerin has been suggested to be linked to insulin resistance and type 2 diabetes mellitus (T2DM). However, the relationship between visceral adiposity and chemerin levels remains unclear in subjects with T2DM. In this study, we investigated the relationship between serum chemerin levels and visceral adiposity. MATERIALS AND METHODS: This study included 102 subjects newly diagnosed with T2DM. The relationships between serum chemerin levels and clinical and biochemical parameters were examined...
March 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28114280/rarres2-functions-as-a-tumor-suppressor-by-promoting-%C3%AE-catenin-phosphorylation-degradation-and-inhibiting-p38-phosphorylation-in-adrenocortical-carcinoma
#5
Y Liu-Chittenden, M Jain, K Gaskins, S Wang, M J Merino, S Kotian, S Kumar Gara, S Davis, L Zhang, E Kebebew
Tumor suppressor genes and the immune system are critical players in inhibiting cancer initiation and/or progression. However, little is known about whether a tumor suppressor gene can function through both immune-dependent and -independent mechanisms. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally downregulated in multiple cancer types. Previous studies suggested that it can serve as an immune-dependent tumor suppressor by acting as a chemoattractant to recruit anticancer immune cells expressing its receptor, the chemerin chemokine receptor 1 (CMKLR1), to sites of tumor...
January 23, 2017: Oncogene
https://www.readbyqxmd.com/read/28071854/serum-chemerin-is-associated-with-inflammatory-and-metabolic-parameters-results-of-a-population-based-study
#6
Stephanie Zylla, Maik Pietzner, Jens-Peter Kühn, Henry Völzke, Marcus Dörr, Matthias Nauck, Nele Friedrich
OBJECTIVE: This study aimed to confirm existing assumptions about the associations of circulating chemerin with inflammatory and metabolic parameters in a large population-based study. METHODS: Data of 3,986 subjects from the Study of Health in Pomerania were analyzed. Residual method was used to investigate the different associations of visceral (VAT) and subcutaneous adipose tissue (SAT) with serum chemerin levels. Multivariable regression models were applied to examine the association of chemerin with high-sensitivity C-reactive protein, fibrinogen, glucose, glycated hemoglobin, lipid profile, blood pressure, diabetes, dyslipidemia, and hypertension...
January 10, 2017: Obesity
https://www.readbyqxmd.com/read/28029186/adipokine-chemerin-bridges-metabolic-dyslipidemia-and-alveolar-bone-loss-in-mice
#7
Erivan S Ramos-Junior, Gisele A Leite, Cecilia C Carmo-Silva, Thaise M Taira, Karla B Neves, David F Colón, Lea Ab da Silva, Sergio L Salvador, Rita C Tostes, Fernando Q Cunha, Sandra Y Fukada
Chemerin is an adipokine that regulates adipogenesis and metabolic functions of mature adipocytes mainly through the activation of chemokine-like receptor 1 (CMKLR1). Elevated levels of chemerin have been found in individuals with obesity, type-2 diabetes, and osteoporosis. This adipokine was identified as an inflammatory and metabolic syndrome marker. Considering that the association between metabolic syndrome and bone health remains unclear, the present study aimed to clarify the role of chemerin in the pathophysiology of bone loss induced by dyslipidemia, particularly modulating osteoclastogenesis...
December 28, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27990086/are-adipokines-associated-with-gestational-diabetes-mellitus
#8
Ümit Görkem, Ferit Kerim Küçükler, Cihan Toğrul, Tayfun Güngör
OBJECTIVE: To investigate the association of maternal serum levels of chemerin, retinol binding protein-4 (RBP-4), and visfatin with gestational diabetes mellitus (GDM). MATERIAL AND METHODS: 158 pregnant women were screened between 24 and 28 weeks of gestation. They were divided into two groups: GDM group (n=76) and control group (n=82). Maternal serum concentrations of chemerin, RBP-4, visfatin, insulin, and homeostasis model assessment-insulin resistance (HOMA-IR) were assessed...
2016: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/27941174/nocturnal-levels-of-chemerin-and-progranulin-in-adolescents-influence-of-sex-body-mass-index-glucose-metabolism-and-sleep
#9
Johann Daxer, Theresa Herttrich, Ying Y Zhao, Mandy Vogel, Andreas Hiemisch, Kathrin Scheuermann, Antje Körner, Jürgen Kratzsch, Wieland Kiess, Mirja Quante
BACKGROUND: Adipokines have been implicated in obesity, insulin resistance and sleep regulation. However, the role of chemerin and progranulin, two recently described adipokines, in the context of sleep remains unclear. The aim of this study was to compare nocturnal serum chemerin and progranulin levels between overweight/obese and normal-weight adolescents and to assess variations by sex, across different sleep stages and in relation to glucose metabolism. METHODS: The study sample included 34 overweight/obese and 32 normal-weight adolescents from secondary schools and the Leipzig Research Center for Civilization Diseases (LIFE) Child study cohort...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27939374/mesenchymal-stromal-cell-secreted-chemerin-is-a-novel-immunomodulatory-molecule-driving-the-migration-of-chemr23-expressing-cells
#10
Paola Vinci, Antonio Bastone, Silvia Schiarea, Claudia Cappuzzello, Annalisa Del Prete, Erica Dander, Andrea Biondi, Giovanna D'Amico
BACKGROUND: Mesenchymal stromal cells (MSCs) are multipotent cells characterized by broad immunomodulatory properties exploited for the treatment of inflammatory disorders. However, the efficacy of MSC-based therapy is highly variable and tightly linked to MSC culture conditions and treatment schedule. Thus, the identification of novel key molecules regulating MSC immunomodulatory activities in vivo might constitute a crucial step toward the optimization of currently available clinical protocols...
February 2017: Cytotherapy
https://www.readbyqxmd.com/read/27907906/senescent-fibroblast-derived-chemerin-promotes-squamous-cell-carcinoma-migration
#11
Vida Farsam, Abhijit Basu, Martina Gatzka, Nicolai Treiber, Lars A Schneider, Medhanie A Mulaw, Tanja Lucas, Stefan Kochanek, Reinhard Dummer, Mitchell P Levesque, Meinhard Wlaschek, Karin Scharffetter-Kochanek
Aging is associated with a rising incidence of cutaneous squamous cell carcinoma (cSCC), an aggressive skin cancer with the potential for local invasion and metastasis. Acquisition of a senescence-associated secretory phenotype (SASP) in dermal fibroblasts has been postulated to promote skin cancer progression in elderly individuals. The underlying molecular mechanisms are largely unexplored. We show that Chemerin, a previously unreported SASP factor released from senescent human dermal fibroblasts, promotes cSCC cell migration, a key feature driving tumor progression...
November 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27898966/postweaning-changes-in-the-expression-of-chemerin-and-its-receptors-in-calves-are-associated-with-the-modification-of-glucose-metabolism
#12
Y Suzuki, S Haga, M Nakano, H Ishizaki, M Nakano, S Song, K Katoh, S Roh
Chemerin, originally known as a chemoattractant derived from adipose tissue and the liver, has been reported to have regulatory functions in gluconeogenesis, peripheral insulin sensitivity, and insulin secretion. This study was conducted to assess the postweaning changes in expression of this cytokine and its physiological role in the modification of glucose metabolism associated with weaning. Eighteen tissue samples were collected from Holstein calves (90 d of age; n = 4) to investigate the tissue distributions of chemerin and its receptors genes...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27890480/chemerin-induced-arterial-contraction-is-gi-and-calcium-dependent
#13
David J Ferland, Emma S Darios, Richard R Neubig, Benita Sjögren, Nguyen Truong, Rosa Torres, Thomas S Dexheimer, Janice M Thompson, Stephanie W Watts
Chemerin is an adipokine associated with increased blood pressure, and may link obesity with hypertension. We tested the hypothesis that chemerin-induced contraction of the vasculature occurs via calcium flux in smooth muscle cells. Isometric contraction of rat aortic rings was performed in parallel with calcium kinetics of rat aortic smooth muscle cells to assess the possible signaling pathway. Chemerin-9 (nonapeptide of the chemerin S(157) isoform) caused a concentration-dependent contraction of isolated aorta (EC50 100nM) and elicited a concentration-dependent intracellular calcium response (EC50 10nM)...
January 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/27882931/plasma-sfrp5-and-adiponectin-levels-in-relation-to-blood-pressure-among-obese-children
#14
C Yin, H Chu, H Li, Y Xiao
The aim was to clarify the associations of five adipocytokines: Sfrp5, Wnt5a, adiponectin, chemerin and high-sensitivity C-reactive protein (hsCRP) with blood pressure (BP), and to examine whether BP can be influenced by changes in these adipocytokines in obese children after a 6-month lifestyle intervention. We conducted a cross-sectional study in 263 obese children and performed a 6-month lifestyle intervention in a subgroup of 89 obese children with hypertension. Anthropometric data, adiponectin, chemerin, Sfrp5 and Wnt5a were assessed at baseline and after 6-month lifestyle intervention...
November 24, 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/27881447/cmklr1-activation-ex-vivo-does-not-increase-proportionally-to-serum-total-chemerin-in-obese-humans
#15
Jay Toulany, Sebastian D Parlee, Christopher J Sinal, Kathryn Slayter, Shelly McNeil, Kerry B Goralski
Prochemerin is the inactive precursor of the adipokine chemerin. Proteolytic processing is obligatory for the conversion of prochemerin into active chemerin and subsequent regulation of cellular processes via the chemokine-like receptor 1 (CMKLR1). Elevated plasma or serum chemerin concentrations and differential processing of prochemerin have been reported in obese humans. The impact of these changes on CMKLR1 signalling in humans is unknown. The objective of this pilot study was to develop a cellular bioassay to measure CMKLR1 activation by chemerin present in human serum and to characterise how obesity modifies serum activation of CMKLR1 under fasted and fed conditions...
November 2016: Endocrine Connections
https://www.readbyqxmd.com/read/27866414/chemerin-level-in-pregnancies-complicated-by-preeclampsia-and-its-relation-with-disease-severity-and-neonatal-outcomes
#16
Orkun Cetin, Zehra Kurdoglu, Mertihan Kurdoglu, H Guler Sahin
The aims of this prospective study were to detect maternal serum chemerin level in patients with preeclampsia and investigate its association with disease severity and neonatal outcomes. Maternal serum chemerin levels were significantly elevated in severe preeclamptic women (394.72 ± 100.01 ng/ml) compared to mild preeclamptic women (322.11 ± 37.60 ng/ml) and healthy pregnant women (199.96 ± 28.05 ng/ml) (p = .001). Maternal serum chemerin levels were positively correlated with systolic and diastolic blood pressure, C-reactive protein levels, homeostasis model assessment of insulin resistance, proteinuria, AST, ALT, and duration of hospitalisation...
November 21, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27806063/biomarker-profiles-in-women-with-pcos-and-pcos-offspring-a-pilot-study
#17
Nadine M P Daan, Maria P H Koster, Marlieke A de Wilde, Gerdien W Dalmeijer, Annemieke M V Evelein, Bart C J M Fauser, Wilco de Jager
OBJECTIVE: To study metabolic/inflammatory biomarker risk profiles in women with PCOS and PCOS offspring. DESIGN: Cross-sectional comparison of serum biomarkers. SETTING: University Medical Center Utrecht. PATIENTS: Hyperandrogenic PCOS women (HA-PCOS, n = 34), normoandrogenic PCOS women (NA-PCOS, n = 34), non-PCOS reference population (n = 32), PCOS offspring (n = 14, age 6-8 years), and a paedriatic reference population (n = 30)...
2016: PloS One
https://www.readbyqxmd.com/read/27797398/hepatic-chemerin-mrna-expression-is-reduced-in-human-nonalcoholic-steatohepatitis
#18
Rebekka Pohl, Elisabeth M Haberl, Lisa Rein-Fischboeck, Sebastian Zimny, Maximilian Neumann, Charalampos Aslanidis, Doris Schacherer, Sabrina Krautbauer, Kristina Eisinger, Thomas S Weiss, Christa Buechler
BACKGROUND: Chemerin is associated with insulin resistance and is expressed in the liver. Nonalcoholic fatty liver disease (NAFLD) is related to impaired insulin sensitivity, but studies evaluating hepatic and serum chemerin in NAFLD resulted in discordant data. MATERIALS AND METHODS: Chemerin mRNA was determined in the liver tissue obtained from 33 controls and 76 NAFLD patients. Chemerin serum levels were measured in a different cohort of patients with ultrasound-diagnosed NAFLD and the respective controls...
January 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27792771/tumor-necrosis-factor-alpha-and-the-erk-pathway-drive-chemerin-expression-in-response-to-hypoxia-in-cultured-human-coronary-artery-endothelial-cells
#19
Su-Kiat Chua, Kou-Gi Shyu, Yuh-Feng Lin, Huey-Ming Lo, Bao-Wei Wang, Hang Chang, Li-Ming Lien
BACKGROUND: Chemerin, a novel adipokine, plays a role in the inflammation status of vascular endothelial cells. Hypoxia causes endothelial-cell proliferation, migration, and angiogenesis. This study was aimed at evaluating the protein and mRNA expression of chemerin after exposure of human coronary artery endothelial cells (HCAECs) to hypoxia. METHODS AND RESULTS: Cultured HCAECs underwent hypoxia for different time points. Chemerin protein levels increased after 4 h of hypoxia at 2...
2016: PloS One
https://www.readbyqxmd.com/read/27792753/chemerin-stimulates-vascular-smooth-muscle-cell-proliferation-and-carotid-neointimal-hyperplasia-by-activating-mitogen-activated-protein-kinase-signaling
#20
Wei Xiong, Yu Luo, Lin Wu, Feng Liu, Huadong Liu, Jianghua Li, Bihong Liao, Shaohong Dong
Vascular neointimal hyperplasia and remodeling arising from local inflammation are characteristic pathogeneses of proliferative cardiovascular diseases, such as atherosclerosis and post angioplasty restenosis. The molecular mechanisms behind these pathological processes have not been fully determined. The adipokine chemerin is associated with obesity, metabolism, and control of inflammation. Recently, chemerin has gained increased attention as it was found to play a critical role in the development of cardiovascular diseases...
2016: PloS One
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