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Chemerin

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https://www.readbyqxmd.com/read/29781079/the-role-of-new-adipokines-in-gestational-diabetes-mellitus-pathogenesis
#1
Radzisław Mierzyński, Elżbieta Poniedziałek-Czajkowska, Dominik Dłuski, Bożena Leszczyńska-Gorzelak
Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition dur-ing pregnancy. Explanation of the GDM pathogenesis is important due to preventing gestational complications. During pregnancy there are significant changes in maternal metabolism. Many of these changes are influenced by different adi-pokines produced in the placenta and adipose tissue. The exact role of adipokines in the pathogenesis of GDM remains still unknown. Several adipokines have been analysed throughout gestation and their levels have been suggested as biomarkers of maternal-perinatal outcomes...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29780640/plasma-chemerin-levels-are-increased-in-st-elevation-myocardial-infarction-patients-with-high-thrombus-burden
#2
Ahmet Hakan Ateş, Uğur Arslan, Aytekin Aksakal, Ahmet Yanık, Metin Özdemir, Selim Kul
Objective: To investigate plasma chemerin levels in ST elevation myocardial infarction (STEMI) patients and find out possible relationships between plasma chemerin levels and angiographic characteristics. Patients and Methods: Ninety-seven consecutive patients who presented with STEMI and underwent primary percutaneous coronary intervention (PCI) with coronary stents were enrolled, and 30 age- and sex-matched patients with stable angina pectoris who underwent coronary angiography formed the control group...
2018: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29760587/the-role-of-adipokines-in-skeletal-muscle-inflammation-and-insulin-sensitivity
#3
REVIEW
Thomas Nicholson, Chris Church, David J Baker, Simon W Jones
Background: There is currently an unmet clinical need to develop better pharmacological treatments to improve glucose handling in Type II Diabetes patients with obesity. To this end, determining the effect of obesity-associated adipokines on skeletal muscle insulin sensitivity has emerged as an important area of drug discovery research. This review draws together the data on the functional role of adipokines on skeletal muscle insulin signalling, highlights several understudied novel adipokines and provides a perspective on the direction of future research...
2018: Journal of Inflammation
https://www.readbyqxmd.com/read/29739418/circulating-adipokines-are-associated-with-kawasaki-disease
#4
Xin-Yan Zhang, Ting-Ting Yang, Xiu-Fen Hu, Yu Wen, Feng Fang, Hui-Ling Lu
BACKGROUND: The pathogenesis of Kawasaki disease are still not well understood. It was designed to investigate the relationship between adipokines including chemerin, omentin-1, adiponectin and acute Kawasaki disease. METHODS: Enzyme-linked immunosorbent (ELISA) was used to detect serum levels of chemerin, omentin-1, adiponectin, and inflammatory cytokines IL-1β and TNF-α in 80 cases of patients diagnosed with Kawasaki disease (KD). In addition, 20 cases of children with fever and 20 cases of healthy children were selected as febrile and normal controls...
May 8, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29738484/human-macrophages-preferentially-infiltrate-the-superficial-adipose-tissue
#5
Giuseppe Cappellano, Evi M Morandi, Johannes Rainer, Philipp Grubwieser, Katharina Heinz, Dolores Wolfram, David Bernhard, Susanne Lobenwein, Gerhard Pierer, Christian Ploner
Human abdominal subcutaneous adipose tissue consists of two individual layers—the superficial adipose tissue (SAT) and deep adipose tissue (DAT)—separated by the Scarpa’s fascia. The present study focuses on the analysis of morphological and immunological differences of primary adipocytes, adipose-derived stem cells (ASC), and tissue-infiltrating immune cells found in SAT and DAT. Adipocytes and stromal vascular fraction (SVF) cells were isolated from human SAT and DAT specimens and phenotypically characterized by in vitro assays...
May 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29720894/pleiotropic-associations-of-rarres2-gene-variants-and-circulating-chemerin-levels-potential-roles-of-chemerin-involved-in-the-metabolic-and-inflammation-related-diseases
#6
Leay-Kiaw Er, Semon Wu, Lung-An Hsu, Ming-Sheng Teng, Yu-Ching Sun, Yu-Lin Ko
Chemerin, an adipokine and inflammatory mediator, is associated with metabolic, inflammation- and immune-mediated diseases. The genetic, clinical, and biomarker correlates of circulating chemerin levels have not been completely elucidated. We analyzed the determinants and correlates of retinoic acid receptor responder 2 ( RARRES2 ; encoding chemerin) gene variants and chemerin levels in the Taiwanese population. In total, 612 individuals were recruited. Clinical and metabolic phenotypes, 13 inflammatory markers, 5 adipokines, and 6 single-nucleotide polymorphisms (SNPs) covering the RARRES2 region were analyzed...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29717200/chemerin-suppresses-hepatocellular-carcinoma-metastasis-through-cmklr1-pten-akt-axis
#7
Jing-Jing Li, Hong-Kun Yin, Dong-Xian Guan, Jiang-Sha Zhao, Yu-Xiong Feng, Yue-Zhen Deng, Xiang Wang, Nan Li, Xiao-Fan Wang, Shu-Qun Cheng, Ying Bao, Dong Xie
BACKGROUND: Chemerin, a known chemoattractant, participates in multiple biological events. However, its role in cancer remains largely unknown. METHODS: Chemerin expression was evaluated by real-time PCR, western blot and immunohistochemistry. Forced expression, RNAi, immunoprecipitation, etc. were used in function and mechanism study. Mouse models of extrahepatic and intrahepatic metastasis were employed to evaluate the therapeutic potential of chemerin. RESULTS: Chemerin expression was significantly downregulated in hepatocellular carcinoma, and associated with poor prognosis of HCC patients...
May 2, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29715085/chemerin-in-a-mouse-model-of-non-alcoholic-steatohepatitis-and-hepatocarcinogenesis
#8
Elisabeth M Haberl, Rebekka Pohl, Lisa Rein-Fischboeck, Susanne Feder, Christopher J Sinal, Christa Buechler
BACKGROUND/AIM: Non-alcoholic steatohepatitis (NASH) is a risk factor for hepatocellular carcinoma (HCC). The adipokine chemerin protects from HCC and is reduced in human HCC. In this study, chemerin expression was analyzed in a murine model of NASH-HCC. MATERIALS AND METHODS: Serum and hepatic chemerin, and ex vivo chemerin receptor activation were monitored in NASH and NASH-HCC in mice fed a low-methionine diet deficient in choline after initiation of tumors by injection of diethylnitrosamine...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29710512/anaphylatoxin-c5a-induces-inflammation-and-reduces-insulin-sensitivity-by-activating-tlr4-nf-kb-pi3k-signaling-pathway-in-3t3-l1-adipocytes
#9
Xin-Yan Zhang, Yan Liu, Ting He, Ting-Ting Yang, Jing Wu, Katherine Cianflone, Hui-Ling Lu
Obesity closely correlates with metaflammation and characterizes with systemic-chronic-low inflammation. This study aims to evaluate effects of C5a on the inflammatory response and insulin resistance in 3T3-L1 adipocytes. 3T3-L1 pre-adipocytes were induced to the mature 3T3-L1 adipocytes. Then, 3T3-L1 were intervened with anaphylatoxin C5a, lipopolysaccharide (LPS) and C5a + LPS, respectively. Levels of Omentin, Chemerin, Vaspin and Apelin 12 in supernatants of medium were examined using ELISA. C5L2, C5a receptor (C5aR), I kappa B (IkB), IkB kinase (IKK), insulin receptor substrate 1 (IRS-1), IRS-2, PI3 K, p-PI3 K and β-actin were examined using RT-PCR and western blot assay, respectively...
April 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29703632/plasma-n-6-polyunsaturated-fatty-acid-levels-and-survival-in-renal-transplantation
#10
Helga Skaare, My Svensson, Trond Jenssen, Anders Åsberg, Erik Berg Schmidt, Anupam Chandra, Thor Ueland, Tom Eirik Mollnes, Anders Hartmann, Ivar Anders Eide
OBJECTIVE: The major n-6 polyunsaturated fatty acids linoleic acid (LA) and arachidonic acid (AA) play a role in inflammation and glucose metabolism, which could affect patient and renal transplant survival. DESIGN AND METHODS: In this single center cohort study of 1988 Norwegian renal transplant recipients, we assessed associations between plasma levels of LA and AA at baseline, measured by gas chromatography, and patient and graft survival, as well as inflammation and cardiovascular risk markers...
April 24, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29701774/associations-between-plasma-chemerin-concentrations-and-bone-quality-in-adults-from-the-general-population
#11
Lejla Kadric, Stephanie Zylla, Matthias Nauck, Henry Völzke, Nele Friedrich, Anke Hannemann
Chemerin is an adipokine associated with parameters of inflammation and the metabolic syndrome. Small observational studies suggested that high circulating chemerin levels are also related to bone erosion. We aimed to determine whether plasma chemerin levels are related to bone quality in the general population and to investigate the influence of body mass index (BMI) on that relation. For our analyses we obtained data from 3,583 adults who participated in the population-based Study of Health in Pomerania (SHIP)-Trend...
April 25, 2018: Endocrinology
https://www.readbyqxmd.com/read/29688269/polycystic-ovary-syndrome-possible-involvement-of-androgen-induced-chemerin-mediated-ovarian-recruitment-of-monocytes-macrophages
#12
Patricia D A Lima, Anne-Laure Nivet, Qi Wang, Yi-An Chen, Arthur Leader, Annie Cheung, Chii-Ruey Tzeng, Benjamin K Tsang
Polycystic ovary syndrome (PCOS) is a continuum of endocrine and reproductive disorders characterized by hyperandrogenism, antral follicle growth arrest and chronic inflammation. Macrophages play key role in inflammation and the balance between M1 (inflammatory) and M2 (anti-inflammatory) macrophages determines physiological/pathological outcomes. Here, we investigated if hyperandrogenism increases ovarian chemerin altering the balance of M1 and M2 macrophages and the granulosa cell death. Ovarian chemerin was up-regulated by 5α-dihydrotestosterone (DHT) in lean and overweight rats; while increased serum chemerin levels were only evident in overweight rats, suggesting that the serum chemerin may be reflective of a systemic response and associated with obesity, whereas increased ovarian chemerin expression is a localized response independent of the metabolic status...
April 24, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29686704/the-change-of-left-ventricular-function-in-rats-with-subclinical-hypothyroid-and-the-effects-of-thyroxine-replacement
#13
Xuedi Chen, Cuixia Gao, Ningning Gong, Yu Wang, Limin Tian
Objective: The main purpose of this study was to explore the relationships between serca2a, Ryr2, adipokines, and the left ventricular function in the subclinical hypothyroidism with different TSH levels and to determine the impact of L-T4 treatment on these indexes. Methods: Sixty-five male Wistar rats were randomly divided into five groups: control group; sHT A, B, and C group; and sHT + T4 group. The sHT rats were induced by methimazole (MMI), and the sHT + T4 rats were administered with L-T4 treatment after 8 weeks of MMI administration...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29682177/chemerin-induces-endothelial-cell-inflammation-activation-of-nuclear-factor-kappa-beta-and-monocyte-endothelial-adhesion
#14
Georgios K Dimitriadis, Jaspreet Kaur, Raghu Adya, Alexander D Miras, Harman S Mattu, John G Hattersley, Gregory Kaltsas, Bee K Tan, Harpal S Randeva
Chemerin, a chemoattractant protein, acts via a G-protein coupled chemokine receptor, i.e. Chemokine like Receptor 1/ChemR23; levels of which are elevated in pro-inflammatory states such as obesity and type 2 diabetes mellitus (T2DM). Obesity and T2DM patients are at high risk of developing cardiovascular disorders such as atherosclerosis. We have reported that chemerin induces human endothelial cell angiogenesis and since dysregulated angiogenesis and endothelial dysfunction are hallmarks of vascular disease; we sought to determine the effects of chemerin on monocyte-endothelial adhesion, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a critical pro-inflammatory transcription factor...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29669464/adiponectin-and-chemerin-contrary-adipokines-in-regulating-reproduction-and-metabolic-disorders
#15
Anusha Singh, Mayank Choubey, Puran Bora, Amitabh Krishna
Metabolic disorders such as obesity and type 2 diabetes are one of the most familiar risk factors in the present time among every age-group. It is associated with altered levels of adipokines such as adiponectin, chemerin, leptin, resistin, visfatin, and so on. Adiponectin is one of the adipocyte-specific protein with novel applications pertaining to metabolism by promoting insulin sensitivity and regulating glucose and fatty acid catabolism, while chemerin is considered as an inhibitor of insulin signaling and glucose catabolism...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29668463/changes-to-trimethylamine-n-oxide-and-its-precursors-in-nascent-metabolic-syndrome
#16
Daniella Lent-Schochet, Ryan Silva, Matthew McLaughlin, Beverley Huet, Ishwarlal Jialal
Background Metabolic syndrome (MetS), a cardio-metabolic cluster afflicting 35% of American adults, increases cardiovascular disease (CVD) and type-2 diabetes (T2DM) risk. Increased levels of trimethylamine N-oxide (TMAO), a metabolite derived from choline and L-carnitine, correlates with CVD and T2DM. However, the precise role of TMAO and its precursors in MetS remains unclear. We tested the hypothesis that choline, L-carnitine and TMAO in MetS patients without CVD or T2DM would be altered and correlate with inflammatory markers...
April 18, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29662759/investigation-of-bioeffects-of-g-protein-coupled-receptor-1-on-bone-turnover-in-male-mice
#17
Jian Li, Liang Xiang, Xiaotong Jiang, Bin Teng, Yutao Sun, Guanlian Chen, Jie Chen, Jian V Zhang, Pei-Gen Ren
Maintenance of healthy bone quality and quantity requires a well-coordinated balance between bone formation by osteoblasts and bone resorption by osteoclasts. Chemerin is a novel adipokine with known functions such as regulating immunity and energy homeostasis through activation of chemokine-like receptor 1 (CMKLR1). G protein-coupled receptor 1 (GPR1) is the second mammalian chemerin receptor with similar binding affinity as CMKLR1. In male GPR1-/- mice, a phenotype with significantly low bone mineral density was observed...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29658354/serum-chemerin-level-in-women-with-pcos-and-its-relation-with-the-risk-of-spontaneous-abortion
#18
Xuezhou Yang, Xiaozhen Quan, Yanli Lan, Qipeng Wei, Jinhai Ye, Xiaofang Yin, Zhisong Ji, Hui Xing, Ying Yang
BACKGROUND AND AIM: Insulin resistance (IR) was recognized as a risk factor for the occurrence of abortion in patients with polycystic ovary syndrome (PCOS). Chemerin was an adipokine which could induce IR and associated with reproductive process closely. However, few studies have inquired the relativity between chemerin and the occurrence of abortion in patients with PCOS. The aim of this study was to evaluate the relationship between serum chemerin and the occurrence of abortion in women with PCOS...
April 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29653259/bisphenol-a-and-its-derivatives-decrease-expression-of-chemerin-which-reverses-its-stimulatory-action-in-ovarian-cancer-cells
#19
Marta Hoffmann, Agnieszka Rak, Anna Ptak
Chemerin is an adipocyte-secreted protein that associates with obesity, inflammation, metabolic dysfunction, and carcinogenesis. Previous studies have shown human granulosa cells to produce bioactive chemerin and its receptor CMKLR1. In the present study, we demonstrated that the mRNA level of chemerin receptor is higher in a granulosa cell tumor cell line than in epithelial cancer cells, whereas chemerin expression and secretion were lower. Various exogenous factors, such as bisphenol A and its halogenated derivatives tetrabromobisphenol A and tetrachlorobisphenol A, can affect adipokine expression...
April 10, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29644922/chemerin-rs17173608-and-vaspin-rs2236242-gene-variants-on-the-risk-of-end-stage-renal-disease-esrd-and-correlation-with-plasma-malondialdehyde-mda-level
#20
Hamid Nomani, Hamid Khanmohamadian, Asad Vaisi-Raygani, Ebrahim Shakiba, Maryam Tanhapour, Zohreh Rahimi
INTRODUCTION: End-stage renal disease (ESRD) is associated with critical kidney illness that seriously affects the lifespan. Genetic factors and oxidative stress could play critical role in the development of ESRD. We assessed the association between chemerin rs17173608 T/G and vaspin rs2236242 T/A genes variants with the risk of ESRD and their correlation with plasma malondialdehyde (MDA) level. MATERIALS AND METHODS: In a case-control study, 131 gender and age-matched unrelated healthy controls and 110 ESRD patients were enrolled...
November 2018: Renal Failure
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