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https://www.readbyqxmd.com/read/28090710/fibrillatory-wave-amplitude-on-transesophageal-ecg-as-a-marker-of-left-atrial-low-voltage-areas-in-patients-with-persistent-atrial-fibrillation
#1
Ran Yin, Yongnan Fu, Zhongming Yang, Bingong Li, Jintian Pen, Zeqi Zheng
BACKGROUND: Low-voltage areas (LVAs) are frequently observed in patients with persistent atrial fibrillation (PeAF) and may represent adverse atrial remodeling. However, noninvasive method of evaluating LAVs is not well established. METHODS: In a cohort of 68 patients with PeAF, endocardial voltage maps of left atrium (LA) were created during sinus rhythm after pulmonary vein isolation (PVI). LVAs were defined as areas with electrogram amplitudes <0.5 mV. LA-LVAs were correlated with clinical, echocardiographic, surface, and transesophageal electrocardiography (TE-ECG) variables...
January 16, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28079528/assessing-the-evolution-of-redundancy-synergy-of-spontaneous-variability-regulation-with-age
#2
Alberto Porta, Vlasta Bari, Beatrice De Maria, Natália Maria Perseguini, Juliana Milan, Patricia Rehder-Santos, Vinícius Minatel, Anielle Takahashi, Aparecida Catai
We exploited a model-based Wiener-Granger causality method in the information domain for the evaluation of the transfer entropy (TE) and interaction TE (ITE), the latter taken as a measure of the net balance between redundancy and synergy, to describe the interactions between the spontaneous variability of heart period (HP) and systolic arterial pressure (SAP) and the effect of respiration (R) on both variables. Cardiac control was typified via the genuine TE from SAP to HP, that from R to HP, and the ITE from SAP and R to HP, while vascular control was characterized via the genuine TE from HP to SAP, that from R to SAP, and the ITE from HP and R to SAP...
January 12, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28069705/multilevel-analyses-of-scn5a-mutations-in-arrhythmogenic-right-ventricular-dysplasia-cardiomyopathy-suggest-non-canonical-mechanisms-for-disease-pathogenesis
#3
Anneline S J M Te Riele, Esperanza Agullo-Pascual, Cynthia A James, Alejandra Leo-Macias, Marina Cerrone, Mingliang Zhang, Xianming Lin, Bin Lin, Nara L Sobreira, Nuria Amat-Alarcon, Roos F Marsman, Brittney Murray, Crystal Tichnell, Jeroen F van der Heijden, Dennis Dooijes, Toon A B van Veen, Harikrishna Tandri, Steven J Fowler, Richard N W Hauer, Gordon Tomaselli, Maarten P van den Berg, Matthew R G Taylor, Francesca Brun, Gianfranco Sinagra, Arthur A M Wilde, Luisa Mestroni, Connie R Bezzina, Hugh Calkins, J Peter van Tintelen, Lei Bu, Mario Delmar, Daniel P Judge
AIMS: Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) is often associated with desmosomal mutations. Recent studies suggest an interaction between the desmosome and sodium channel protein Nav1.5. We aimed to determine the prevalence and biophysical properties of mutations in SCN5A (the gene encoding Nav1.5) in ARVD/C. METHODS AND RESULTS: We performed whole-exome sequencing in six ARVD/C patients (33% male, 38.2 ± 12.1 years) without a desmosomal mutation...
January 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28065517/peritoneal-macrophage-heterogeneity-is-associated-with-different-peritoneal-dialysis-outcomes
#4
Chia-Te Liao, Robert Andrews, Leah E Wallace, Mohd Wajid A Khan, Ann Kift-Morgan, Nicholas Topley, Donald J Fraser, Philip R Taylor
Peritonitis remains the major obstacle for the maintenance of long-term peritoneal dialysis and dysregulated host peritoneal immune responses may compromise local anti-infectious defense, leading to treatment failure. Whilst, tissue mononuclear phagocytes, comprising macrophages and dendritic cells, are central to a host response to pathogens and the development of adaptive immune responses, they are poorly characterized in the human peritoneum. Combining flow cytometry with global transcriptome analysis, the phenotypic features and lineage identity of the major CD14(+) macrophage and CD1c(+) dendritic cell subsets in dialysis effluent were defined...
January 5, 2017: Kidney International
https://www.readbyqxmd.com/read/28057296/routine-post-operative-esophagram-is-not-necessary-after-repair-of-esophageal-atresia
#5
Jamie Golden, Natalie E Demeter, Joanna C Lim, Henri R Ford, Jeffrey S Upperman, Christopher P Gayer
INTRODUCTION: Esophagrams are routinely performed following repair of esophageal atresia (EA) with or without tracheoesophageal fistula (TEF); however, its utility has not been validated. METHODS: EA/TEF repair performed from 2003 to 2014 at a single pediatric hospital and from 2004 to 2014 in the Pediatric Health Information System (PHIS) database were retrospectively reviewed to determine utility of esophagrams. RESULTS: Esophagram was performed in 99% of patients at our institution (N = 105)...
December 30, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/28051188/superconductivity-bordering-rashba-type-topological-transition
#6
M L Jin, F Sun, L Y Xing, S J Zhang, S M Feng, P P Kong, W M Li, X C Wang, J L Zhu, Y W Long, H Y Bai, C Z Gu, R C Yu, W G Yang, G Y Shen, Y S Zhao, H K Mao, C Q Jin
Strong spin orbital interaction (SOI) can induce unique quantum phenomena such as topological insulators, the Rashba effect, or p-wave superconductivity. Combining these three quantum phenomena into a single compound has important scientific implications. Here we report experimental observations of consecutive quantum phase transitions from a Rashba type topological trivial phase to topological insulator state then further proceeding to superconductivity in a SOI compound BiTeI tuned via pressures. The electrical resistivity measurement with V shape change signals the transition from a Rashba type topological trivial to a topological insulator phase at 2 GPa, which is caused by an energy gap close then reopen with band inverse...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28048351/su-g-jep2-04-comparison-between-fricke-type-3d-radiochromic-dosimeters-for-real-time-dose-distribution-measurements-in-mr-guided-radiation-therapy
#7
H Lee, M Alqathami, M Kadbi, J Wang, A Blencowe, G Ibbott
PURPOSE: To assess MR signal contrast for different ferrous ion compounds used in Fricke-type gel dosimeters for real-time dose measurements for MR-guided radiation therapy applications. METHODS: Fricke-type gel dosimeters were prepared in 4% w/w gelatin prior to irradiation in an integrated 1.5 T MRI and 7 MV linear accelerator system (MR-Linac). 4 different ferrous ion (Fe2?) compounds (referred to as A, B, C, and D) were investigated for this study. Dosimeter D consisted of ferrous ammonium sulfate (FAS), which is conventionally used for Fricke dosimeters...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048234/su-f-i-19-mri-positive-contrast-visualization-of-prostate-brachytherapy-seeds-using-an-integrated-laplacian-based-phase-processing
#8
A Soliman, R Nosrati, H Safigholi, A Owrangi, G Morton, W Song
PURPOSE: To propose a new method that provides a positive contrast visualization of the prostate brachytherapy seeds using the phase information from MR images. Additionally, the feasibility of using the processed phase information to distinguish seeds from calcifications is explored. METHODS: A gel phantom was constructed using 2% agar dissolved in 1 L of distilled water. Contrast agents were added to adjust the relaxation times. Four iodine-125 (Eckert & Ziegler SML86999) dummy seeds were placed at different orientations with respect to the main magnetic field (B0)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047652/su-f-sps-07-magnetic-resonance-spectroscopy-findings-in-early-phase-psychosis
#9
A Wright, R Ma, T Hummer, M Francis, N Mehdiyoun, U Dydak, A Breier
PURPOSE: Schizophrenia is a psychiatric disorder characterized by disordered thoughts, abnormal social behaviors, flat affect, and auditory or visual hallucinations. The current study aims to investigate alterations in brain metabolism in patients near the onset of psychosis (early-phase psychosis, EPP), to characterize abnormalities during the early stages of schizophrenia. To this end, we used magnetic resonance imaging (MRI) and spectroscopy (MRS) to measure metabolite levels and subsequently monitor the effect of treatment with N-acetylcysteine (NAC)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047631/we-fg-206-04-comprehensive-evaluation-of-left-ventricular-lv-filling-and-ejection-using-high-frame-rate-cine-mr-imaging-key-technical-and-methodological-requirements
#10
J Zhang, B Cheong, A Pednekar, C Arena, D Dees, R Muthupillai
PURPOSE: Unlike echocardiography which can quantify both LV filling and ejection, cine steady state free precession sequence (SSFP)-despite its high intrinsic signal and contrast to noise ratio, accuracy and precision of volume measurements-, is mostly relegated to quantifying LV ejection. The steady-state requirement typically constrains SSFP sequence to a breathhold (and limited temporal resolution). We describe: (a) free breathing cine SSFP approach that meets the SS requirement allowing high frame rate acquisition, (b) two MRI indices based on time-LV volume (TV) change during filling and compare against echocardiagraphic diastolic index (E/A ratio), and (c) evaluate the effect of temporal resolution on: LV volumes; ejection and filling rates; and normalized indices of systolic and diastolic function...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047470/su-f-r-32-evaluation-of-mri-acquisition-parameter-variations-on-texture-feature-extraction-using-acr-phantom
#11
Y Xie, J Wang, C Wang, Z Chang
PURPOSE: To investigate the sensitivity of classic texture features to variations of MRI acquisition parameters. METHODS: This study was performed on American College of Radiology (ACR) MRI Accreditation Program Phantom. MR imaging was acquired on a GE 750 3T scanner with XRM explain gradient, employing a T1-weighted images (TR/TE=500/20ms) with the following parameters as the reference standard: number of signal average (NEX) = 1, matrix size = 256×256, flip angle = 90°, slice thickness = 5mm...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047423/su-f-i-63-relaxation-times-of-lipid-resonances-in-nafld-animal-model-using-enhanced-curve-fitting
#12
K-H Song, C-H Yoo, S-I Lim, B-Y Choe
PURPOSE: The objective of this study is to evaluate the relaxation time of methylene resonance in comparison with other lipid resonances. METHODS: The examinations were performed on a 3.0T MRI scanner using a four-channel animal coil. Eight more Sprague-Dawley rats in the same baseline weight range were housed with ad libitum access to water and a high-fat (HF) diet (60% fat, 20% protein, and 20% carbohydrate). In order to avoid large blood vessels, a voxel (0.8×0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046902/su-d-207a-03-potential-role-of-bold-mri-in-discrimination-of-aggressive-tumor-habitat-in-prostate-cancer
#13
J Ford, C Lopez, Y Tschudi, A Breto, K Padgett, A Pollack, R Stoyanova
PURPOSE: To determine whether blood oxygenation level dependent (BOLD) MRI signal measured in prostate cancer patients, in addition to quantitative diffusion and perfusion parameters from multiparametric (mp)MRI exams, can help discriminate aggressive and/or radioresistant lesions. METHODS: Several ongoing clinical trials in our institution require mpMRI exam to determine eligibility (presence of identifiable tumor lesion on mpMRI) and prostate volumes for dose escalation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046749/su-g-iep1-01-a-novel-mri-post-processing-algorithm-for-visualization-of-the-prostate-ldr-brachytherapy-seeds-and-calcifications-based-on-b0-field-inhomogeneity-correction-and-hough-transform
#14
R Nosrati, A Soliman, A Owrangi, N Ghugre, G Morton, A Pejovic-Milic, W Song
PURPOSE: This study aims at developing an MRI-only workflow for post-implant dosimetry of the prostate LDR brachytherapy seeds. The specific goal here is to develop a post-processing algorithm to produce positive contrast for the seeds and prostatic calcifications and differentiate between them on MR images. METHODS: An agar-based phantom incorporating four dummy seeds (I-125) and five calcifications of different sizes (from sheep cortical bone) was constructed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28030770/-fe-no-2-9-dinitrosyl-iron-complex-acting-as-a-vehicle-for-the-no-radical
#15
Chun-Hung Ke, Chien-Hong Chen, Ming-Li Tsai, Hsuan-Chi Wang, Fu-Te Tsai, Yun-Wei Chiang, Wei-Chih Shih, D Scott Bohle, Wen-Feng Liaw
To carry and deliver nitric oxide with a controlled redox state and rate is crucial for its pharmaceutical/medicinal applications. In this study, the capability of cationic {Fe(NO)2}(9) dinitrosyl iron complexes (DNICs) [((R)DDB)Fe(NO)2](+) (R = Me, Et, Iso; (R)DDB = N,N'-bis(2,6-dialkylphenyl)-1,4-diaza-2,3-dimethyl-1,3-butadiene) carrying nearly unperturbed nitric oxide radical to form [((R)DDB)Fe(NO)2((•)NO)](+) was demonstrated and characterized by IR, UV-vis, EPR, NMR, and single-crystal X-ray diffractions...
December 28, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28024849/diminished-force-production-and-mitochondrial-respiratory-deficits-are-strain-dependent-myopathies-of-subacute-limb-ischemia
#16
Cameron A Schmidt, Terence E Ryan, Chien-Te Lin, Melissa M R Inigo, Tom D Green, Jeffrey J Brault, Espen E Spangenburg, Joseph M McClung
OBJECTIVE: Reduced skeletal muscle mitochondrial function might be a contributing mechanism to the myopathy and activity based limitations that typically plague patients with peripheral arterial disease (PAD). We hypothesized that mitochondrial dysfunction, myofiber atrophy, and muscle contractile deficits are inherently determined by the genetic background of regenerating ischemic mouse skeletal muscle, similar to how patient genetics affect the distribution of disease severity with clinical PAD...
December 23, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28018353/embracing-complexity-beyond-systems-medicine-a-new-approach-to-chronic-immune-disorders
#17
Anje A Te Velde, Tjitske Bezema, Antoine H C van Kampen, Aletta D Kraneveld, Bert A 't Hart, Henriët van Middendorp, Erik C Hack, Joris M van Montfrans, Clara Belzer, Lilian Jans-Beken, Raymond H Pieters, Karen Knipping, Machteld Huber, Annemieke M H Boots, Johan Garssen, Tim R Radstake, Andrea W M Evers, Berent J Prakken, Irma Joosten
In order to combat chronic immune disorders (CIDs), it is an absolute necessity to understand the bigger picture, one that goes beyond insights at a one-disease, molecular, cellular, and static level. To unravel this bigger picture we advocate an integral, cross-disciplinary approach capable of embracing the complexity of the field. This paper discusses the current knowledge on common pathways in CIDs including general psychosocial and lifestyle factors associated with immune functioning. We demonstrate the lack of more in-depth psychosocial and lifestyle factors in current research cohorts and most importantly the need for an all-encompassing analysis of these factors...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/28013145/iso-manm-an-imitation-based-optimization-tool-for-multilayer-microwave-absorbers
#18
A Cheraghi, R Malekfar, S Moemen Bellah, M Parishani
We investigate the performance of 109 types of composition with complex permittivity and permeability properties in the frequency range of 1-12GHz. The components of these compositions are based on conductive and nonconductive polymer composites, ferrites, hexaferrites, and carbon materials. A new swarm-based algorithm has been introduced to solve microwave absorbing nanomaterials (MANM) problem, called Imitation Based Optimization (ISO). The individuals in the ISO imitate each other and move to better locations...
November 30, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28000665/a-somatic-pirna-pathway-in-the-drosophila-fat-body-ensures-metabolic-homeostasis-and-normal-lifespan
#19
Brian C Jones, Jason G Wood, Chengyi Chang, Austin D Tam, Michael J Franklin, Emily R Siegel, Stephen L Helfand
In gonadal tissues, the Piwi-interacting (piRNA) pathway preserves genomic integrity by employing 23-29 nucleotide (nt) small RNAs complexed with argonaute proteins to suppress parasitic mobile sequences of DNA called transposable elements (TEs). Although recent evidence suggests that the piRNA pathway may be present in select somatic cells outside the gonads, the role of a non-gonadal somatic piRNA pathway is not well characterized. Here we report a functional somatic piRNA pathway in the adult Drosophila fat body including the presence of the piRNA effector protein Piwi and canonical 23-29 nt long TE-mapping piRNAs...
December 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27993999/natural-conception-repeated-predictions-over-time
#20
R van Eekelen, I Scholten, R I Tjon-Kon-Fat, J W van der Steeg, P Steures, P Hompes, M van Wely, F van der Veen, B W Mol, M J Eijkemans, E R Te Velde, N van Geloven
STUDY QUESTION: How can we predict chances of natural conception at various time points in couples diagnosed with unexplained subfertility? SUMMARY ANSWER: We developed a dynamic prediction model that can make repeated predictions over time for couples with unexplained subfertility that underwent a fertility workup at a fertility clinic. WHAT IS KNOWN ALREADY: The most frequently used prediction model for natural conception (the 'Hunault model') estimates the probability of natural conception only once per couple, that is, after completion of the fertility workup...
December 18, 2016: Human Reproduction
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