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https://www.readbyqxmd.com/read/28236510/a-strategy-for-dual-inhibition-of-the-proteasome-and-fatty-acid-synthase-with-belactosin-c-orlistat-hybrids
#1
Mingzhao Zhu, Wayne D Harshbarger, Omar Robles, Joanna Krysiak, Kenneth G Hull, Sung Wook Cho, Robyn D Richardson, Yanyan Yang, Andres Garcia, Lindsey Spiegelman, Bianca Ramirez, Christopher T Wilson, Ju Anne Yau, James T Moore, Caitlen B Walker, James C Sacchettini, Wenshe R Liu, Stephan A Sieber, Jeffrey W Smith, Daniel Romo
The proteasome, a validated cellular target for cancer, is central for maintaining cellular homeostasis, while fatty acid synthase (FAS), a novel target for numerous cancers, is responsible for palmitic acid biosynthesis. Perturbation of either enzymatic machine results in decreased proliferation and ultimately cellular apoptosis. Based on structural similarities, we hypothesized that hybrid molecules of belactosin C, a known proteasome inhibitor, and orlistat, a known inhibitor of the thioesterase domain of FAS, could inhibit both enzymes...
January 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28231488/the-value-of-elastpq-for-the-evaluation-of-liver-stiffness-in-patients-with-b-and-c-chronic-hepatopathies
#2
Ruxandra Mare, Ioan Sporea, Raluca Lupuşoru, Roxana Şirli, Alina Popescu, Mirela Danila, Corina Pienar
: The aim of this study was to evaluate the diagnostic performance of a point shear wave elastography using ARFI technique - ElastPQ, in patients with B and C chronic hepatopathies, using Transient Elastography (TE) as the reference method, since it is a validated method for liver fibrosis assessment. SUBJECTS AND METHODS: the study included 228 consecutive subjects with chronic hepatopathies (26% HBV, 74% HCV) from whom 51% had liver cirrhosis. Liver stiffness (LS) was evaluated in the same session by means of 2 elastographic methods: TE (FibroScan, EchoSens) and ElastPQ (Affinity, Philips) techniques...
February 9, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28226871/identifying-depressed-patients-with-and-without-suicidal-ideation-by-finger-photo-plethysmography
#3
A H Khandoker, V Luthra, Y Abouallaban, S Saha, K I Ahmed, R Mostafa, N Chowdhury, H F Jelinek, A H Khandoker, V Luthra, Y Abouallaban, S Saha, K I Ahmed, R Mostafa, N Chowdhury, H F Jelinek, A H Khandoker, R Mostafa, H F Jelinek, N Chowdhury, Y Abouallaban, S Saha, K I Ahmed, V Luthra
Major Depressive Disorder (MDD) is a serious mental disorder that if untreated not only affects physical health but also has a high risk of suicide. While the neurophysiological phenomena that contribute to the formation of Suicidal Ideation (SI) are still ill-defined, clear links between MDD and cardiovascular disease have been reported. The aim of this study is to extract suitable features from arterial pulse signals with a view to predicting SI within MDD and control groups. Sixteen unmedicated MDD patients with a history of SI (MDDSI+), sixteen without SI (MDDSI-) and twenty-nine healthy subjects (CONT) were recruited at a psychiatric clinic in the UAE...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222335/sensitive-simultaneous-quantitation-of-testosterone-and-estradiol-in-serum-by-lc-ms-ms-without-derivatization-and-comparison-with-the-cdc-host-program
#4
Ryan C Schofield, Damodara R Mendu, Lakshmi V Ramanathan, Melissa S Pessin, Dean C Carlow
BACKGROUND: Very sensitive measurements of serum estrogens and testosterone are important in adult and pediatric endocrinology and immunoassays are known to lack the required performance at very low levels. Our aim was to develop a sensitive HPLC-MS/MS assay for both estradiol (E2) and testosterone (Te) in serum without the need for chemical derivatization and using commercially available calibrators. METHODS: Serum samples were prepared by the addition of internal standards followed by extraction using hexane:ethyl acetate...
February 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28214948/reduced-anticoagulation-variability-in-patients-on-warfarin-monitored-with-fiix-prothrombin-time-associates-with-reduced-thromboembolism-the-fiix-trial
#5
Alma Rut Oskarsdóttir, Brynja R Gudmundsdottir, Olafur S Indridason, Sigrun H Lund, David O Arnar, Einar S Bjornsson, Magnus K Magnusson, Hulda M Jensdottir, Brynjar Vidarsson, Charles W Francis, Pall T Onundarson
Fiix-prothrombin time (Fiix-PT) differs from traditional PT in being affected by reduced factor (F) II or FX only. In the randomized controlled Fiix-trial, patients on warfarin monitored with Fiix-PT (Fiix-warfarin patients) had fewer thromboembolisms (TE), similar major bleeding (MB) and more stable anticoagulation than patients monitored with PT (PT-warfarin patients). In the current Fiix-trial report we analyzed how reduced anticoagulation variability during Fiix-PT monitoring was reflected in patients with TE or bleeding...
February 18, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28205838/p-09-recurrent-tracheoesophageal-fistula-in-esophageal-atresia-a-multicenter-study
#6
M R Revillion, F G Gottrand, L M Michaud
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28201916/artificial-neural-network-for-the-configuration-problem-in-solids
#7
Hyunjun Ji, Yousung Jung
A machine learning approach based on the artificial neural network (ANN) is applied for the configuration problem in solids. The proposed method provides a direct mapping from configuration vectors to energies. The benchmark conducted for the M1 phase of Mo-V-Te-Nb oxide showed that only a fraction of configurations needs to be calculated, thus the computational burden significantly decreased, by a factor of 20-50, with R(2) = 0.96 and MAD = 0.12 eV. It is shown that ANN can also handle the effects of geometry relaxation when properly trained, resulting in R(2) = 0...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28196547/validation-of-a-mathematical-model-of-the-bovine-estrous-cycle-for-cows-with-different-estrous-cycle-characteristics
#8
H M T Boer, S T Butler, C Stötzel, M F W Te Pas, R F Veerkamp, H Woelders
A recently developed mechanistic mathematical model of the bovine estrous cycle was parameterized to fit empirical data sets collected during one estrous cycle of 31 individual cows, with the main objective to further validate the model. The a priori criteria for validation were (1) the resulting model can simulate the measured data correctly (i.e. goodness of fit), and (2) this is achieved without needing extreme, probably non-physiological parameter values. We used a least squares optimization procedure to identify parameter configurations for the mathematical model to fit the empirical in vivo measurements of follicle and corpus luteum sizes, and the plasma concentrations of progesterone, estradiol, FSH and LH for each cow...
February 15, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28193737/exogenous-transposable-elements-circumvent-identity-based-silencing-permitting-the-dissection-of-expression-dependent-silencing
#9
Dalen Fultz, R Keith Slotkin
The propagation of epigenetic marks has received a great deal of attention, yet the initiation of epigenetic silencing of a new transgene, virus, or transposable element (TE) remains enigmatic. The overlapping and simultaneous function of multiple silencing mechanisms has obscured this area of investigation. Here, we have revealed two broad mechanisms that can initiate silencing independently: identity-based and expression-dependent silencing. We found that identity-based silencing is targeted by 21-22 or 24 nucleotide small interfering RNAs (siRNAs) generated from previously silenced regions of the genome...
February 13, 2017: Plant Cell
https://www.readbyqxmd.com/read/28193502/development-of-a-preclinical-211-rn-211-at-generator-system-for-targeted-alpha-therapy-research-with-211-at
#10
Jason R Crawford, Hua Yang, Peter Kunz, D Scott Wilbur, Paul Schaffer, Thomas J Ruth
INTRODUCTION: The availability of (211)At for targeted alpha therapy research can be increased by the (211)Rn/(211)At generator system, whereby (211)At is produced by (211)Rn electron capture decay. This study demonstrated the feasibility of using generator-produced (211)At to label monoclonal antibody (BC8, anti-human CD45) for preclinical use, following isolation from the (207)Po contamination also produced by these generators (by (211)Rn α-decay). METHODS: (211)Rn was produced by (211)Fr electron capture decay following mass separated ion beam implantation and chemically isolated in liquid alkane hydrocarbon (dodecane)...
January 29, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28179159/in-vivo-osteogenic-differentiation-of-stem-cells-inside-compartmentalized-capsules-loaded-with-co-cultured-endothelial-cells
#11
Clara R Correia, Tírcia C Santos, Rogério P Pirraco, Mariana T Cerqueira, Alexandra P Marques, Rui L Reis, João F Mano
: Capsules coated with polyelectrolytes and co-encapsulating adipose stem (ASCs) and endothelial (ECs) cells with surface modified microparticles are developed. Microparticles and cells are freely dispersed in a liquified core, responsible to maximize the diffusion of essential molecules and allowing the geometrical freedom for the autonomous three-dimensional (3D) organization of cells. While the membrane wraps all the instructive cargo elements within a single structure, the microparticles provide a solid 3D substrate for the encapsulated cells...
February 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28174994/p094-dna-methylation-patterns-in-crohn-s-disease-mucosal-derived-fibroblasts
#12
A A Te Velde, A Y Li Yim, J R de Bruyn, N W Duijvis, W J de Jonge, M E Wildenberg, M M Mannens, G R D'Haens, P Henneman
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28166998/isolated-tracheoesophageal-fistula-versus-esophageal-atresia-early-morbidity-and-short-term-outcome-a-single-institution-series
#13
R B Tröbs, W Finke, M Bahr, C Roll, M Nissen, M R Vahdad, G Cernaianu
PURPOSE: We compared the postnatal course, morbidity and early results after repair for cases of isolated or "pure" TEF with those for cases of esophageal atresia (EA) with distal tracheoesophageal fistula (TEF). METHODS: Twenty-four consecutive infants were divided into two groups: isolated TEF [TEF group] (n = 5) and EA with distal TEF [EA group] (n = 19). RESULTS: A high rate of prematurity (29%) and major cardiac and other surgically-relevant malformations (0...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28163789/a-porcine-gluteus-medius-muscle-genome-wide-transcriptome-analysis-dietary-effects-of-omega-6-and-omega-3-fatty-acids-on-biological-mechanisms
#14
Magdalena Ogłuszka, Agnieszka Szostak, Marinus F W Te Pas, Ewa Poławska, Paweł Urbański, Tadeusz Blicharski, Chandra S Pareek, Edyta Juszczuk-Kubiak, Jenelle R Dunkelberger, Jarosław O Horbańczuk, Mariusz Pierzchała
BACKGROUND: The level of omega-6 and omega-3 polyunsaturated fatty acids can affect many cellular systems and function via nuclear receptors or the bioactive lipid regulation of gene expression. The objective of this study was to investigate changes in the muscle transcriptome and the biological functions regulated by increased consumption of omega-3 and omega-6 fatty acids in the pig gluteus medius muscle. RESULTS: The transcriptome of the gluteus medius muscle was studied for pigs subjected to either a control diet or a diet supplemented with linseed and rapeseed oil to increase polyunsaturated fatty acid content...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28163122/comparison-of-bold-diffusion-weighted-fmri-and-adc-fmri-for-stimulation-of-the-primary-visual-system-with-a-block-paradigm
#15
R Nicolas, H Gros-Dagnac, F Aubry, P Celsis
The blood oxygen level-dependent (BOLD) effect is extensively used for functional MRI (fMRI) but presents some limitations. Diffusion-weighted fMRI (DfMRI) has been proposed as a method more tightly linked to neuronal activity. This work proposes a protocol of DfMRI acquired for several b-values and diffusion directions that is compared to gradient-echo BOLD (GE-BOLD) and to repeated spin-echo BOLD (SE-BOLD, acquisitions performed with b=0s/mm(2)), which was also used to ensure the reproducibility of the response...
February 3, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28162053/cell-and-growth-factor-loaded-keratin-hydrogels-for-treatment-of-volumetric-muscle-loss-vml-in-a-mouse-model
#16
Hannah B Baker, Juliana A Passipieri, Mevan Siriwardane, Mary Ellenburg, Manasi Vadhavkar, Christopher R Bergman, Justin M Saul, Seth Tomblyn, Luke Burnett, George Joseph Christ
Wounds to the head, neck and extremities have been estimated to account for ~84% of reported combat injuries to military personnel. Volumetric muscle loss (VML), defined as skeletal muscle injuries in which tissue loss results in permanent functional impairment, are common among these injuries. The present standard of care entails the use of muscle flap transfers, which suffer from the need for additional surgery when using autografts or the risk of rejection when cadaveric grafts are used. Tissue engineering (TE) strategies for skeletal muscle repair have been investigated as a means to overcome current therapeutic limitations...
February 4, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28158397/profoundly-expanded-t-cell-clones-in-the-inflamed-and-uninflamed-intestine-of-patients-with-crohn-s-disease
#17
M E Doorenspleet, L Westera, C P Peters, T B M Hakvoort, R E Esveldt, E Vogels, A H C van Kampen, F Baas, C Buskens, W A Bemelman, G D'Haens, C Y Ponsioen, A A Te Velde, N de Vries, G R van den Brink
No abstract text is available yet for this article.
February 2, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28155858/disorder-enabled-band-structure-engineering-of-a-topological-insulator-surface
#18
Yishuai Xu, Janet Chiu, Lin Miao, Haowei He, Zhanybek Alpichshev, A Kapitulnik, Rudro R Biswas, L Andrew Wray
Three-dimensional topological insulators are bulk insulators with Z2 topological electronic order that gives rise to conducting light-like surface states. These surface electrons are exceptionally resistant to localization by non-magnetic disorder, and have been adopted as the basis for a wide range of proposals to achieve new quasiparticle species and device functionality. Recent studies have yielded a surprise by showing that in spite of resisting localization, topological insulator surface electrons can be reshaped by defects into distinctive resonance states...
February 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/28149701/relocate2-a-high-resolution-transposable-element-insertion-site-mapping-tool-for-population-resequencing
#19
Jinfeng Chen, Travis R Wrightsman, Susan R Wessler, Jason E Stajich
BACKGROUND: Transposable element (TE) polymorphisms are important components of population genetic variation. The functional impacts of TEs in gene regulation and generating genetic diversity have been observed in multiple species, but the frequency and magnitude of TE variation is under appreciated. Inexpensive and deep sequencing technology has made it affordable to apply population genetic methods to whole genomes with methods that identify single nucleotide and insertion/deletion polymorphisms...
2017: PeerJ
https://www.readbyqxmd.com/read/28148846/tumor-homing-cytotoxic-human-induced-neural-stem-cells-for-cancer-therapy
#20
Juli R Bagó, Onyi Okolie, Raluca Dumitru, Matthew G Ewend, Joel S Parker, Ryan Vander Werff, T Michael Underhill, Ralf S Schmid, C Ryan Miller, Shawn D Hingtgen
Engineered neural stem cells (NSCs) are a promising approach to treating glioblastoma (GBM). The ideal NSC drug carrier for clinical use should be easily isolated and autologous to avoid immune rejection. We transdifferentiated (TD) human fibroblasts into tumor-homing early-stage induced NSCs (h-iNSC(TE)), engineered them to express optical reporters and different therapeutic gene products, and assessed the tumor-homing migration and therapeutic efficacy of cytotoxic h-iNSC(TE) in patient-derived GBM models of surgical and nonsurgical disease...
February 1, 2017: Science Translational Medicine
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