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https://www.readbyqxmd.com/read/29933522/deuterium-reinforced-linoleic-acid-lowers-lipid-peroxidation-and-mitigates-cognitive-impairment-in-the-q140-knock-in-mouse-model-of-huntington-s-disease
#1
Asa Hatami, Chunni Zhu, Aroa Relaño-Gines, Chris Elias, Arpine Galstyan, Michael Jun, Ginger Milne, Charles R Cantor, Marie-Francoise Chesselet, Mikhail S Shchepinov
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease which has no effective treatment and is characterized by psychiatric disorders, motor alterations, and dementia, with the cognitive deficits representing a devastating aspect of the disorder. Oxidative stress and elevated levels of lipid peroxidation (LPO) products are found in mouse models and patients with HD, suggesting that strategies to reduce LPO may be beneficial in HD. In contrast to traditional antioxidants, substituting hydrogen with deuterium at bis-allylic sites in polyunsaturated fatty acids (D-PUFA) decreases the rate-limiting initiation step of PUFA autoxidation, a strategy that has shown benefits in other neurodegenerative diseases...
June 22, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29933514/malate-valves-old-shuttles-with-new-perspectives
#2
REVIEW
Jennifer Selinski, Renate Scheibe
Malate valves act as powerful systems for balancing the ATP/NAD(P)H ratio required in various subcellular compartments in plant cells. As components of malate valves, isoforms of malate dehydrogenases (MDHs) and dicarboxylate translocators catalyze the reversible interconversion of malate and oxaloacetate and their transport. Depending on the coenzyme specificity of the MDH isoforms, either NADH or NADPH can be transported indirectly. Arabidopsis thaliana possesses nine genes encoding MDH isoenzymes: Activities of NAD-dependent MDHs have been detected in mitochondria, peroxisomes, cytosol and plastids, respectively...
June 22, 2018: Plant Biology
https://www.readbyqxmd.com/read/29933507/measurement-of-the-biomechanical-function-and-structure-of-ex-vivo-drying-skin-using-raman-spectral-analysis-and-its-modulation-with-emollient-mixtures
#3
Krysta Biniek, Ali Tfayli, Raoul Vyumvuhore, Alessia Quatela, Marie-Florence Galliano, Alexandre Delalleau, Arlette Baillet-Guffroy, Reinhold H Dauskardt, Helene Duplan
An important aspect of the biomechanical behavior of the stratum corneum (SC) is the drying stresses that develop with water loss. These stresses act as a driving force for damage in the form of chapping and cracking. Betasitosterol is a plant sterol with a structure similar to cholesterol, a key component in the intercellular lipids of the outermost layer of human skin, the SC. Cholesterol plays an important role in stabilizing the SC lipid structure, and altered levels of cholesterol have been linked with SC barrier abnormalities...
June 22, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29933506/pharmacodynamic-analysis-of-eribulin-safety-in-breast-cancer-patients-using-real-world-post-marketing-surveillance-data
#4
Takahisa Kawamura, Hidefumi Kasai, Valentina Fermanelli, Toshiaki Takahashi, Yukinori Sakata, Toshiyuki Matsuoka, Mika Ishii, Yusuke Tanigawara
Post-marketing surveillance is useful to collect safety data in real-world clinical settings. In this study, we firstly applied the post-marketing real-world data on a mechanistic model analysis for neutropenic profiles of eribulin in patients with recurrent or metastatic breast cancer (RBC/MBC). Demographic and safety data were collected using an active surveillance method from eribulin-treated RBC/MBC patients. Changes in neutrophil counts over time were analyzed using a mechanistic pharmacodynamic model...
June 22, 2018: Cancer Science
https://www.readbyqxmd.com/read/29933504/unique-variant-of-nod2-pediatric-granulomatous-arthritis-with-severe-1-25-dihydroxyvitamin-d-mediated-hypercalcemia-and-generalized-osteosclerosis
#5
Michael P Whyte, Emilina Lim, William H McAlister, Gary S Gottesman, Lien Trinh, Deborah J Veis, Vinieth N Bijanki, Matthew G Boden, Angela Nenninger, Steven Mumm, David Buchbinder
Pediatric granulomatous arthritis (PGA) refers to two formerly separate entities; autosomal dominant Blau syndrome (BS) and its sporadic phenocopy early-onset sarcoidosis (EOS). In 2001 BS and in 2005 EOS became explained by heterozygous mutations within the gene that encodes nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also called caspase recruitment domain-containing protein 15 (CARD15). NOD2 is a microbe sensor in leukocyte cytosol that activates and regulates inflammation. PGA is characterized by a triad of auto-inflammatory problems (dermatitis, uveitis, and arthritis) in early childhood, which suggests the causal NOD2/CARD15 mutations are activating defects...
June 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29933493/the-impact-of-aphasia-camp-participation-on-quality-of-life-a-primary-progressive-aphasia-perspective
#6
Esther S Kim, Mathieu Figeys, H Isabel Hubbard, Carlee Wilson
Individuals with primary progressive aphasia (PPA) and their caregivers are at risk for decreased quality of life (QoL) due to their progressive condition. Aphasia camps are an intervention that can improve QoL, yet individuals with PPA are underrepresented at aphasia camps relative to those with poststroke aphasia. The purpose of this exploratory case study was to examine the effect of participation in aphasia camp on the QoL of a couple impacted by PPA. The Living with Aphasia: Framework for Outcome Measurement (A-FROM) was used to guide a semistructured interview with an individual with PPA and her spouse, both of whom had attended the Alberta Aphasia Camp for 4 years...
July 2018: Seminars in Speech and Language
https://www.readbyqxmd.com/read/29933487/dementia-and-hearing-loss-interrelationships-and-treatment-considerations
#7
H Isabel Hubbard, Sara K Mamo, Tammy Hopper
Hearing loss is common among typically aging older adults and those with dementia. In recent years, there has been a renewed interest in the relationship between hearing and cognition among older adults, and in hearing loss as a modifiable risk factor for dementia. However, relatively less attention has been focused on the management of hearing loss among individuals with dementia and the key roles of speech-language pathologists and audiologists in providing such care. In this article, the authors review the literature on hearing loss and dementia, and analyze the research evidence for treatment of hearing loss in the context of major neurocognitive disorders, such as Alzheimer's disease...
July 2018: Seminars in Speech and Language
https://www.readbyqxmd.com/read/29933462/protective-effects-of-an-obesity-associated-polymorphism-cdkal1-rs9356744-on-prediabetes-the-cardiometabolic-risk-in-chinese-crc-study
#8
J Liang, Y Zhu, X-K Liu, Q-Q Qiu, Y-T Sun, Y Wang, Y Pei, M-Q Yang, L Qi
BACKGROUND: Obesity is strongly associated with insulin resistance and elevated plasma glucose levels. The rs9356744 polymorphism in the CDKAL1 gene is associated with body mass index (BMI) only in East Asians. Here, we examined the effect of the rs9356744 polymorphism on glucose-related traits and prediabetes in Chinese adults. METHODS: A total of 2 357 participants were enrolled from the Cardiometabolic Risk in Chinese (CRC) Study, including 499 persons with prediabetes, 204 persons with type 2 diabetes, and 1 654 normoglycemic controls...
June 22, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29933431/learned-protein-embeddings-for-machine-learning
#9
Kevin K Yang, Zachary Wu, Claire N Bedbrook, Frances H Arnold
No abstract text is available yet for this article.
June 22, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29933411/time-trends-in-dyspepsia-and-association-with-h-pylori-and-work-related-stress-an-observational-study-in-white-collar-employees-in-1996-and-2015
#10
Stefanie Braig, Simon Berger, David Rothenbacher, Stefanie Schmid, Thomas Seufferlein, Hermann Brenner, Dietrich Rothenbacher, Harald Gündel
PURPOSE: We aimed to describe time trends in functional dyspepsia and the association of dyspepsia-related factors, Helicobacter pylori (H. pylori) and work-related stress with functional dyspepsia in white collar employees in 1996 and 2015. MATERIALS AND METHODS: Repeat cross-sectional study conducted in 1996 (n = 190, response rate = 76.1) and 2015 (n = 195, response rate = 40.2) within a health insurance company in South-West Germany. Dyspeptic symptoms measured according to the Rome III criteria, effort-reward imbalance and further work- or dyspepsia-related factors were assessed by self-administered questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29933376/inner-ear-exosomes-and-their-potential-use-as-biomarkers
#11
Eugene H C Wong, You Yi Dong, Mali Coray, Maurizio Cortada, Soledad Levano, Alexander Schmidt, Yves Brand, Daniel Bodmer, Laurent Muller
Exosomes are nanovesicles involved in intercellular communications. They are released by a variety of cell types; however, their presence in the inner ear has not been described in the literature. The aims of this study were to determine if exosomes are present in the inner ear and, if present, characterize the changes in their protein content in response to ototoxic stress. In this laboratory investigation, inner ear explants of 5-day-old Wistar rats were cultured and treated with either cisplatin or gentamicin...
2018: PloS One
https://www.readbyqxmd.com/read/29933369/meditation-or-exercise-for-preventing-acute-respiratory-infection-mepari-2-a-randomized-controlled-trial
#12
Bruce Barrett, Mary S Hayney, Daniel Muller, David Rakel, Roger Brown, Aleksandra E Zgierska, Shari Barlow, Supriya Hayer, Jodi H Barnet, Elisa R Torres, Christopher L Coe
BACKGROUND: Practice of meditation or exercise may enhance health to protect against acute infectious illness. OBJECTIVE: To assess preventive effects of meditation and exercise on acute respiratory infection (ARI) illness. DESIGN: Randomized controlled prevention trial with three parallel groups. SETTING: Madison, Wisconsin, USA. PARTICIPANTS: Community-recruited adults who did not regularly exercise or meditate...
2018: PloS One
https://www.readbyqxmd.com/read/29933360/lead-induces-genotoxicity-via-oxidative-stress-and-promoter-methylation-of-dna-repair-genes-in-human-lymphoblastoid-tk6-cells
#13
Xiangquan Liu, Jingying Wu, Wenyan Shi, Wenhua Shi, Hekun Liu, Xiaonan Wu
BACKGROUND Lead (Pb) is a widely used metal in modern industry and is regarded as a health hazard. Although lead-induced genotoxicity has been confirmed, the direct evidence that lead induces genotoxicity in human cells and its related mechanisms has not been fully elucidated. In this study, for the first time, we evaluated the genotoxicity induced by lead in human lymphoblastoid TK6 cells. MATERIAL AND METHODS The TK6 cells were incubated with various concentrations of Pb(Ac)2 for 6 h, 12 h, or 24 h. Cell viability was detected by CCK8 assay...
June 22, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29933350/psychodiagnostics-classification-of-the-yips-phenomenon-based-on-musician-s-dystonia
#14
Christos I Ioannou, Martin K Klämpfl, Babett H Lobinger, Markus Raab, Eckart Altenmüller
PURPOSE: Similar to musician's focal dystonia a task-specific phenomenon, known as yips has also been reported in professional athletes. Yips is usually described as focal dystonia, or choking under pressure, or as lying on a continuum between both. Based on the common occupational conditions across musicians and athletes, the present exploratory study aimed to investigate whether musicians diagnosed with focal dystonia and golfers affected with yips, can be similarly sub-classified based on their psychological profiles...
June 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29933343/impact-of-a-graded-exercise-program-on-vo2peak-and-survival-in-heart-failure-patients
#15
Johan A Snoek, Thijs M H Eijsvogels, Arnoud W J van 't Hof, Eva Prescott, Maria T Hopman, Evelien Kolkman, Ed P de Kluiver
INTRODUCTION: Although exercise therapy has the potential to improve health outcomes of patients with Chronic Heart Failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines one year after Cardiac Rehabilitation (CR). We aimed to assess the effects of an extended CR program with 12-months of Graded Exercise Therapy (GET) and resistance exercise training (RT) on exercise capacity and long-term survival in patients with CHF. METHODS: This prospective cohort study included sixty CHF patients between 2009 and 2010...
June 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29933333/-as-black-as-ink-a-case-of-alkaptonuria-associated-myelopathy-and-a-review-of-the-literature
#16
Callum J Donaldson, Stuart L Mitchell, Lee H Riley, Khaled Kebaish
STUDY DESIGN: Case report and literature review. OBJECTIVE: To characterize the rare presentati on of myelopathy occurring secondary to alkaptonuria and to evaluate the available evidence regarding its treatment. SUMMARY OF BACKGROUND DATA: Alkaptonuria is an autosomal recessive genetic condition with an estimated incidence of 1 in 250,000 to 1 in 1,000,000 people. Mutation of the enzyme homogentisate 1,2-dioxygenase leads to the production of high levels of homogentisic acid (HGA), with subsequent deposition in ligaments, cartilage, and menisci...
June 21, 2018: Spine
https://www.readbyqxmd.com/read/29933271/propofol-attenuates-the-myocardial-protection-properties-of-desflurane-by-modulating-mitochondrial-permeability-transition
#17
Johan Heiberg, Colin F Royse, Alistair G Royse, David T Andrews
BACKGROUND: Desflurane and propofol are cardioprotective, but relative efficacy is unclear. The aim was to compare myocardial protection of single, simultaneous, and serial administration of desflurane and propofol. METHODS: Sixty New Zealand White rabbits and 65 isolated Sprague Dawley rat hearts randomly received desflurane, propofol, simultaneous desflurane and propofol, or sequential desflurane then propofol. Rabbits were subdivided to receive either ischemia-reperfusion with temporary occlusion of the left anterior descending artery or a time-matched, nonischemic perfusion protocol, whereas rat hearts were perfused in a Langendorff model with global ischemia-reperfusion...
June 20, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29933262/factors-associated-with-inadequate-intraoperative-baseline-lower-extremity-somatosensory-evoked-potentials
#18
Jonathan H Chen, Parastou Shilian, Justin Cheongsiatmoy, Andres A Gonzalez
PURPOSE: Intraoperative neurophysiologic monitoring involves the use of various modalities, including somatosensory evoked potentials (SEP), to assess the integrity of the at-risk nervous system during surgeries. Reliable baseline tracings are important because they are data against which future tracings are compared to detect potential injury. In some cases, adequate baselines may be difficult to achieve. Therefore, we analyzed several patient-specific factors to determine which variables are associated with inadequate intraoperative SEP baseline signals...
June 21, 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29933243/antioxidant-mediated-neuroprotection-by-allium-schoenoprasum-l-leaf-extract-against-ischemia-reperfusion-induced-cerebral-injury-in-mice
#19
Varinder Singh, Pawan Krishan, Richa Shri
BACKGROUND: Oxidative stress is strongly implicated in ischemia reperfusion (IR)-mediated functional and neuronal impairment. Therefore, strategies employing antioxidants to reverse the damage due to IR are being investigated. Allium schoenoprasum L. is a culinary medicine whose antioxidant properties are well documented but whose neuroprotective potential has not been examined. Hence, the present study was designed to evaluate the effect of A. schoenoprasum leaf extract (ASLE) on functional deficit against IR-induced cerebral injury in mice...
June 22, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29933239/time-to-epileptiform-activity-and-eeg-background-recovery-are-independent-predictors-after-cardiac-arrest
#20
E Westhall, I Rosén, M Rundgren, J Bro-Jeppesen, J Kjaergaard, C Hassager, H Lindehammar, J Horn, S Ullén, N Nielsen, H Friberg, T Cronberg
OBJECTIVE: Investigate the temporal development of EEG and prognosis. METHODS: Prospective observational substudy of the Target Temperature Management trial. Six sites performed simplified continuous EEG-monitoring (cEEG) on comatose patients after cardiac arrest, blinded to treating physicians. We determined time-points of recovery of a normal-voltage continuous background activity and the appearance of an epileptiform EEG, defined as abundant epileptiform discharges, periodic/rhythmic discharges or electrographic seizure activity...
June 9, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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