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https://www.readbyqxmd.com/read/28631963/tumor-penetrating-peptide-integrated-thermally-sensitive-liposomal-doxorubicin-enhances-efficacy-of-radiofrequency-ablation-in-liver-tumors
#1
Fei Yan, Song Wang, Wei Yang, S Nahum Goldberg, Hao Wu, Wan-Lu Duan, Zhi-Ting Deng, Hai-Bo Han, Hai-Rong Zheng
Purpose To investigate the role of a tumor-penetrating peptide (internalizing CRGDRGPDC [iRGD])-integrated thermally sensitive liposomal (TSL) doxorubicin (DOX) in combination with radiofrequency (RF) ablation of liver tumors in an animal model. Materials and Methods Approval from the institutional animal care and use committee was obtained. Characterization of iRGD-TSL-DOX was performed in vitro. Next, H22 liver adenocarcinomas were implanted in 138 mice in vivo. The DOX accumulation and cell apoptosis of iRGD-TSL-DOX and TSL-DOX with or without RF were evaluated (n = 5) at different time points after treatment with quantitative analysis or pathologic staining...
June 19, 2017: Radiology
https://www.readbyqxmd.com/read/28612086/comparison-of-6-mm-versus-8-mm-tip-cryoablation-catheter-for-the-treatment-of-atrioventricular-nodal-reentrant-tachycardia-in-children-a-prospective-study
#2
Volkan Tuzcu, Enes Elvin Gul, Mehmet Karacan, Hacer Kamali, Nida Celik, Celal Akdeniz
Due to its safety profile, cryoablation (Cryo) for atrioventricular nodal reentrant tachycardia (AVNRT) is more commonly preferred over radiofrequency (RF) ablation in children in recent years. Recent studies demonstrated high long-term success rates comparable to radiofrequency ablation. The aim of this prospective study was to compare the efficacy and safety of an 8-mm-tip versus 6-mm-tip Cryo catheter in the treatment of AVNRT in children. A total of 125 consecutive patients over 10 years of age with AVNRT were included...
June 13, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28611425/pancreatic-adenocarcinoma-response-to-chemotherapy-enhanced-with-non-invasive-radio-frequency-evaluated-via-an-integrated-experimental-computational-approach
#3
Matthew J Ware, Louis T Curtis, Min Wu, Jason C Ho, Stuart J Corr, Steven A Curley, Biana Godin, Hermann B Frieboes
Although chemotherapy combined with radiofrequency exposure has shown promise in cancer treatment by coupling drug cytotoxicity with thermal ablation or thermally-induced cytotoxicity, limited access of the drug to tumor loci in hypo-vascularized lesions has hampered clinical application. We recently showed that high-intensity short-wave capacitively coupled radiofrequency (RF) electric-fields may reach inaccessible targets in vivo. This non-invasive RF combined with gemcitabine (Gem) chemotherapy enhanced drug uptake and effect in pancreatic adenocarcinoma (PDAC), notorious for having poor response and limited therapeutic options, but without inducing thermal injury...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28604815/temperature-sensitive-liposomes-combined-with-thermal-ablation-effects-of-duration-and-timing-of-heating-in-mathematical-models-and-in-vivo
#4
Christian Rossmann, M A McCrackin, Kent E Armeson, Dieter Haemmerich
BACKGROUND: Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug at hyperthermic temperatures, typically above ~40°C. TSL have been combined with various heating modalities, but there is no consensus on required hyperthermia duration or ideal timing of heating relative to TSL administration. The goal of this study was to determine changes in drug uptake when heating duration and timing are varied when combining TSL with radiofrequency ablation (RF) heating...
2017: PloS One
https://www.readbyqxmd.com/read/28597788/the-non-fluoroscopic-navigation-reduces-significantly-not-only-the-fluoroscopic-exposure-during-catheter-ablation-of-the-cavotricuspid-isthmus-but-the-total-radiofrequency-time-as-well
#5
Tchavdar Shalganov, Milko Stoyanov, Boyan Kunev
Objective The non-fluoroscopic navigation (NFN) is known to reduce the fluoroscopic time during catheter ablation of various arrhythmias. We aimed to study the impact of NFN over several procedural parameters during radiofrequency (RF) catheter ablation of the cavo-tricuspid isthmus (CTI) in patients with CTI-dependent atrial flutter. Methods Data about 124 consecutive patients with CTI ablation performed were retrospectively collected. The patients were divided into two groups: (1) ablation with two diagnostic catheters deployed in the coronary sinus and around the tricuspid annulus (NFN-, n = 62); (2) ablation with the same two catheters plus NFN system using cutaneous patches (NFN+, n = 62)...
April 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28569422/role-of-contact-force-guided-radiofrequency-catheter-ablation-for-treatment-of-atrial-fibrillation-a-systematic-review-and-meta-analysis
#6
Hui Lin, Yi-He Chen, Jian-Wen Hou, Zhao-Yang Lu, Yin Xiang, Yi-Gang Li
INTRODUCTION: CF-sensing catheter emerged as a novel ablation technology and was increasingly used in clinical practice. Nonetheless, available evidence of efficacy and safety comparison between CF-guided RF catheter ablation and non-CF-guided ablation for treatment of AF was still lacking. METHODS AND RESULTS: Twenty-two eligible studies were included after systematic review through the MEDLINE, Google Scholar, the Cochrane Library and PubMed databases. AF/atrial tachycardia-free survival was markedly improved in CF-guided catheter ablation compared with non-CF-guided ablation at a median 12-month follow-up (RR: 1...
June 1, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28568013/a-multicenter-review-of-ablation-in-the-aortic-cusps-in-young-people
#7
Minh B Nguyen, Scott R Ceresnak, Christopher M Janson, Steven B Fishberger, Barry A Love, Andrew D Blaufox, Kara S Motonaga, Anne M Dubin, Lynn Nappo, Robert H Pass
BACKGROUND: Ablation within the aortic cusp is safe and effective in adults. There are little data on aortic cusp ablation in the pediatric literature. We investigated the safety and efficacy of aortic cusp ablation in young patients. METHODS: A retrospective, descriptive study of aortic cusp ablation in 5 pediatric EP centers from 2008-2014 was performed. All patients < 21 years of age who underwent ablation in the aortic cusps were included. Factors analyzed included patient demographics, procedural details, outcomes and complications...
June 1, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28545407/cryoballoon-vs-open-irrigated-radiofrequency-ablation-for-paroxysmal-atrial-fibrillation-long-term-freezeaf-outcomes
#8
Armin Luik, Kevin Kunzmann, Patrick Hörmann, Kerstin Schmidt, Andrea Radzewitz, Peter Bramlage, Thomas Schenk, Gerhard Schymik, Matthias Merkel, Meinhard Kieser, Claus Schmitt
BACKGROUND: Effective treatment of paroxysmal atrial fibrillation (AF) is essential for reducing the risk of stroke and heart failure. Cryoballoon (CB) ablation has been developed as an alternative to the use of radiofrequency (RF) energy for electrical isolation of the pulmonary veins. Herein, we provide long-term data regarding the efficacy of CB ablation in comparison to RF. METHODS: FreezeAF was a randomised non-inferiority study comparing CB ablation with RF ablation for the treatment of patients with drug-refractory paroxysmal AF...
May 25, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28545338/radiofrequency-ablation-of-small-follicular-neoplasms-initial-clinical-outcomes
#9
Su Min Ha, Jin Yong Sung, Jung Hwan Baek, Dong Gyu Na, Ji-Hoon Kim, Hyunju Yoo, Ducky Lee, Dong Whan Choi
BACKGROUND: In thyroid gland, radiofrequency ablation (RFA) has been applied to both recurrent cancers and benign nodules, although, according to the American Thyroid Association (ATA) and the Korean Society of Thyroid Radiology (KSThR) guidelines, surgery is the first-line treatment for follicular neoplasm. However, it has been argued that follicular neoplasm with lower risk of malignancy can be managed by close follow-up. In this study, we evaluated the effectiveness of RFA of small follicular neoplasms, examining reductions in volume and related clinical problems, and making observations over long-term follow-up...
May 25, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28543788/automated-verification-of-pulmonary-vein-isolation-in-radiofrequency-and-cryoballoon-guided-ablation
#10
Jan De Pooter, Thomas Phlips, Milad El Haddad, Frederic van Heuverswyn, Liesbeth Timmers, René Tavernier, Sebastien Knecht, Yves Vandekerckhove, Mattias Duytschaever
BACKGROUND: Verification of pulmonary vein isolation (PVI) can be challenging due to the coexistence of pulmonary vein potentials (PVP) and far field potentials. This study aimed to prospectively validate a novel algorithm for automated verification of PVI in radiofrequency-guided (RF) and cryoballoon-guided (CB) ablation strategies. METHODS: A dataset of 620 (RF: 516 EGMs and CB: 104 EGMs) bipolar electrograms (EGM), recorded by circular mapping catheter (CMC) placed at the left atrium-pulmonary vein (PV) junction, were prospectively analyzed by a two-step algorithm...
May 25, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28540798/pathological-effects-of-lung-radiofrequency-ablation-that-contribute-to-pneumothorax-using-a-porcine-model
#11
Jean Izaaryene, Frederic Cohen, Philippe Souteyrand, Pierre-Henri Rolland, Vincent Vidal, Jean-Michel Bartoli, Veronique Secq, Jean-Yves Gaubert
OBJECTIVES: The incidence of pneumothorax is 7 times higher after lung radiofrequency ablation (RFA) than after lung biopsy. The reasons for such a difference have never been objectified. The histopathologic changes in lung tissue are well-studied and established for RF in the ablation zone. However, it has not been previously described what the nature of thermal injury might be along the shaft of the RF electrode as it traverses through normal lung tissue to reach the ablation zone. The purpose of this study was to determine the changes occurring around the RF needle along the pathway between the ablated zone and the pleura...
April 17, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540780/persistent-pathways-after-lung-radiofrequency-ablation-as-a-risk-factor-of-drain-placement
#12
Marie Lignieres, Nicolas Roux, Roch Giorgi, Jean-Yves Gaubert, Kathia Chaumoitre, Jean-Michel Bartoli, Vincent Vidal, Jean Izaaryene
PURPOSE: The risk factors of pneumothorax after lung radiofrequency (RF) ablation are long known. The objective was to demonstrate that the visualisation of an aeric RF path after the needle withdrawal was predictive of pneumothorax occurrence and chest tube placement. MATERIALS AND METHODS: A total of 70 patients were retrospectively included in this study. For each patient, we determined the pneumothorax risk factors (age, gender, previous surgery, emphysema, lesion size, distance between pleura and lesion), visualisation of a RF track, length and thickness, presence of pneumothorax, volume, chest tube placement, duration of drainage and hospital stay...
March 15, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28520908/shortening-of-the-atrial-his-bundle-interval-during-atrial-pacing-as-a-predictor-of-successful-ablation-for-typical-atrioventricular-nodal-re-entrant-tachycardia
#13
Masahiro Nakano, Marehiko Ueda, Yusuke Kondo, Tomohiko Hayashi, Miyo Nakano, Kazuo Miyazawa, Masayuki Ishimura, Yoshio Kobayashi
Aims: Shortening of the atrial-His bundle (AH) interval during the sinus rhythm is occasionally observed after slow pathway ablation for atrioventricular nodal re-entrant tachycardia (AVNRT). In addition, high-rate atrial pacing is useful for avoiding atrioventricular block. We hypothesized that shortening of the AH interval during slow pathway ablation under high-rate atrial pacing would lead to successful ablation of typical AVNRT. Methods and results: This retrospective study included 37 patients in whom successful ablation of typical AVNRT was performed under atrial pacing...
May 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28515824/cardiogenic-shock-acute-severe-mitral-regurgitation-and-complete-heart-block-after-cavo-tricuspid-isthmus-atrial-flutter-ablation
#14
Thein Tun Aung, Edward Samuel Roberto, Kevin D Kravitz
Radiofrequency (RF) ablation is the first-line management of cavo-tricuspid isthmus dependent atrial flutter. It has been performed with 95% success rate. Adverse events are very rare. We report the first case of acute severe mitral regurgitation (MR) and complete heart block developed after successful atrial flutter ablation. A 62-year-old female with mild MR presented with palpitations. Surface electrocardiogram was suggestive of isthmus dependent atrial flutter. A duodecapolar mapping catheter showed an atrial flutter with cycle length of 280 ms...
April 2017: Cardiology Research
https://www.readbyqxmd.com/read/28515594/radiofrequency-ablation-of-osteoid-osteoma-in-common-and-technically-challenging-locations-in-pediatric-population
#15
Shaileshkumar Garge, Shyamkumar N Keshava, Vinu Moses, George K Chiramel, Munawwar Ahmed, Suraj Mammen, Vrisha Madhuri
CONTEXT: Percutaneous radiofrequency ablation (RFA) of osteoid osteoma has a high technical and clinical success rate. However, there is limited data on its use in the pediatric population, especially in technically challenging locations. OBJECTIVE: To assess the safety and efficacy of computed tomography (CT)-guided percutaneous RFA of osteoid osteoma in pediatric population. PATIENTS AND METHODS: From June 2009 to May 2014, 30 patients with osteoid osteoma were treated with CT-guided RFA in common (25 cases) and technically challenging (five cases: four near articular surface and one in sacrum) locations...
January 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28513287/contact-force-technology-integrated-with-3d-navigation-system-for-atrial-fibrillation-ablation-improving-results
#16
Roberto Rordorf, Antonio Sanzo, Vincenzo Gionti
Pulmonary veins isolation (PVI) by radiofrequency (RF) ablation is currently an established treatment for symptomatic, drug-resistant paroxysmal atrial fibrillation. Although the effectiveness of the therapy has been clearly demonstrated, success rate after a single procedure is still sub-optimal. The main reason for recurrences after PVI is electrical pulmonary vein-atrium reconnection. In order to increase the likelihood of permanent PVI, the creation of a transmural, durable lesion is mandatory. The main determinants of lesion size and transmurality are power, stability, duration and contact-force during RF application...
June 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28513144/rapid-elemental-analysis-of-aerosols-using-atmospheric-glow-discharge-optical-emission-spectroscopy
#17
Lina Zheng, Pramod Kulkarni
A new, low-cost approach based on the application of atmospheric radio frequency glow discharge (rf-GD) optical emission spectroscopy (OES) has been developed for near real-time measurement of multielemental concentration in airborne particulate phase. This method involves deposition of aerosol particles on the tip of a cathode in a coaxial microelectrode system, followed by ablation, atomization, and excitation of the particulate matter using the rf-GD. The resulting atomic emissions are recorded using a spectrometer for elemental identification and quantification...
June 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28512586/cryoablation-for-ventricular-tachycardia-originating-from-anterior-papillary-muscle-of-left-ventricle-guided-by-intracardiac-echocardiography
#18
Ibrahim Marai, Nizar Andria, Osnat Gurevitz
Papillary muscles (PMs) were reported to be origin of ventricular arrhythmia (VA). Radiofrequency (RF) ablation was reported to be acutely effective in eliminating VA. However, the recurrence rate is high. Recently, cryoablation guided by intracardiac echocardiography, 3-dimensional mapping system, and image integration was introduced as alternative strategy for this challenging ablation. We present a case of ventricular tachycardia originating from anterior PM of left ventricle treated by cryoablation guided only by intracardiac echocardiography...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28496936/strategies-to-improve-safety-and-efficacy-of-atrial-fibrillation-ablation-using-electrode-multipolar-phased-rf-pvac%C3%A2-catheter-a-case-report
#19
Fabio Dorfman, Cristiano Dietrich, Paulo Costa, Evandro Sbaraini, Rafael Abt, Dalmo Moreira, Cézar Mesas
Phased radiofrequency ablation with a single catheter technique, using a 9-electrode circumferential catheter, is a viable approach to pulmonary vein isolation for the treatment of atrial fibrillation. However, creating effective transmural lesions with such technique, while avoiding serious complications like atrioesophageal fistula, can be difficult. This case illustrates a challenging scenario, where catheter maneuvers fail to allow safe radiofrequency delivery, due to esophageal temperature rise, despite extensive navigating maneuvers...
October 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/28496925/cryoballoon-versus-radiofrequency-ablation-for-atrial-fibrillation-a-meta-analysis-of-16-clinical-trials
#20
Jalaj Garg, Rahul Chaudhary, Chandrasekar Palaniswamy, Neeraj Shah, Parasuram Krishnamoorthy, Babak Bozorgnia, Andrea Natale
Introduction: We aimed to study the procedural characteristics, efficacy and safety of cryoballoon ablation (CBA) versus radiofrequency ablation (RFA) for catheter ablation of paroxysmal atrial fibrillation (AF). Methods: A systematic literature search was performed using PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials to clinical trials comparing CBA and RFA for AF. Outcomes were evaluated for efficacy, procedure characteristics and safety. For each study, odd ratio (OR) and 95% confidence intervals (CIs) were calculated for endpoints for both approaches...
October 2016: Journal of Atrial Fibrillation
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