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https://www.readbyqxmd.com/read/29050394/cortical-neurons-and-networks-are-dormant-but-fully-responsive-during-isoelectric-brain-state
#1
Tristan Altwegg-Boussac, Adrien E Schramm, Jimena Ballestero, Fanny Grosselin, Mario Chavez, Sarah Lecas, Michel Baulac, Lionel Naccache, Sophie Demeret, Vincent Navarro, Séverine Mahon, Stéphane Charpier
A continuous isoelectric electroencephalogram reflects an interruption of endogenously-generated activity in cortical networks and systematically results in a complete dissolution of conscious processes. This electro-cerebral inactivity occurs during various brain disorders, including hypothermia, drug intoxication, long-lasting anoxia and brain trauma. It can also be induced in a therapeutic context, following the administration of high doses of barbiturate-derived compounds, to interrupt a hyper-refractory status epilepticus...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29049985/insight-into-the-structure-function-relationships-of-deep-eutectic-solvents-during-rice-straw-pretreatment
#2
Xue-Dan Hou, Ao-Lin Li, Kai-Peng Lin, Yuan-Yuan Wang, Zhi-Yin Kuang, Shi-Lin Cao
Rice straw pretreatment mediated by choline chloride (ChCl) or lactic acid (Lac) sequences deep eutectic solvents (DESs) was investigated in this work. Hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs) proved to be both important for DESs pretreatment efficiency. DESs containing lots of hydroxyl or amino groups with a high intermolecular hydrogen-bond (H-bond) strength exhibited weak biomass deconstruction abilities. The presence of strong electron-withdrawing groups in DESs was benefit for xylan removal, thus furnishing higher cellulose digestibility...
October 7, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29049420/production-of-proinflammatory-mediators-in-activated-microglia-is-synergistically-regulated-by-notch-1-glycogen-synthase-kinase-gsk-3%C3%AE-and-nf-%C3%AE%C2%BAb-p65-signalling
#3
Qiong Cao, Aparna Karthikeyan, S Thameem Dheen, Charanjit Kaur, Eng-Ang Ling
Microglia activation and associated inflammatory response are involved in the pathogenesis of different neurodegenerative diseases. We have reported that Notch-1 and NF-κB/p65 signalling pathways operate in synergy in regulating the production of proinflammatory mediators in activated microglia. In the latter, there is also evidence by others that glycogen synthase kinase 3β (GSK-3β) mediates the release of proinflammatory cytokines but the interrelationships between the three signalling pathways have not been fully clarified...
2017: PloS One
https://www.readbyqxmd.com/read/29048858/-simultaneous-determination-of-diminazene-aceturate-and-isometamidium-chloride-residues-in-cattle-tissues-by-high-performance-liquid-chromatography-with-solid-phase-extraction
#4
Yuhui Zhou, Zhenling Zeng, Jingxian Yu, Rong Liu, Lihua Pan, Qiuyu Zhong, Hong Chen
A method for the simultaneous determination of trypanocidal diminazene aceturate (DIM) and isometamidium chloride (ISM) that containing benzamidine groups in cattle tissues was developed by high performance liquid chromatography (HPLC) with solid-phase extraction (SPE). The tissue samples were extracted with different proportions of water-acetonitrile, then were cleaned up by Oasis WCX cartridges. DIM and ISM were separated by HPLC with a Spherisorb CN column (250 mm×4.6 mm, 5 μm). Acetonitrile-0.05 mol/L ammonium formate solution (pH 2...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048781/-preparation-of-large-pore-silica-microspheres-using-templating-method-and-their-applications-to-protein-separation-with-high-performance-liquid-chromatography
#5
Mengna Niu, Hongyan Ma, Fei Hu, Shige Wang, Lu Liu, Haizhou Chang, Mingxian Huang
Large-pore silica microspheres were synthesized by utilizing weak cation exchange polymer beads as templates, N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride (TMSPTMA) as a structure-directing agent, tetraethoxysilane (TEOS) as a silica precursor, and triethanolamine as a weak base catalyst. The hydrolysis and condensation of the silica precursors occurred inside the templating polymer beads yielded polymer/silica composite microspheres. After the organic polymer templates were removed in the calcination step, large-pore silica microspheres were produced...
June 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048492/stability-indicating-uplc-and-tlc-densitometric-methods-for-determination-of-benztropine-mesylate-and-its-carcinogenic-degradation-product
#6
Michel Y Fares, Nada S Abdelwahab, Maha M Abdelrahman, Hamdy M Abdel-Rahman
Two accurate, precise and highly selective stability-indicating methods were adopted for simultaneous determination of benztropine mesylate (BNZ) in presence of its hepatotoxic and carcinogenic degradation product, benzophenone (BPH) either in pure form or in the pharmaceutical formulation without any preliminary separation steps. The first method is a thin layer chromatography (TLC)-densitometric method that depended on separation of BNZ from its degradate on TLC aluminum plates precoated with silica gel 60 F254 as the stationary phase using a developing system consisted of hexane:methylene chloride:triethylamine (5:5:0...
October 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29048154/hexanuclear-and-trinuclear-metal-complexes-of-a-giant-octadecaaza-macrocycle
#7
Janusz Gregoliński, Katarzyna Ślepokura, Jerzy Lisowski
A large macrocyclic ligand containing six pyridine fragments and six diaminocyclopentane fragments is able to form hexanuclear Zn(II) and Ni(II) complexes as well as a trinuclear Zn(II) complex. X-ray crystal structures of these complexes indicate quite different ligand conformations. In the hexanuclear Zn(II) derivative with chloride counteranions metal ions have a distorted-trigonal-bipyramidal geometry and occupy loop sections formed by the highly folded macrocycle, which adopts a globular shape. In the hexanuclear Ni(II) derivative with nitrate counteranions metal ions exhibit a distorted-octahedral geometry and the ligand conformation is much more open, while in the trinuclear Zn(II) complex the macrocycle wraps around the octahedral metal ions...
October 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29047747/wavelength-and-concentration-dependent-optical-constants-of-nacl-kcl-mgcl2-cacl2-and-na2so4-multi-component-mixed-salt-solutions
#8
C C Wang, J Y Tan, L H Liu
The optical constants of sodium chloride (NaCl), potassium chloride (KCl), magnesium chloride (MgCl2), calcium chloride (CaCl2) and sodium sulfate (Na2SO4) solutions at weight fractions ranging from 0 to 16.6667% are measured by the combined ellipsometry-transmission method in the spectral range 0.3-1.0 μm. In the combined method, a modified ellipsometry method is used to measure the refractive indices of liquids, and then the transmission method is conducted to obtain the extinction coefficients using the refractive indices obtained by the ellipsometry method...
September 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047325/synthesis-of-biocl-using-cl-source-from-industrial-wastewater-and-its-application-for-wastewater-treatment
#9
Yao Kun, Jia Manke, Wu Huanhuan, Li Yonggang, Chen Chuncheng, Huang Yingping
Cl(-) in industrial wastewater from glyphosate production has been used as Cl source to synthesize BiOCl photocatalyst via a simple solvothermal route. The crystalline, morphology, specific surface area and optical properties of photocatalysts prepared under various conditions have been investigated. BiOCl photocatalyst prepared in acidic solution shows the highest crystallinity and without impurities and microcellular structure. The degradation of industrial wastewater contaminants demonstrates the possibility of this BiOCl used in industrial wastewater treatment and phosphorus recycling through the subsequent phosphorus recovery processes...
October 19, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29047123/parallel-implementation-of-efficient-charge-charge-interaction-evaluation-scheme-in-periodic-divide-and-conquer-density-functional-tight-binding-calculations
#10
Yoshifumi Nishimura, Hiromi Nakai
A low-computational-cost algorithm and its parallel implementation for periodic divide-and-conquer density-functional tight-binding (DC-DFTB) calculations are presented. The developed algorithm enables rapid computation of the interaction between atomic partial charges, which is the bottleneck for applications to large systems, by means of multipole- and interpolation-based approaches for long- and short-range contributions. The numerical errors of energy and forces with respect to the conventional Ewald-based technique can be under the control of the multipole expansion order, level of unit cell replication, and interpolation grid size...
October 18, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29046856/synthesis-of-4h-benzo-e-1-3-oxazin-4-ones-by-a-carbonylation-cyclization-domino-reaction-of-ortho-halophenols-and-cyanamide
#11
Linda Åkerbladh, Shiao Y Chow, Luke R Odell, Mats Larhed
A mild and convenient one-step preparation of 4H-1,3-benzoxazin-4-ones by a domino carbonylation-cyclization process is developed. Readily available ortho-iodophenols are subjected to palladium-catalyzed carbonylative coupling with Mo(CO)6 and cyanamide, followed by a spontaneous, intramolecular cyclization to afford 4H-1,3-benzoxazin-4-ones in moderate to excellent yields. Furthermore, the scope of the reaction is extended to include challenging ortho-bromophenols. Finally, to highlight the versatility of the developed method, Mo(CO)6 is successfully replaced with a wide array of CO-releasing reagents, such as oxalyl chloride, phenyl formate, 9-methylfluorene-9-carbonyl chloride, and formic acid, making this an appealing strategy for the synthesis of 4H-benzo[e][1,3]oxazin-4-ones...
October 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29046823/functionalization-of-ti-40nb-implant-material-with-strontium-by-reactive-sputtering
#12
Markus Göttlicher, Marcus Rohnke, Yannik Moryson, Jürgen Thomas, Joachim Sann, Anja Lode, Matthias Schumacher, Romy Schmidt, Stefan Pilz, Annett Gebert, Thomas Gemming, Jürgen Janek
BACKGROUND: Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone building therapeutic agent, at the fracture site would diminish side effects, which could occur otherwise by oral administration. Strontium surface functionalization of specially designed titanium-niobium (Ti-40Nb) implant alloy would provide an advanced implant system that is mechanically adapted to altered bone with the ability to stimulate bone formation...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29046300/manganese-promotes-intracellular-accumulation-of-aqp2-via-modulating-f-actin-polymerization-and-reduces-urinary-concentration-in-mice
#13
Lei Lei, Ming Huang, Limin Su, Dongping Xie, Fahmy A Mamuya, Onju Ham, Kenji Tsuji, Teodor G Păunescu, Baoxue Yang, Hua A Jenny Lu
Aquaporin-2 (AQP2) is a water channel protein expressed in principal cells (PCs) of the kidney collecting ducts (CDs) and plays a critical role in mediating water reabsorption and urine concentration. AQP2 undergoes both regulated trafficking mediated by vasopressin (VP) and constitutive recycling, which is independent of VP. For both pathways, actin cytoskeletal dynamics is a key determinant of AQP2 trafficking. We report here that manganese chloride (MnCl2) is a novel and potent regulator of AQP2 trafficking in cultured cells and in the kidney...
October 18, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29046169/response-of-epiphytic-algae-to-heavy-pollution-of-water-bodies
#14
(no author information available yet)
The objective of the present work was to study the structure of epiphyton in water bodies significantly differing in the degree of their contamination. In the studied water bodies, the concentration of ammonia (NH4+-N) accounted for 0.04-74.00 mg/L, nitrite (NO2--N) - 0.002-1.750 mg/L, nitrate (NO3--N) - 0.13-58.00 mg/L, inorganic compounds of phosphorus (Pinorg) - 0.041-0.272 mg/L, chloride (Cl-) - 34.5-560.5 mg/L, whereas the content of organic matter (DO) - 18.0-81.0 mg O/L. The numbers of algae were determined by the method of a direct count...
October 17, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/29045814/role-of-kcc2-dependent-potassium-efflux-in-4-aminopyridine-induced-epileptiform-synchronization
#15
Oscar C González, Zahra Shiri, Giri P Krishnan, Timothy L Myers, Sylvain Williams, Massimo Avoli, Maxim Bazhenov
A balance between excitation and inhibition is necessary to maintain stable brain network dynamics. Traditionally, seizure activity is believed to arise from the breakdown of this delicate balance in favor of excitation with loss of inhibition. Surprisingly, recent experimental evidence suggests that this conventional view may be limited, and that inhibition plays a prominent role in the development of epileptiform synchronization. Here, we explored the role of the KCC2 co-transporter in the onset of inhibitory network-induced seizures...
October 15, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29045746/identification-of-natural-products-as-inhibitors-of-human-organic-anion-transporters-oat1-and-oat3-and-their-protective-effect-on-mercury-induced-toxicity
#16
Xue Wang, Lifeng Han, Gentao Li, Wei Peng, Xiumei Gao, Curtis D Klaassen, Guanwei Fan, Youcai Zhang
Mercury accumulates in kidneys and produces acute kidney injury. Semen cassiae (SC), a widely consumed tea and herbal medicine in Eastern Asia, has been reported to have protective effects on kidneys. In this study, SC extract was shown to almost abolish the histological alterations induced by mercuric chloride (HgCl2) in rat kidneys. A total of 22 compounds were isolated from SC, and 1,7,8-methoxyl-2-hydroxyl-3-methyl-anthraquinone was detected in SC for the first time. Among the 8 compounds identified in the blood of rats after SC treatment, 6 were strong inhibitors of human organic anion transporter 1 and 3 (OAT1 and OAT3)...
October 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29045125/polyacrylonitrile-separator-for-high-performance-aluminum-batteries-with-improved-interface-stability
#17
Giuseppe Antonio Elia, Jean-Baptiste Ducros, Dane Sotta, Virginie Delhorbe, Agnès Brun, Krystan Marquardt, Robert Hahn
Herein we report, for the first time, an overall evaluation of commercially available battery separators to be used for aluminum batteries, revealing that most of them are not stable in the highly-reactive 1-ethyl-3-methylimidazolium chloride : aluminum trichloride (EMIMCl:AlCl3) electrolyte conventionally employed in rechargeable aluminum batteries. Subsequently, a novel highly-stable polyacrylonitrile (PAN) separator obtained by the electrospinning technique for application in high-performance aluminum batteries has been prepared...
October 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29044704/biomimetic-inspired-core-canopy-quantum-dots-ions-trapped-in-voids-induce-kinetic-fluorescence-switching
#18
Arpita Saha, Elena Oleshkevich, Clara Vinas, Francesc Teixidor
Closely packed hollow spheres connected through pillars to a CdSe quantum dot (QD) core produce channels through which ions navigate. This particular structure is well represented by [CdSe@CarbOPH(O)]@Cl/[N(Caprylyl)3 Me1 ] indicating that in the channels between the canopy made by the carboranyl spheres (carboranylphosphinate, CarbOPH(O)) and the CdSe core exist chloride anions. Due to the close packing, the spheres produce openings. These are converted into gates because [N(Caprylyl)3 Me1 ] acts as a plug...
October 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29043863/preparation-and-evaluation-of-vinpocetine-self-emulsifying-ph-gradient-release-pellets
#19
Mengqi Liu, Shiming Zhang, Shuxia Cui, Fen Chen, Lianqun Jia, Shu Wang, Xiumei Gai, Pingfei Li, Feifei Yang, Weisan Pan, Xinggang Yang
The main objective of this study was to develop a pH gradient release pellet with self-emulsifying drug delivery system (SEDDS), which could not only improve the oral bioavailability of Vinpocetine (VIN), a poor soluble drug, but reduce the fluctuation of plasma concentration. First, the liquid VIN SEDDS formulation was prepared. Then the self-emulsifying pH gradient release pellets were prepared by extrusion spheronization technique, and formulation consisted by the liquid SEDDS, absorbent (colloidal silicon dioxide), penetration enhancer (sodium chloride), microcrystalline cellulose, ethyl alcohol, and three coating materials (HPMC, Eudragit L30D55, Eudragit FS30D) were eventually selected...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29043813/catalyst-selection-facilitates-the-use-of-heterocyclic-sulfinates-as-general-nucleophilic-coupling-partners-in-palladium-catalyzed-coupling-reactions
#20
Tim Markovic, Benjamin N Rocke, David C Blakemore, Vincent Mascitti, Michael C Willis
A range of 5- and 6-membered heterocycle-derived sulfinates are shown to be effective nucleophilic coupling partners with aryl chlorides and bromides using Pd(0) catalysis. The use of optimal reaction conditions, specifically incorporating a P(t-Bu)2Me-derived Pd catalyst, allowed reactions to be performed at moderate temperatures and enabled the inclusion of a variety of sensitive functional groups. Challenging heterocyclic sulfinates, including pyrazine, pyridazine, pyrimidine, pyrazole, and imidazole, were all shown to perform well...
October 18, 2017: Organic Letters
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