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Matthew Musielak, John McCall
Pain control is a major concern for patients suffering burns. The addition of bupivacaine to the donor site infiltration solution containing epinephrine could offer a safe and effective means to treat postanesthesia pain. Despite the addition of epinephrine to localize the effects, systemic absorption occurs, and there exists the possibility of inadvertent intravascular injection, with potential CNS and cardiac toxicity. The patient is a 6-year-old boy who sustained flame burns to bilateral lower extremities and buttocks...
July 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
Francisco J Leyva, Rahul P Bakshi, Edward J Fuchs, Liye Li, Brian S Caffo, Arthur J Goldsmith, Ana Ventuneac, Alex Carballo-Diéguez, Yong Du, Jeffrey P Leal, Linda A Lee, Michael S Torbenson, Craig W Hendrix
Rectally applied antiretroviral microbicides for preexposure prophylaxis (PrEP) of HIV infection are currently in development. Since enemas (rectal douches) are commonly used by men who have sex with men prior to receptive anal intercourse, a microbicide enema could enhance PrEP adherence by fitting seamlessly within the usual sexual practices. We assessed the distribution, safety, and acceptability of three enema types-hyperosmolar (Fleet), hypoosmolar (distilled water), and isoosmolar (Normosol-R)-in a crossover design...
November 2013: AIDS Research and Human Retroviruses
Edward J Fuchs, Lisa A Grohskopf, Linda A Lee, Rahul P Bakshi, Craig W Hendrix
BACKGROUND: Microbicide toxicity may reduce the efficacy of topical preexposure prophylaxis for human immunodeficiency virus (HIV) transmission. Noninvasive quantitative measures of microbicide toxicity would usefully inform microbicide development. METHODS: Ten subjects received 3 one-time interventions: 5 mL of Normosol-R fluid alone (negative control), 5 mL of 2% nonoxynol-9 (N-9) gel, and 5 mL of Normosol-R with coital simulation and sigmoidoscopic biopsy (CS + BX)...
May 1, 2013: Journal of Infectious Diseases
Hugues Beaufrère, Mark Acierno, Mark Mitchell, David Sanchez-Migallon Guzman, Heather Bryant, Thomas N Tully
Birds are routinely presented to veterinarians for dehydration. Success with these cases ultimately depends on providing replacement fluids and re-establishing fluid homeostasis. Few studies have been done to determine reference ranges for plasma osmolality in birds. The goals of this study were to determine reference values for plasma osmolality in 3 species of parrots and to provide recommendations on fluid selection for replacement therapy in these species. Blood samples were collected from 21 adult Hispaniolan Amazon parrots (Amazona ventralis), 21 Congo African grey parrots (Psittacus erithacus erithacus), and 9 red-fronted macaws (Ara rubrogenys), and were placed into lithium heparin containers...
June 2011: Journal of Avian Medicine and Surgery
Charlene S Dezzutti, Craig W Hendrix, Jeanne M Marrazzo, Zhenyu Pan, Lei Wang, Nicolette Louissaint, Sabah Kalyoussef, N Merna Torres, Florian Hladik, Urvi Parikh, John Mellors, Sharon L Hillier, Betsy C Herold
BACKGROUND: Measurement of immune mediators and antimicrobial activity in female genital tract secretions may provide biomarkers predictive of risk for HIV-1 acquisition and surrogate markers of microbicide safety. However, optimal methods for sample collection do not exist. This study compared collection methods. METHODS: Secretions were collected from 48 women (24 with bacterial vaginosis [BV]) using vaginal and endocervical Dacron and flocked swabs. Cervicovaginal lavage (CVL) was collected with 10 mL of Normosol-R (n = 20), saline (n = 14), or water (n = 14)...
2011: PloS One
Dominic M Clarke, David J Yadock, Ian B Nicoud, Aby J Mathew, Shelly Heimfeld
BACKGROUND AIMS: Peripheral blood stem cells (PBSC) have become the preferred stem cell source for autologous hematopoietic transplantation. A critical aspect of this treatment modality is cryopreservation of the stem cell products, which permits temporal separation of the PBSC mobilization/collection phase from the subsequent high-dose therapy. While controlled rate-freezing and liquid nitrogen storage have become 'routine' practice in many cell-processing facilities, there is clearly room for improvement as current cryopreservation media formulations still result in significant loss and damage to the stem/progenitor cell populations essential for engraftment, and can also expose the patients to relatively undefined serum components and larger volumes of dimethylsulfoxide (DMSO) that can contribute to the morbidity and mortality of the transplant therapy...
2009: Cytotherapy
G Kelmer, T J Doherty, S Elliott, A Saxton, M M Fry, F M Andrews
REASONS FOR PERFORMING STUDY: Endotoxaemia is one of the most severe and ubiquitous disease processes in horses. Although dimethyl sulphoxide (DMSO) is used clinically in horses, there is no study indicating its efficacy in endotoxaemic horses. HYPOTHESIS: DMSO ameliorates the clinical response to i.v. lipopolysaccharide (LPS) administration. METHODS: Eighteen horses were assigned randomly to one of 4 groups: Normosol-LPS (0.2 mug/kg bwt, i...
June 2008: Equine Veterinary Journal
Cathryn Peltz, Thies Schroeder, Mark W Dewhirst
Hypoxia is a common cause of reduced tumor response to treatment such as irradiation. The purpose of this study was to establish a method in a rat model that is clinically applicable to monitor the efficiency of glucose transport to both tumor and normal tissue following the induction of hyperglycemia. Female Fischer 344 rats bearing subcutaneous R3230 rat mammary adenocarcinomas received glucose (1 g/kg in 200 mg/ml Normosol) injected in the femoral vein with an infusion pump at a rate of 0.1 ml/min. Microdialysis sampling was performed on all animals...
2005: Advances in Experimental Medicine and Biology
R A Fisher, M P Posner, M L Shiffman, A S Mills, M J Contos, J Beeston, T Bowman, L Wolfe, H M Lee
OBJECTIVE: The study was aimed at determining whether the vasodilator, adenosine, shown to produce dramatic improvement in liver graft and animal acute and long-term survival, would be beneficial in human liver transplantation. METHODS: A prospective, randomized, double-blind trial of an adenosine rinse preservation solution in human orthotopic liver transplantation (OLTX) was conducted in 43 consecutive transplants. Intraoperative and postoperative care was performed by a single transplant team utilizing a quadruple drug immunosuppressive protocol, with complete 5-year patient follow-up...
1999: International Journal of Surgical Investigation
T Lightfoot, J Gallelli, K Matsuo, S W Kwon, S F Leitman, D F Stroncek
BACKGROUND: High cell counts in granulocyte colony-stimulating factor (G-CSF)-mobilized granulocytes are detrimental to concentrate storage. An eightfold dilution with autologous plasma improves storage, but this method is impractical. The purpose of this study was to identify an infusible solution that could be used in place of autologous plasma to dilute and store granulocytes. MATERIALS AND METHODS: Granulocytes collected from donors given dexamethasone (8 mg per os) and/or G-CSF (5 micrograms/kg subcutaneously [SQ]) were diluted eightfold in the following cell culture media: X-Vivo 10, Dulbecco's modified Eagle's minimal essential medium (DMEM) or Iscoves modified Dulbecco's medium (IMDM); or in the following infusible solutions: Plasma-Lyte A; Normosol R; lactated ringers, supplemented with 1% human serum albumin and 50 mM histidine (LRAH); or Plasma-Lyte A supplemented with 50 mM histidine buffer or 25 mM HEPES buffer plus 1% human serum albumin...
February 2001: Vox Sanguinis
G J Myers, J F Légaré
There seems to be a wide range of practice in relation to the optimum oxygen setting before, and at the start of, cardiopulmonary bypass. Even manufacturers of blood oxygenators vary in their suggestions for this phase of extracorporeal circulation. Most of these suggestions are based on peak performance, Association for the Advancement of Medical Instrumentation (AAMI) standards, experience, and legal considerations. Therefore, suggested gas:blood flow ratios will vary from no gas flow at the start of bypass, to a ratio setting of 1:1...
September 1999: Journal of Extra-corporeal Technology
J F Nasuti, S R Fleisher, B C Cobbs, P K Gupta
The present study was designed to compare cytomorphologic features and diagnostic value of thyroid fine-needle aspiration (FNA) specimens stored in Saccomano's (Carbowax(R) solution) fixative and Normosol(R) solutions. Equivalent amounts of aspirate material obtained from nonlesional areas of 17 freshly resected thyroidectomy specimens were placed in room temperature Carbowax(R) solution and refrigerated Normosol(R) solution for a time period of up to 60 hr. Millipore(R) filter preparations were made from both fluids for each of the 17 thyroidectomy specimens...
May 2000: Diagnostic Cytopathology
Y Tamari, J A Tortolani, M Maguine, F Czegledy
We studied the effects of acetate (Ac), the buffer in crystalloids used during cardiopulmonary bypass (CPB) (e.g. Normosol-R and Plasma-Lyte, Ac = 27mEq/l), on coronary resistance (R) for the empty beating heart, and on vascular resistance (SVR) of 19 dogs on CPB. Control R with Ac = O (R c) was obtained by adjusting flow to give a pressure of 90 +/- 10mmHg (R = 532 +/- 32 dynes sec/cm 5g, other Rs are given as a percentage of their respective R c). Continuous addition of Ac = 1.6 or 7.1mEq/L of blood resulted in a rapid decrease in R to 34 +/- 3 and 17 +/- 2% of R c, followed by a recovery to higher steady values of 53 +/- 3 and 27 +/- 2% respectively (p less than 0...
1990: Perfusion
R A Prince, D S Lucas, J L Fox
OBJECTIVE: To determine the degree to which a dual-lumen peripheral catheter prevented precipitation of solutions known to be incompatible due to pH during simultaneous infusion in an in vitro model. METHODS: An in vitro model was devised to simulate peripheral venous blood flow from an antecubital source to systemic circulation. Ondansetron was simultaneously infused with fluorouracil, aminophylline, sodium bicarbonate, and ampicillin sodium in concentrations reflective of clinical conditions into the Twin Cath 20/22 (the dual-lumen catheter used in this experiment)...
September 1998: Annals of Pharmacotherapy
S Mangiameli, V Calabrese, G Cantarella, G Milazzo, D Nicolosi, V Rizza
BACKGROUND: Reduced glutathione (GSH) an antioxidant used for i.v. or i.m. administrations, prepared as powder to be diluted in distilled water just before injection (Tationil 600), could lose its antioxidant properties when added to various infusions currently utilized in anesthesia and reanimation. AIM OF THE WORK: Evaluate in vitro the compatibility of the compound marketed under the trade nome "Tationil 600" with the intravenous infusions in common use in anesthesia and reanimation...
October 1995: Minerva Anestesiologica
K Luo, G Wu, Q Wang, Y Sun, H Liu
Fractionated human bone marrow cells, isolated by density centrifugation, could be well cryopreserved in both a DMSO/HES/albumin mixture and the conventional cryoprotectant (DMSO/serum) with either a programmed freezer or a -80 degrees C freezer. A lower initial temperature rise and a delayed plateau phase in the mixture in comparison with those in the DMSO/serum were observed using a programmed procedure without heat fusion compensation. Plateau phase in the mixture could also be shortened with increased liquid nitrogen to minimize the transition phase duration...
August 1994: Cryobiology
M H Shiu, J G Fortner
The feasibility and efficacy of treating peritoneal cancer implants by applying heat to the peritoneal surfaces were studied in inbred Buffalo A rats given i.p. injections of Morris hepatoma 5123TC tumor cells. Heat was delivered to the peritoneum by contact with a heated physiological salt solution (Normosol-R) in the peritoneal cavity. A treatment temperature of 43.3 +/- 0.3 degrees was maintained for 30 min by an immersed stainless steel coil through which hot liquid circulated. Rats implanted with 0.5 to 1...
November 1980: Cancer Research
R E Clark, I Y Christlieb, J A Spratt, P D Henry, A E Fischer, J R Williamson, B E Sobel
Sixty-four dogs were placed on normothermic total cardiopulmonary bypass, and global ischemia was induced for 1 hour during which continuous infusions (240 ml per hour) (N = 39) or bolus injections (150 to 200 ml every 30 minutes) (N = 23) into the proximal aortic root were performed. The control groups (N = 26) had infusion or injection of normal saline solution, normal saline solution + 25 mEq/L of potassium chloride, or Normosol-R pH 7.4. The cardioplegic solution (N = 15) contained 25 mEq/L of potassium chloride in Normosol-R pH 7...
January 1981: Annals of Thoracic Surgery
R D Acland, L L Lubbers, R B Grafton, R Bensimon
Rat femoral vessels were clamped and perfused internally in situ for 30 minutes using five different irrigating solutions (normal saline, lactated Ringer's solution, Normosol R, pH 6.2 and 7.4, and glutathione buffered Ringer's solution). After the blood flow was reestablished, the vessels were excised at 30 minutes or 48 hours after irrigation and were sectioned longitudinally for light microscopy. Normal saline consistently produced the most severe damage. None of the agents tested proved biochemically atraumatic, and none were consistently superior to lactated Ringer's solution...
April 1980: Plastic and Reconstructive Surgery
E M Yuhas, F T Lofton, D Mayron, J G Baldinus, H A rosenberg
The visual compatibility and chemical stability of cimetidine hydrochloride diluted in 19 intravenous infusion fluids were investigated. Cimetidine hydrochloride injection was added aseptically to large-volume parenteral solutions at concentrations of 120 and 500 mg/100 ml. Cimetidine concentration was analyzed by high-pressure liquid chromatography initially and after storage periods of 24, 48, 72, and 168 hours at room temperature. Cimetidine hydrochloride in each of the dilutions remained visually compatible for one week, exhibiting no changes in color, clarity, or odor; pH values remained constant...
June 1981: American Journal of Hospital Pharmacy
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