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https://www.readbyqxmd.com/read/29352746/the-common-bean-cok-4-and-the-arabidopsis-fer-kinase-domain-share-similar-function-in-plant-growth-and-defense
#1
Rafhael Felipin Azevedo, Maria Celeste Gonçalves Vidigal, Paula Rodrigues Oblessuc, Maeli Melotto
Receptor-like kinases are membrane proteins that can be shared by diverse signaling pathways. Among them, the Arabidopsis thaliana FERONIA (FER) plays a role in the balance between distinct signals to control growth and defense. We have found that COK-4, a putative kinase encoded in the common bean anthracnose resistance locus Co-4 that is transcriptionally regulated during immune response, is highly similar to the kinase domain of FER. To assess whether COK-4 is a functional ortholog of FER, we expressed COK-4 in the wild type Col-0 and the fer-5 mutant of Arabidopsis and evaluated FER-associated traits...
January 20, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29352669/tms-of-primary-motor-cortex-with-a-biphasic-pulse-activates-two-independent-sets-of-excitable-neurones
#2
Martin Sommer, Matteo Ciocca, Raffaella Chieffo, Paul Hammond, Andreas Neef, Walter Paulus, John C Rothwell, Ricci Hannah
BACKGROUND: Biphasic pulses produced by most commercially available TMS machines have a cosine waveform, which makes it difficult to study the interaction between the two phases of stimulation. OBJECTIVE: We used a controllable pulse TMS (cTMS) device delivering quasi-rectangular pulse outputs to investigate whether monophasic are more effective than biphasic pulses. METHODS: Temporally symmetric ("biphasic") or highly asymmetric ("monophasic") charge-balanced biphasic stimuli were used to target the hand area of motor cortex in the anterior-posterior (AP) or posterior-anterior (PA) initial current direction...
January 5, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29352615/gene-circuits-for-dynamically-regulating-metabolism
#3
Xiulai Chen, Liming Liu
Gene circuits are a functional innovation in synthetic biology for engineering cellular behavior. Recent advances have demonstrated that gene circuits can be exploited for dynamically controlling pathway redirection and pathway balance to produce valuable chemicals. The next frontier is to engineer robust, sensitive, and efficient circuits that adapt to changing conditions.
January 15, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29352607/integrated-lung-tissue-mechanics-one-piece-at-a-time-computational-modeling-across-the-scales-of-biology
#4
REVIEW
Kelly S Burrowes, Amin Iravani, Wendy Kang
The lung is a delicately balanced and highly integrated mechanical system. Lung tissue is continuously exposed to the environment via the air we breathe, making it susceptible to damage. As a consequence, respiratory diseases present a huge burden on society and their prevalence continues to rise. Emergent function is produced not only by the sum of the function of its individual components but also by the complex feedback and interactions occurring across the biological scales - from genes to proteins, cells, tissue and whole organ - and back again...
January 12, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29352600/placental-control-of-metabolic-adaptations-in-the-mother-for-an-optimal-pregnancy-outcome-what-goes-wrong-in-gestational-diabetes
#5
David J Hill
As pregnancy progresses the placental syncytiotrophoblast increasingly assumes control of maternal glucose homeostasis through the release and counter-balancing effects of placental lactogen (PL) and placental variant growth hormone (GH-V). While local actions of these hormones on placental growth and function are likely to exist, each also exerts indirect actions to ensure fetal nutritional availability through modulation of the maternal insulin/insulin-like growth factor axis. Peripheral insulin resistance results from the increasing levels of GH-V in the maternal circulation and is counter-balanced by an increase in insulin availability through an expansion of maternal pancreatic β-cell mass...
January 9, 2018: Placenta
https://www.readbyqxmd.com/read/29352526/ectrims-ean-guideline-on-the-pharmacological-treatment-of-people-with-multiple-sclerosis
#6
X Montalban, R Gold, A J Thompson, S Otero-Romero, M P Amato, D Chandraratna, M Clanet, G Comi, T Derfuss, F Fazekas, H P Hartung, E Havrdova, B Hemmer, L Kappos, R Liblau, C Lubetzki, E Marcus, D H Miller, T Olsson, S Pilling, K Selmaj, A Siva, P S Sorensen, M P Sormani, C Thalheim, H Wiendl, F Zipp
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a complex disease of the central nervous system. As new drugs are becoming available, knowledge on diagnosis and treatment must continuously evolve. There is therefore a need for a reference tool compiling current data on benefit and safety, to aid professionals in treatment decisions and use of resources across Europe. The European Committee of Treatment and Research in Multiple Sclerosis (ECTRIMS) and the European Academy of Neurology (EAN) have joined forces to meet this need...
January 19, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29352353/regarding-loads-after-spinal-fusion-every-level-should-be-seen-separately-a-musculoskeletal-analysis
#7
A Benditz, S Auer, J F Spörrer, S Wolkerstorfer, J Grifka, F Suess, S Dendorfer
INTRODUCTION: The number of spinal fusion surgeries is steadily increasing and biomechanical consequences are still in debate. The aim of this study is to provide biomechanical insights into the sagittal balance of the spine and to compare spinal load before and after spinal fusion. METHOD: The joint reaction forces of 52 patients were analyzed in proximo-distal and antero-posterior direction from the levels T12-L1 to L5-S1 using musculoskeletal simulations. RESULTS: In 104 simulations, pre-surgical forces were equal to post-surgical...
January 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29352115/stil-balancing-primary-microcephaly-and-cancer
#8
REVIEW
Patwardhan Dhruti, Mani Shyamala, Passemard Sandrine, Gressens Pierre, El Ghouzzi Vincent
Cell division and differentiation are two fundamental physiological processes that need to be tightly balanced to achieve harmonious development of an organ or a tissue without jeopardizing its homeostasis. The role played by the centriolar protein STIL is highly illustrative of this balance at different stages of life as deregulation of the human STIL gene expression has been associated with either insufficient brain development (primary microcephaly) or cancer, two conditions resulting from perturbations in cell cycle and chromosomal segregation...
January 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29352088/an-archaeal-fluoride-responsive-riboswitch-provides-an-inducible-expression-system-for-hyperthermophiles
#9
Michael Clayton Speed, Brett W Burkhart, Jonathan W Picking, Thomas J Santangelo
Robust genetic systems for the hyperthermophilic Thermococcales have facilitated overexpression of native genes, allowed for the addition of sequences encoding secretion signals, epitope, and affinity tags to coding regions, and permitted the introduction of sequences encoding new proteins in these fast growing fermentative heterotrophs. Tightly controlled and easily manipulated systems permitting regulated gene expression are however limited for these hosts. Here we describe an alternative method for regulatory control reliant on a cis-encoded functional riboswitch in the model archaeon Thermococcus kodakarensis Despite the hyperthermophilic growth temperatures, the proposed structure of the riboswitch conforms to a fluoride-responsive riboswitch encoded in many bacteria, and similarly functions to regulate a component conserved fluoride export pathway...
January 19, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29351997/spatiotemporal-organization-of-exocytosis-emerges-during-neuronal-shape-change
#10
Fabio L Urbina, Shawn M Gomez, Stephanie L Gupton
Neurite elongation and branching in developing neurons requires plasmalemma expansion, hypothesized to occur primarily via exocytosis. We posited that exocytosis in developing neurons and nonneuronal cells would exhibit distinct spatiotemporal organization. We exploited total internal reflection fluorescence microscopy to image vesicle-associated membrane protein (VAMP)-pHluorin-mediated exocytosis in mouse embryonic cortical neurons and interphase melanoma cells, and developed computer-vision software and statistical tools to uncover spatiotemporal aspects of exocytosis...
January 19, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29351726/paper-tools-and-periodic-tables-newlands-and-mendeleev-draw-grids
#11
Michael D Gordin
This essay elaborates on Ursula Klein's methodological concept of "paper tools" by drawing on several examples from the history of the periodic table. Moving from John A. R. Newlands's "Law of Octaves," to Dmitrii Mendeleev's first drafts of his periodic system in 1869, to Mendeleev's chemical speculations on the place of the ether within his classification, one sees that the ways in which the scientists presented the balance between empirical data and theoretical manipulation proved crucial for the chemical community's acceptance or rejection of their proposed innovations...
January 19, 2018: Ambix
https://www.readbyqxmd.com/read/29351650/are-evidence-based-community-engaged-energy-balance-interventions-enough-for-extremely-vulnerable-populations
#12
Nancy E Schoenberg, Yelena N Tarasenko, Claire Snell-Rood
Well-documented associations between lifestyle behaviors and disease outcomes necessitate evidence-based health promotion interventions. To enhance potential efficacy and effectiveness, interventionists increasingly respond to community priorities, employ comprehensive theoretical frameworks, invest heavily to ensure cultural fit, implement evidence-based programming, and deploy research gold standards. We describe a project that followed all of these recommended strategies, but did not achieve desired outcomes...
January 17, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29351514/the-ace2-angiotensin-1-7-mas-axis-of-the-renin-angiotensin-system-focus-on-angiotensin-1-7
#13
Robson Augusto Souza Santos, Walkyria Oliveira Sampaio, Andreia C Alzamora, Daisy Motta-Santos, Natalia Alenina, Michael Bader, Maria Jose Campagnole-Santos
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and hydroelectrolyte balance, with an influence on organs and functions throughout the body. The classical view of this system saw it as a sequence of many enzymatic steps that culminate in the production of a single biologically active metabolite, the octapeptide angiotensin (ANG) II, by the angiotensin converting enzyme (ACE). The past two decades have revealed new functions for some of the intermediate products, beyond their roles as substrates along the classical route...
January 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29351513/neuroimmune-interactions-from-the-brain-to-the-immune-system-and-vice-versa
#14
Robert Dantzer
Because of the compartmentalization of disciplines that shaped the academic landscape of biology and biomedical sciences in the past, physiological systems have long been studied in isolation from each other. This has particularly been the case for the immune system. As a consequence of its ties with pathology and microbiology, immunology as a discipline has largely grown independently of physiology. Accordingly, it has taken a long time for immunologists to accept the concept that the immune system is not self-regulated but functions in close association with the nervous system...
January 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29351504/a-systematic-literature-review-of-physiotherapy-and-rehabilitation-approaches-to-lower-limb-amputation
#15
Özlem Ülger, Tezel Yıldırım Şahan, Seher Erol Çelik
BACKGROUND: Successful use of prostheses after lower-limb amputation (LLA) depends on undergoing physiotherapy and rehabilitation both physically and psychologically. The aim of this systematic literature review is to systematically review the scientific evidence regarding prosthetic rehabilitation and physiotherapy after LLA. METHODS: A systematic literature search was conducted using PubMed, Web of Science, Cochrane, CINAHL, EMBASE, SCOPUS, and EMB Reviews databases on December 31, 2015...
January 19, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29351490/significant-improvement-in-cardiometabolic-health-in-healthy-non-obese-individuals-during-caloric-restriction-induced-weight-loss-and-weight-loss-maintenance
#16
Jasper Most, L Anne Gilmore, Steven R Smith, Hongmei Han, Eric Ravussin, Leanne M Redman
Caloric restriction (CR) triggers benefits for healthspan including decreased risk of cardiometabolic disease. In an ancillary study to CALERIE 2, a 24-month 25% CR study, we assessed the cardiometabolic effects of CR in 53 non-obese (BMI: 22-28 kg/m2) men (n=17) and women (n=36). According to the energy-balance method (doubly labeled water and changes in body energy stores), the 25% CR intervention (n=34) produced 17{plus minus}1% (mean{plus minus}SE) and 14{plus minus}1% CR after 12 and 24 months (M12, M24), resulting in significant weight loss (M12: -9{plus minus}0...
December 12, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29351446/mechanisms-and-consequences-of-oxidative-stress-in-lung-disease-therapeutic-implications-for-an-aging-populace
#17
Louise Hecker
The rapid expansion of the elderly population has led to the recent epidemic of age-related diseases, including increased incidence and mortality of chronic and acute lung diseases. Numerous studies have implicated aging and oxidative stress in the pathogenesis of various pulmonary diseases; however, despite recent advances in these fields, the specific contributions of aging and oxidative stress remain elusive. This review will discuss the consequences of aging on lung morphology and physiology, and how redox imbalance with aging contributes to lung disease susceptibility...
December 14, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29351361/pathways-of-nitric-oxide-metabolism-and-operation-of-phytoglobins-in-legume-nodules-missing-links-and-future-directions
#18
Antoine Berger, Renaud Brouquisse, Pradeep Kumar Pathak, Imène Hichri, Inderjit Singh, Sabhyata Bhatia, Alexandre Boscari, Abir U Igamberdiev, Kapuganti Jagadis Gupta
The interaction between legumes and rhizobia leads to the establishment of a beneficial symbiotic relationship. Recent advances in legume - rhizobium symbiosis revealed that various reactive oxygen and nitrogen species including nitric oxide (NO) play important roles during this process. Nodule development occurs with a transition from a normoxic environment during the establishment of symbiosis to a microoxic environment in functional nodules. Such oxygen dynamics are required for activation and repression of various NO production and scavenging pathways...
January 19, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29351305/gender-stereotypes-and-education-a-comparative-content-analysis-of-malaysian-indonesian-pakistani-and-bangladeshi-school-textbooks
#19
Kazi Md Mukitul Islam, M Niaz Asadullah
Using government secondary school English language textbooks from Malaysia, Indonesia, Pakistan and Bangladesh, we conducted a quantitative content analysis in order to identify gender stereotypes in school education. In total, 21 categories of exclusion and quality of representation were used to study gender stereotypes. Our analysis confirms a pro-male bias in textbooks: the aggregate female share is 40.4% in textual and pictorial indicators combined. Female occupations are mostly traditional and less prestigious while the characters are predominantly introverted and passive in terms of personality traits...
2018: PloS One
https://www.readbyqxmd.com/read/29351128/fluid-removal-with-ultrasound-guided-protocol-improves-the-efficacy-and-safety-of-dehydration-in-post-resuscitated-critically-ill-patients-a-quasi-experimental-before-and-after-study
#20
Luhao Wang, Chunfang Qiu, Xiangdong Guan, Minying Chen, Juan Chen, Xiang Si, Zhicheng Du, Yanqiu Liu, Bin Ouyang
Fluid overload is associated with increased morbidity and mortality in critically ill patients. However, researches rarely study the precise start or end point of fluid removal and no protocol was developed to control the fluid removal process. We hypothesized that individualized fluid removal with ultrasound-guided protocol could improve the efficacy and safety of fluid removal in post-resuscitated critically ill patients. A quasi-experimental, before and after trial was conducted to identify the benefits of ultrasound-guided fluid removal...
January 18, 2018: Shock
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