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https://www.readbyqxmd.com/read/28927034/cyclin-d3-deficiency-inhibits-skin-tumor-development-but-does-not-affect-normal-keratinocyte-proliferation
#1
Sung Hyun Lee, Xian Wang, Sun Hye Kim, Yongbaek Kim, Marcelo L Rodriguez-Puebla
Rearrangement and amplification of the D-type cyclin genes have been reported in human cancer. Previous studies have demonstrated that Ras-mediated skin tumorigenesis depends on pathways that act through cyclin D1 and D2; however, the role of cyclin D3 remains unknown. The present study demonstrates that cyclin D3 ablation does not affect keratinocyte proliferation, but instead increases apoptosis levels in the bulge region of the hair follicle. Consequently, cyclin D3 ablation reduces skin papilloma development in a Ras-dependent carcinogenesis model...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927007/carrier-multiplication-mechanisms-and-competing-processes-in-colloidal-semiconductor-nanostructures
#2
REVIEW
Stephen V Kershaw, Andrey L Rogach
Quantum confined semiconductor nanoparticles, such as colloidal quantum dots, nanorods and nanoplatelets have broad extended absorption spectra at energies above their bandgaps. This means that they can absorb light at high photon energies leading to the formation of hot excitons with finite excited state lifetimes. During their existence, the hot electron and hole that comprise the exciton may start to cool as they relax to the band edge by phonon mediated or Auger cooling processes or a combination of these...
September 18, 2017: Materials
https://www.readbyqxmd.com/read/28926994/the-metabolic-response-to-stress-and-infection-in-critically-ill-children-the-opportunity-of-an-individualized-approach
#3
REVIEW
Valentina De Cosmi, Gregorio Paolo Milani, Alessandra Mazzocchi, Veronica D'Oria, Marco Silano, Edoardo Calderini, Carlo Agostoni
The metabolic response to stress and infection is closely related to the corresponding requirements of energy and nutrients. On a general level, the response is driven by a complex endocrine network and related to the nature and severity of the insult. On an individual level, the effects of nutritional interventions are highly variable and a possible source of complications. This narrative review aims to discuss the metabolic changes in critically-ill children and the potential of developing personalized nutritional interventions...
September 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28926958/an-eccentricity-based-data-routing-protocol-with-uniform-node-distribution-in-3d-wsn
#4
A S M Sanwar Hosen, Gi Hwan Cho, In-Ho Ra
Due to nonuniform node distribution, the energy consumption of nodes are imbalanced in clustering-based wireless sensor networks (WSNs). It might have more impact when nodes are deployed in a three-dimensional (3D) environment. In this regard, we propose the eccentricity based data routing (EDR) protocol in a 3D WSN with uniform node distribution. It includes network partitions called 3D subspaces/clusters of equal member nodes, an energy-efficient routing centroid (RC) nodes election and data routing algorithm...
September 16, 2017: Sensors
https://www.readbyqxmd.com/read/28926931/comparison-of-sociodemographic-and-nutritional-characteristics-between-self-reported-vegetarians-vegans-and-meat-eaters-from-the-nutrinet-sant%C3%A3-study
#5
Benjamin Allès, Julia Baudry, Caroline Méjean, Mathilde Touvier, Sandrine Péneau, Serge Hercberg, Emmanuelle Kesse-Guyot
BACKGROUND: There is a growing trend for vegetarian and vegan diets in many Western countries. Epidemiological evidence suggesting that such diets may help in maintaining good health is rising. However, dietary and sociodemographic characteristics of vegetarians and vegans are not well known. The aim of this cross-sectional study was to describe sociodemographic and nutritional characteristics of self-reported, adult vegetarians and vegans, compared to meat-eaters, from the French NutriNet-Santé study...
September 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28926856/positive-effects-of-promoting-physical-activity-and-balanced-diets-in-a-primary-school-setting-with-a-high-proportion-of-migrant-school-children
#6
Katharina S Weber, Olaf Spörkel, Melina Mertens, Alem Freese, Klaus Strassburger, Boris Kemper, Clemens Bachmann, Knut Diehlmann, Theodor Stemper, Anette E Buyken, Kerstin Ketelhut, Karsten Müssig
Background Children with migration background are at particular risk for overweight. We assessed the effects of a primary school-based initiative targeted at enhancing physical activity and dietary education among children with a high proportion of migration background. Methods Four 3(rd) and 4(th) grade classes (n=70 children, 77% with migration background) participated in a 10-months intervention comprising 2 additional exercise lessons weekly and 10 nutrition lessons per school year. 6 school classes (n=125 children, 65% with migration background) served as control...
September 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926635/a-comparison-of-running-kinetics-in-children-with-and-without-genu-varus-a-cross-sectional-study
#7
Amir Ali Jafarnezhadgero, Morteza Madadi Shad, Mahdi Majlesi, Urs Granacher
INTRODUCTION: Varus knee alignment has been identified as a risk factor for the progression of medial knee osteoarthritis. However, the underlying mechanisms have not been elucidated yet in children. Thus, the aims of the present study were to examine differences in ground reaction forces, loading rate, impulses, and free moment values during running in children with and without genu varus. METHODS: Thirty-six boys aged 9-14 volunteered to participate in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28926627/tiger-sharks-can-connect-equatorial-habitats-and-fisheries-across-the-atlantic-ocean-basin
#8
André S Afonso, Ricardo Garla, Fábio H V Hazin
Increasing our knowledge about the spatial ecology of apex predators and their interactions with diverse habitats and fisheries is necessary for understanding the trophic mechanisms that underlie several aspects of marine ecosystem dynamics and for guiding informed management policies. A preliminary assessment of tiger shark (Galeocerdo cuvier) population structure off the oceanic insular system of Fernando de Noronha (FEN) and the large-scale movements performed by this species in the equatorial Atlantic Ocean was conducted using longline and handline fishing gear and satellite telemetry...
2017: PloS One
https://www.readbyqxmd.com/read/28926574/correction-lumpgem-systematic-generation-of-subnetworks-and-elementally-balanced-lumped-reactions-for-the-biosynthesis-of-target-metabolites
#9
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pcbi.1005513.].
September 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28926482/is-there-an-optimal-time-to-initiate-an-active-rehabilitation-protocol-for-concussion-management-in-children-a-case-series
#10
Danielle M Dobney, Lisa Grilli, Helen Kocilowicz, Christine Beaulieu, Meghan Straub, Debbie Friedman, Isabelle J Gagnon
OBJECTIVE: To estimate the time frame during which initiating an active rehabilitation intervention (aerobic exercise, balance, and sport specific skills) after concussion contributed to improvement in symptoms at follow-up in children and adolescents who are slow to recover (symptoms persisting beyond 2 weeks) from concussion. SETTING: Concussion clinic at a tertiary care pediatric teaching hospital. PARTICIPANTS: A total of 677 children and adolescents with concussion aged 7 to 18 years...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28926476/the-effects-of-brief-swaying-on-postural-control
#11
Sara Pagé, Maxime Maheu, Simon P Landry, François Champoux
Postural control can be improved with balance training. However, the nature and duration of the training required to enhance posture remains unclear. We studied the effects of 5 min of a self-initiated balance exercise along a single axis on postural control in healthy individuals. Postural control was measured before and after a 5-min period where members of the experimental group were asked to lean their entire body forward and backward and members of the control group were asked to remain seated. A significant improvement for sway velocity, a postural control variable significantly associated with an increased risk of falls, was found in the experimental group following the body sway exercise...
September 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/28926253/understanding-the-role-of-dna-topology-in-target-search-dynamics-of-proteins
#12
Anupam Mondal, Arnab Bhattacherjee
A wide range of cellular processes initiates upon recognising and binding of proteins to specific DNA sites. Typically, the recognition process is incredibly fast owing to a complex mechanism that combines different 3D and 1D modes of translocation of the protein. While few studies performed on selected DNA topologies suggested that the DNA topology might alter the balance between these two modes and therefore the target search kinetics, its detail role in target search mechanism remains unclear. Here, we present a discrete-state stochastic approach that allows us to incorporate the topological information of DNA molecule explicitly and predict its role during the process when proteins search for their specific binding sites on DNA...
September 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28926189/environmental-peer-pressure-cd4-t-cell-help-in-tolerance-and-transplantation
#13
REVIEW
Dana Tedesco, Arash Grakoui
The liver participates in a multitude of metabolic functions that are critical for sustaining human life. Despite constant encounters with antigenic-rich intestinal blood, oxidative stress and metabolic intermediates, there is no appreciable immune response. Interestingly, patients undergoing orthotopic liver transplantation benefit from a high rate of graft acceptance in comparison to other solid organ transplant recipients. In fact, co-transplantation of a donor liver in tandem with a rejection-prone graft increases the likelihood of graft acceptance...
September 19, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28926066/electrostatic-interactions-between-particles-through-heterogeneous-fluid-phases
#14
Dong Woo Kang, Mina Lee, Kyung Hak Kim, Ming Xia, Sang Hyuk Im, Bum Jun Park
We investigated the electrostatic interactions between particles acting through heterogeneous fluid phases. An oil lens system floating on the surface of water was used to trap particles at different fluid-fluid interfaces. The inner particles are located at the centrosymmetrically curved oil-water interface inside the oil lens while satellite particles are located at the curved air-water interface, separated by a particular distance from the triple phase boundary. The satellite particles are likely to be captured in an energy minimum state due to electrostatic repulsions by the inner particles balanced with the gravity-induced potential energy...
September 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28925902/adipose-triglyceride-lipase-regulation-an-overview
#15
Ines Katrin Cerk, Lisa Wechselberger, Monika Oberer
Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy production. There is growing evidence that the products and intermediates from lipolytic breakdown during the FA mobilization process also have fundamental regulatory functions affecting cell signaling, gene expression, metabolism, cell growth, cell death, and lipotoxicity. Regulation of ATGL is therefore vital for maintaining a defined balance between lipid storage and mobilization...
September 18, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28925890/the-use-of-hemodynamic-and-cerebral-monitoring-to-study-pharmacodynamics-in-neonates
#16
A Smits, L Thewissen, A Dereymaeker, E Dempsey, A Caicedo, Gunnar Naulaers
BACKGROUND: Drugs acting on the cardiovascular and central nervous system often display relatively fast clinical responses, which may differ in neonates compared to children and adults. Introduction of bedside monitoring tools might be of additional value in the pharmacodynamic (PD) assessment of such drugs in neonates. METHODS: We aim to provide an overview of the frequently used monitoring tools to assess drug effects on the hemodynamic status as well as the cerebral circulation, oxygenation and cerebral metabolism in neonates...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925746/impact-of-extended-monitoring-guided-intensive-care-on-outcome-after-severe-traumatic-brain-injury-a-prospective-multicentre-cohort-study-paris-tbi-study
#17
Joaquim Mateo, Didier Payen, Idir Ghout, Fabrice Vallée, Thomas Lescot, Stephane Welschbillig, Karim Tazarourte, Philippe Azouvi, Jean-Jacques Weiss, Philippe Aegerter, Bernard Vigué
OBJECTIVE: We evaluated whether an integrated monitoring with systemic and specific monitoring affect mortality and disability in adults with severe traumatic brain injury (sTBI). METHODS: Adults with severeTBI (Glasgow Coma Scale [GCS] ≤ 8) admitted alive in intensive care units (ICUs) were prospectively included. Primary endpoints were in-hospital 30-day mortality and extended Glasgow outcome score (GOSE) at 3 years. Association with the intensity of monitoring and outcome was studied by comparing a high level of monitoring (HLM) (systemic and ≥3 specific monitoring) and low level of monitoring (LLM) (systemic and 0-2 specific monitoring) and using inverse probability weighting procedure...
September 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28925664/preventing-falls-in-older-persons
#18
Lainie Van Voast Moncada, L Glen Mire
The American Geriatrics Society and British Geriatrics Society recommend that all adults older than 65 years be screened annually for a history of falls or balance impairment. The U.S. Preventive Services Task Force and American Academy of Family Physicians recommend exercise or physical therapy and vitamin D supplementation to prevent falls in community-dwelling older adults who are at increased risk of falls. Although the U.S. Preventive Services Task Force and American Academy of Family Physicians do not recommend routine multifactorial intervention to prevent falls in all community-dwelling older adults, they state that it may be appropriate in individual cases...
August 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28925545/methane-delays-the-senescence-and-browning-in-daylily-buds-by-re-established-redox-homeostasis
#19
Huali Hu, Dan Liu, Pengxia Li
BACKGROUND: During the postharvest senescence of fruits and vegetables, redox imbalance occurs. Although the release of methane (CH4 ) has been observed for a long time and its antioxidant properties have recently been demonstrated in animals and plants, the corresponding physiological role of CH4 in regulating plant senescence has not yet been elucidated. RESULTS: Here, our results indicate that the postharvest deterioration of daylily buds during storage is greatly ameliorated by the exogenous application of CH4 , particularly in the inhibition of tissue browning...
September 19, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28925518/chemistry-of-peptidoglycan-in-mycobacterium-tuberculosis-life-style-an-off-the-wall-balance-of-synthesis-and-degradation
#20
Flavia Squeglia, Alessia Ruggiero, Rita Berisio
The cell wall envelope of mycobacteria is structurally distinct from that of both Gram-positive and Gram-negative bacteria. In Mycobacterium tuberculosis, this cell wall has unique structural features and plays a crucial role in drug resistance and macrophage survival under stress conditions. Peptidoglycan is the major constituent of this cell wall, with an important structural role, giving structural strength, and counteracting the osmotic pressure of the cytoplasm. Synthesis of this complex polymer takes place in three stages that occur at three different locations in the cell, from the cytoplasm to the external side of the cell membrane, where polymerization occurs...
September 19, 2017: Chemistry: a European Journal
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