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https://www.readbyqxmd.com/read/29303841/mirror-imaging-of-finger-mechanical-stimulation-affects-secondary-somatosensory-response
#1
Kazuyoshi Nakanishi, Tomoshi Watanabe, Toru Sunagawa, Hiroshi Kurumadani, Hanan Abd El-Rahman, Mitsuo Ochi, Nobuo Adachi
The aim of this study was to investigate the effect of finger-tip touch on the somatosensory cortex under mirror imaging conditions. Magnetoencephalographic recordings of somatosensory-evoked field responses to mechanical tactile stimulation of the index finger in both hands were obtained for the right-handed healthy participants as part of the following mirror or nonmirror tasks. Both hands were screened and mechanical stimuli were delivered to the right index finger pulp. A mirror was placed in front of the patient with the right hand facing the reflective surface, as if it were the left side (mirror task)...
January 4, 2018: Neuroreport
https://www.readbyqxmd.com/read/29303370/the-effects-of-subcutaneous-insulin-infusion-versus-multiple-insulin-injections-on-glucose-variability-in-young-adults-with-type-1-diabetes-the-2-year-follow-up-of-the-observational-metro-study
#2
Maria Ida Maiorino, Giuseppe Bellastella, Ofelia Casciano, Paolo Cirillo, Vittorio Simeon, Paolo Chiodini, Michela Petrizzo, Maurizio Gicchino, Ornella Romano, Paola Caruso, Dario Giugliano, Katherine Esposito
BACKGROUND: Type 1 diabetic patients have high instability of daily glucose levels. The aim of this study was to evaluate the long-term effects of continuous subcutaneous insulin infusion (CSII) therapy, compared with multiple daily injections of insulin (MDI), on glucose variability, in young type 1 diabetic patients transitioned to the adult diabetes care. METHODS: Patients aged 18-30 years and considered eligible for insulin pump therapy were included in the study...
January 5, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29278712/a-national-survey-on-the-efficacy-and-safety-of-continuous-subcutaneous-insulin-infusion-in-patients-with-type-1-diabetes-in-spain
#3
P Beato-Víbora, Ana Chico-Ballesteros, Marga Giménez, Raquel Guerrero-Vázquez, Raquel Barrio-Castellanos, María José Goñi-Iriarte, Gonzalo Díaz-Soto, Juan Francisco Merino-Torres, Jesús Moreno-Fernández, María Asunción Martínez-Brocca
AIMS: To assess safety and benefits of continuous subcutaneous insulin infusion (CSII) therapy in a cohort of type 1 diabetes patients in Spain. METHODS: A web-based national registry was created by the Working Group of the Spanish Diabetes Association. All patients on CSII being followed at selected referral centers were included. A cross-sectional analysis was performed. RESULTS: A total of 1,275 patients were included. Data completion for patients on CSII was 67 ± 32%...
December 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29224132/treatment-of-mild-to-moderate-hypoglycemia-in-patients-with-type-1-diabetes-treated-with-insulin-pump-therapy-are-current-recommendations-effective
#4
Véronique Gingras, Katherine Desjardins, Mohamed Raef Smaoui, Valérie Savard, Virginie Messier, Ahmad Haidar, Laurent Legault, Rémi Rabasa-Lhoret
AIMS: Mild-to-moderate hypoglycemia (blood glucose < 4.0 mmol/L) is recommended to be treated with 15 g of carbohydrates and to repeat the treatment if hypoglycemia persists after 15 min. This recommendation was established before intensive insulin therapy and based on studies using insulin with different pharmacokinetic profiles from actual insulin analogs showing that 15 g of glucose increases blood glucose by ~ 1.5 mmol/L in 15 min. We aimed to explore the effect of current recommended treatment of mild-to-moderate hypoglycemia in type 1 diabetes (T1D) participants and factors associated with treatment effectiveness...
December 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29215299/complex-assessment-of-metabolic-effectiveness-of-insulin-pump-therapy-in-patients-with-type-2-diabetes-beyond-hba1c-reduction
#5
Rudolf Chlup, Sarah Runzis, Javier Castaneda, Scott W Lee, Xuan Nguyen, Ohad Cohen
BACKGROUND: This prospective single-center study recruited insulin-resistant continuous subcutaneous insulin infusion (CSII) therapy-naive patients with type 2 diabetes (T2D) using insulin analog-based multiple daily injections (MDI) therapy and metformin. METHODS: A total of 23 individuals with T2D (70% male), aged a mean ± standard deviation 57.2 ± 8.03 years, with body mass index of 36.2 ± 7.02 kg/m2, diabetes duration of 13.3 ± 4.64 years, and HbA1c of 10...
December 7, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29180640/young-onset-type-2-diabetic-patients-might-be-more-sensitive-to-metformin-compared-to-late-onset-type-2-diabetic-patients
#6
Feng-Fei Li, Bing-Li Liu, Guo-Ping Yin, Dan-Feng Zhang, Xiao-Fang Zhai, Mao-Yuan Chen, Xiao-Fei Su, Jin-Dan Wu, Lei Ye, Jian-Hua Ma
It is unknown whether YOD (young onset diabetes) and LOD (late onset diabetes) require similar insulin doses for intensive insulin therapy with a metformin add-on to achieve glycemic control. We analyzed data from our two previously performed randomized, controlled open-label trials. Patients were randomized to receive either continuous subcutaneous insulin infusion (CSII) therapy or CSII combined with metformin therapy for 4 weeks. The studies concentrated on the differences in the insulin doses used for the two groups...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29178356/effects-of-observing-normal-and-abnormal-goal-directed-hand-movements-on-somatosensory-cortical-activation
#7
Chia-Hsiung Cheng
Existing evidence indicates the importance of observing correct, normal actions on the motor cortical activities. However, the exact neurophysiological mechanisms, particularly in the somatosensory system, remain unclear. The present study aimed to elucidate the effects of observing normal and abnormal hand movements on the contralateral primary somatosensory (cSI), contralateral (cSII), and ipsilateral (iSII) secondary somatosensory activities. Experiment I was designed to investigate the effects of motor outputs on the somatosensory processing, in which subjects were instructed to relax or manipulate a small cube...
November 27, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29118986/sensor-augmented-csii-therapy-with-predictive-low-glucose-suspend-following-total-pancreatectomy
#8
E S Scott, G R Fulcher, R J Clifton-Bligh
Pancreatogenic diabetes is characterised by recurrent severe hypoglycaemia due to changes in both endocrine and exocrine functions. There are no guidelines to manage these individuals. Herein, we describe the post-operative management of two people who developed pancreatogenic diabetes following total pancreatectomy for neuroendocrine malignancy. In both individuals, diabetes was managed using sensor-augmented predictive low-glucose suspend continuous subcutaneous insulin infusion (CSII). We demonstrate the benefit of sensor-augmented CSII in averting hypoglycaemia whilst optimising glycaemic control...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29091477/evaluation-of-a-new-digital-automated-glycemic-pattern-detection-tool
#9
María José Comellas, Emma Albiñana, Maite Artes, Rosa Corcoy, Diego Fernández-García, Jorge García-Alemán, Beatriz García-Cuartero, Cintia González, María Teresa Rivero, Núria Casamira, Jörg Weissmann
BACKGROUND: Blood glucose meters are reliable devices for data collection, providing electronic logs of historical data easier to interpret than handwritten logbooks. Automated tools to analyze these data are necessary to facilitate glucose pattern detection and support treatment adjustment. These tools emerge in a broad variety in a more or less nonevaluated manner. The aim of this study was to compare eDetecta, a new automated pattern detection tool, to nonautomated pattern analysis in terms of time investment, data interpretation, and clinical utility, with the overarching goal to identify early in development and implementation of tool areas of improvement and potential safety risks...
November 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29077488/perspectives-on-long-distance-air-travel-with-type-1-diabetes
#10
Jordan E Pinsker, Benjamen E Schoenberg, Colleen Garey, Asher Runion, Arianna Larez, David Kerr
We sought to determine the real-life experiences of individuals traveling long distance (across five or more time-zones) with type 1 diabetes (T1D). Five hundred three members of the T1D Exchange online community ( www.myglu.org ) completed a 45-question survey about their travel experiences flying long distance. The cohort was stratified by duration of T1D and whether or not participants used continuous subcutaneous insulin infusion (CSII) therapy and/or a continuous glucose monitor (CGM). In the last 5 years, 71% of participants had flown long distance...
October 27, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29032696/impact-of-improving-postprandial-glycemic-control-with-intensifying-insulin-therapy-in-type-2-diabetes
#11
Tamer Yacoub
Worldwide, many people with type 2 diabetes are not at recommended glycemic targets and remain at increased risk of microvascular and macrovascular complications. Reaching recommended glycemic targets requires normalizing both fasting and postprandial glucose (PPG). For some patients, this will require addition of a prandial insulin delivered by injection to control PPG excursions. Evidence from epidemiological studies suggests an association between postprandial hyperglycemia and cardiovascular disease, and thus, expert guidelines recommend that treatment for elevated PPG not be delayed...
October 14, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28981324/detailed-analysis-of-insulin-absorption-variability-and-the-tissue-response-to-continuous-subcutaneous-insulin-infusion-catheter-implantation-in-swine
#12
Jasmin R Hauzenberger, Brian R Hipszer, Channy Loeum, Peter A McCue, Mark DeStefano, Marc C Torjman, Mahmut T Kaner, Alek R Dinesen, Inna Chervoneva, Thomas R Pieber, Jeffrey I Joseph
BACKGROUND: Worldwide, ∼1 million people manage their type 1 diabetes with an insulin pump and a continuous subcutaneous insulin infusion (CSII) catheter. Patients routinely insert a new catheter every 2-3 days due to increasing variability of insulin absorption over time. Catheter insertion and maintenance damage capillaries, lymphatics, cells, and connective tissue leading to an acute inflammatory response. METHODS: We compared an investigational CSII catheter (IC) and a commercial CSII catheter (CC) regarding insulin absorption pharmacokinetics (PK) and tissue inflammation...
November 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28976785/type-1-diabetes-and-long-term-continuous-subcutaneous-insulin-infusion-therapy-a-10-year-experience-from-macedonia
#13
Goran Petrovski, Marija Zivkovic, Slavica Subeska Stratrova, Biljana Jovanovska Todorova
BACKGROUND: Subcutaneous insulin infusion (CSII) therapy is a challenge for both patients and healthcare providers. The long-term CSII use is scarce. The aim of this study is to describe the impact of CSII therapy for 10 years of use at our center. METHODS: This single-center retrospective study includes 162 type 1 diabetes patients using CSII for >3 years during October 2004 until October 2014. Data were collected through the electronic medical record system, cross-sectional analysis (telephone, e-mail, or social media), and CSII reports generated by Carelink Therapy Management Software (Medtronic, Northridge, CA)...
October 4, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28951342/the-impact-of-ethnicity-educational-and-economic-status-on-the-prescription-of-insulin-therapeutic-regimens-and-on-glycemic-control-in-patients-with-type-1-diabetes-a-nationwide-study-in-brazil
#14
Marilia Brito Gomes, Melanie Rodacki, Elizabeth João Pavin, Roberta Arnoldi Cobas, João S Felicio, Lenita Zajdenverg, Carlos Antonio Negrato
AIMS: Establish the relationship between demographic, educational and economic status on insulin therapeutic regimens (ITRs) and on glycemic control in patients with type 1 diabetes. METHODS: This was a cross-sectional, multicenter study with 1760 patients conducted between August 2011 and August 2014 in 10 Brazilian cities. RESULTS: Patients were stratified according to ITRs as follows: only NPH insulin (group 1, n=80(4.5%)); only long-acting insulin analogs (group 2, n=6(0...
September 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28918652/investigation-of-pump-compatibility-of-fast-acting-insulin-aspart-in-subjects-with-type-1-diabetes
#15
Eric Zijlstra, Marek Demissie, Tina Graungaard, Tim Heise, Leszek Nosek, Bruce Bode
BACKGROUND: Ultra-fast-acting insulins, such as fast-acting insulin aspart (faster aspart), have pharmacokinetic properties that may be advantageous for patients using continuous subcutaneous insulin infusion (CSII), provided that they are compatible with and safe to use in CSII. METHODS: Randomized, double-blind, parallel-group, actively controlled trial evaluating compatibility, efficacy, and safety of faster aspart in adults with type 1 diabetes using their own MiniMed Paradigm pump with Quick-Set or Silhouette infusion sets...
September 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28913778/neural-basis-of-early-somatosensory-change-detection-a-magnetoencephalography-study
#16
G Naeije, T Vaulet, V Wens, B Marty, S Goldman, X De Tiège
The mismatch negativity (MMN) reflects the early detection of changes in sensory stimuli at the cortical level. The mechanisms underlying its genesis remain debated. This magnetoencephalography study investigates the spatio-temporal dynamics and the neural mechanisms of the magnetic somatosensory MMN. Somatosensory evoked magnetic fields elicited by tactile stimulation of the right fingertip (Single), tactile stimulation of the right middle phalanx and fingertip (Double) or omissions (Omitted) of tactile stimuli were studied in different paradigms: in oddballs where Double/Omitted followed a sequence of four Single, in sequences of two stimuli where Double occurred after one Single, and in random presentation of Double only...
September 14, 2017: Brain Topography
https://www.readbyqxmd.com/read/28902790/impact-of-treatments-on-diabetic-control-and-gastrointestinal-symptoms-after-total-pancreatectomy
#17
Maarten R Struyvenberg, Zhi Ven Fong, Camilia R Martin, Jennifer F Tseng, Thomas E Clancy, Carlos Fernández-Del Castillo, Hanna J Tillman, Melena D Bellin, Steven D Freedman
OBJECTIVES: The aims of this study were to compare the safety, efficacy, and patients' quality of life with continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDIs) in type 3c diabetes mellitus (T3cDM) following total pancreatectomy (TP) and pancreatic enzyme usage. METHODS: Thirty-nine patients with T3cDM (18 CSII patients vs 21 MDI patients) who underwent TP between 2000 and 2016 at 3 Harvard-affiliated hospitals and the University of Minnesota returned prospectively obtained questionnaires examining quality of life and both endocrine and exocrine pancreatic functions...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28898340/-from-insulin-pump-and-continuous-glucose-monitoring-to-the-artificial-pancreas
#18
REVIEW
Pamela Apablaza, Néstor Soto, Ethel Codner
Technology for diabetes care has undergone major development during recent decades. These technological advances include continuous subcutaneous insulin infusion (CSII), also known as insulin pumps, and real-time continuous glucose monitoring system (RT-CGMS). The integration of CSII and RT-CGMS into a single device has led to sensor-augmented pump therapy and more recently, a technology that has automated delivery of basal insulin therapy, known as hybrid system. These new technologies have led to benefits in attaining better metabolic control and decreasing the incidence of severe hypoglycemia, especially in patients with type 1 diabetes...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28880188/a-review-of-safety-and-hazards-associated-with-the-artificial-pancreas
#19
Charrise M Ramkissoon, Brian Aufderheide, B Wayne Bequette, Josep Vehi
The artificial pancreas (AP) is a closed-loop (CL) device with the potential to reduce the complications associated with type 1 diabetes mellitus (T1DM) by maintaining euglycemia in patients. The AP encompasses an algorithm that determines the amount of insulin (and other hormones) to be administered to the patient via a continuous subcutaneous insulin infusion (CSII) pump using information provided by a continuous glucose monitor (CGM) and other sensors. As the AP approaches commercialization special attention must be given to safety within all the individual components, including physiological changes in the patient, as well as, safety issues that can arise when these components are combined into a single system...
September 4, 2017: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/28871565/cost-effectiveness-analysis-of-sensor-augmented-insulin-pump-therapy-with-automated-insulin-suspension-versus-standard-insulin-pump-therapy-in-patients-with-type-1-diabetes-in-sweden
#20
Johan Jendle, Jayne Smith-Palmer, Alexis Delbaere, Simona de Portu, Natalie Papo, William Valentine, Stéphane Roze
INTRODUCTION: In Sweden an estimated 10,000 people with type 1 diabetes use continuous subcutaneous insulin infusion (CSII). Sensor-augmented pump therapy (SAP) is associated with higher acquisition costs but provides additional clinical benefits (e.g. reduced rate of hypoglycemic events) over and above that of CSII alone. The aim of the analysis was to assess the cost-effectiveness of SAP with automated insulin suspension relative to CSII alone in two different groups of patients with type 1 diabetes in Sweden...
October 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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