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Vulva and vaginal atrophy

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https://www.readbyqxmd.com/read/27896230/evaluation-of-symptoms-and-prevention-of-cancer-in-menopause-the-value-of-vulvar-exam
#1
A R Palumbo, C Fasolino, G Santoro, V Gargano, M Rinaldi, B Arduino, M Belli, M Guida
Vulvar and vaginal atrophy (VVA), is a chronic medical condition experienced by postmenopausal women, with prevalence estimated ranging from 10% to 50% [1]. VVA is characterized by a constellation of symptoms, that may affect daily activities, sexuality, relationships, and quality of life [3]. Early recognition and effective treatment of VVA may enhance sexual health and the quality of life of women and their partners. Some vulvar conditions such as lichen sclerosus are more prevalent in the postmenopausal years...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27830882/histological-changes-in-the-vulva-and-vagina-from-ovariectomised-rats-undergoing-oestrogen-treatment
#2
Radu Florin Mocan-Hognogi, Nicolae Costin, Andrei Malutan, Razvan Ciortea, Ioana Alexandra Trif, Andras Laszlo Nagy, Marian Liviu Bogdan, Dan Mihu
BACKGROUND: The purpose of this study was to assess the histological changes occurring in the vagina and vulva in ovariectomised female rats, as well as the response to the administration of injectable oestrogens. MATERIAL AND METHODS: We used 30 female Wistar white rats, distributed as follows: group 1 - the control group, group 2 - the operated but untreated rats, and groups 3, 4 and 5, operated rats, to which oestrogenic treatment was administered (Estradiol, Estradurin, Sintofolin), at a dosage of 0...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/26366797/treatment-of-the-genitourinary-syndrome-of-menopause
#3
S Palacios, A Mejía, J L Neyro
The vagina, vulva, vestibule, labia majora/minora, and bladder trigone have a high concentration of estrogen receptors; therefore, they are a sensitive biological indicator of serum levels of these hormones in women. The estrogen loss in postmenopausal women produces a dysfunction called genitourinary syndrome of menopause. The principal therapeutic goal in the genitourinary syndrome of menopause is to relieve symptoms. Treatment options, as well as local and systemic hormonal treatment are changes in lifestyle and non-hormonal treatments mainly based on the use of moisturizers and lubricants...
October 2015: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/26366796/the-urogenital-system-and-the-menopause
#4
J Calleja-Agius, M P Brincat
The major cause of urogenital atrophy in menopausal women is estrogen loss. The symptoms are usually progressive in nature and deteriorate with time from the menopausal transition. The most prevalent urogenital symptoms are vaginal dryness, vaginal irritation and itching. The genitourinary syndrome of menopause includes vulvovaginal atrophy and the postmenopausal modifications of the lower urinary tract. Dyspareunia and vaginal bleeding from fragile atrophic skin are common problems. Other urogenital complaints include frequency, nocturia, urgency, stress urinary incontinence and urinary tract infections...
October 2015: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/23383564/-local-estrogen-therapy-clinical-implications-2012-update
#5
REVIEW
Marta Kokot-Kierepa, Aleksandra Bartuzi, Beata Kulik-Rechberger, Tomasz Rechberger
With increasing longevity in Poland, women can now expect to live around 40% of their lives after menopause, and there is a growing desire for older women to preserve their vitality sexual function and quality of life. The most common urogenital symptoms associated with menopause are dryness, followed by irritation or itching, and discharge, with a substantial number of post-menopausal women also being affected by dysuria. These symptoms are the result of vaginal atrophy which is in turn caused by reduced transudation through the vaginal epithelium and reduced cervical gland secretions resulting from post-menopausal estrogen depletion...
October 2012: Ginekologia Polska
https://www.readbyqxmd.com/read/22853444/bazedoxifene-conjugated-estrogens-for-menopausal-symptom-treatment-and-osteoporosis-prevention
#6
REVIEW
J V Pinkerton, J H Pickar, J Racketa, S Mirkin
Postmenopausal women with vasomotor and vaginal symptoms are commonly treated with estrogens or combined estrogen/progestin therapy (hormone therapy). However, hormone therapy is associated with some safety and tolerability concerns and its benefit/risk profile may vary for women based on their time since menopause. The tissue selective estrogen complex (TSEC) pairs a selective estrogen receptor modulator with one or more estrogens, with the goal of relieving menopausal symptoms and preserving bone mineral density without stimulating the breast or endometrium...
October 2012: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/22011753/management-of-vulvovaginal-atrophy-related-sexual-dysfunction-in-postmenopausal-women-an-up-to-date-review
#7
REVIEW
Orkun Tan, Karen Bradshaw, Bruce R Carr
OBJECTIVE: Menopause and its transition represent significant risk factors for the development of vulvovaginal atrophy-related sexual dysfunction. The objective of this study was to review the hormonal and nonhormonal therapies available for postmenopausal women with vulvovaginal atrophy-related sexual dysfunction, focusing on practical recommendations through a literature review of the most relevant publications in this field. METHODS: This study is a literature review...
January 2012: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/21710922/vulvovaginal-atrophy-a-common-and-commonly-overlooked-problem
#8
Mary H Hohenhaus
No abstract text is available yet for this article.
May 2011: Medicine and Health, Rhode Island
https://www.readbyqxmd.com/read/21536225/treating-menopausal-symptoms-with-a-tissue-selective-estrogen-complex
#9
REVIEW
Jeffrey P Levine
Vasomotor symptoms and vulvar-vaginal atrophy are common consequences of menopause, and the only treatment approved by the US Food and Drug Administration is hormone therapy. Because both physicians and women are concerned with the tolerability and safety profile of estrogen and estrogen plus progestin treatments, alternative menopause therapies are needed. An ideal menopause treatment modality would relieve menopausal vasomotor and vulvar-vaginal symptoms, maintain bone mass, and have neutral or beneficial cardiovascular effects, without stimulating the breast or endometrium...
April 2011: Gender Medicine
https://www.readbyqxmd.com/read/20464782/selective-estrogen-receptor-modulators-and-vulvovaginal-atrophy-can-we-improve-the-lives-of-our-patients-with-new-therapeutic-options
#10
EDITORIAL
Lee P Shulman
No abstract text is available yet for this article.
May 2010: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/20429673/pharmacologic-evaluation-of-ospemifene
#11
REVIEW
Jamie L McCall, Michael W DeGregorio
IMPORTANCE OF THE FIELD: Millions of women worldwide suffer from vulvovaginal atrophy (VVA) associated with menopause, and many women report that this adversely affects their quality of life. Ospemifene is a non-hormonal estrogen receptor agonist/antagonist effective in the treatment of VVA. Although similar in structure to other estrogen receptor agonists/antagonists that have antagonistic effects on the vagina, ospemifene has an estrogen-like effect on vaginal epithelium. This review focuses on ospemifene including its pharmacologic properties, clinical efficacy and safety...
June 2010: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/20156082/recognizing-and-treating-urogenital-atrophy-in-postmenopausal-women
#12
Irwin Goldstein
Urogenital atrophy resulting from postmenopausal estrogen deficiency has numerous clinical effects, including vaginal dryness, sexual dysfunction, urinary incontinence, and recurrent urinary tract infections (UTIs), all of which can cause significant distress and reduction in quality of life. Although nearly one third to one half of postmenopausal women experience these symptoms, they are often overlooked because patients may be reluctant to discuss them and clinicians fail to screen for them. As these symptoms are unlikely to resolve without treatment, the prompt diagnosis and treatment of urogenital atrophy is essential...
March 2010: Journal of Women's Health
https://www.readbyqxmd.com/read/20032798/ospemifene-effectively-treats-vulvovaginal-atrophy-in-postmenopausal-women-results-from-a-pivotal-phase-3-study
#13
RANDOMIZED CONTROLLED TRIAL
Gloria A Bachmann, Janne O Komi et al.
OBJECTIVE: The aim of this study was to study the efficacy and safety of ospemifene, a new selective estrogen receptor modulator, in the treatment of vulvovaginal atrophy in postmenopausal women. METHODS: A randomized, double-blind phase 3 study in which 826 postmenopausal women were randomized 1:1:1 to receive treatment with ospemifene 30 or 60 mg/day or placebo orally for 12 weeks was conducted. The primary inclusion criteria were having 5% or less superficial cells on the vaginal smear (maturation index), vaginal pH greater than 5...
May 2010: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/19863455/effects-of-bazedoxifene-conjugated-estrogens-on-quality-of-life-in-postmenopausal-women-with-symptoms-of-vulvar-vaginal-atrophy
#14
RANDOMIZED CONTROLLED TRIAL
G Bachmann, J Bobula, S Mirkin
OBJECTIVE: To evaluate the effects of the tissue selective estrogen complex (TSEC) pairing bazedoxifene (BZA) with conjugated estrogens (CE) on sexual function and quality of life in postmenopausal women. METHODS: In this 12-week, double-blind, placebo-controlled study, postmenopausal, non-hysterectomized women (n = 652) with symptoms of moderate to severe vulvar/vaginal atrophy were randomized to once-daily treatment with BZA 20 mg/CE 0.45 or 0.625 mg, BZA 20 mg, or placebo...
April 2010: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/19779382/a-randomized-placebo-and-active-controlled-trial-of-bazedoxifene-conjugated-estrogens-for-treatment-of-moderate-to-severe-vulvar-vaginal-atrophy-in-postmenopausal-women
#15
RANDOMIZED CONTROLLED TRIAL
Risa Kagan, R Stan Williams, Kaijie Pan, Sebastian Mirkin, James H Pickar
OBJECTIVES: The primary objective of the Selective estrogen Menopause And Response to Therapy 3 (SMART-3) trial was to compare the efficacy and safety of two doses of bazedoxifene (BZA)/conjugated estrogens (CE) versus placebo for the treatment of moderate to severe vulvar/vaginal atrophy (VVA) associated with menopause. METHODS: This was a phase 3, multicenter, double-blind, randomized, placebo-controlled, and active comparator-controlled study. Healthy postmenopausal women (n = 664; aged 40-65 y) were randomized to BZA 20 mg/CE 0...
March 2010: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/19493278/prevalence-and-impact-of-vaginal-symptoms-among-postmenopausal-women
#16
Nanette Santoro, Janne Komi
INTRODUCTION: Vulvovaginal atrophy (VVA) is reported by one-quarter to one-half of postmenopausal women. AIM: We evaluated the prevalence, inconvenience of, and issues surrounding hormone use for VVA symptoms in women who were current, past, and never users of menopausal hormone therapy (MHT), along with the relationship of sexual activity to VVA symptoms. METHODS: An online survey was sent to 3,471 women >or=45 years old participating in a panel of approximately 43,000 U...
August 2009: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/19466874/ospemifene-use-in-postmenopausal-women
#17
REVIEW
Luigi Gennari, Daniela Merlotti, Fabrizio Valleggi, Ranuccio Nuti
BACKGROUND: Selective estrogen receptor modulators (SERMs) are structurally different compounds that interact with intracellular estrogen receptors in target organs as estrogen agonists and antagonists. These drugs have been intensively studied over the past decades and have proven to be a highly versatile group for the treatment of different conditions associated with menopause, including hormone-responsive cancer and osteoporosis. However, currently available SERMS are also responsible for side effects such as thromboembolic disorders, or gynecological symptoms (especially vaginal dryness and hot flushes)...
June 2009: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/19458560/microdose-transdermal-estrogen-therapy-for-relief-of-vulvovaginal-symptoms-in-postmenopausal-women
#18
RANDOMIZED CONTROLLED TRIAL
Gloria A Bachmann, Matthias Schaefers, Alkaz Uddin, Wulf H Utian
OBJECTIVE: The aim of this study was to investigate the effectiveness of microdose transdermal 17beta-estradiol (E2) therapy in postmenopausal women with moderate to severe vulvovaginal symptoms. METHODS: This report is based on a subset of 121 women who reported most bothersome moderate or severe vulvovaginal symptoms at baseline, from a previous randomized, double-blind, placebo-controlled, multicenter study of 425 healthy, symptomatic, postmenopausal women. Recruits had experienced at least 7 moderate or severe hot flushes daily for at least 1 week or at least 50 moderate or severe hot flushes per week for at least 1 week...
September 2009: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/19387880/urogenital-atrophy
#19
REVIEW
J Calleja-Agius, M P Brincat
The major cause of urogenital atrophy in menopausal women is estrogen loss. The symptoms are usually progressive in nature and deteriorate with time from the menopausal transition. The most prevalent urogenital symptoms are vaginal dryness, vaginal irritation and itching. The classical changes in an atrophic vulva include loss of labial and vulvar fullness, with narrowing of the introitus and inflamed mucosal surfaces. Dyspareunia and vaginal bleeding from fragile atrophic skin are common problems. Other urogenital complaints include frequency, nocturia, urgency, incontinence and urinary tract infections...
August 2009: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/19229162/conjugated-estrogens-premarin-vaginal-cream
#20
(no author information available yet)
An old conjugated estrogens vaginal cream (Premarin Vaginal Cream--Wyeth) has been newly approved by the FDA specifically for treatment of moderate to severe dyspareunia due to vulvar and vaginal atrophy associated with menopause. Synthetic conjugated estrogens A vaginal cream (Barr) has also been approved for this indication, but has not yet been marketed.
February 23, 2009: Medical Letter on Drugs and Therapeutics
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