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https://www.readbyqxmd.com/read/28812438/acute-formaldehyde-exposure-induced-early-alzheimer-like-changes-in-mouse-brain
#1
Xudong Liu, Yuchao Zhang, Ruliu Wu, Meng Ye, Yuqing Zhao, Jun Kang, Ping Ma, Jinquan Li, Xu Yang
Alzheimer's disease (AD) is a serious, common, global disease, yet its etiology and pathogenesis are incompletely understood. Although an association between AD and exposure to air pollutants has been discussed, the effects of pollutants on the functioning of the brain remain unclear. The indoor environment is where exposure to formaldehyde (FA) can occur. Whether exposure to FA contributes to the development of AD needs to be investigated. To determine the objective, C57BL/6 mice were exposed daily to FA (0, 0...
August 16, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28810560/effects-of-taohongsiwu-decoction-on-the-expression-of-%C3%AE-sma-and-tgf-%C3%AE-1-mrna-in-the-liver-tissues-of-a-rat-model-of-hepatic-cirrhosis
#2
Tongsheng Wang, Deling Wu, Peipei Li, Ke Zhang, Shanjun Tao, Zhu Li, Jun Li
The present study aimed to explore the treatment effects of Taohongsiwu decoction on the liver fibrosis in a rat model, as few prior studies have investigated the anti-fibrotic effects of Taohongsiwu decoction. High-performance liquid chromatography was used to measure the concentration of ferulic acid and hydrosafflower flavin A in the decoction. Male Sprague-Dawley rats were randomly divided into control, model, colchicine (positive group), Taohongsiwu-high, Taohongsiwu-moderate and Taohongsiwu-low groups; 50% carbon tetrachloride (CCl4) of peanut oil solution was subcutaneously injected to the rats except for the control group, and the drugs were intragastrically administered (10 ml/kg) starting at week 7 for 6 continuous weeks...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808972/chromosome-conformation-capture-for-research-on-innate-antiviral-immunity
#3
Yoon Jung Kim, Tae Hoon Kim
Chromosome conformation capture (3C) technology has revolutionized our knowledge on chromatin folding and nuclear organization. This cis-loop detection approach can be used to identify candidate regulatory elements interacting with target gene of interest. This chapter introduces the application of 3C technique to investigate a dynamic alteration in the chromosome folding structure or genomic architecture resulting from interaction changes between the enhancer and its target gene. Innate antiviral immunity is one of the well-known gene induction systems, involving rapid first-line response to virus or pathogen to trigger gene expression changes in order to protect cells and to limit further infection...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28808738/formaldehyde-passive-sampler-using-an-optical-chemical-sensor-how-to-limit-the-humidity-interference
#4
Jane Vignau-Laulhere, Pierre Mocho, Hervé Plaisance, Katarzyna Raulin-Woznica, Thu-Hoa Tran-Thi, Valérie Desauziers
The behaviour of a new formaldehyde diffusive sampler using an optical chemical sensor with respect to high humidity conditions is examined in controlled atmospheres. Five prototypes of the radial diffusion sampler having the same chemical sensor and different designs were tested. In addition, a set of experiments were performed on the chemical sensor to characterise its efficiency of trapping water vapour in the absence and in the presence of the reactants, Fluoral-P and formaldehyde. Differences in humidity interference between the five diffusive sampler prototypes were studied and discussed...
August 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28805371/wavelength-resolved-photon-fluxes-of-indoor-light-sources-implications-for-hox-production
#5
Shawn Finley Kowal, Seth Robert Allen, Tara F Kahan
Photochemistry is a largely-unconsidered potential source of reactive species such as hydroxyl and peroxy radicals (OH and HO2, "HOx") indoors. We present measured wavelength-resolved photon fluxes and distance dependences of indoor light sources including halogen, incandescent, and compact fluorescent lights (CFL) commonly used in residential buildings; fluorescent tubes common in industrial and commercial settings; and sunlight entering buildings through windows. We use these measurements to predict indoor HOx production rates from the photolysis of nitrous acid (HONO), hydrogen peroxide (H2O2), ozone (O3), formaldehyde (HCHO) and acetaldehyde (CH3CHO)...
August 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28805226/the-reaction-of-criegee-intermediate-ch2oo-with-water-dimer-primary-products-and-atmospheric-impact
#6
Leonid Sheps, Brandon Rotavera, Arkke J Eskola, David L Osborn, Craig A Taatjes, Kendrew Au, Dudley E Shallcross, M Anwar H Khan, Carl J Percival
The rapid reaction of the smallest Criegee intermediate, CH2OO, with water dimers is the dominant removal mechanism for CH2OO in the Earth's atmosphere, but its products are not well understood. This reaction was recently suggested as a significant source of the most abundant tropospheric organic acid, formic acid (HCOOH), which is consistently underpredicted by atmospheric models. However, using time-resolved measurements of reaction kinetics by UV absorption and product analysis by photoionization mass spectrometry, we show that the primary products of this reaction are formaldehyde and hydroxymethyl hydroperoxide (HMHP), with direct HCOOH yields of less than 10%...
August 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28802526/sodium-hyaluronate-functionalized-urea-formaldehyde-monolithic-column-for-hydrophilic-in-tube-solid-phase-microextraction-of-melamine
#7
Jiabin Wang, Nan Jiang, Zhengmiao Cai, Wenbang Li, Jianhua Li, Xucong Lin, Zenghong Xie, Lijun You, Qiqing Zhang
A novel sodium hyaluronate-functionalized urea-formaldehyde (UF) monolithic column has been developed by in-situ polycondensation of urea, formaldehyde and sodium hyaluronate (HA). HA plays both the roles of crosslinking and hydrophilic functionalization. The preparation factors including different molecular weights of HA and different amounts of HA were optimized, and then a uniform monolith with satisfactory permeability and hydrophilic binding capacity was obtained. Due to the excellent hydrophilicity of HA, HA-functionalized UF monolith showed higher hydrophilic extraction efficiency than UF monolith, and was applied for hydrophilic in-tube solid-phase microextraction (SPME) of melamine (MEL)...
August 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28799678/processing-and-characterization-of-canine-mixed-mammary-tumor-using-transmission-electron-microscopy
#8
Beltrán Audrey, Debut Alexis, Vaca Andrea, Ortiz Julio, Proaño-Pérez Freddy
Canine mammary gland tumors represent the second most frequent type of neoplasm in dogs, being an important problem within veterinary medical field. Canine mixed mammary tumors are the most common; the use of a transmission electron microscope (TEM) can contribute as a tool in its diagnosis by determining the characteristics of cellular components from numerous neoplasms. The aim of this study was to characterize cytologically canine mammary mixed tumor by the use of the TEM. A biopsy collected from an 11 years old bitch Shih-Tzu and analyzed by histopathology was used for ultrastructural analysis...
August 11, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28798007/industrial-pollutants-and-nasopharyngeal-cancer-an-open-question
#9
Roberto Menicagli, Gianni Bolla, Laura Menicagli, Anastassia Esseiridou
INTRODUCTION AND OBJECTIVES: Nasopharyngeal Carcinoma represents 0.7% of the total cancer cases in the world with an ASR index of 1.7 and is widely associated with Epstein-Barr virus. It is not common in Italy (ASR index of 0.5) while in China (ASR 1.9), one third of the clinical cases are observed in Guangdong (ASR index 11.3). It is also quite common in Malaysia and Indonesia. The activation of the cancerogenesis process happens after the exposure to some environmental parameters that epidemiological studies have indicated with various dietary habits, mainly for salted fish consumption...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28796828/acid-free-glyoxal-as-a-substitute-of-formalin-for-structural-and-molecular-preservation-in-tissue-samples
#10
Gianni Bussolati, Laura Annaratone, Enrico Berrino, Umberto Miglio, Mara Panero, Marco Cupo, Patrizia Gugliotta, Tiziana Venesio, Anna Sapino, Caterina Marchiò
Tissue fixation in phosphate buffered formalin (PBF) remains the standard procedure in histopathology, since it results in an optimal structural, antigenic and molecular preservation that justifies the pivotal role presently played by diagnoses on PBF-fixed tissues in precision medicine. However, toxicity of formaldehyde causes an environmental concern and may demand substitution of this reagent. Having observed that the reported drawbacks of commercially available glyoxal substitutes of PBF (Prefer, Glyo-fix, Histo-Fix, Histo-CHOICE, and Safe-Fix II) are likely related to their acidity, we have devised a neutral fixative, obtained by removing acids from the dialdehyde glyoxal with an ion-exchange resin...
2017: PloS One
https://www.readbyqxmd.com/read/28795574/molecularly-imprinted-porous-monolithic-materials-from-melamine-formaldehyde-for-selective-trapping-of-phosphopeptides
#11
Mingquan Liu, Tri Minh Tran, Ahmed Awad Abbas Elhaj, Silje Bøen Torsetnes, Ole Nørregaard Jensen, Börje Sellergren, Knut Irgum
Thirty-five melamine-formaldehyde (MF) monolithic materials with bimodal pore distributions were synthesized in fused silica capillaries by catalyst-free polycondensation, starting with an aqueous MF precondensate, using acetonitrile as macroporogen and a variety of aliphatic polyethers and triblock copolymeric surfactants as porogens and mesoporogens, respectively. By varying the prepolymer composition and the type and molecular weights of the polymeric porogen components, a library of porous monolithic materials were produced, covering a range of meso- and macroporous properties...
August 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28795241/papillomavirus-genotyping-on-formaldehyde-fixed-paraffin-embedded-tissues-in-vulvar-intraepithelial-neoplasia
#12
S Mazellier, B Dadone-Montaudie, A Chevallier, C Loubatier, S Vitale, N Cardot-Leccia, K Angeli, C Trastour, J Delotte, V Giordanengo, D Ambrosetti
PURPOSE: Few studies have described the epidemiology of human papillomavirus (HPV) in vulvar intraepithelial neoplasia (VIN). The aim of this study was to genotype HPV on formalin fixed paraffin-embedded tissues in VIN lesions. METHODS: A 5-year retrospective study was conducted by including all patients attending the teaching hospital of Nice with a diagnosis of VIN between 1st January 2010 and 31st December 2014. For all patients, HPV genotyping was performed with the PapilloCheck(®) microarray kit, routinely used on cervical cytology samples, and optimized for formaldehyde fixed paraffin-embedded tissues in VIN...
August 9, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28793761/miniaturized-thermal-assisted-purge-and-trap-technique-coupling-with-surface-enhanced-raman-scattering-for-trace-analysis-of-complex-samples
#13
Zhengyi Chen, Gongke Li, Zhuomin Zhang
It still remains a great challenge for quantification of trace analytes in complex samples by surface-enhanced Raman scattering (SERS) technique due to potential matrix influence or weak SERS responses of analytes. In this work, a miniaturized thermal-assisted purge-and-trap (MTAPT) device was designed and developed to eliminate matrix influence coupled with derivatization method before SERS analysis. The design of MTAPT chamber was optimized based on quantitative calculation of its dead volume by computational fluid dynamics simulation...
August 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28792433/electrospinning-hetero-nanofibers-in%C3%A2-o%C3%A2-sno%C3%A2-of-homotype-heterojunction-with-high-gas-sensing-activity
#14
Haiying Du, PengJun Yao, Yanhui Sun, Jing Wang, Huisheng Wang, Naisen Yu
In₂O₃/SnO₂ composite hetero-nanofibers were synthesized by an electrospinning technique for detecting indoor volatile organic gases. The physical and chemical properties of In₂O₃/SnO₂ hetero-nanofibers were characterized and analyzed by X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), Energy Dispersive X-Ray Spectroscopy (EDX), specific surface Brunauer-Emmett-Teller (BET) and X-ray photoelectron spectroscopy (XPS). Gas sensing properties of In₂O₃/SnO₂ composite hetero-nanofibers were measured with six kinds of indoor volatile organic gases in concentration range of 0...
August 9, 2017: Sensors
https://www.readbyqxmd.com/read/28789553/rrkm-and-master-equation-kinetic-analysis-of-parallel-addition-reactions-of-isomeric-radical-intermediates-in-hydrocarbon-flames
#15
Pierre M Winter, Michael Rheaume, Andrew L Cooksy
We have calculated the temperature-dependent rate coefficients of the addition reactions of butadien-2-yl (C4H5) and acroylyl (C3H3O) radicals with ethene (C2H4), carbon monoxide (CO), formaldehyde (H2CO), hydrogen cyanide (HCN), and ketene (H2CCO), in order to explore the balance between kinetic and thermodynamic control in these combustion-related reactions. For the C4H5 radical, the 1,3-diene form of the addition products is more stable than the 1,2-diene, but the 1,2-diene form of the radical intermediate is stabilized by an allylic delocalization, which may influence the relative activation energies...
August 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28783598/economic-human-and-environmental-health-benefits-of-replacing-formaldehyde-in-the-preservation-of-corpses
#16
Jussara Rocha Ferreira, Lorenna Cardoso Rezende, Abel De Souza Barbosa, Phellip De Carvalho, Natácia Evangelista De Lima, Alexandre Assis Carvalho
Formaldehyde has been prominent in preserving biological tissues since the nineteenth century. Despite being admittedly harmful to health and to the environment, it is still widely used. The Morphology Department of the University of Brasília - Brazil, applied the rethink, reduce, reuse, recycle and responsibility methodology to their activities in an effort to protect the health of laboratory workers and users, save resources and reduce damage to the environment. Here we evaluate the results obtained a decade after the implementation of this proposal (2005-2015)...
August 4, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28777534/poly-4-vinylphenol-pvp-and-poly-melamine-co-formaldehyde-pmf-based-atomic-switching-device-and-its-application-to-logic-gate-circuits-with-low-operating-voltage
#17
Dong-Ho Kang, Woo-Young Choi, Hyunsuk Woo, Sungkyu Jang, Hyung-Youl Park, Jaewoo Shim, Jae-Woong Choi, Sungho Kim, Sanghun Jeon, Sungjoo Lee, Jin-Hong Park
In this study, we demonstrate a high-performance solid polymer electrolyte (SPE) atomic switching device with low SET/RESET voltages (0.25 and -0.5 V, respectively), high on/off-current ratio (10(5)), excellent cyclic endurance (>10(3)), and long retention time (>10(4) s), where poly-4-vinylphenol (PVP)/poly(melamine-co-formaldehyde) (PMF) is used as an SPE layer. To accomplish these excellent device performance parameters, we reduce the off-current level of the PVP/PMF atomic switching device by improving the electrical insulating property of the PVP/PMF electrolyte through adjustment of the number of cross-linked chains...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28774612/biomarkers-of-end-of-shift-exposure-to-disinfection-byproducts-in-nurses
#18
Solomon Ioannou, Xanthi D Andrianou, Pantelis Charisiadis, Konstantinos C Makris
Increased disinfectant use commonly takes place in hospitals and other health care settings. A cross-sectional study among active nurses in two Cypriot public hospitals (n=179) was conducted to examine the prevalence of exposure to disinfection byproducts (DBPs), such as trihalomethanes (THMs) using both self-reported information and biomarker measurements. The objectives of this study were to: i) quantify the magnitude and variability of occupational exposure to disinfectants/DBPs in nurses, ii) generate job exposure matrices (JEM) and job task exposure matrices (JTEM) for disinfectants, and iii) assess the major determinants of urinary THMs in nurses...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28774144/micromechanical-properties-of-a-new-polymeric-microcapsule-for-self-healing-cementitious-materials
#19
Leyang Lv, Erik Schlangen, Zhengxian Yang, Feng Xing
Self-healing cementitious materials containing a microencapsulated healing agent are appealing due to their great application potential in improving the serviceability and durability of concrete structures. In this study, poly(phenol-formaldehyde) (PF) microcapsules that aim to provide a self-healing function for cementitious materials were prepared by an in situ polymerization reaction. Size gradation of the synthesized microcapsules was achieved through a series of sieving processes. The shell thickness and the diameter of single microcapsules was accurately measured under environmental scanning electron microscopy (ESEM)...
December 20, 2016: Materials
https://www.readbyqxmd.com/read/28774009/fabrication-of-glass-fiber-reinforced-composites-based-on-bio-oil-phenol-formaldehyde-resin
#20
Yong Cui, Jianmin Chang, Wenliang Wang
In this study, bio-oil from fast pyrolysis of renewable biomass was added by the mass of phenol to synthesize bio-oil phenol formaldehyde (BPF) resins, which were used to fabricate glass fiber (GF) reinforced BPF resin (GF/BPF) composites. The properties of the BPF resin and the GF/BPF composites prepared were tested. The functional groups and thermal property of BPF resin were thoroughly investigated by Fourier transform infrared (FTIR) spectra and dynamic thermomechanical analysis (DMA). Results indicated that the addition of 20% bio-oil exhibited favorable adaptability for enhancing the stiffness and heat resistance of phenol formaldehyde (PF) resin...
November 1, 2016: Materials
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