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postoperative cognitive decline

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https://www.readbyqxmd.com/read/28911287/effect-of-sugammadex-versus-neostigmine-atropine-combination-on-postoperative-cognitive-dysfunction-after-elective-surgery
#1
C Batistaki, M Riga, F Zafeiropoulou, G Lyrakos, G Kostopanagiotou, P Matsota
This study aimed to assess the effects of sugammadex and neostigmine/atropine on postoperative cognitive dysfunction (POCD) in adult patients after elective surgery. A randomised, double-blind controlled trial was carried out on 160 American Society of Anesthesiologists physical status I to III patients who were >40 years. The Mini-Mental State Evaluation, clock-drawing test and the Isaacs Set test were used to assess cognitive function at three timepoints: 1) preoperatively, 2) one hour postoperatively, and 3) at discharge...
September 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28890320/neuropsychologist-s-re-view-resective-versus-ablative-amygdalohippocampectomies
#2
REVIEW
Juri-Alexander Witt, Christian Hoppe, Christoph Helmstaedter
Pharmacoresistant mesial temporal lobe epilepsy (mTLE) represents the major indication for epilepsy surgery. Since epilepsy surgery is an elective treatment option, preserving cognition is a high priority. Given the essential role of temporomesial structures in declarative long-term memory formation, surgical treatment for mTLE is primarily associated with a risk of material-specific memory decline, but other cognitive domains may be affected as well. The major determinants for the neuropsychological outcome are the functional integrity of surgically affected tissues, the functional reserve capacities of the remnant brain, the postoperative seizure outcome, as well as the quantitative and qualitative changes of antiepileptic drugs...
September 1, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28881691/critical-role-of-matrix-metallopeptidase-9-in-postoperative-cognitive-dysfunction-and-age-dependent-cognitive-decline
#3
Jiangjiang Bi, Weiran Shan, Ailin Luo, Zhiyi Zuo
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome. Neuroinflammation is an important pathological process for POCD. However, it is not clear how systemic inflammation induced by surgery on peripheral tissues or organs is transmitted into the brain. We determined whether matrix metallopeptidase 9 (MMP9), a protein that can increase blood-brain barrier permeability, is critical in this transmission. The role of MMP9 in age-dependent cognitive decline was also determined...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28854542/association-between-delirium-and-cognitive-change-after-cardiac-surgery
#4
A C Sauër, D S Veldhuijzen, T H Ottens, A J C Slooter, C J Kalkman, D van Dijk
Background: Previous studies provide inconsistent data on whether postoperative delirium (POD) is a risk factor for postoperative cognitive decline (POCD). We thus investigated the relationship between POD and cognitive change after cardiac surgery and assessed the relationship between preoperative cognitive domain scores and POD. Methods: Postoperative delirium was assessed with the Confusion Assessment Method (CAM) adapted for the intensive care unit and the conventional CAM accompanied by chart review...
August 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28854532/association-of-intraoperative-changes-in-brain-derived-neurotrophic-factor-and-postoperative-delirium-in-older-adults
#5
J Wyrobek, A LaFlam, L Max, J Tian, K J Neufeld, K M Kebaish, J D Walston, C W Hogue, L H Riley, A D Everett, C H Brown
Background: Delirium is common after surgery, although the aetiology is poorly defined. Brain-derived neurotrophic factor (BDNF) is a neurotrophin important in neurotransmission and neuroplasticity. Decreased levels of BDNF have been associated with poor cognitive outcomes, but few studies have characterized the role of BDNF perioperatively. We hypothesized that intraoperative decreases in BDNF levels are associated with postoperative delirium. Methods: Patients undergoing spine surgery were enrolled in a prospective cohort study...
August 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28851286/influence-of-the-postoperative-inflammatory-response-on-cognitive-decline-in-elderly-patients-undergoing-on-pump-cardiac-surgery-a-controlled-prospective-observational-study
#6
Endre Nemeth, Katalin Vig, Kristof Racz, Kinga B Koritsanszky, Klara I Ronkay, Fumiko P Hamvas, Csaba Borbély, Ajandek Eory, Bela Merkely, Janos Gal
BACKGROUND: The role of non-infective inflammatory response (IR) in the aetiology of postoperative cognitive dysfunction (POCD) is still controversial. The aim of this controlled, prospective observational study was to assess the possible relationship between the grade of IR, defined by procalcitonin (PCT) changes, and development of POCD related to cardiac surgery. METHODS: Forty-two patients, who were ≥ 60 years of age and scheduled for elective cardiac surgery, were separated into the low inflammatory (LIR) and high inflammatory (HIR) response groups based on their PCT levels measured on the first postoperative day...
August 29, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28816833/perioperative-use-of-erythromycin-reduces-cognitive-decline-after-coronary-artery-bypass-grafting-surgery-a-pilot-study
#7
Evanthia Thomaidou, Helena Argiriadou, Georgios Vretzakis, Kalliopi Megari, Nikolaos Taskos, Georgios Chatzigeorgiou, Kyriakos Anastasiadis
OBJECTIVES: Adverse neurologic outcome can be a debilitating complication after cardiac surgery. The aim of this study was to investigate the potential neuroprotective action of erythromycin, a well known antibiotic agent, regarding postoperative cognitive decline in patients undergoing cardiac surgery. METHODS: Forty patients scheduled for elective coronary artery bypass grafting surgery were prospectively randomly assigned in 2 groups: the erythromycin group (n = 19) who received erythromycin at a dose of 25 mg/kg before and after surgery and the control group (n = 21) who did not receive it...
September 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28802800/state-of-the-art-and-promise-of-structural-neuroimaging-in-postoperative-delirium-and-postoperative-cognitive-decline
#8
EDITORIAL
Michele Cavallari, Charles R G Guttmann, Sharon K Inouye, David C Alsop
No abstract text is available yet for this article.
July 14, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28802070/memantine-for-the-treatment-of-general-neuropathic-pain-a-narrative-review
#9
REVIEW
Gisèle Pickering, Véronique Morel
Neuropathic pain (NP) is difficult to treat and is associated with a decline in quality of life. NP aetiologies are numerous and a number of pathologies display neuropathic characteristics. Of the various N-Methyl-D-Aspartate antagonists that are alternatives to recommended in first-line NP treatment, memantine has the safest side-effect profile and has long been approved in Alzheimer's disease. The review covers memantine studies in post-herpetic neuralgia, diabetic pain, postoperative pain, complex regional pain syndrome, chronic phantom limb pain, opioid refractory pain, and fibromyalgia...
August 12, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28782464/nimodipine-activates-neuroprotective-signaling-events-and-inactivates-autophages-in-the-vcid-rat-hippocampus
#10
Ming Hu, Zhijuan Liu, Peiyuan Lv, Hebo Wang, Yifei Zhu, Qianqian Qi, Jing Xu, Lei Gao
BACKGROUND: Autophagy and phosphatidylinositol 3-kinase (PI3K)/Akt kinase pathways are implicated in cognitive decline associated with cerebrovascular lesions. This decline is reflected in the concept of vascular cognitive impairment and dementia (VCID). However, the underlying molecular mechanism and specific details regarding these types of cognitive deficits induced by chronic brain hypoperfusion have not been elucidated. METHODS: We designed a method to evaluate these mechanisms...
August 7, 2017: Neurological Research
https://www.readbyqxmd.com/read/28760515/mri-markers-of-neurodegenerative-and-neurovascular-changes-in-relation-to-postoperative-delirium-and-postoperative-cognitive-decline
#11
REVIEW
Ilse M J Kant, Jeroen de Bresser, Simone J T van Montfort, Arjen J C Slooter, Jeroen Hendrikse
Postoperative delirium (POD) and postoperative cognitive decline (POCD) are common in elderly patients. The aim of the present review was to explore the association of neurodegenerative and neurovascular changes with the occurrence of POD and POCD. Fifteen MRI studies were identified by combining multiple search terms for POD, POCD, and brain imaging. These studies described a total of 1,422 patients and were all observational in design. Neurodegenerative changes (global and regional brain volumes) did not show a consistent association with the occurrence of POD (four studies) or POCD (two studies)...
June 28, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28752905/the-quality-of-life-of-patients-developed-delirium-after-coronary-artery-bypass-grafting-is-determined-by-cognitive-function-after-discharge-a-cross-sectional-study
#12
Yuling Chen, Shu Ding, Xiangjun Tao, Xinwei Feng, Sai Lu, Yuzhi Shen, Ying Wu, Xiangguang An
AIMS: Postoperative delirium (POD) and declined cognitive function were common in patients (especially elderly patients) who underwent coronary artery bypass grafting (CABG), which may affect quality of life (QoL). The aim of this study was to determine the relationships among age, POD, declined cognitive function, and QoL in patients who underwent CABG. METHODS: Consecutive patients who underwent first time elective CABG and assessed for POD using Confusion Assessment Method for intensive care unit for 5 postoperative days from November 2013 to March 2015 were recruited...
July 28, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28717525/differential-effects-of-awake-glioma-surgery-in-critical-language-areas-on-cognition-4-case-studies
#13
Djaina Satoer, Elke De Witte, Marion Smits, Roelien Bastiaanse, Arnaud Vincent, Peter Mariën, Evy Visch-Brink
Awake surgery with electrocorticosubcortical stimulation is the golden standard treatment for gliomas in eloquent areas. Preoperatively, mostly mild cognitive disturbances are observed with postoperative deterioration. We describe pre- and postoperative profiles of 4 patients (P1-P4) with gliomas in "critical" language areas ("Broca," "Wernicke," and the arcuate fasciculus) undergoing awake surgery to get insight into the underlying mechanism of neuroplasticity. Neuropsychological examination was carried out preoperatively (at T1) and postoperatively (at T2, T3)...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28700610/perioperative-hemodynamics-and-risk-for-delirium-and-new-onset-dementia-in-hip-fracture-patients-a-prospective-follow-up-study
#14
Bjørn Erik Neerland, Maria Krogseth, Vibeke Juliebø, Anette Hylen Ranhoff, Knut Engedal, Frede Frihagen, Johan Ræder, Torgeir Bruun Wyller, Leiv Otto Watne
BACKGROUND: Delirium is common in hip fracture patients and many risk factors have been identified. Controversy exists regarding the possible impact of intraoperative control of blood pressure upon acute (delirium) and long term (dementia) cognitive decline. We explored possible associations between perioperative hemodynamic changes, use of vasopressor drugs, risk of delirium and risk of new-onset dementia. METHODS: Prospective follow-up study of 696 hip fracture patients, assessed for delirium pre- and postoperatively, using the Confusion Assessment Method...
2017: PloS One
https://www.readbyqxmd.com/read/28687377/postoperative-stereotactic-radiosurgery-compared-with-whole-brain-radiotherapy-for-resected-metastatic-brain-disease-ncctg-n107c-cec%C3%A2-3-a-multicentre-randomised-controlled-phase-3-trial
#15
Paul D Brown, Karla V Ballman, Jane H Cerhan, S Keith Anderson, Xiomara W Carrero, Anthony C Whitton, Jeffrey Greenspoon, Ian F Parney, Nadia N I Laack, Jonathan B Ashman, Jean-Paul Bahary, Costas G Hadjipanayis, James J Urbanic, Fred G Barker, Elana Farace, Deepak Khuntia, Caterina Giannini, Jan C Buckner, Evanthia Galanis, David Roberge
BACKGROUND: Whole brain radiotherapy (WBRT) is the standard of care to improve intracranial control following resection of brain metastasis. However, stereotactic radiosurgery (SRS) to the surgical cavity is widely used in an attempt to reduce cognitive toxicity, despite the absence of high-level comparative data substantiating efficacy in the postoperative setting. We aimed to establish the effect of SRS on survival and cognitive outcomes compared with WBRT in patients with resected brain metastasis...
August 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28676310/an-investigation-into-the-effects-and-prognostic-factors-of-cognitive-decline-following-subthalamic-nucleus-stimulation-in-patients-with-parkinson-s-disease
#16
Taro Nimura, Ken-Ichi Nagamatsu, Tadashi Ando, Arifumi Matsumoto, Kinya Hisanaga, Teiji Tominaga
We retrospectively investigated the effects of subthalamic nucleus stimulation (STN-DBS) on new postoperative onset of cognitive decline and prognostic factors for advanced Parkinson's disease (PD). We studied 39 PD patients who had received bilateral STN-DBS. Clinical symptoms, cognitive function, psychiatric function, and health-related quality of life (HRQOL) were assessed before and six months after surgery. Based on the results of neuropsychological examinations six months after the surgery, the subjects were divided into those with and those without cognitive decline...
October 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28672938/edaravone-improves-spatial-memory-and-modulates-endoplasmic-reticulum-stress-mediated-apoptosis-after-abdominal-surgery-in-mice
#17
Ayong Tian, Hong Ma, Rongwei Zhang, Yong Cui, Chengfu Wan
Patients who receive major surgery often develop postoperative cognitive dysfunction (POCD); however, there is a lack of effective management as the pathogenesis of this disorder has not been fully elucidated. The neuroprotective effects of edaravone have been characterized in both in vitro cultured cells and in experimental animal models. The present study aimed to determine the potential role of edaravone in surgery-induced cognitive decline in mice. Animals were assigned to three groups: Control group (n=32), where mice received local anesthesia; surgery group (n=32), where mice underwent abdominal surgery under anesthesia; and edaravone group (n=32), where mice received abdominal surgery and were administered with edaravone (3 mg/kg)...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28631454/quality-of-recovery-after-gastroscopy-colonoscopy-or-both-endoscopic-procedures-an-observational-pilot-study
#18
Aiden M Brumby, Johan Heiberg, Cindy Te, Colin F Royse
BACKGROUND: Gastroscopy and colonoscopy are procedures with low complication rates and patients are usually discharged few hours after the procedures. Nevertheless, postoperative cognitive decline is a common condition, is often missed, and can potentially affect patients' ability to drive and undertake other daily living activities. The primary aim was to assess the incidence of failure to recover at Day 1 after either colonoscopy, gastroscopy, or both procedures combined. METHODS: In an observational pilot study, participants of 18 years or above undergoing endoscopy procedures, including colonoscopy (reference group), gastroscopy, or both, were included...
June 14, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28616001/development-and-validation-of-arabic-version-of-the-postoperative-quality-of-recovery-scale
#19
Abdullah Sulieman Terkawi, Siny Tsang, Waleed Riad, Sumaya Nemer Nassar, Maissa Mahmoud, Ghadah Jumaan AlKahtani, Hanin Hussain Alsharif, Khalid S Doais, Fatima Jaina Sala, Anas Abdulrahman, Colin F Royse
INTRODUCTION: The postoperative quality of recovery scale (PostopQRS) is a widely used tool to assess the postoperative quality of recovery. Our aim was to translate, culturally adapt, and validate the PostopQRS questionnaire in Arabic. METHODOLOGY: A systematic translation process was used to translate the original English PostopQRS into Arabic. After the pilot study, the translated version was validated among patients who underwent different types of surgeries...
May 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28614179/molecular-hydrogen-inhalation-attenuates-postoperative-cognitive-impairment-in-rats
#20
Yuchang Xin, Huiying Liu, Peng Zhang, Liuhui Chang, Keliang Xie
Postoperative cognitive decline is a major clinical problem with high morbidity and mortality after surgery. Many studies have found that molecular hydrogen (H2) has significant neuroprotection against acute and chronic neurological injury by regulating inflammation and apoptosis. In this study, we hypothesized that H2 treatment could ameliorate the development of cognitive impairment following surgery. Adult male rats were subjected to stabilized tibial fracture operation under anesthesia. Two percent of H2 was inhaled for 3 h beginning at 1 h after surgery...
August 2, 2017: Neuroreport
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