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postoperative cognitive decline

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https://www.readbyqxmd.com/read/29331847/longitudinal-hippocampal-and-extra-hippocampal-microstructural-and-macrostructural-changes-following-temporal-lobe-epilepsy-surgery
#1
Cameron A Elliott, Donald W Gross, B Matt Wheatley, Christian Beaulieu, Tejas Sankar
OBJECTIVES: 1) Characterize the evolution of microstructural changes in the contralateral, non-operated hippocampus-using longitudinal diffusion tensor imaging (DTI)-following surgery for temporal lobe epilepsy (TLE). 2) Characterize the downstream extra-hippocampal volumetric changes of the fornix and mammillary bodies after TLE surgery. 3) Examine the relationship between these measures and seizure/cognitive outcome. METHODS: Serial structural and DTI brain MRI scans were collected in 25 TLE patients pre- and post-surgery (anterior temporal lobectomy, ATL - 13; selective amygdalohippocampectomy, SelAH - 12) and in 12 healthy controls...
January 6, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29328416/endotoxin-tolerance-induced-by-lipopolysaccharide-preconditioning-protects-against-surgery%C3%A2-induced-cognitive-impairment-in-aging-mice
#2
Zhijie Zhang, Muhuo Ji, Yanlin Liao, Jianjun Yang, Jun Gao
Postoperative cognitive dysfunction (POCD) is a clinical syndrome characterized by varying degrees of cognitive functional decline in patients following major surgery. Inflammation and a dysregulated innate immune system exert broad effects in the periphery and central nervous system, yet the mechanisms underlying POCD remain poorly understood and without effective therapy. It has been reported that modulation of the dysregulated inflammatory response with low‑dose lipopolysaccharide (LPS) preconditioning, a phenomenon additionally referred to as endotoxin tolerance, has the potential to reduce neuroinflammation, blood‑brain barrier disruption, and cognitive impairment in a number of disease states...
January 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29325567/identifying-older-adults-at-risk-of-harm-following-elective-surgery-a-systematic-review-and-meta-analysis
#3
Jennifer Watt, Andrea C Tricco, Catherine Talbot-Hamon, Ba' Pham, Patricia Rios, Agnes Grudniewicz, Camilla Wong, Douglas Sinclair, Sharon E Straus
BACKGROUND: Elective surgeries can be associated with significant harm to older adults. The present study aimed to identify the prognostic factors associated with the development of postoperative complications among older adults undergoing elective surgery. METHODS: Medline, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, and AgeLine were searched for articles published between inception and April 21, 2016. Prospective studies reporting prognostic factors associated with postoperative complications (composite outcome of medical and surgical complications), functional decline, mortality, post-hospitalization discharge destination, and prolonged hospitalization among older adults undergoing elective surgery were included...
January 12, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29322428/feasibility-of-the-evidence-based-cognitive-telerehabilitation-program-remind-for-patients-with-primary-brain-tumors
#4
Sophie D van der Linden, Margriet M Sitskoorn, Geert-Jan M Rutten, Karin Gehring
Many patients with primary brain tumors experience cognitive deficits. Cognitive rehabilitation programs focus on alleviating these deficits, but availability of such programs is limited. Our large randomized controlled trial (RCT) demonstrated positive effects of the cognitive rehabilitation program developed by our group. We converted the program into the iPad-based cognitive rehabilitation program ReMind, to increase its accessibility. The app incorporates psychoeducation, strategy training and retraining...
January 10, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29321231/chronic-traumatic-encephalopathy-in-an-epilepsy-surgery-cohort-clinical-and-pathologic-findings
#5
Amy L Jones, Jeffrey W Britton, Melissa M Blessing, Joseph E Parisi, Gregory D Cascino
OBJECTIVE: To determine the occurrence of chronic traumatic encephalopathy (CTE) in young adult patients undergoing epilepsy surgery. METHODS: Ten patients who underwent epilepsy surgery were randomly selected for this retrospective study. The patients were 18-45 years of age, had preoperative neuropsychological evaluation, and had 1 year postoperative follow-up. Microscopic sections from resections were evaluated for the presence of CTE with standard stains and antibodies to tau (clone AT8)...
January 10, 2018: Neurology
https://www.readbyqxmd.com/read/29287674/-effects-of-cerebral-oxygen-changes-during-coronary-bypass-surgery-on-postoperative-cognitive-dysfunction-in-elderly-patients-a-pilot-study
#6
Cenk Şahan, Zerrin Sungur, Emre Çamcı, Nükhet Sivrikoz, Ömer Sayin, Hakan Gurvit, Mert Şentürk
BACKGROUND AND OBJECTIVES: Postoperative cognitive dysfunction is common after cardiac surgery. Adequate cerebral perfusion is essential and near infrared spectroscopy (NIRS) can measure cerebral oxygenation. Aim of this study is to compare incidence of early and late postoperative cognitive dysfunction in elderly patients treated with conventional or near infrared spectroscopy monitoring. METHODS: Patients undergoing coronary surgery above 60 years, were included and randomized to 2 groups; control and NIRS groups...
December 26, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29260313/post-operative-cognitive-decline-pocd-after-gynaecologic-surgery-current-opinions-and-future-applications
#7
Zarbo Cristina, Brivio Michela, Brugnera Agostino, Malandrino Chiara, Trezzi Gaetano, Rabboni Massimo, Bondi Emi, Compare Angelo, Frigerio Luigi
OBJECTIVE: Postoperative cognitive decline (POCD) is known to occur quite frequently after a cardiac surgery, especially in older population. Few studies specifically focused on its incidence and characteristics in gynecological setting. METHODS: Current opinions and future applications of POCD studies in gynecological setting have been discussed. RESULT: There are still many questions and issues about POCD in gynecological setting that remain unanswered as well as numerous research fields that have not been still explored...
December 19, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29259553/indication-of-cognitive-change-and-associated-risk-factor-after-thoracic-surgery-in-the-elderly-a-pilot-study
#8
Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima
Background: This pilot study investigated the effects of partial pulmonary lobectomy lung surgery on cognitive functions of elderly Japanese patients. It is recognized that elderly patients undergoing surgery have increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more likely to exhibit symptoms of POCD, the incidence is increasing as the population receiving surgery is aging. Methods: Cognitive function was measured for all subjects (n = 12) before and after surgery using three different cognitive tests: Mini-Mental Status Exam-Japanese (MMSE-J), Frontal Assessment Battery (FAB), and a computerized Cogstate Brief Battery (CBB)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29187661/-inflammation-relevant-mechanisms-for-postoperative-cognitive-dysfunction-and-the-preventive-strategy
#9
Yujie Tang, Wen Ouyang
Postoperative cognitive dysfunction (POCD) is thought to be a mild cognitive disorder. It means that patients without cognitive diseases before surgery suffer from subtle changes in psychomotility, personality, social skills and cognitive function after the surgery. A decline in memory is the core characteristics of these symptoms. POCD is mainly seen in the elderly people following surgery. It can prolong hospital stay, reduce quality of life, increase mortality, and thus aggravate the burden of public health...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29175959/disrupted-neuro-glial-metabolic-coupling-after-peripheral-surgery
#10
Teresa Femenía, Alfredo Giménez-Cassina, Simone Codeluppi, Teresa Fernández-Zafra, Yurika Katsu-Jiménez, Niccolò Terrando, Lars I Eriksson, Marta Gómez-Galán
Immune-related events in the periphery can remotely affect brain function, contributing to neurodegenerative processes and cognitive decline. In mice, peripheral surgery induces a systemic inflammatory response associated with changes in hippocampal synaptic plasticity and transient cognitive decline, however the underlying mechanisms remain unknown. Here we investigated the effect of peripheral surgery on neuronal-glial function within hippocampal neuronal circuits of relevance to cognitive processing in male mice at 6, 24, and 72h post-surgery...
November 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29164774/task-related-changes-in-degree-centrality-and-local-coherence-of-the-posterior-cingulate-cortex-after-major-cardiac-surgery-in-older-adults
#11
Jeffrey N Browndyke, Miles Berger, Patrick J Smith, Todd B Harshbarger, Zachary A Monge, Viral Panchal, Tiffany L Bisanar, Donald D Glower, John H Alexander, Roberto Cabeza, Kathleen Welsh-Bohmer, Mark F Newman, Joseph P Mathew
OBJECTIVES: Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in response to increased working memory load demands in cardiac surgery patients and nonsurgical controls. EXPERIMENTAL DESIGN: Older cardiac surgery patients (n = 25) completed a verbal N-back working memory task during MRI scanning and cognitive testing before and 6 weeks after surgery; nonsurgical controls with cardiac disease (n = 26) underwent these assessments at identical time intervals...
November 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29125432/association-between-baseline-cognitive-impairment-and-postoperative-delirium-in-elderly-patients-undergoing-surgery-for-adult-spinal-deformity
#12
Owoicho Adogwa, Aladine A Elsamadicy, Victoria D Vuong, Jared Fialkoff, Joseph Cheng, Isaac O Karikari, Carlos A Bagley
OBJECTIVE Postoperative delirium is common in elderly patients undergoing spine surgery and is associated with a longer and more costly hospital course, functional decline, postoperative institutionalization, and higher likelihood of death within 6 months of discharge. Preoperative cognitive impairment may be a risk factor for the development of postoperative delirium. The aim of this study was to investigate the relationship between baseline cognitive impairment and postoperative delirium in geriatric patients undergoing surgery for degenerative scoliosis...
November 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29120931/perioperative-neurocognition-in-elderly-patients
#13
Huiqun Fu, Long Fan, Tianlong Wang
PURPOSE OF REVIEW: The extrinsic risk factors for postoperative cognitive disturbance have been a source of concern during the perioperative period, and these risk factors remain the subject of controversy. This review of recent studies focuses on the effect of these factors on postoperative cognitive disturbance during the perioperative period. RECENT FINDINGS: Impairment of cerebral autoregulation may predispose patients to intraoperative cerebral malperfusion, which may subsequently induce postoperative cognitive disturbance...
February 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29117924/red-flags-in-epilepsy-surgery-identifying-the-patients-who-pay-a-high-cognitive-price-for-an-unsuccessful-surgical-outcome
#14
Sallie Baxendale, Pamela Thompson
Preoperative estimates of cognitive and seizure outcome must be as accurate as possible if the candidate is to make an informed decision about epilepsy surgery. Significant declines in memory function are reported in approximately 30% of temporal lobe surgery patients. The percentage varies according to the ways in which a postoperative deterioration is defined but since the majority of outcome studies do not take into account the patient's capacity to deteriorate if they are functioning at or close to the floor of a memory test prior to surgery, the published percentages may be an underrepresentation of the true extent of memory decline following epilepsy surgery...
January 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29100194/cognitive-decline-after-major-oncological-surgery-in-the-elderly
#15
M Plas, E Rotteveel, G J Izaks, J M Spikman, H van der Wal-Huisman, B van Etten, A R Absalom, M J E Mourits, G H de Bock, B L van Leeuwen
BACKGROUND: Elderly patients undergoing oncological surgery experience postoperative cognitive decline. The aims of this study were to examine the incidence of cognitive decline 3 months after surgery and identify potential patient-, disease- and surgery-related risk factors for postoperative cognitive decline in onco-geriatric patients. METHODS: A consecutive series of elderly patients (≥65 years) undergoing surgery for the removal of a solid tumour were included (n = 307)...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29097068/evaluation-of-cognitive-function-following-transcatheter-aortic-valve-replacement
#16
Masieh Abawi, Rehana de Vries, Pieter R Stella, Pierfrancesco Agostoni, Dirk H M Boelens, Romy C van Jaarsveld, Charlotte S van Dongen, Pieter A F M Doevendans, Mariëlle H Emmelot-Vonk
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is associated with procedural-related neurological events and acute cognitive decline. However, data on the effect of TAVR on mid-term cognitive outcome are scarce. Therefore, we aimed to assess the impact of TAVR on mid-term cognitive outcome using different neurocognitive test batteries. METHODS: Patients with severe aortic valve stenosis scheduled for TAVR were enrolled. Cognitive assessment was performed at baseline and 4 months post-TAVR using an eight-word verbal-learning test ("Immediate Recall Memory Test" [IRMT], "Delayed Recall Memory Test" [DRMT], "Recognition of Verbal Information Test" [RVIT]), global cognitive function ("Mini Mental State Examination" [MMSE]), and executive function ("Trail Making Test" [TMT], "Clock-Drawing Test" [CDT])...
October 20, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29058145/vitamin-status-and-the-development-of-postoperative-cognitive-decline-in-elderly-surgical-oncologic-patients
#17
Linda B M Weerink, Barbara L van Leeuwen, Sofie A M Gernaat, Anthony R Absalom, Monique G Huisman, Hanneke van der Wal-Huisman, Gerbrand J Izaks, Geertruida H de Bock
BACKGROUND: This study aimed to evaluate the influence that serum levels of vitamin B12, folate, and homocysteine have on the development of short-term postoperative cognitive decline in the elderly surgical oncology patient. METHODS: This study was part of a prospective cohort study focused on postoperative cognitive outcomes for patients 65 years of age or older undergoing surgery for a solid malignancy. Postoperative cognitive decline was defined as the change in the combined results of the Ruff Figural Fluency Test and the Trail-Making Test Parts A and B...
October 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29054389/optimizing-surgical-quality-datasets-to-care-for-older-adults-lessons-from-the-american-college-of-surgeons-nsqip-geriatric-surgery-pilot
#18
Julia R Berian, Lynn Zhou, Melissa A Hornor, Marcia M Russell, Mark E Cohen, Emily Finlayson, Clifford Y Ko, Thomas N Robinson, Ronnie A Rosenthal
BACKGROUND: Surgical quality datasets can be better tailored toward older adults. The American College of Surgeons (ACS) NSQIP Geriatric Surgery Pilot collected risk factors and outcomes in 4 geriatric-specific domains: cognition, decision-making, function, and mobility. This study evaluated the contributions of geriatric-specific factors to risk adjustment in modeling 30-day outcomes and geriatric-specific outcomes (postoperative delirium, new mobility aid use, functional decline, and pressure ulcers)...
September 28, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29044209/cell-penetrating-interactomic-inhibition-of-nuclear-factor-kappa-b-in-a-mouse-model-of-postoperative-cognitive-dysfunction
#19
So Yeong Cheon, Jeong Min Kim, Eun Hee Kam, Chun-Chang Ho, Eun Jung Kim, Seungsoo Chung, Ji-Hyun Jeong, Diane Da-Hyun Lee, Sang-Won Lee, Bon-Nyeo Koo
Some patients experience impaired cognitive functioning after surgery, a phenomenon referred to as postoperative cognitive dysfunction (POCD). Signs of POCD are closely associated with the development of systemic or hippocampal inflammation. However, the precise pathophysiological mechanisms of prevention/treatment options for POCD still remain unclear. After injury, the transcriptional factor nuclear factor-kappa B (NF-κB) is thought to regulate or stimulate inflammation amplification. Therefore, we designed a cell-penetrating fusion protein called nt-p65-TMD, which inhibits NF-κB p65 activation by translocating into the nucleus...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29039829/-factors-for-the-development-of-persistent-postoperative-cognitive-dysfunction-in-patients-undergoing-coronary-artery-bypass-surgery-under-extracorporeal-circulation
#20
O A Trubnikova, I V Tarasova, O V Maleva, E S Kagan, O L Barbarash, L S Barbarash
AIM: To analyze the factors contributing to the increased risk of persistent postoperative cognitive dysfunction (POCD) in patients undergoing coronary artery bypass surgery (CABS) under extracorporeal circulation (EC). SUBJECTS AND METHODS: 257 male patients aged 45 to 69 years with coronary heart disease (CHD) undergoing elective CABS under EC were examined. In addition to conventional clinical examination, all the patients underwent neuropsychological testing 3-5 days before, 7-14 days and 1 year after CABS...
2017: Terapevticheskiĭ Arkhiv
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