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https://www.readbyqxmd.com/read/29222544/association-of-age-related-hearing-loss-with-cognitive-function-cognitive-impairment-and-dementia-a-systematic-review-and-meta-analysis
#1
David G Loughrey, Michelle E Kelly, George A Kelley, Sabina Brennan, Brian A Lawlor
Importance: Epidemiologic research on the possible link between age-related hearing loss (ARHL) and cognitive decline and dementia has produced inconsistent results. Clarifying this association is of interest because ARHL may be a risk factor for outcomes of clinical dementia. Objectives: To examine and estimate the association between ARHL and cognitive function, cognitive impairment, and dementia through a systematic review and meta-analysis. Data Sources and Study Selection: A search of PubMed, the Cochrane Library, EMBASE, and SCOPUS from inception to April 15, 2016, with cross-referencing of retrieved studies and personal files for potentially eligible studies was performed...
December 7, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29221166/high-salt-induced-hypertension-leads-to-cognitive-defect
#2
Cui-Ping Guo, Zhen Wei, Fang Huang, Min Qin, Xing Li, Yu-Man Wang, Qun Wang, Jian-Zhi Wang, Rong Liu, Bin Zhang, Hong-Lian Li, Xiao-Chuan Wang
Although increasing evidences suggest a relationship between hypertension and brain function for years, it is still unclear whether hypertension constitutes a risk factor for cognitive decline and its underlying mechanism. In the present study, an experimental animal model of hypertension simply by feeding rats with high salt diet was employed. We found that long-term high salt intake caused a marked increase of systolic blood pressure linked to a declined regional cerebral blood flow. Fear conditioning and morris water maze behavioral test revealed that high salt diet induced hippocampal dependent spatial reference memory deficits, while a decreased synaptogenesis without neuronal loss in hippocampus was observed in high salt treated rats...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220627/neuropsychological-functioning-in-older-adults-with-mild-cognitive-impairment-and-insomnia-randomized-to-cbt-i-or-control-group
#3
Erin Cassidy-Eagle, Allison Siebern, Lisa Unti, Jill Glassman, Ruth O'Hara
OBJECTIVES: Improving the sleep of older adults with mild cognitive impairment (MCI) represents a first step in discovering whether interventions directed at modifying this risk factor also have the potential to alter the cognitive decline trajectory. METHODS: A six-session, adapted version of a cognitive behavioral therapy for insomnia (CBT-I) was administered to older adults (N = 28; 14 per group) with MCI across two residential facilities. Participants were randomly assigned to either the sleep intervention or an active control group and completed a neuropsychological battery at three time points (e...
October 24, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29220623/the-aging-well-through-interaction-and-scientific-education-agewise-program
#4
Maureen K O'Connor, Malissa L Kraft, Ryan Daley, Michael A Sugarman, Erika L Clark, Arielle A J Scoglio, Steven D Shirk
OBJECTIVE: We conducted a randomized controlled trial of the Aging Well through Interaction and Scientific Education (AgeWISE) program, a 12-week manualized cognitive rehabilitation program designed to provide psychoeducation to older adults about the aging brain, lifestyle factors associated with successful brain aging, and strategies to compensate for age related cognitive decline. METHODS: Forty-nine cognitively intact participants ≥ 60 years old were randomly assigned to the AgeWISE program (n = 25) or a no-treatment control group (n = 24)...
November 2, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29220349/neural-correlates-of-motor-cognitive-dual-tasking-in-young-and-old-adults
#5
Selma Papegaaij, Tibor Hortobágyi, Ben Godde, Wim A Kaan, Peter Erhard, Claudia Voelcker-Rehage
When two tasks are performed simultaneously, performance often declines in one or both tasks. These so-called dual-task costs are more pronounced in old than in young adults. One proposed neurological mechanism of the dual-task costs is that old compared with young adults tend to execute single-tasks with higher brain activation. In the brain regions that are needed for both tasks, the reduced residual capacity may interfere with performance of the dual-task. This competition for shared brain regions has been called structural interference...
2017: PloS One
https://www.readbyqxmd.com/read/29218782/therapy-development-in-huntington-disease-from-current-strategies-to-emerging-opportunities
#6
REVIEW
Audrey S Dickey, Albert R La Spada
Huntington disease (HD) is a progressive autosomal dominant neurodegenerative disorder in which patients typically present with uncontrolled involuntary movements and subsequent cognitive decline. In 1993, a CAG trinucleotide repeat expansion in the coding region of the huntingtin (HTT) gene was identified as the cause of this disorder. This extended CAG repeat results in production of HTT protein with an expanded polyglutamine tract, leading to pathogenic HTT protein conformers that are resistant to protein turnover, culminating in cellular toxicity and neurodegeneration...
December 8, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29218504/temporal-spatial-profiling-of-pedunculopontine-galanin-cholinergic-neurons-in-the-lactacystin-rat-model-of-parkinson-s-disease
#7
Joanna L Elson, Rafael Kochaj, Richard Reynolds, Ilse S Pienaar
Parkinson's disease (PD) is conventionally seen as resulting from single-system neurodegeneration affecting nigrostriatal dopaminergic neurons. However, accumulating evidence indicates multi-system degeneration and neurotransmitter deficiencies, including cholinergic neurons which degenerate in a brainstem nucleus, the pedunculopontine nucleus (PPN), resulting in motor and cognitive impairments. The neuropeptide galanin can inhibit cholinergic transmission, while being upregulated in degenerating brain regions associated with cognitive decline...
December 7, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29218262/neurologic-outcomes-following-care-in-the-pediatric-intensive-care-unit
#8
Sherrill D Caprarola, Sapna R Kudchadkar, Melania M Bembea
Purpose of review: With increasing survival of children requiring admission to pediatric intensive care units (PICU), neurodevelopmental outcomes of these patients are an area of increased attention. Our goal was to systematically review recently published literature on neurologic outcomes of PICU patients. Recent Findings: Decline in neurofunctional status occurs in 3%-20% of children requiring PICU care. This proportion varies based on primary diagnosis and severity of illness, with children admitted for primary neurologic diagnosis, children who suffer cardiac arrest or who require invasive interventions during the PICU admission, having worse outcomes...
September 2017: Current Treatment Options in Pediatrics
https://www.readbyqxmd.com/read/29217146/the-association-between-adherence-to-a-mediterranean-style-diet-and-cognition-in-older-people-the-impact-of-medication
#9
Roy J Hardman, Denny Meyer, Greg Kennedy, Helen Macpherson, Andrew B Scholey, Andrew Pipingas
BACKGROUND: Recent reviews indicate that adherence to a Mediterranean diet may be associated with better cognitive functioning. In assessing these relationships in older individuals, previous studies have not taken into account medication usage that may support or compromise cognitive functioning. OBJECTIVE: To investigate the association between adherence to a Mediterranean style diet, cognition and medication usage in cognitively healthy older individuals. DESIGN: Data were assessed from individuals aged 60-90 years (mean = 77...
October 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29216341/use-and-importance-of-nonhuman-primates-in-metabolic-disease-research-current-state-of-the-field
#10
Peter J Havel, Paul Kievit, Anthony G Comuzzie, Andrew A Bremer
Obesity and its multiple metabolic sequelae, including type 2 diabetes, cardiovascular disease, and fatty liver disease, are becoming increasingly widespread in both the developed and developing world. There is an urgent need to identify new approaches for the prevention and treatment of these costly and prevalent metabolic conditions. Accomplishing this will require the use of appropriate animal models for preclinical and translational investigations in metabolic disease research. Although studies in rodent models are often useful for target/pathway identification and testing hypotheses, there are important differences in metabolic physiology between rodents and primates, and experimental findings in rodent models have often failed to be successfully translated into new, clinically useful therapeutic modalities in humans...
December 5, 2017: ILAR Journal
https://www.readbyqxmd.com/read/29216339/exercise-training-for-preventing-dementia-mild-cognitive-impairment-and-clinically-meaningful-cognitive-decline-a-systematic-review-and-meta-analysis
#11
Philipe de Souto Barreto, Laurent Demougeot, Bruno Vellas, Yves Rolland
BACKGROUND: To assess the effects of long-term exercise on the onset of dementia, mild cognitive impairment (MCI), and other clinically meaningful cognitive decline in the elderly. METHODS: Systematic review with preplanned meta-analysis. Electronic searches were performed between November 2016 and May 2017. RCTs examining the effects of long-term exercise (intervention length 12 months or longer) on the onset of dementia, MCI, or clinically meaningful cognitive decline in older adults without dementia at baseline were eligible...
December 5, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29215310/apolipoprotein-e4-mediates-insulin-resistance-associated-cerebrovascular-dysfunction-and-the-post-prandial-response
#12
Lance A Johnson, Eileen Ruth Torres, Sydney Weber Boutros, Esha Patel, Tunde Akinyeke, Nabil J Alkayed, Jacob Raber
Metabolic dysfunction, commonly a result of diets high in saturated fats and sugar, is associated with impaired cognitive function and an increased risk of age-related cognitive decline (ACD) and Alzheimer's disease (AD). Compared to the E3 isoform of apolipoprotein (apoE), the E4 isoform is a major genetic risk factor for ACD, AD, and for developing cognitive impairments following various environmental challenges, including dietary challenges such as a high-fat diet (HFD). Both insulin resistance (IR) and E4 are associated with metabolic and vascular impairments...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29214828/dose-response-association-between-physical-activity-and-cognitive-function-in-a-national-sample-of-older-adults
#13
Paul D Loprinzi, Meghan K Edwards, Elizabeth Crush, Toshikazu Ikuta, Alberto Del Arco
PURPOSE: Previous research demonstrates a favorable effect of physical activity on cognitive function among older adults. The potential dose-response relationship between physical activity and cognitive function in this population is less understood, which was the purpose of this study. SETTING: Data from the 1999 to 2002 National Health and Nutrition Examination Survey were employed. PARTICIPANTS: A total of 2157 older adults aged 60 to 85 years...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29214734/increased-serum-level-of-igf-1-correlates-with-better-cognitive-status-in-end-stage-renal-disease-patients-undergoing-hemodialysis
#14
Vladimir Prelevic, Danilo Radunovic, Tanja Antunovic, Marina Ratkovic, Najdana Gligorovic-Bahranovic, Branka Gledovic, Snezana Vujosevic, Mirjana Nedovic-Vukovic, Nikolina Basic-Jukic
Prevalence of cognitive function decline in end stage renal disease (ESRD) patients undergoing hemodialysis is higher than in the general population. We analyzed risk factors for cognitive function decline in those patients. This study included 93 ESRD patients undergoing hemodialysis two or three times a week in three centers for hemodialysis in Montenegro. The cognitive status of patients was assessed using the mini mental score examination (MMSE) test. All 93 patients have been divided into three groups according to the results of MMSE...
December 7, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29214403/executive-functioning-academic-skills-and-quality-of-life-in-pediatric-patients-with-brain-tumors-post-proton-radiation-therapy
#15
Lea M Ventura, Julie A Grieco, Casey L Evans, Karen A Kuhlthau, Shannon M MacDonald, Nancy J Tarbell, Torunn I Yock, Margaret B Pulsifer
Radiation therapy (RT) is integral in the treatment of pediatric brain tumors; however, photon RT (XRT) often results in intellectual decline, executive functioning (EF) deficits, academic underachievement/failure, and lower health-related quality of life (HRQoL). Proton RT (PRT) provides more targeted therapy, minimizing damage to the developing brain, yet few studies have examined its neuropsychological effects. This study investigated the role of EF in academic skills and HRQoL in a sample of children treated with PRT...
December 6, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29213527/high-education-accelerates-cognitive-decline-in-dementia-a-brief-report-from-the-population-based-nedices-cohort
#16
Israel Contador, Félix Bermejo-Pareja, D Lora Pablos, Alberto Villarejo, Julián Benito-León
High education has been associated with faster cognitive decline after diagnosis of Alzheimer's disease (AD), but it is unclear whether these findings extend to other dementia subtypes. OBJECTIVE: We investigated whether educational attainment influences the cognitive trajectories of older adults with different dementia subtypes. METHODS: All participants were selected from NEDICES, a prospective population-based cohort study of Spanish older adults. A total sample of 53 individuals with dementia completed the MMSE-37 at Times 1 and 2 (mean follow-up=2...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213513/prolonged-delirium-misdiagnosed-as-a-mood-disorder
#17
Fei Cao, Haitham Salem, Caesa Nagpal, Antonio L Teixeira
Delirium can be conceptualized as an acute decline in cognitive function that typically lasts from hours to a few days. Prolonged delirium can also affect patients with multiple predisposing and/or precipitating factors. In clinical practice, prolonged delirium is often unrecognized, and can be misdiagnosed as other psychiatric disorders. We describe a case of a 59-year-old male presenting with behavioral and cognitive symptoms that was first misdiagnosed as a mood disorder in a general hospital setting. After prolonged delirium due to multiple factors was confirmed, the patient was treated accordingly with symptomatic management...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213510/actively-station-effects-on-global-cognition-of-mature-adults-and-healthy-elderly-program-using-eletronic-games
#18
Tiago Nascimento Ordonez, Felipe Borges, Camila Sato Kanashiro, Carolina Carneiro das Neves Santos, Samara Santos Hora, Thais Bento Lima-Silva
Studies show that aging is accompanied by decline in cognitive functions but also indicate that interventions, such as training on electronic games, can enhance performance and promote maintenance of cognitive abilities in healthy older adults. Objective: To investigate the effects of an electronic game program, called Actively Station, on the performance of global cognition of adults aged over 50 years. Methods: 124 mature and elderly adults enrolled in the "Actively Station" cognitive stimulation program of São Caetano do Sul City, in the State of São Paulo, participated in training for learning of electronic games...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213507/sundown-syndrome-and-symptoms-of-anxiety-and-depression-in-hospitalized-elderly
#19
Marcello Weynes Barros Silva, Rilva Lopes Sousa-Muñoz, Heitor Cabral Frade, Priscilla Alencar Fernandes, Andrêssa de Oliveira Magalhães
Sundown syndrome is characterized by the sudden appearance of neuropsychiatric symptoms such as agitation, confusion and anxiety in a chronologic fashion, usually during late afternoon or early evening. Objective: To evaluate the prevalence of sundown syndrome in university hospital wards and its relationship with anxiety/depression symptoms, cognitive decline, and clinical and demographic variables. Methods: We evaluated 70 patients admitted to the Lauro Wanderley University Hospital (HULW), João Pessoa-PB, Brazil...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213505/planning-ability-impairments-in-probable-alzheimer-s-disease-patients-evidence-from-the-tower-of-london-test
#20
Corina Satler, Luiza Guimarães, Carlos Tomaz
Alzheimer's disease (AD) is associated with progressive impairment of higher-level cognitive abilities. Previous research suggests that early impairment of executive functions occurs during the course of the disease, but few studies have specifically investigated planning ability in an AD population. Objective: The purpose of the current study was to examine whether AD patients retain the ability to plan ahead, by analyzing specificities of their behavior in successfully achieving a pre-established goal...
April 2017: Dementia & Neuropsychologia
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