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https://www.readbyqxmd.com/read/28337079/comparison-of-amikacin-pharmacokinetics-in-neonates-following-implementation-of-a-new-dosage-protocol
#1
Kaitlin M Hughes, Peter N Johnson, Michael P Anderson, Kris C Sekar, Robert C Welliver, Jamie L Miller
OBJECTIVES: The primary aim was to compare attainment of goal serum amikacin concentrations using two dosage regimens in patients admitted to a neonatal intensive care unit. Secondary objectives included comparison of percentages of supratherapeutic trough concentrations, and subtherapeutic and supratherapeutic peak concentrations. METHODS: This was an Institutional Review Board-approved, retrospective study of neonates receiving amikacin during January-December 2013 (group 1) and January-December 2014 (group 2)...
January 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28336756/empirical-gentamicin-dosing-based-on-serum-creatinine-levels-in-premature-and-term-neonates
#2
Taylar L Antolik, Kelli J Cunningham, Samir Alabsi, Rachel A Reimer
PURPOSE: Empirical gentamicin dosing based on serum creatinine (SCr) levels in premature and term neonates was evaluated. METHODS: This single-center, retrospective cohort study was conducted in a standalone children's hospital with a level IIIB, 44-bed neonatal intensive care unit (NICU). Data were abstracted and collected for all neonates admitted to the NICU from March 5, 2012, through March 5, 2014. Patients were included in the study if gentamicin was administered within the first 7 days of life, a trough gentamicin level was measured, and the neonate had a baseline SCr level measured within the first 24 hours of life...
April 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28329458/type-iv-total-anomalous-pulmonary-venous-connection
#3
James D St Louis, Elizabeth M Turk, Jeffrey P Jacobs, James E O'Brien
BACKGROUND: Mortality associated with correction of type IV total anomalous pulmonary venous connection (TAPVC) is generally reported in combination with other anatomic types. The objective of this study is to review surgical outcomes associated with the repair of type IV TAPVC by analyzing a multi-institutional cohort specific for this group. We also analyze patient-specific variables that may contribute to poor operative outcomes. METHODS: A retrospective review of the Pediatric Cardiac Care Consortium (PCCC) registry identified patients who underwent repair of type IV TAPVC between 1982 and 2007...
March 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28328698/reduced-sufentanil-doses-are-effective-for-postoperative-analgesia-after-ductal-closure-in-extremely-premature-infants-a-10-years-retrospective-cohort-study
#4
Yohan Soreze, Etienne Audureau, Fabrice Decobert, Olivier Jaby, Sabine Blary, Claude Danan, Xavier Durrmeyer
OBJECTIVES: The objective of the study was to assess the efficacy of reduced sufentanil doses for postoperative analgesia following surgical ductal closure in extremely premature infants. METHODS: This was a retrospective, single-center, cohort study comparing 2 sufentanil dosing regimens used between 2001 and 2010 and included all infants born at <28 weeks of gestation with surgical ductal closure. Sufentanil doses were reduced in 2007 as a standard of care...
March 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28325857/treatment-trends-for-retinopathy-of-prematurity-in-the-uk-active-surveillance-study-of-infants-at-risk
#5
Gillian G W Adams, Catey Bunce, Wen Xing, Lucilla Butler, Vernon Long, Aravind Reddy, Annegret H Dahlmann-Noor
OBJECTIVES: To estimate the incidence of severe retinopathy of prematurity (ROP) requiring treatment and describe current treatment patterns in the UK. DESIGN: Nationwide population-based case ascertainment study via the British Ophthalmic Surveillance Unit and a national collaborative ROP special interest group. Practitioners completed a standardised case report form (CRF). SETTING: All paediatric ophthalmologists providing screening and/or treatment for retinopathy in the UK were invited to take part...
March 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28324991/features-of-cerebral-oxygenation-detects-brain-injury-in-premature-infants
#6
John M O'Toole, Mmoloki Kenosi, Daragh Finn, Geraldine B Boylan, Eugene M Dempsey
Babies born prematurely can develop brain injury within days after birth. Early identification of high-risk infants enables appropriate clinical care to mitigate potential lifelong disabilities. Near infra-red spectroscopy is an established technology that can provide continuous measurements of cerebral oxygen saturation (rcSO2) over this critical period. We develop a feature set of the rcSO2 signal for the purpose of detecting brain injury. Our feature set contains amplitude, spectral, and fractal dimension features within 5 frequency bands...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324112/recurrence-of-retinopathy-of-prematurity-after-intravitreal-ranibizumab-monotherapy-timing-and-risk-factors
#7
Jiao Lyu, Qi Zhang, Chun-Li Chen, Yu Xu, Xun-Da Ji, Jia-Kai Li, Qiu-Jing Huang, Pei-Quan Zhao
Purpose: To investigate timing and risk factors of recurrent retinopathy of prematurity (ROP) after intravitreal ranibizumab (IVR) monotherapy. Methods: Fifty eyes (the more severe eye) of 50 infants treated with IVR monotherapy for type 1 ROP were studied retrospectively. The mean follow-up time was 31 weeks after IVR. Recurrent ROP (recurrence of extraretinal fibrovascular proliferation [EFP]) was determined by RetCam wide-angle fundus imaging and binocular indirect ophthalmoscopy...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28322643/perceived-needs-of-parents-of-premature-infants-in-nicu
#8
Li Wang, Jun Li He, Shu Lan Fei
To investigate the needs of parents of premature infants hospitalized in a neonatal intensive care unit (NICU) and explore associated factors. This study includes a convenience sample of 198 parents of premature infants hospitalized in a NICU in Chenzhou, Hunan province, China. Parents completed a study-specific questionnaire and the Chinese version of Critical Care Family Need Inventory (CCFNI). Analysis was conducted by multiple linear regression. Parents rated 30 of 45 items on the Chinese version of the CCFNI as important or very important...
December 1, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28322431/exploring-societal-solidarity-in-the-context-of-extreme-prematurity
#9
Manya J Hendriks, Hans Ulrich Bucher, Sabine D Klein, Jürg C Streuli, Ruth Baumann-Hölzle, Jean-Claude Fauchère
QUESTION: Extreme prematurity can result in long-term disabilities. Its impact on society is often not taken into account and deemed controversial. Our study examined attitudes of the Swiss population regarding extreme prematurity and people's perspectives regarding the question of solidarity with disabled people. METHODS: We conducted a nationwide representative anonymous telephone survey with 1210 Swiss residents aged 18 years or older. We asked how people estimate their own personal solidarity, the solidarity of their social environment and the solidarity across the country with disabled persons...
March 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28321391/inadequate-utilization-of-prenatal-care-services-socioeconomic-status-and-educational-attainment-are-associated-with-low-birth-weight-in-zimbabwe
#10
Sanni Yaya, Ghose Bishwajit, Michael Ekholuenetale, Vaibhav Shah
BACKGROUND: Globally, low birth weight (LBW) remains a leading cause of neonatal and infant mortality and poses significant challenges toward the progress of achieving infant mortality-related goals. Experience from developed countries shows that two major causes of LBW (premature delivery and intrauterine growth restriction) can be averted to a great extent by adequate utilization of maternal health-care services, during pregnancy. In this study, we attempt to measure the prevalence of LBW in Zimbabwe and explore the association between adequate utilization of prenatal care (PNC) services and LBW in Zimbabwe...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28319507/recombinant-factor-viia-is-associated-with-increased-thrombotic-complications-in-pediatric-cardiac-surgery-patients
#11
Laura Downey, Morgan L Brown, David Faraoni, David Zurakowski, James A DiNardo
BACKGROUND: Recombinant factor VIIa (rFVIIa) is routinely used as an off-label hemostatic agent in children undergoing cardiac surgery. Despite evidence that rFVIIa use is associated with an increased incidence of thrombotic complications in adult cardiac surgery, the safety of rFVIIa as a rescue hemostatic agent in the pediatric cardiac surgical population is less definitively delineated. In this retrospective study, we used propensity score matching to compare the incidence of thrombotic complications between children treated with rFVIIa and their matched controls...
March 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28318973/the-dual-nature-of-early-life-experience-on-somatosensory-processing-in-the-human-infant-brain
#12
Nathalie L Maitre, Alexandra P Key, Olena D Chorna, James C Slaughter, Pawel J Matusz, Mark T Wallace, Micah M Murray
Every year, 15 million preterm infants are born, and most spend their first weeks in neonatal intensive care units (NICUs) [1]. Although essential for the support and survival of these infants, NICU sensory environments are dramatically different from those in which full-term infants mature and thus likely impact the development of functional brain organization [2]. Yet the integrity of sensory systems determines effective perception and behavior [3, 4]. In neonates, touch is a cornerstone of interpersonal interactions and sensory-cognitive development [5-7]...
March 15, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28317816/hemophagocytic-syndrome-secondary-to-tuberculosis-at-24-week-gestation
#13
Alexandra Arteaga Fernández, David Fernández de Velasco Pérez, M C Jiménez Fournier, J C Moreno Del Prado, B Paraíso Torras, M L Cañete Palomo
Hemophagocytic syndrome is a life-threatening disease characterized by the uncontrolled activation of macrophages, resulting in hemophagocytosis of blood cells in the bone marrow. A 20-year-old gravida at 23-week and 5-day gestation was admitted to hospital to evaluate fever up to 104°F of unknown origin, moderate cytopenia, and elevated levels of liver enzymes. Bone marrow biopsy confirmed hemophagocytic syndrome, and polymerase chain reaction came back positive for Mycobacterium tuberculosis. Supportive care and tuberculosis treatment resulted in clinical improvement...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28315736/colorado-retinopathy-of-prematurity-screening-algorithm-co-rop-a-validation-study-at-a-tertiary-care-center
#14
Jason M Huang, Xihui Lin, Yu-Guang He, Jennifer H Cao
PURPOSE: The Colorado Retinopathy of Prematurity Screening Algorithm (CO-ROP) recommends screening for infants meeting the following criteria for retinopathy of prematurity (ROP): gestational age ≤30 weeks, birth weight of ≤1500 g, and net weight gain of ≤650 g between birth and 4 weeks of age. This study was performed to evaluate the validity of CO-ROP in a tertiary referral county hospital. METHODS: CO-ROP was used to retrospectively analyze the data from consecutive newborns screened for ROP using national screening guidelines at Parkland Hospital, Dallas, Texas, between April 1, 2009, to August 30, 2013...
March 15, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28304316/perspectives-and-attitudes-of-pediatricians-concerning-post-discharge-care-practice-of-premature-infants
#15
A Gad, E Parkinson, N Khawar, A Elmeki, P Narula, D Hoang
OBJECTIVE: Survival rates of premature infants are at a historical high and increasingly more pediatricians are caring for former premature infants. The goal of this study was to describe the perspectives and attitudes of pediatricians, as well as, the challenges of rendering post-neonatal intensive care unit (NICU) discharge care for premature infants. METHODS: An anonymous 22-question web-based survey was emailed to pediatricians who are current members of the American Academy of Pediatrics (AAP) and practicing in Kings County, New York...
March 16, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28304297/information-and-communication-technologies-for-the-activities-of-daily-living-in-older-patients-with-dementia-a-systematic-review
#16
Grazia D'Onofrio, Daniele Sancarlo, Francesco Ricciardi, Francesco Panza, Davide Seripa, Filippo Cavallo, Francesco Giuliani, Antonio Greco
BACKGROUND: Significant innovations have been introduced in recent years in the application of information and communication technologies (ICTs) to support healthcare for patients with dementia. OBJECTIVE: In the present systematic review, our goal is to keep track of ICT concepts and approaches to support the range of activities of daily living for people with dementia and to provide a snapshot of the effect that technology is having on patients' self-reliance...
March 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28302697/abstention-or-intervention-for-isolated-hypotension-in-the-first-3%C3%A2-days-of-life-in-extremely-preterm-infants-association-with-short-term-outcomes-in-the-epipage-2-cohort-study
#17
Xavier Durrmeyer, Laetitia Marchand-Martin, Raphaël Porcher, Geraldine Gascoin, Jean-Christophe Roze, Laurent Storme, Geraldine Favrais, Pierre-Yves Ancel, Gilles Cambonie
OBJECTIVE: To compare outcomes at hospital discharge for preterm infants born before 29 weeks of gestation who had at least one episode of isolated hypotension during their first 72 hours of life for which they did or did not receive antihypotensive treatment. DESIGN: Etude Epidémiologique sur les Petits Ages Gestationnels 2 (EPIPAGE 2) French national prospective population-based cohort study in 2011. SETTING: 60 neonatal intensive care units...
March 16, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28302630/prevalence-of-microcephaly-in-eight-south-eastern-and-midwestern-brazilian-neonatal-intensive-care-units-2011-2015
#18
Maria Clara de Magalhães-Barbosa, Arnaldo Prata-Barbosa, Jaqueline Rodrigues Robaina, Carlos Eduardo Raymundo, Fernanda Lima-Setta, Antonio José Ledo Alves da Cunha
OBJECTIVE: To describe the prevalence of microcephaly in infants admitted to the neonatal intensive care units (NICUs) in eight private hospitals in south-eastern and midwestern Brazil, from 2011 to 2015. DESIGN: Observational, cross-sectional study in a cohort of neonates. SETTING: Eight private NICUs situated in the cities of Rio de Janeiro (RJ), São Paulo (SP) and Federal District of Brasilia (FDB). PATIENTS: Neonates up to 7 days of age and >23 weeks of gestational age...
March 16, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28301792/systemic-lupus-erythematosus-an-update
#19
Vera Golder, Alberta Hoi
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease predominantly affecting women of childbearing age. New classification criteria for SLE have greater sensitivity and therefore improve the diagnostic certainty for some patients, especially those who may previously have been labelled as having undifferentiated symptoms. Uncontrolled disease activity leads to irreversible end-organ damage, which in turn increases the risk of premature death; early and sustained control of disease activity can usually be achieved by conventional immunosuppressant therapy...
March 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28299868/impact-of-a-nurse-practitioner-role-on-metabolic-monitoring-completion-and-referrals-for-consumers-admitted-to-the-intensive-care-area-of-an-acute-inpatient-psychiatric-unit
#20
Trudy Brown, Brian McKenna, Trentham Furness
Mental illness increases a person's risk of physical health issues, including cardiovascular disease, leading to premature morbidity and mortality. Screening for cardiovascular disease through metabolic monitoring is recommended to aid in early detection. The aim of the present study was to ascertain whether consumers admitted to an inpatient mental health unit receive routine metabolic monitoring, and to explore the contribution of a nurse practitioner to metabolic monitoring and the actioning of abnormal results...
March 16, 2017: International Journal of Mental Health Nursing
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