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https://www.readbyqxmd.com/read/29452786/preliminary-results-of-a-single-arm-pilot-study-to-assess-the-safety-and-efficacy-of-visnadine-prenylflavonoids-and-bovine-colostrum-in-postmenopausal-sexually-active-women-affected-by-vulvovaginal-atrophy
#1
Antonio Simone Laganà, Salvatore Giovanni Vitale, Lily Stojanovska, Irene Lambrinoudaki, Vasso Apostolopoulos, Benito Chiofalo, Laura Rizzo, Francesca Basile
This single-arm pilot study enrolled 47 post-menopausal women affected by vulvovaginal atrophy (VVA). The Vaginal Health Index Score (VHIS) was evaluated for all women and all completed the Female Sexual Function Index (FSFI) questionnaire at baseline (T0) and after 15 days of vaginal cream treatment with one application per day (T1). Following treatment there was a significant improvement in all VHIS parameters and total score (p < 0.0001). Similarly, there was a significant improvement on four FSFI domains (lubrication, orgasm, satisfaction and pain) and total score (p = 0...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29411346/post-menopausal-vulvovaginal-atrophy-an-overview-of-the-current-treatment-options
#2
Jacek Krzysztof Szymański, Bogumił Paweł Siekierski, Anna Kajdy, Grzegorz Jakiel
Sex hormone deficiency in post-menopausal women causes changes in the lower urinary tract. Vulvovaginal atrophy is a pathology resulting from those changes. VVA has a negative effect on the quality of life therefore prompting a search for new therapeutic options. The aim of this article is to summarize the current treatment modalities, both hormonal and non-hormonal for post-menopausal vaginal atrophy. Topical oestrogen therapy remains the "golden standard". Alternatives, although promising, require well-designed control studies...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29381086/treatment-of-vaginal-atrophy-with-estriol-and-lactobacilli-combination-a-clinical-review
#3
A O Mueck, X Ruan, V Prasauskas, P Grob, O Ortmann
In recent years, a vast quantity of clinical data has been accumulated on the pathophysiology of symptomatic vulvovaginal atrophy (VVA)/genitourinary syndrome of menopause (GSM) in peri- and postmenopausal women and on the treatment options for these conditions. Guidelines from several societies have recently been updated in favor of VVA/GSM vaginal therapy with the lowest possible doses of estrogens. The combination of a vaginal ultra-low dose of 0.03 mg of estriol (E3) and lyophilized, viable Lactobacillus acidophilus KS400 (0...
January 30, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29286987/a-systematic-review-of-intravaginal-testosterone-for-the-treatment-of-vulvovaginal-atrophy
#4
Robin J Bell, Farwa Rizvi, Rakabul M Islam, Susan R Davis
OBJECTIVES: Intravaginal testosterone has emerged as a potential treatment for vulvovaginal atrophy (VVA) in women, in general, and women taking an aromatase inhibitor (AI). A systematic review of the literature was undertaken to determine whether available clinical trial data support efficacy and safety of intravaginal testosterone for the treatment of VVA. METHODS: Scopus, MEDLINE, EMBASE, and the Cochrane Library databases were systematically searched on July 26, 2017, for human studies published in English of clinical trials of intravaginal testosterone...
December 28, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29286986/fractional-microablative-co2-laser-in-breast-cancer-survivors-affected-by-iatrogenic-vulvovaginal-atrophy-after-failure-of-nonestrogenic-local-treatments-a-retrospective-study
#5
Tiziana Pagano, Pasquale De Rosa, Roberta Vallone, Francesco Schettini, Grazia Arpino, Mario Giuliano, Rossella Lauria, Irene De Santo, Alessandro Conforti, Alessandra Gallo, Giovanni Nazzaro, Sabino De Placido, Mariavittoria Locci, Giuseppe De Placido
OBJECTIVE: Vulvovaginal atrophy (VVA) is a condition frequently observed in menopause. Its symptoms can significantly affect the quality of life of patients. Since VVA is related to estrogen deficiency, chemotherapy and hormone therapy for breast cancer (BC) might cause VVA by inducing menopause. Given the lack of effective treatment for VVA in BC survivors, we retrospectively evaluated the efficacy and tolerability of fractional microablative CO2 laser therapy in these patients. METHODS: We treated 82 BC survivors with three cycles of CO2 laser after failure of topical nonestrogenic therapy...
December 28, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29206779/concentration-range-of-serum-sex-steroids-in-normal-postmenopausal-women-and-those-with-diagnosis-of-vulvovaginal-atrophy
#6
Yuyong Ke, Alain Bélanger, Jean-Nicolas Simard, Renaud Gonthier, Céline Martel, Mario Vaillancourt, Fernand Labrie
OBJECTIVE: The aim of the study was to determine the range of serum sex-related steroids in normal postmenopausal women and in women of the same age with a diagnosis of vulvovaginal atrophy (VVA). METHODS: Validated mass spectrometry-based assays coupled to gas or liquid chromatography were used over a 10-year period for steroid measurements. Serum samples were obtained in up to 1,512 women aged 55 to 65 years. RESULTS: Serum estrone sulfate (E1S) and androsterone glucuronide (ADT-G), the main metabolites of estrogens and androgens, respectively, were 16...
December 4, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29193980/a-randomized-multicenter-double-blind-study-to-evaluate-the-safety-and-efficacy-of-estradiol-vaginal-cream-0-003-in-postmenopausal-women-with-vaginal-dryness-as-the-most-bothersome-symptom
#7
David F Archer, Thomas D Kimble, F D Yuhua Lin, Simona Battucci, Vilma Sniukiene, James H Liu
BACKGROUND: Vulvovaginal atrophy (VVA) is characterized by vaginal/vulvar dryness, irritation, dyspareunia, or dysuria. The objective of this study was to examine the efficacy and safety of a very low-dose estradiol vaginal cream (0.003%) applied twice per week in postmenopausal women with VVA-related vaginal dryness. MATERIALS AND METHODS: In this phase 3, randomized, double-blind, placebo-controlled, multicenter study, postmenopausal women with moderate-severe vaginal dryness as the most bothersome VVA symptom were randomized (1:1) to estradiol cream 0...
December 1, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29120766/the-enrichment-and-characterization-of-ginger-derived-glycoprotein-using-magnetic-particles
#8
Wenzhu Zhao, Yuejiao Chen, Hanjie Yu, Hongling Zhang, Zhipeng Yu, Long Ding, Jingbo Liu, Jianrong Li, Feng Chen
Ginger-derived glycoproteins are a widely distributed group of biological macromolecules with multiple functions. To date, the structure of ginger-derived glycoproteins has not been clarified with regard to their complexity, their sequence diversity and their uneven micro-distribution. In this study, a lectin microarray was used to evaluate 37 types of lectins and determine the optimal lectins that can conjugate with glycoproteins based on the fluorescence intensity. Subsequently, the lectins were immobilized on magnetic beads, coupled with glycoproteins to enrich ginger-derived glycoproteins, and evaluated using SDS-PAGE...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29104812/evaluation-of-the-co2-laser-therapy-on-vulvo-vaginal-atrophy-vva-in-oncological-patients-preliminary-results
#9
Isabella Pagano, Stefania Gieri, Francesca Nocera, Giuseppe Scibilia, Filippo Fraggetta, Antonio Galia, Mauro Gioè, Basilio Pecorino, Paolo Scollo
Objective: To evaluate the impact of fractionated CO2 laser therapy on vaginal atrophy and mild/moderate stress urinary incontinence (SUI) symptoms in patients with physiological or surgically-induced menopause. Materials and Methods: Post-menopausal patients (n = 33) presenting vaginal atrophy and/or SUI, underwent three vaginal CO2 laser treatment sessions, performed at 1-month intervals. Vaginal symptoms were evaluated using the Vaginal Health Index Score (VHI-S), Visual Analogue Scales (VAS) for dyspareunia and global patient satisfaction...
May 2017: Journal of Cancer Therapy
https://www.readbyqxmd.com/read/29094304/perineuronal-nets-labeled-by-monoclonal-antibody-vc1-1-ensheath-interneurons-expressing-parvalbumin-and-calbindin-in-the-rat-amygdala
#10
Alexander J McDonald, Patricia G Hamilton, Colin J Barnstable
Perineuronal nets (PNNs) are specialized condensations of extracellular matrix that ensheath particular neuronal subpopulations in the brain and spinal cord. PNNs regulate synaptic plasticity, including the encoding of fear memories by the amygdala. The present immunohistochemical investigation studied PNN structure and distribution, as well as the neurochemistry of their ensheathed neurons, in the rat amygdala using monoclonal antibody VC1.1, which recognizes a glucuronic acid 3-sulfate glycan associated with PNNs in the cerebral cortex...
November 1, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29057583/a-medical-device-containing-purified-bovine-colostrum-monurelle-biogel-in-the-treatment-of-vulvovaginal-atrophy-in-postmenopausal-women-retrospective-analysis-of-urinary-symptoms-sexual-function-and-quality-of-life
#11
M C Schiavi, C Di Tucci, V Colagiovanni, P Faiano, A Giannini, O D'Oria, G Prata, G Perniola, M Monti, M A Zullo, L Muzii, P Benedetti Panici
OBJECTIVE: This study assessed the effectiveness and safety of a medical device containing purified bovine colostrum (Monurelle Biogel; Zambon, Bresso, Italy) in improving vulvovaginal atrophy (VVA), sexual function, urinary symptoms, and quality of life (QoL) in postmenopausal women. METHODS: In all, 172 postmenopausal women with VVA were included in the study. All women were treated with vaginal Monurelle Biogel daily for 12 weeks. Patients underwent clinical examinations, completed a 3-day voiding diary, and had VVA graded using the Vaginal Health Index (VHI) at baseline and 12 weeks...
October 23, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29029805/glycan-diversity-in-the-vomeronasal-organ-of-the-korean-roe-deer-capreolus-pygargus-a-lectin-histochemical-study
#12
Taekyun Shin, Jeongtae Kim, Yuna Choi, Meejung Ahn
Glycans in the epithelium play an important role in cell-to-cell communication and adhesion. No detailed evaluation of glycoconjugates in the vomeronasal organs (VNO) of the roe deer has been published previously. The aim of this study was to characterize glycan epitopes in the vomeronasal sensory epithelium (VSE) and non-sensory epithelium (VNSE) using lectin histochemistry. Glycan epitopes identified by lectin histochemistry were grouped as follows: N-acetylglucosamine (s-WGA, WGA, BSL-II, DSL, LEL, STL), mannose (Con A, LCA, PSA), galactose (RCA120, BSL-I, Jacalin, PNA, ECL), N-acetylgalactosamine (VVA, DBA, SBA, and SJA), fucose (UEA-I) and complex type N-glycan (PHA-E and PHA-L) groups...
October 10, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28985703/escalation-of-extracorporeal-life-support-as-a-bridge-to-lung-transplantation-in-end-stage-lung-disease
#13
Prashant N Mohite, Alexander Rosenberg, Clara Hernández Caballero, Simona Soresi, Javid Fatullayev, Anna Reed, Aron-Frederik Popov, Anton Sabashnikov, André R Simon
Extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplant (LTx) is not uncommon, but it is not commonplace yet. We present a case of a 45-year-old man with cystic fibrosis with recent deterioration in lung function who was initially supported with veno-venous (VV) ECMO. However, he subsequently required conversion to veno-veno-arterial (VVA) ECMO. After 21 days of support, he underwent double lung transplantation, with an uneventful postoperative course. This case shows that, in patients with end-stage respiratory failure awaiting lung transplantation, extracorporeal life support may require escalation to improve gas exchange and address circulatory requirements...
October 2017: Perfusion
https://www.readbyqxmd.com/read/28956066/erratum-to-long-term-reliability-of-fractioned-co2-laser-as-a-treatment-for-vulvovaginal-atrophy-vva-symptoms
#14
Annalisa Pieralli, Claudia Bianchi, Manuela Longinotti, Serena Corioni, Noemi Auzzi, Angelamaria Becorpi, Maria Grazia Fallani, Giuseppe Cariti, Felice Petraglia
In original publication, the Fig. 1 was incorrect. The correct figure has been given below.
September 27, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28934376/managing-menopausal-symptoms-and-associated-clinical-issues-in-breast-cancer-survivors
#15
REVIEW
Richard J Santen, Cynthia A Stuenkel, Susan R Davis, JoAnn V Pinkerton, Anne Gompel, Mary Ann Lumsden
Objective: Review evidence to guide management of menopausal signs and symptoms in women after breast cancer and make recommendations accordingly. Evidence: Randomized controlled clinical trials, observational studies, evidence-based guidelines, and expert opinion from professional societies. Background: Symptoms and clinical problems associated with estrogen depletion-sleep disorders, vulvovaginal atrophy (VVA), vasomotor symptoms (VMS), mood changes, depressive symptoms, cardiovascular disease, osteopenia, and osteoporosis-confront the estimated 9...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28926514/a-randomized-multicenter-double-blind-study-to-evaluate-the-safety-and-efficacy-of-estradiol-vaginal-cream-0-003-in-postmenopausal-women-with-dyspareunia-as-the-most-bothersome-symptom
#16
Robin Kroll, David F Archer, Yuhua Lin, Vilma Sniukiene, James H Liu
OBJECTIVE: Vulvovaginal atrophy (VVA) is characterized by vaginal changes, dyspareunia, and itching/irritation. Efficacy and safety of a lower-dose estradiol vaginal cream (0.003%) were evaluated in postmenopausal women with VVA-related dyspareunia. METHODS: This was a phase 3, randomized, double-blind, placebo-controlled study. Sexually active postmenopausal women with moderate-severe dyspareunia as the most bothersome symptom, ≤5% vaginal superficial cells, and vaginal pH >5...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28894392/fractional-co2-laser-treatment-for-vulvovaginal-atrophy-symptoms-and-vaginal-rejuvenation-in-perimenopausal-women
#17
César Arroyo
BACKGROUND: This study investigated a novel fractional carbon dioxide (CO2) laser for treatment of symptoms associated with vulvovaginal atrophy (VVA) in perimenopausal women. METHODS: The study included 21 perimenopausal women (mean age 45±7 years) treated three times by CO2 laser resurfacing and coagulation of the vaginal canal tissue and mucosal tissue of the introitus. Vaginal health index (VHI) scores were computed by the investigator at baseline and follow-ups...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28871230/comparative-analysis-for-glycopatterns-and-complex-type-n-glycans-of-glycoprotein-in-sera-from-chronic-hepatitis-b-and-c-infected-patients
#18
Xinmin Qin, Yonghong Guo, Haoqi Du, Yaogang Zhong, Jiaxu Zhang, Xuetian Li, Hanjie Yu, Zhiwei Zhang, Zhansheng Jia, Zheng Li
Background: Chronic infection with HBV (CHB) or HCV (CHC) is the most common chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma in humans, their infections have distinct pathogenic processes, however, little is known about the difference of glycoprotein glycopatterns in serum between hepatitis B virus (HBV)- and hepatitis C virus (HCV)-infected patients. Methods: A method combining the lectin microarrays, letin-mediated affinity capture glycoproteins, and MALDI-TOF/TOF-MS was employed to analyze serum protein glycopatterns and identify the glycan structures from patients with CHB (n = 54) or CHC(n = 47), and healthy volunteers (HV, n = 35)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28866727/long-term-reliability-of-fractioned-co2-laser-as-a-treatment-for-vulvovaginal-atrophy-vva-symptoms
#19
Annalisa Pieralli, Claudia Bianchi, Manuela Longinotti, Serena Corioni, Noemi Auzzi, Angelamaria Becorpi, Maria Grazia Fallani, Giuseppe Cariti, Felice Petraglia
PURPOSE: The aim of this study was to evaluate long-term effects of the fractional CO2 laser for the treatment of vulvovaginal atrophy (VVA) symptoms. METHODS: Women presenting with VVA symptoms and meeting inclusion criterion were enrolled to fractioned CO2 laser therapy. Patient's satisfaction was measured on five-point Likert scale at 4 weeks and 6, 12, 18, 24 months after treatment by interview and clinical examination for vaginal livability. RESULTS: 184 patients constituted the final study group: 128 women were spontaneous menopause and 56 were oncological menopause...
November 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28864904/veno-veno-arterial-extracorporeal-membrane-oxygenation-for-acute-respiratory-distress-syndrome-with-septic-induced-cardiomyopathy-due-to-severe-pulmonary-tuberculosis
#20
Seok In Lee, Hyun Joong Hwang, So Young Lee, Chang Hyu Choi, Chul-Hyun Park, Kook Yang Park, Yu Jin Kim
We describe the rare experience of veno-veno-arterial (VVA) extracorporeal membrane oxygenation (ECMO) in a patient with acute respiratory distress syndrome and septic-induced cardiomyopathy due to pulmonary tuberculosis (TB). A 24-year-old male patient who developed septic-induced cardiomyopathy secondary to pulmonary TB was administered veno-arterial (VA) ECMO for cardiac support. Six days later, the ECMO configuration mode was changed from VA to VVA to improve hypoxemia of the upper body and to prevent further lung injury...
December 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
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