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https://www.readbyqxmd.com/read/28525626/skin-pigmentation-and-risk-of-hearing-loss-in-women
#1
Brian M Lin, Wen-Qing Li, Sharon G Curhan, Konstantina M Stankovic, Abrar A Qureshi, Gary C Curhan
Black individuals have a lower risk of hearing loss than do whites, possibly because of differences in cochlear melanocytes. Previous studies have suggested that darker-skinned individuals tend to have more inner ear melanin, and cochlear melanocytes are important in generating the endocochlear potential. We investigated the relationship between self-reported hearing loss and skin pigmentation by using hair color, skin tanning ability, and skin reaction to prolonged sun exposure as surrogate measures of pigmentation among 49,323 white women in the Nurses' Health Study...
May 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28513251/comparison-of-the-effects-of-665-nm-low-level-diode-laser-hat-versus-and-a-combination-of-665-nm-and-808nm-low-level-diode-laser-scanner-of-hair-growth-in-androgenic-alopecia
#2
Behrooz Barikbin, Zeinab Khodamrdi, Leila Kholoosi, Mohammad Reza Akhgri, Majid Haj Abbasi, Mojgan Hajabbasi, Zahra Razzaghi, Samaneh Akbarpour
BACKGROUND: This study aimed to evaluate the effectiveness of a combined set of low level diode laser scanner (665 nm and 808nm) on hair growth, and assessment of safety and effectiveness of a new laser scanner on hair growth treatment procedure in androgenic alopecia. METHODS: 90 patients (18 to 70 years) with androgenic alopecia were randomized into three groups. The first group (n=30) received 655 nm red light using laser hat, the second group (n=30) received 655 nm red laser plus 808 nm infrared laser using a laser scanner of hair growth device (with the patent number: 77733) and the third group (n=30) received no laser as the control group...
May 17, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28502801/genome-wide-association-reveals-pigmentation-genes-play-a-role-in-skin-aging
#3
Matthew H Law, Sarah E Medland, Gu Zhu, Seyhan Yazar, Ana Viñuela, Leanne Wallace, Sri Niranjan Shekar, David L Duffy, Veronique Bataille, Dan Glass, Tim D Spector, Diane Wood, Scott D Gordon, Julie M Barbour, Anjali K Henders, Alex W Hewitt, Grant W Montgomery, Richard A Sturm, David A Mackey, Adèle C Green, Nicholas G Martin, Stuart MacGregor
Loss of fine skin patterning is a sign of both aging and photoaging. Studies investigating the genetic contribution to skin patterning offer an opportunity to better understand a trait that influences both physical appearance and risk of keratinocyte skin cancer. We undertook a meta-analysis of genome-wide association studies (GWAS) of a measure of skin pattern (microtopography score) damage in 1,671 twin pairs and 1,745 singletons (N = 5,087) drawn from three independent cohorts. We identified that rs185146 near SLC45A2 is associated with a skin aging trait (p = 4...
May 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28502649/post-implantation-development-of-red-rumped-agouti-dasyprocta-leporina-linnaeus-1758
#4
Gleidson Benevides de Oliveira, Hélio Noberto de Araújo Júnior, Herson da Silva Costa, Alexandre Rodrigues Silva, Carlos Eduardo Bezerra de Moura, Hugo Alexandre de Oliveira Rocha, Maria Angélica Miglino, Moacir Franco de Oliveira
Fourteen pregnant agouti (Dasyprocta leporina Linnaeus, 1758) females at gestational ages of 30-100days and two at gestational ages of 55-100days, were studied, including 24 embryos/fetuses and two neonates (single offspring from two females). Females were euthanized and embryos/fetuses were examined, measured, and photographed. Embryos at 30days post-copulation were "C-shaped," with paddle-shaped limb buds and 10.75±0.11mm crown-rump length (CRL). In embryos at 35days post-copulation, paddle-shaped forelimbs, fin-shaped pelvic limbs, and a liver bud were evident, with 15...
May 2, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28457509/haplotypes-from-the-slc45a2-gene-are-associated-with-the-presence-of-freckles-and-eye-hair-and-skin-pigmentation-in-brazil
#5
Nádia Carolina de Aguiar Fracasso, Edilene Santos de Andrade, Cláudia Emília Vieira Wiezel, Claudia Caixeta Franco Andrade, Lídia Renata Zanão, Mateus Spinelli da Silva, Leonardo Arduino Marano, Eduardo Antônio Donadi, Erick C Castelli, Aguinaldo Luiz Simões, Celso Teixeira Mendes-Junior
The Solute Carrier Family 45, Member 2 (SLC45A2) gene encodes the Membrane-Associated Transporter Protein (MATP), which mediates melanin synthesis by tyrosinase trafficking and proton transportation to melanosomes. At least two SLC45A2 coding SNPs [E272K (rs26722) and L374F (rs16891982)] were reported influencing normal variation of human pigmentation. Here we aimed at evaluating the influence of haplotypes of 12 SNPs within SLC45A2 in the determination of eye, hair and skin pigmentation in a highly admixed population sample and comparing their frequencies with the ones found in data retrieved from the 1000 Genomes Project...
March 2017: Legal Medicine
https://www.readbyqxmd.com/read/28456452/oral-mass-revealing-ch%C3%A3-diak-higashi-syndrome
#6
T Tsuji, Y Uemura, Y Nakamura, S Nonoyama
This case report describes common oral inflammatory findings leading to the identification of Chédiak-Higashi syndrome (CHS). A 15-year-old girl presented with an enlarging and painful mass on the upper lip. Two weeks after the initial visit, the mass showed further protrusion in the absence of fever. Magnetic resonance imaging revealed a well-circumscribed cystic lesion with a thick capsule, and suggested an abscess derived from the mucous cyst in the upper lip. Inflammation indices were not elevated; however neutrophils were significantly lower than the normal level...
April 26, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28421029/a-historical-view-of-motion-sickness-a-plague-at-sea-and-on-land-also-with-military-impact
#7
Doreen Huppert, Judy Benson, Thomas Brandt
Seasickness and its triggers, symptoms, and preventive measures were well known in antiquity. This chapter is based on an analysis of descriptions of motion sickness, in particular seasickness, in ancient Greek, Roman, and Chinese literature. A systematic search was made from the Greek period beginning with Homer in 800 BC to the late Roman period and ending with Aetios Amidenos in 600 AD, as well as in the Chinese medical classics dating from around 300 AD. Major aspects are the following: body movements caused by waves were identified in all cultures as the critical stimuli...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28418107/a-new-path-in-defining-light-parameters-for-hair-growth-discovery-and-modulation-of-photoreceptors-in-human-hair-follicle
#8
Serena Buscone, Andrei N Mardaryev, Bianca Raafs, Jan W Bikker, Carsten Sticht, Norbert Gretz, Nilofer Farjo, Natallia E Uzunbajakava, Natalia V Botchkareva
BACKGROUND AND OBJECTIVE: Though devices for hair growth based on low levels of light have shown encouraging results, further improvements of their efficacy is impeded by a lack of knowledge on the exact molecular targets that mediate physiological response in skin and hair follicle. The aim of this study was to investigate the expression of selected light-sensitive receptors in the human hair follicle and to study the impact of UV-free blue light on hair growth ex vivo. MATERIAL AND METHODS: The expression of Opsin receptors in human skin and hair follicles has been characterized using RT-qPCR and immunofluorescence approaches...
April 18, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28384239/induction-of-osteoblastic-differentiation-of-neural-crest-derived-stem-cells-from-hair-follicles
#9
Eri Urano-Morisawa, Masamichi Takami, Tetsuo Suzawa, Akifumi Matsumoto, Noriko Osumi, Kazuyoshi Baba, Ryutaro Kamijo
The neural crest (NC) arises near the neural tube during embryo development. NC cells migrate throughout the embryo and have potential to differentiate into multiple cell types, such as peripheral nerves, glial, cardiac smooth muscle, endocrine, and pigment cells, and craniofacial bone. In the present study, we induced osteoblast-like cells using whisker follicles obtained from the NC of mice. Hair follicle cells derived from the NC labeled with enhanced green fluorescent protein (EGFP) were collected from protein zero-Cre/floxed-EGFP double transgenic mice and cultured, then treated and cultured in stem cell growth medium...
2017: PloS One
https://www.readbyqxmd.com/read/28369851/evaluation-of-clinical-signs-and-early-and-late-trichoscopy-findings-in-traction-alopecia-patients-with-fitzpatrick-skin-type-ii-and-iii-a-single-center-clinical-study
#10
Mualla Polat
BACKGROUND: Traction alopecia refers to (often permanent) hair loss caused by prolonged physical damage. No study has yet described the unique trichoscopic findings of the condition. We describe the trichoscopic findings of traction alopecia and its relationships with the duration of traction. METHODS: We studied 25 patients who were clinically diagnosed with traction alopecia. The patients were divided into two groups in terms of traction duration. Trichoscopy was performed at a minimum of two scalp locations in each patient...
March 30, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28336458/nile-red-nanosuspensions-as-investigative-model-to-study-the-follicular-targeting-of-drug-nanocrystals
#11
Francesco Corrias, Michele Schlich, Chiara Sinico, Rosa Pireddu, Donatella Valenti, Anna Maria Fadda, Salvatore Marceddu, Francesco Lai
The strategy of formulating poorly soluble actives as nanosuspension has been explored by more than a thousand research papers, with some medicinal products for oral and intravenous use having reached the market or advanced clinical trials. Interestingly, there is a limited number of reports of nanosuspensions formulated for dermal and transdermal drug delivery. In the present work, a nanocrystals suspension of the fluorescent, water-insoluble dye Nile Red, is prepared through a media milling technique and exploited to characterize the fate of the nanosuspended drug when applied on the skin...
March 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28334693/fabrication-of-human-hair-keratin-jellyfish-collagen-eggshell-derived-hydroxyapatite-osteoinductive-biocomposite-scaffolds-for-bone-tissue-engineering-from-waste-to-regenerative-medicine-products
#12
Yavuz Emre Arslan, Tugba Sezgin Arslan, Burak Derkus, Emel Emregul, Kaan C Emregul
In the present study, we aimed at fabricating an osteoinductive biocomposite scaffold using keratin obtained from human hair, jellyfish collagen and eggshell-derived nano-sized spherical hydroxyapatite (nHA) for bone tissue engineering applications. Keratin, collagen and nHA were characterized with the modified Lowry method, free-sulfhydryl groups and hydroxyproline content analysis, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR) and thermal gravimetric analysis (TGA) which confirmed the success of the extraction and/or isolation processes...
June 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28331352/skin-disorders-in-parkinson-s-disease-potential-biomarkers-and-risk-factors
#13
REVIEW
Astrid-Helene Ravn, Jacob P Thyssen, Alexander Egeberg
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, characterized by a symptom triad comprising resting tremor, rigidity, and akinesia. In addition, non-motor symptoms of PD are well recognized and often precede the overt motor manifestations. Cutaneous manifestations as markers of PD have long been discussed, and cumulative evidence shows an increased prevalence of certain dermatological disorders in PD. Seborrheic dermatitis is considered to occur as a premotor feature of PD referable to dysregulation of the autonomic nervous system...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28326184/unilateral-demodicidosis-of-face-mimicking-hansens-disease
#14
Deepak Vashisht, Jatinder Singh, Sukriti Baveja, Rohit Tiwari, Anuj Bhatnagar
Demodicosis is a common parasitic infection of the hair follicles and the pilosebaceous unit by the Demodex mites viz. Demodex folliculorum and Demodex brevis. Infection by this parasite is common among immunocompromised and elderly. We report a case of facial Demodicosis which presented like atypical rosacea with a gradually progressing swelling and redness on right side of face which was initially diagnosed as a case of Hansen's disease. Skin biopsy revealed follicular dilatation with presence of Demodex mite along with intense perifollicular lymphomononuclear infiltrate...
June 15, 2016: Dermatology Reports
https://www.readbyqxmd.com/read/28315019/an-endophytic-fungus-gibberella-moniliformis-from-lawsonia-inermis-l-produces-lawsone-an-orange-red-pigment
#15
Hatnagar Sarang, Pijakala Rajani, Madhugiri Mallaiah Vasanthakumari, Patel Mohana Kumara, Ramamoorthy Siva, Gudasalamani Ravikanth, R Uma Shaanker
Lawsone (2-hydroxy-1, 4-napthoquinone), also known as hennotannic acid, is an orange red dye used as a popular skin and hair colorant. The dye is produced in the leaves of Lawsonia inermis L, often referred to as the "henna" tree. In this study, we report the production of lawsone by an endophytic fungus, Gibberella moniliformis isolated from the leaf tissues of Lawsonia inermis. The fungus produced the orange-red dye in potato dextrose agar and broth, independent of the host tissue. Presence of lawsone was confirmed spectrometrically using HPLC and ESI-MS/MS analysis...
March 17, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28275654/red-hair-mc1r-variants-and-risk-for-parkinson-s-disease-a-meta-analysis
#16
Xiqun Chen, Danielle Feng, Michael A Schwarzschild, Xiang Gao
Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair-associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta-analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p...
March 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28274810/non-clinical-safety-evaluation-and-risk-assessment-to-human-of-aleglitazar-a-dual-ppar-%C3%AE-%C3%AE-agonist-and-its-major-human-metabolite
#17
Martin Bopst, Elke-Astrid Atzpodien
The non-clinical safety profile of aleglitazar, a peroxisome proliferator activated receptor alpha/gamma agonist, and its major human metabolite M6 was studied in a complete package consisting of drug metabolism and pharmacokinetics characterization, safety pharmacology, genotoxicity, repeat dose toxicity, reproductive toxicity and carcinogenicity studies. These studies identified the following main targets similar to other PPAR agonists: red blood cell parameters, liver, heart, kidney, ovaries, testes, bone marrow, adipose tissue, and fluid accumulation...
March 6, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28243491/pityriasis-lichenoides-et-varioliformis-acuta-in-skin-of-color-new-observations-by-dermoscopy
#18
Balachandra S Ankad, Savitha L Beergouder
BACKGROUND: Pityriasis lichenoides is an uncommon skin disease that presents in three different forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic-Mucha-Habermann disease. These represent a spectrum of a disease. PLEVA presents as skin eruption of multiple, small, red papules that develop into polymorphic lesions with periods of varying remissions, as well as possible sequels of hyper/hypopigmentation and varicella-like scars...
January 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28242083/association-of-five-snps-with-human-hair-colour-in-the-polish-population
#19
A Siewierska-Górska, A Sitek, E Żądzińska, G Bartosz, D Strapagiel
Twenty-two variants (single nucleotide polymorphisms - SNPs) of the genes involved in hair pigmentation (OCA2, HERC2, MC1R, SLC24A5, SLC45A2, TPCN2, TYR, TYRP1) were genotyped in a group of 186 Polish participants, representing a range of hair colours (45 red, 64 blond, 77 dark). A genotype-phenotype association analysis was performed. Using z-statistics we identified three variants highly associated with different hair colour categories (rs12913832:A>G in HERC2, rs1805007:T>C and rs1805008:C>T in MC1R)...
February 4, 2017: Homo: Internationale Zeitschrift Für die Vergleichende Forschung Am Menschen
https://www.readbyqxmd.com/read/28214221/relationship-between-the-melanocortin-1-receptor-mc1r-variant-r306ter-and-physiological-responses-to-mechanical-or-thermal-stimuli-in-labrador-retriever-dogs
#20
Tania E Perez, Katrina L Mealey, Neal S Burke, Tamara L Grubb, Michael H Court, Stephen A Greene
OBJECTIVE: Variants in the MC1R gene have been associated with red hair color and sensitivity to pain in humans. The study objective was to determine if a relationship exists between MC1R genotype and physiological thermal or mechanical nociceptive thresholds in Labrador Retriever dogs. STUDY DESIGN: Prospective experimental study. ANIMALS: Thirty-four Labrador Retriever dogs were included in the study following public requests for volunteers...
January 11, 2017: Veterinary Anaesthesia and Analgesia
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