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https://www.readbyqxmd.com/read/27800573/pharmacokinetic-modeling-and-monte-carlo-simulation-to-predict-interindividual-variability-in-human-exposure-to-oseltamivir-and-its-active-metabolite-ro-64-0802
#1
Mototsugu Ito, Hiroyuki Kusuhara, Atsushi Ose, Tsunenori Kondo, Kazunari Tanabe, Hideki Nakayama, Shigeru Horita, Takuya Fujita, Yuichi Sugiyama
Oseltamivir (Tamiflu®) is a prodrug of Ro 64-0802, a selective inhibitor of influenza virus neuraminidase. There is a possible relationship between oseltamivir treatment and neuropsychiatric adverse events; although this has not been established, close monitoring is recommended on the prescription label. The objective of this study was to predict interindividual variability of human exposure to oseltamivir and its active metabolite Ro 64-0802. By leveraging mathematical models and computations, physiological parameters in virtual subjects were generated with population means and coefficient of variations collected from the literature or produced experimentally...
October 31, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27567070/fda-approves-first-generic-version-of-tamiflu
#2
Patricia Lobo
No abstract text is available yet for this article.
October 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27522128/an-evaluation-of-the-use-of-short-message-service-during-an-avian-influenza-outbreak-on-a-poultry-farm-in-young
#3
Lisa M Stephenson, Janice S Biggs, Vicky Sheppeard, Tracey L Oakman
In 2013 an avian influenza outbreak occurred in a large poultry farm in Young (approximately 2 hours north-west of Canberra.) The responsible strain was H7N2, which is highly pathogenic and can affect humans. Daily surveillance was required for those individuals who were possibly exposed. This was conducted through the use of daily message through the short message service (SMS). A total of 55 people were identified as having had high risk exposure and requiring monitoring during the surveillance period from 16 to 25 October 2013...
2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/27490658/patient-perceptions-of-oseltamivir-for-the-treatment-of-influenza
#4
Steven G Schauer, Shawn M Varney, James K Aden, Vikhyat S Bebarta
OBJECTIVES: Oseltamivir (Tamiflu) is approved by the Food and Drug Administration and is advertised for the treatment of influenza types A and B. Patient perceptions of its efficacy have not been adequately studied. Recent systematic reviews have called the benefits of this drug into question relative to the cost and adverse effect profile. We hypothesized that most people would be unaware of the efficacy, cost, or adverse effect profile of the drug. Our objective was to determine patient perceptions of efficacy, cost, and adverse effect profile of oseltamivir for the treatment of influenza...
August 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27454847/shikimic-acid-inhibits-lps-induced-cellular-pro-inflammatory-cytokines-and-attenuates-mechanical-hyperalgesia-in-mice
#5
Thallita Kelly Rabelo, Adriana Gibara Guimarães, Marlange Almeida Oliveira, Juciano Gasparotto, Mairim Russo Serafini, Adriano Antunes de Souza Araújo, Lucindo José Quintans-Júnior, José Cláudio Fonseca Moreira, Daniel Pens Gelain
BACKGROUND AND AIMS: Shikimic acid (SA) is present in a wide variety of plants and microorganisms used in traditional and folk medicine and also is an essential starting material for the synthesis of the antiviral drug Oseltamivir (Tamiflu®). Some pharmacological actions observed in SA-enriched products include antioxidant and anti-inflammatory activities. Here, we investigated the anti-inflammatory and antinociceptive actions of isolated SA. METHODS: RAW 264.7 macrophage cells were treated with bacterial LPS (1μg/mL) and the effect of SA on the modulation of cell viability, nitric oxide (NO) production, TNF-α, and IL-1β content and MAPK (ERK1/2 and p38) activation was evaluated...
October 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27351973/two-escape-mechanisms-of-influenza-a-virus-to-a-broadly-neutralizing-stalk-binding-antibody
#6
Ning Chai, Lee R Swem, Mike Reichelt, Haiyin Chen-Harris, Elizabeth Luis, Summer Park, Ashley Fouts, Patrick Lupardus, Thomas D Wu, Olga Li, Jacqueline McBride, Michael Lawrence, Min Xu, Man-Wah Tan
Broadly neutralizing antibodies targeting the stalk region of influenza A virus (IAV) hemagglutinin (HA) are effective in blocking virus infection both in vitro and in vivo. The highly conserved epitopes recognized by these antibodies are critical for the membrane fusion function of HA and therefore less likely to be permissive for virus mutational escape. Here we report three resistant viruses of the A/Perth/16/2009 strain that were selected in the presence of a broadly neutralizing stalk-binding antibody...
June 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27339308/studies-on-the-production-of-shikimic-acid-using-the-arok-knockout-strain-of-bacillus-megaterium
#7
Saptarshi Ghosh, Utpal Mohan, Uttam Chand Banerjee
Shikimic acid has various pharmaceutical and industrial applications. It is the sole chemical building block for the antiviral drug oseltamivir (Tamiflu(®)) and one of the potent pharmaceutical intermediates with three chiral centres. Here we report a modified strain of Bacillus megaterium with aroK (shikimate kinase) knock out to block the aromatic biosynthetic pathway downstream of shikimic acid. Homologous recombination based gene disruption approach was used for generating aroK knock out mutant of B. megaterium...
August 2016: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27252237/sixty-seconds-on-tamiflu
#8
Nigel Hawkes
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27251383/debate-on-whether-tamiflu-prevents-flu-deaths-reignites-after-new-analysis
#9
Nigel Hawkes
No abstract text is available yet for this article.
May 31, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27246259/neuraminidase-inhibitors-for-influenza-a-systematic-review-and-meta-analysis-of-regulatory-and-mortality-data
#10
Carl J Heneghan, Igho Onakpoya, Mark A Jones, Peter Doshi, Chris B Del Mar, Rokuro Hama, Matthew J Thompson, Elizabeth A Spencer, Kamal R Mahtani, David Nunan, Jeremy Howick, Tom Jefferson
BACKGROUND: Neuraminidase inhibitors (NIs) are stockpiled and recommended by public health agencies for treating and preventing seasonal and pandemic influenza. They are used clinically worldwide. OBJECTIVES: To (1) describe the potential benefits and harms of NIs for influenza in all age groups by reviewing all clinical study reports (CSRs) of published and unpublished randomised, placebo-controlled trials and regulatory comments; and (2) determine the effect of oseltamivir (Tamiflu(®), Roche) treatment on mortality in patients with 2009A/H1N1 influenza...
May 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27168446/more-on-data-sharing
#11
LETTER
Peter J Embi, Jessica D Tenenbaum
No abstract text is available yet for this article.
May 12, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27168445/more-on-data-sharing
#12
LETTER
Carl T Bergstrom
No abstract text is available yet for this article.
May 12, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27168444/more-on-data-sharing
#13
LETTER
Stuart Buck
No abstract text is available yet for this article.
May 12, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27168443/more-on-data-sharing
#14
LETTER
Dan L Longo, Jeffrey M Drazen
No abstract text is available yet for this article.
May 12, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27036721/treatment-and-prevention-of-pandemic-h1n1-influenza
#15
REVIEW
Suresh Rewar, Dashrath Mirdha, Prahlad Rewar
BACKGROUND: Swine influenza is a respiratory infection common to pigs worldwide caused by type A influenza viruses, principally subtypes H1N1, H1N2, H2N1, H3N1, H3N2, and H2N3. Swine influenza viruses also can cause moderate to severe illness in humans and affect persons of all age groups. People in close contact with swine are at especially high risk. Until recently, epidemiological study of influenza was limited to resource-rich countries. The World Health Organization declared an H1N1 pandemic on June 11, 2009, after more than 70 countries reported 30,000 cases of H1N1 infection...
September 2015: Annals of Global Health
https://www.readbyqxmd.com/read/27002612/in-vitro-and-in-vivo-stability-of-oseltamivir-within-a-bioequivalence-trial
#16
Alexander Grigoriev, Irina Borisova, Irina Yaroshenko, Alla Sidorova
A simple, precise, and rapid method to simultaneously determine the levels of oseltamivir (OS) and oseltamivir carboxylate (OSC) in human plasma was developed. Additionally, the stability of both substances in plasma was investigated under different conditions. The method involved protein precipitation (0.01 % HCl in acetonitrile), and then the supernatant was injected into the high-performance liquid chromatography (HPLC)-MS/MS. The chromatographic separation was achieved on a YMC-Triart C18 (100 × 2...
May 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/26892220/carboxylesterases-general-detoxifying-enzymes
#17
M Jason Hatfield, Robyn A Umans, Janice L Hyatt, Carol C Edwards, Monika Wierdl, Lyudmila Tsurkan, Michael R Taylor, Philip M Potter
Carboxylesterases (CE) are members of the esterase family of enzymes, and as their name suggests, they are responsible for the hydrolysis of carboxylesters into the corresponding alcohol and carboxylic acid. To date, no endogenous CE substrates have been identified and as such, these proteins are thought to act as a mechanism to detoxify ester-containing xenobiotics. As a consequence, they are expressed in tissues that might be exposed to such agents (lung and gut epithelia, liver, kidney, etc.). CEs demonstrate very broad substrate specificities and can hydrolyze compounds as diverse as cocaine, oseltamivir (Tamiflu), permethrin and irinotecan...
February 15, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/26872862/meeting-report-4th-isirv-antiviral-group-conference-novel-antiviral-therapies-for-influenza-and-other-respiratory-viruses
#18
REVIEW
Jennifer L McKimm-Breschkin, Alicia M Fry
The International Society for Influenza and other Respiratory Virus Diseases (isirv) held its 4th Antiviral Group Conference at the University of Texas on 2-4 June, 2015. With emerging resistance to the drugs currently licensed for treatment and prophylaxis of influenza viruses, primarily the neuraminidase inhibitor oseltamivir phosphate (Tamiflu) and the M2 inhibitors amantadine and rimantadine, and the lack of effective interventions against other respiratory viruses, the 3-day programme focused on the discovery and development of inhibitors of several virus targets and key host cell factors involved in virus replication or mediating the inflammatory response...
May 2016: Antiviral Research
https://www.readbyqxmd.com/read/26838018/the-cobas%C3%A2-egfr-mutation-test-v2-assay
#19
Paul Brown
Paul Brown speaks to Gemma Westcott, Commissioning Editor: Paul Brown has served as the Head of Roche Molecular Diagnostics at Roche Diagnostics Corporation since February 2010 having previously held a variety of positions within Roche Pharma. After completing his doctorate in organic chemistry he was awarded a post-doctoral fellowship at the California Institute of Technology in Pasadena, CA, USA, but soon returned to his native UK to join Roche Pharma Research. Paul's first post within Roche was as group leader, doing drug discovery and making new small molecule drugs, but later moved into the business part of the company...
February 2016: Future Oncology
https://www.readbyqxmd.com/read/26659206/detection-of-rare-drug-resistance-mutations-by-digital-pcr-in-a-human-influenza-a-virus-model-system-and-clinical-samples
#20
Alexandra S Whale, Claire A Bushell, Paul R Grant, Simon Cowen, Ion Gutierrez-Aguirre, Denise M O'Sullivan, Jana Žel, Mojca Milavec, Carole A Foy, Eleni Nastouli, Jeremy A Garson, Jim F Huggett
Digital PCR (dPCR) is being increasingly used for the quantification of sequence variations, including single nucleotide polymorphisms (SNPs), due to its high accuracy and precision in comparison with techniques such as quantitative PCR (qPCR) and melt curve analysis. To develop and evaluate dPCR for SNP detection using DNA, RNA, and clinical samples, an influenza virus model of resistance to oseltamivir (Tamiflu) was used. First, this study was able to recognize and reduce off-target amplification in dPCR quantification, thereby enabling technical sensitivities down to 0...
February 2016: Journal of Clinical Microbiology
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