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https://www.readbyqxmd.com/read/28655145/partitioned-learning-of-deep-boltzmann-machines-for-snp-data
#1
Moritz Hess, Stefan Lenz, Tamara J Blätte, Lars Bullinger, Harald Binder
Motivation: Learning the joint distributions of measurements, and in particular identification of an appropriate low-dimensional manifold, has been found to be a powerful ingredient of deep leaning approaches. Yet, such approaches have hardly been applied to single nucleotide polymorphism (SNP) data, probably due to the high number of features typically exceeding the number of studied individuals. Results: After a brief overview of how deep Boltzmann machines (DBMs), a deep learning approach, can be adapted to SNP data in principle, we specifically present a way to alleviate the dimensionality problem by partitioned learning...
June 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28654982/genetic-african-ancestry-is-associated-with-central-corneal-thickness-and-intraocular-pressure-in-primary-open-angle-glaucoma
#2
Pieter W M Bonnemaijer, Colin Cook, Abhishek Nag, Christopher J Hammond, Cornelia M van Duijn, Hans G Lemij, Caroline C W Klaver, Alberta A H J Thiadens
Purpose: To unravel the relationship between African ancestry, central corneal thickness (CCT), and intraocular pressure (IOP) by estimating the genetic African ancestry (GAA) proportion in primary open-angle glaucoma (POAG) patients and controls from an admixed South African Colored (SAC) and a South African Black (SAB) population. Methods: In this case-control study, 268 POAG patients and 137 controls were recruited from a university clinic in Cape Town, South Africa...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28654765/a-traffic-light-grading-system-of-hip-dysplasia-to-predict-the-success-of-arthroscopic-hip-surgery
#3
George Grammatopoulos, Owain L I Davies, Ahmed El-Bakoury, Harinderjit S Gill, Tom C B Pollard, Antonio J Andrade
BACKGROUND: The role of hip arthroscopic surgery in dysplasia is controversial. PURPOSE: To determine the 7-year joint preservation rate after hip arthroscopic surgery in hip dysplasia and identify anatomic and intraoperative features that predict the success of hip preservation with arthroscopic surgery, allowing the formulation of an evidence-based classification system. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Between 2008 and 2013, 111 hips with dysplastic features (acetabular index [AI] >10° and/or lateral center-edge angle [LCEA] <25°) that underwent arthroscopic surgery were identified...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28654734/can-a-rapid-measure-of-self-exposure-to-drugs-of-abuse-provide-dimensional-information-on-depression-comorbidity
#4
Eduardo Roque Butelman, Silvia Bacciardi, Angelo Giovanni Icro Maremmani, Maya Darst-Campbell, Joel Correa da Rosa, Mary Jeanne Kreek
BACKGROUND AND OBJECTIVES: Addictions to heroin or to cocaine are associated with substantial psychiatric comorbidity, including depression. Poly-drug self-exposure (eg, to heroin, cocaine, cannabis, or alcohol) is also common, and may further affect depression comorbidity. METHODS: This case-control study examined the relationship of exposure to the above drugs and depression comorbidity. Participants were recruited from methadone maintenance clinics, and from the community...
June 27, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28653964/a-comparison-of-clinical-outcome-between-athletes-and-nonathletes-undergoing-hip-arthroscopy-for-femoroacetabular-impingement
#5
Yoichi Murata, Soshi Uchida, Hajime Utsunomiya, Akihisa Hatakeyama, Eiichiro Nakamura, Akinori Sakai
OBJECTIVE: To compare the clinical outcome of arthroscopic surgery for femoroacetabular impingement (FAI) between athlete and nonathlete patients. DESIGN: Retrospective case-control study. Level of Evidence III. PATIENTS AND METHODS: Seventy-four patients who underwent arthroscopic FAI correction from March 2009 to April 2012 were enrolled in this study. The patients were divided into 2 groups, according to their sports participation (47 in the athlete group and 27 in the nonathlete group)...
July 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28653927/detection-of-interleukins-6-and-8-in-saliva-as-potential-biomarkers-of-oral-pre-malignant-lesion-and-oral-carcinoma-a-breakthrough-in-salivary-diagnostics-in-pakistan
#6
Iqbal A Muhammad Khyani, Masood A Qureshi, Talat Mirza, M Umar Farooq
Oral cancer is at rise in our population due to increasing use of areca nut (Betel nut) with or without tobacco. It is the second frequent malignant tumour for both the gender in Pakistan. This non-interventional case control study was carried out with the aim to explore saliva as diagnostic medium for detecting interleukins (IL) 6 and 8 as biomarkers of pre-malignant lesions (PML) and oral carcinoma. Total 105 subjects were recruited and were divided into three groups "A", "B" and "C" each comprising of 35 subjects...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28653886/the-mir-608-rs4919510-polymorphism-may-modify-cancer-susceptibility-based-on-type
#7
Shuangshuang Wu, Weiyan Yuan, Yu Shen, Xiao Lu, Yue Li, Tian Tian, Liying Jiang, Xun Zhuang, Jianqing Wu, Minjie Chu
Previous meta-analysis has not shown different effects of miR-608 rs4919510 polymorphism in specific cancer types and reported no significant association between rs4919510 and cancer risk among Chinese. However, more recent findings have been inconsistent. Therefore, we performed an updated meta-analysis to examine whether this polymorphism is associated with cancer risk based on ethnicity and type. A total of 18 case-control studies, comprising 12,517 cases and 15,624 controls, were included in our study. Surprisingly, in contrast with previous meta-analysis, a significant association between the rs4919510 polymorphism and cancer risk was observed in Chinese (CG vs CC: odds ratio = 1...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653870/osteoarthritis-prevalence-in-retired-national-football-league-players-with-a-history-of-concussion-and-lower-extremity-injury
#8
Robert C Lynall, Brian Pietrosimone, Zachary Y Kerr, Timothy C Mauntel, Jason P Mihalik, Kevin M Guskiewicz
CONTEXT:   Dynamic balance deficits have been described postconcussion, even after athletes return to play. Lower extremity (LE) musculoskeletal injury rates increase for up to 1 year after concussion, but the long-term musculoskeletal implications of concussion are unclear. OBJECTIVE:   To (1) examine the association of concussion and LE injury histories with osteoarthritis (OA) prevalence in retired National Football League players and (2) examine the association of concussion and LE injury histories with OA prevalence in those ≤55 years of age...
June 2, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28653758/periodontitis-and-breast-cancer-a-case-control-study
#9
Camila S Sfreddo, Juliana Maier, Silvia C De David, Cristiano Susin, Carlos Heitor C Moreira
OBJECTIVES: The aim of this case-control study was to evaluate the association between periodontitis and breast cancer in a sample of adult Brazilian women. METHODS: This was a hospital-based study, which included 67 cases and 134 controls (1:2). Women were selected consecutively between April, 2013 and June, 2015 among those attending the Department of Gynecology at the University Hospital of Santa Maria. Cases were selected among women diagnosed with breast cancer (ICD-10 C50), and controls were matched for age (±2 years), and smoking status (never, former and current smoker)...
June 27, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28653322/differentiating-the-cochran-armitage-trend-test-and-pearson-s-%C3%AF-2-test-location-and-dispersion
#10
Zhengyang Zhou, Hung-Chih Ku, Zhipeng Huang, Guan Xing, Chao Xing
In genetic case-control association studies, a standard practice is to perform the Cochran-Armitage (CA) trend test with 1 degree-of-freedom (d.f.) under the assumption of an additive model. However, when the true genetic model is recessive or near recessive, it is outperformed by Pearson's χ(2) test with 2 d.f. In this article, we analytically reveal the statistical basis that leads to the phenomenon. First, we show that the CA trend test examines the location shift between the case and control groups, whereas Pearson's χ(2) test examines both the location and dispersion shifts between the two groups...
June 27, 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/28653247/post-traumatic-headache-in-patients-with-minimal-traumatic-intracranial-hemorrhage-after-traumatic-brain-injury-a-retrospective-matched-case-control-study
#11
Chang-Ki Hong, Yu Shik Shim, Sook Young Sim, Jin-Yang Joo, Min A Kwon, Yong Bae Kim, Joonho Chung
BACKGROUND: No evidence is available on the risks of neurologically asymptomatic minimal traumatic intracranial hemorrhage (mTIH) in patients with traumatic brain injury (TBI) for post-traumatic headache (PTH). The purpose of this study was to investigate whether mTIH in patients with TBI was associated with PTH and to evaluate its risk factors. METHODS: Between September 2009 and December 2014, 1484 patients with TBI were treated at our institution, 57 of whom had mTIH after TBI and were include in this study...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28652657/association-of-keratin-8-18-variants-with-non-alcoholic-fatty-liver-disease-and-insulin-resistance-in-chinese-patients-a-case-control-study
#12
Rui Li, Xian-Hua Liao, Jun-Zhao Ye, Min-Rui Li, Yan-Qin Wu, Xuan Hu, Bi-Hui Zhong
AIM: To test the hypothesis that K8/K18 variants predispose humans to non-alcoholic fatty liver disease (NAFLD) progression and its metabolic phenotypes. METHODS: We selected a total of 373 unrelated adult subjects from our Physical Examination Department, including 200 unrelated NAFLD patients and 173 controls of both genders and different ages. Diagnoses of NAFLD were established according to ultrasonic signs of fatty liver. All subjects were tested for population characteristics, lipid profile, liver tests, as well as glucose tests...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28652501/serum-levels-of-neuroactive-steroids-in-first-episode-antipsychotic-na%C3%A3-ve-schizophrenic-patients-and-its-correlation-with-aggression-a-case-control-study
#13
R K Solanki, P Sharma, A Tyagi, C Singh
BACKGROUND: The evidence of hypothalamic-pituitary-adrenal axis dysfunction in schizophrenia has been reviewed in the context of the stress-diathesis model. Overactivation of this axis leads to altered blood levels of cortisol and dehydroepiandrosterone sulfate (DHEA-S). These neurosteroids in turn act on the hippocampus and interact with gamma-aminobutyric acid and N-methyl-D-aspartate receptors leading to neurotoxicity and may be involved in the neurobiology of aggression. This study aimed to explore the blood level of these neurosteroids and ascertain its correlation with state aggression and psychopathology in first-episode antipsychotic-naïve schizophrenic patients...
June 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/28652441/diagnostic-accuracy-of-pivka-ii-alpha-fetoprotein-and-a-combination-of-both-in-diagnosis-of-hepatocellular-carcinoma-in-patients-affected-by-chronic-hcv-infection
#14
Ivan Gentile, Antonio Riccardo Buonomo, Riccardo Scotto, Emanuela Zappulo, Canio Carriero, Mauro Piccirillo, Francesco Izzo, Marianna Rizzo, Dionigio Cerasuolo, Guglielmo Borgia, Ernesta Cavalcanti
BACKGROUND/AIM: Patients affected by liver cirrhosis are at high risk for developing hepatocellular carcinoma (HCC). The aim of this study was to evaluate the feasibility of PIVKA-II (protein induced by vitamin K absence or antagonist-II) alone or in combination with α-1 fetoprotein (AFP), as a screening marker for development of HCC. MATERIALS AND METHODS: A case-control study was conducted in 2 hospital wards in Naples. All anti-HCV-positive patients affected by HCC were considered as cases, while consecutive anti-HCV-positive patients without HCC were considered as controls...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28652424/the-contribution-of-matrix-metalloproteinase-8-promoter-polymorphism-to-oral-cancer-susceptibility
#15
Yi-Wen Hung, Chia-Wen Tsai, Cheng-Nan Wu, Liang-Chun Shih, Yen-Yu Chen, Yen-Fang Liu, Huey-Shan Hung, Ming-Yi Shen, Wen-Shin Chang, DA-Tian Bau
BACKGROUND/AIM: Metalloproteinases (MMPs) are a family of multifunctional proteins reported to be overexpressed in several types of cancers. However, the contribution of MMP8 genotype to oral cancer has not been elucidated. In this study, we focused on the contribution of polymorphisms in the promoter region of MMP-8 (C-799T) and two non-synonymous polymorphisms (Val436Ala and Lys460Thr) to Taiwanese oral cancer. MATERIALS AND METHODS: In this case-control study, MMP-8 genotype, was examined among 788 patients with oral cancer and 956 gender- and age-matched healthy controls regarding its potential to determine oral cancer risk...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28652120/predictors-of-shunt-dependent-hydrocephalus-after-aneurysmal-subarachnoid-hemorrhage-a-systematic-review-and-meta-analysis
#16
Zhiyi Xie, Xin Hu, Xin Zan, Sen Lin, Hao Li, Chao You
BACKGROUND: Hydrocephalus is a well-recognized complication following aneurysmal subarachnoid hemorrhage (aSAH). This study aimed to identify predictors for shunt-dependent hydrocephalus (SDHC) following aSAH and via a systematic review and meta-analysis. METHODS: A systematic search was conducted using the Embase, MEDLINE, and Web of Science databases for studies pertaining to aSAH and SDHC. Risk factors were assessed by meta-analysis when they were reported by at least two studies...
June 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28652112/multinational-retrospective-case-control-study-of-risk-factors-for-the-development-of-late-invasive-pulmonary-aspergillosis-following-kidney-transplantation
#17
Francisco López-Medrano, Mario Fernández-Ruiz, José Tiago Silva, Peggy L Carver, Christian van Delden, Esperanza Merino, María José Pérez-Saez, Milagros Montero, Julien Coussement, Milene de Abreu Mazzolin, Carlos Cervera, Lidia Santos, Nuria Sabé, Anne Scemla, Elisa Cordero, Leónidas Cruzado-Vega, Paloma Leticia Martín-Moreno, Óscar Len, Eddison Rudas, Alfredo Ponce de León, Mariano Arriola, Ricardo Lauzurica, Miruna D David, Claudia González-Rico, Fernando Henríquez-Palop, Jesús Fortún, Marcio Nucci, Oriol Manuel, José Ramón Paño-Pardo, Miguel Montejo, Antonio Vena, Beatriz Sánchez-Sobrino, Auxiliadora Mazuecos, Julio Pascual, Juan Pablo Horcajada, Thanh Lecompte, Asunción Moreno, Jordi Carratalà, Marino Blanes, Domingo Hernández, Erick Alejandro Hernández-Méndez, María Carmen Fariñas, Manuel Perelló-Carrascosa, Patricia Muñoz, Amado Andrés, José María Aguado
OBJECTIVES: To assess the risk factors for the development of late-onset invasive pulmonary aspergillosis (IPA) after kidney transplantation (KT). METHODS: We performed a multinational case-control study that retrospectively recruited 112 KT recipients diagnosed with IPA between 2000 and 2013. Controls were matched (1:1 ratio) by center and date of transplantation. Immunosuppression-related events (IREs) included the occurrence of non-ventilator-associated pneumonia, tuberculosis, cytomegalovirus disease and/or de novo malignancy...
June 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28651736/thyroid-functions-and-serum-lipid-profile-in-metabolic-syndrome
#18
Manish Gutch, Sumit Rungta, Sukriti Kumar, Avinash Agarwal, Annesh Bhattacharya, Syed Mohd Razi
BACKGROUND: Thyroid hormones are known to affect energy metabolism. Many patients of metabolic syndrome have subclinical or clinical hypothyroidism and vice versa. To study the correlation of thyroid profile and serum lipid profile with metabolic syndrome. METHOD: It is a hospital based cross sectional case-control study carried out in tertiary care health center, we studied thyroid functions test and serum lipid profile in 100 metabolic syndrome patients according to IDF criteria and a similar number of age, gender and ethnicity matched healthy controls...
June 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28651629/risk-factors-person-place-and-time-characteristics-associated-with-hepatitis-e-virus-outbreak-in-napak-district-uganda
#19
Geofrey Amanya, Samuel Kizito, Immaculate Nabukenya, Joan Kalyango, Collins Atuheire, Hellen Nansumba, Stephen Akena Abwoye, Denis Nixon Opio, Edrisa Kibuuka, Charles Karamagi
BACKGROUND: Hepatitis E is self-limiting, but can cause death in most at risk groups like pregnant women and those with preexisting acute liver disease. In developing countries it presents as epidemic, in 2014 Hepatitis E Virus (HEV) outbreak was reported in Napak district Uganda. The role of factors in this setting that might have propagated this HEV epidemic, including host, agent, and environmental characteristics, were still not clear. This study was therefore conducted to investigate the risk factors, person, place and time characteristics, associated with the hepatitis E virus (HEV) epidemic in Napak district...
June 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28651590/effect-of-different-incision-sites-of-phacoemulsification-on-trabeculectomy-bleb-function-prospective-case-control-study
#20
Mohamed Anbar, Hatem Ammar
BACKGROUND: The aim of this study was to compare superior and temporal clear corneal incisions of uneventful phacoemulsification and in-the-bag intraocular lens implantation on intraocular pressure control and the bleb morphology in eyes that have undergone previous successful trabeculectomy. METHODS: In this Prospective case-control study, a total of 100 eyes of 100 patients previously undergone trabeculectomy without antimetabolites, divided into two groups. Group A (temporal group) including 50 patients underwent phacoemulsification with a temporal corneal incision and group B (superior group) including 50 patients underwent phacoemulsification with a superior corneal incision...
June 26, 2017: BMC Ophthalmology
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