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https://www.readbyqxmd.com/read/29786583/incidence-and-risk-factors-of-spina-bifida-in-children
#1
Mariana O Ryznychuk, Mariana I Kryvchanska, Irina V Lastivka, Roman Ye Bulyk
OBJECTIVE: Introduction: The pathogenesis of spina bifida depends on time, region, race and ethnicity. It is found in 4.7 per 10.000 of live born children worldwide. The aim: The incidence in children of Northern Bukovina was analyzed. The spina bifida incidence for 2007-2016 in this region, as well as, compared to some countries according to EUROCAT data was studied. PATIENTS AND METHODS: Materials and methods: A retrospective study to analyze the risk factors for spina bifida was carried out...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786139/one-carbon-metabolite-ratios-as-functional-b-vitamin-markers-and-in-relation-to-colorectal-cancer-risk
#2
Björn Gylling, Robin Myte, Arve Ulvik, Per M Ueland, Øivind Midttun, Jörn Schneede, Göran Hallmans, Jenny Häggström, Ingegerd Johansson, Bethany Van Guelpen, Richard Palmqvist
One-carbon metabolism biomarkers are easily measured in plasma, but analyzing them one at a time in relation to disease does not take into account the interdependence of the many factors involved. The relative dynamics of major one-carbon metabolism branches can be assessed by relating the functional B-vitamin marker total homocysteine (tHcy) to transsulfuration (total cysteine) and methylation (creatinine) outputs. We validated the ratios of tHcy to total cysteine (Hcy:Cys), tHcy to creatinine (Hcy:Cre), and tHcy to cysteine to creatinine (Hcy:Cys:Cre) as functional markers of B-vitamin status...
May 22, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29786123/genetic-variations-in-lta-gene-and-pdcd1-gene-and-intrauterine-infection-of-hepatitis-b-virus-a-case-control-study-in-china
#3
Tingting Liu, Zhihua Wan, Songxu Peng, Yanni Wang, Hongyan Chen, Xiu Li, Yukai Du
Intrauterine infection with hepatitis B virus (HBV) has been suggested to accounting for most cases of chronic HBV infection, which cannot be blocked by combined immunoprophylaxis. The fact that the genetic background might impact the susceptibility to intrauterine infection of HBV has been identified by recent researches. A case-control study included sixty-nine HBsAg-positive mother-newborn pairs with intrauterine infection as cases compared to 138 mother-newborn pairs without intrauterine infection as controls...
May 21, 2018: Amino Acids
https://www.readbyqxmd.com/read/29786043/risk-factors-for-recurrence-of-ovarian-endometriosis-in-chinese-patients-aged-45-and-over
#4
Zheng-Xing He, Ting-Ting Sun, Shu Wang, Hong-Hui Shi, Qing-Bo Fan, Lan Zhu, Jin-Hua Leng, Da-Wei Sun, Jian Sun, Jing-He Lang
Background: When considering the issue of recurrence, perimenopausal women may have more dilemma during management comparing with young women, for example, whether to retain the uterus and ovary during surgery, whether it is necessary to add adjuvant medicine treatment after operation, and there is no evidence for reference about using of gonadotropin-releasing hormone agonist. This study aimed to study the risk factors for the recurrence of ovarian endometriosis (EM) in patients aged 45 and over...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785888/the-impact-of-oprm1-s-genetic-polymorphisms-on-methadone-maintenance-treatment-in-opioid-addicts-a-systematic-review
#5
Bilel Oueslati, Olfa Moula, Rim Ghachem
AIM: Methadone is a long-acting opioid receptor agonist. It is prescribed to patients with opioid-related use disorders. The OPRM1 gene encodes for methadone's main receptor. It appears that polymorphisms in OPRM1 may affect the efficacy of methadone maintenance treatment (MMT). OBJECTIVE: Our purpose was to identify all relevant published papers dealing with the impact ofOPRM1's SNPs  on MMT's efficacy and to summarize results in order to evaluate the relevance of conducting pretherapeutic genotyping in opioid addicts prior to the onset of MMT...
May 22, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29785763/is-bdnf-val66met-polymorphism-associated-with-psychotic-experiences-and-psychotic-disorder-outcome-evidence-from-a-6-years-prospective-population-based-cohort-study
#6
Umut Kirli, Tolga Binbay, Marjan Drukker, Hayriye Elbi, Bülent Kayahan, Duygu Keskin Gökçelli, Ferda Özkınay, Hüseyin Onay, Köksal Alptekin, Jim van Os
There is little research on genetic risk for the extended psychosis phenotype ranging from psychotic experiences (PEs) to psychotic disorders (PDs). In this general population-based prospective cohort study, the longitudinal associations between BDNF-Val66Met polymorphism and the different levels of the extended psychosis phenotype were investigated. Addresses were contacted in a multistage clustered probability sampling frame covering 11 districts and 302 neighborhoods at baseline (n = 4011). A nested case-control study (n = 366) recruited individuals with PEs and PDs as well as individuals with no psychotic symptoms...
May 21, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29785637/frzb1-rs2242070-polymorphisms-is-associated-with-brick-tea-type-skeletal-fluorosis-in-kazakhs-but-not-in-tibetans-china
#7
Yanmei Yang, Qiaoshi Zhao, Yang Liu, Xiaona Liu, Yanru Chu, Huazhu Yan, Yumei Fan, Simeng Huo, Limei Wang, Qun Lou, Ning Guo, Dianjun Sun, Yanhui Gao
Skeletal fluorosis is a metabolic bone and joint disease caused by excessive accumulation of fluoride in the bones. Compared with Kazakhs, Tibetans are more likely to develop moderate and severe brick tea type skeletal fluorosis, although they have similar fluoride exposure. Single nucleotide polymorphisms (SNPs) in frizzled-related protein (FRZB) have been associated with osteoarthritis, but their association with the risk of skeletal fluorosis has not been reported. In this paper, we investigated the association of three SNPs (rs7775, rs2242070 and rs9288087) in FRZB1with brick tea type skeletal fluorosis risk in a cross-sectional case-control study conducted in Sinkiang and Qinghai, China...
May 21, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29785120/association-between-nr5a2-and-the-risk-of-pancreatic-cancer-especially-among-caucasians-a-meta-analysis-of-case-control-studies
#8
Qun Chen, Hao Yuan, Guo-Dong Shi, Yang Wu, Dong-Fang Liu, Yu-Ting Lin, Lei Chen, Wan-Li Ge, Kuirong Jiang, Yi Miao
Background: Previous studies have reported that nuclear receptor subfamily 5, group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C, rs12029406 C>T) are associated with the risk of pancreatic cancer. However, the results of epidemiological investigations are still controversial. In order to explore its potential attributing factors, we pooled the updated literatures to evaluate the association between NR5A2 polymorphism and the risk of pancreatic cancer in this meta-analysis...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29785058/effects-of-maternal-obstructive-sleep-apnea-on-fetal-growth-a-case-control-study
#9
Anna W Kneitel, Marjorie C Treadwell, Louise M O'Brien
OBJECTIVE: To investigate whether maternal obstructive sleep apnea (OSA) is associated with changes in fetal growth trajectory. STUDY DESIGN: Retrospective review of pregnant women who underwent overnight polysomnography. Fetal growth was estimated using sonographic biometric measurements obtained during routine prenatal care. Customized estimated fetal weight and birth weight centiles were calculated and impaired fetal growth was defined as birth weight <10th centile or a slowing of fetal growth by >33% during the last trimester...
May 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29784892/food-insecurity-and-primary-school-girl-students-intelligence-quotients-a-case-control-study
#10
Ahmad Reza Dorosty Motlagh, Peivasteh Safarpour, Milad Daneshi Maskooni, Mostafa Hosseini, Farzaneh Ranjbar Noshari
BACKGROUND: Food insecurity (FI) refers to the lack of sufficient and safe availability of the food. Accumulating studies have suggested associations between dietary intake and Intelligence quotient (IQ). Accordingly, we aimed to examine the association between FI and IQ. STUDY DESIGN: Case-control study. METHODS: In this case-control study, 222 girl students aged 9 to 11 years old were randomly chosen from Bandar-Anzali, Iran in 2013. Students with low and moderate IQ were considered as case (n=111) and control (n=111) group, respectively...
April 15, 2018: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/29784730/association-of-anthropometric-measures-with-prostate-cancer-among-african-american-men-in-the-nci-maryland-prostate-cancer-case-control-study
#11
Margaret S Pichardo, Cheryl J Smith, Tiffany H Dorsey, Christopher A Loffredo, Stefan Ambs
BACKGROUND: Obesity is a cancer risk factor. While it does not increase the risk of localized prostate cancer, it raises the risk of the aggressive disease in men of European ancestry. Few studies investigated obesity as a prostate cancer risk factor in men of African ancestry. Findings from those studies were heterogeneous but some reported an association of excess body fatness with aggressive disease. METHODS: We examined the relationship of body mass index (BMI), waist circumference, and waist-hip ratio with prostate cancer in African-American and European-American men in the NCI-Maryland Prostate Cancer Case-Control study consisting of 798 men with incident prostate cancer (402 African-American and 496 European-American) and 1008 population-based controls (474 African-American and 534 European-American)...
May 21, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29784468/vaccines-and-the-risk-of-acute-disseminated-encephalomyelitis
#12
Yong Chen, Fubao Ma, Yuanling Xu, Xuhua Chu, Jinlin Zhang
BACKGROUND: It is important to examine the risk of Acute disseminated encephalomyelitis (ADEM) after vaccination. METHODS: We conducted a nested case-control study between January 2011 and December 2015. Four controls per case were matched for age, gender, address. An independent expert committee validated the diagnoses of cases and controls. Data on vaccinations were obtained from computerized vaccination records. The analyses were conducted with the use of conditional logistic regression...
May 18, 2018: Vaccine
https://www.readbyqxmd.com/read/29784045/occupational-risk-factors-for-idiopathic-pulmonary-fibrosis-in-southern-europe-a-case-control-study
#13
Giulia Paolocci, Ilenia Folletti, Kjell Torén, Magnus Ekström, Marco Dell'Omo, Giacomo Muzi, Nicola Murgia
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia of unknown cause associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Occupational risk factors have been proposed to be associated with UIP. The aim of this case-control study is to evaluate the relationship between UIP pattern and occupational exposure in Southern Europe. METHODS: Sixty nine cases with a UIP radiological pattern at CT-scan were selected from a clinical database of the University Hospital of Perugia, Umbria, between January 2010 and December 2013...
May 21, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29784038/chronic-traumatic-ankle-and-foot-osteomyelitis-a-nationwide-case-control-study
#14
Maryam Hosseini, Mostafa Allami, Mohammadreza Soroush, Fateme Babaha, Javad Minooeefar, Davood Rahimpoor
BACKGROUND: Osteomyelitis (OM) is an atypical consequence of ankle-foot trauma which is associated with long-term mental and physical morbidity and persistent pain. This study aimed to assess the health status of OM patients with war-related ankle-foot injuries. METHODS: A total of 1129 veterans with ankle-foot injuries participated in a case-control study (2014-2016). Thirty patients with chronic OM of the ankle-foot were compared with 90 non-OM participants as the control group...
May 15, 2018: Military Medical Research
https://www.readbyqxmd.com/read/29783972/major-dietary-patterns-in-relation-to-menstrual-pain-a-nested-case-control-study
#15
Nastaran Najafi, Hamidreza Khalkhali, Fatemeh Moghaddam Tabrizi, Rasoul Zarrin
BACKGROUND: Dysmenorrhea is one of the most prevalent gynecological disorders, experienced by approximately two third of young women during menstruation. According to literature, nutrition can play a key role in the prevalence and severity of dysmenorrhea. This study aims to investigate the relation between dietary patterns and the risk of dysmenorrhea among university students. METHODS: A nested case control study was conducted among 293 students of Urmia University of Medical Sciences who were randomly recruited via a proportional cluster sampling method...
May 21, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29783820/-efficacy-of-bronchoalveolar-lavage-and-its-influence-factors-in-the-treatment-of-mycoplasma-pneumoniae-pneumonia-with-atelectasis
#16
M Yang, D H Yang, X Yang, Y S Wang, L Wu, Z M Chen
Objective: To investigate the efficacy of bronchoalveolar lavage (BAL) and its influence factors in the treatment of Mycoplasma pneumoniae pneumonia (MPP) with atelectasis. Methods: A retrospective case control study was performed on hospitalized MPP patients with atelectasis and received BAL in the Department of Pulmonology, Children's Hospital Zhejiang University School of Medicine from January 1, 2015 to July 31, 2017. Fever relieved in 48 hours and chest imaging improved in one week after BAL were considered effective...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29783819/-value-of-urine-soluble-triggering-receptor-expressed-on-myeloid-cells-1-in-the-early-diagnosis-of-sepsis-associated-acute-kidney-injury
#17
Z K Yuan, F Fang, C J Liu, J Li, Y F Chen, F Xu
Objective: To assess the value of urine soluble triggering receptor expressed on myeloid cells-1(sTREM-1) in early diagnosis and prognosis of sepsis associated acute kidney injury (AKI). Methods: This was a case-control study. A total of 62 patients with sepsis during November 2016 to June 2017 were collected, who were divided into non-AKI sepsis ( n= 49) and AKI sepsis ( n= 13) groups according to the serum creatinine (SCr) or urine output, sepsis with shock ( n= 22) and sepsis without shock ( n= 40) groups according to the presence of shock, survival ( n= 47) and death ( n= 15) groups according to the mortality...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29783069/association-between-the-rs1143634-polymorphism-in-interleukin-1b-and-chronic-periodontitis-results-from-a-meta-analysis-composed-by-54-case-control-studies
#18
REVIEW
Felipe Rodolfo Pereira da Silva, Any Carolina Cardoso Guimarães Vasconcelos, Luiz Felipe de Carvalho França, David Di Lenardo, Hélio Mateus Silva Nascimento, Daniel Fernando Pereira Vasconcelos
Several factors are involved in the periodontitis with host response through cytokines and as well as with influence of polymorphisms in cytokine genes, however the results remained contradictory. This study aimed at evaluating the rs1143634 polymorphism in interleukin-1B gene, a cytokine gene, and the risk of chronic periodontitis with conducting a meta-analysis focusing in ethnicity. A review in literature was performed in several databases to studies published before June 2017. Data extraction was performed by two calibrated investigators and the calculations of the meta-analysis were obtained through Review Manager version 5...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29783039/the-influence-of-bone-cement-and-american-society-of-anesthesiologists-asa-class-on-cardiovascular-status-during-bipolar-hemiarthroplasty-for-displaced-femoral-neck-fracture-a-multicenter-prospective-case-control-study
#19
Shuichi Miyamoto, Junichi Nakamura, Satoshi Iida, Tomonori Shigemura, Shunji Kishida, Isao Abe, Munenori Takeshita, Makoto Otsuka, Yoshitada Harad, Sumihisa Orita, Seiji Ohtori
BACKGROUND: Little is known about how bone cement and American Society of Anesthesiologists (ASA) classification influence the cardiovascular system in elderly patients with femoral-neck fractures treated with cemented hemiarthroplasty. Therefore, we performed a case-control study to investigate these questions and compared the following: 1) ≥ASA III with ≤ASA II patients who underwent cemented hemiarthroplasty; 2) cemented with cementless hemiarthroplasty in ≥ASA III patients. HYPOTHESIS: ASA classification influences the cardiovascular system during cemented hemiarthroplasty and bone cement influences intraoperative blood pressure [IBP] in patients rated ≥ASA III...
May 18, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29782842/paraoxonase-1-pon1-l55m-among-common-variants-in-the-coding-region-of-the-paraoxonase-gene-family-may-contribute-to-the-glycemic-control-in-type-2-diabetes
#20
Abdolkarim Mahrooz, Mohammad Bagher Hashemi-Soteh, Masoud Heydari, Ruzbeh Boorank, Fatemeh Ramazani, Ali Mahmoudi, Anvarsadat Kianmehr, Ahad Alizadeh
OBJECTIVE: Genome studies have shown that the genes encoding paraoxonase 1 (PON1) and PON2 are associated with glucose metabolism. The goal of this study was to simultaneously evaluate the association between functional variants in PON1 and PON2 genes and susceptibility for type 2 diabetes (T2D) and determine whether they can affect glycemic control. METHODS: We performed a case-control study with 145 newly diagnosed patients with T2D and 148 controls. The common variants including PON1-Q192R, PON1-L55M and PON2-S311C were genotyped by PCR-based RFLP...
May 18, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
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