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https://www.readbyqxmd.com/read/29933335/a-national-analysis-on-predictors-of-discharge-to-rehabilitation-after-corrective-surgery-for-adolescent-idiopathic-scoliosis
#1
Rafael De la Garza Ramos, Jonathan Nakhla, Murray Echt, Jacob F Schulz, Jaime A Gomez, Woojin Cho, Reza Yassari
STUDY DESIGN: Retrospective study of a national database. OBJECTIVE: To identify the incidence and risk factors for discharge to a rehabilitation facility after corrective surgery for adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: The vast majority of patients who undergo surgery for AIS are discharged home, with limited data on rates and causes for discharge to a rehabilitation facility. METHODS: The United States National Inpatient Sample database was queried for the years 2012 to 2014...
June 21, 2018: Spine
https://www.readbyqxmd.com/read/29931993/enzymatic-mediastinitis-as-a-fearsome-complication-of-pancreatic-necrosectomy
#2
Marta Paniagua García-Señoráns, María Reyes Meléndez Villar, Paula Senra Del Río, Eva María García Fontán, Fabio Ausania
Several types of thoracic complications can be associated with severe acute pancreatitis. Some are very common, such as pleural effusion, whilst some others are very rare although life threatening, such as enzymatic mediastinitis (EM). Only a few cases of EM (when related to acute pancreatitis) have been described in the literature. Here we describe the case of a 76-year-old female who developed acute respiratory failure and atrial fibrillation during the postoperative period after an open pancreatic necrosectomy, due to an EM episode...
June 22, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29931346/tnnt1-nemaline-myopathy-natural-history-and-therapeutic-frontier
#3
Michael D Fox, Vincent J Carson, Han-Zhong Feng, Michael W Lawlor, John T Gray, Karlla W Brigatti, J-P Jin, Kevin A Strauss
We describe the natural history of 'Amish' nemaline myopathy (ANM), an infantile-onset, lethal disease linked to a pathogenic c.505G>T nonsense mutation of TNNT1, which encodes the slow fiber isoform of troponin T (TNNT1; a.k.a TnT). The TNNT1 c.505G>T allele has a carrier frequency of 6.5% within Old Order Amish settlements of North America. We collected natural history data for 106 ANM patients born between 1923 and 2017. Over the last two decades, mean age of molecular diagnosis was 16 ± 27 days. TNNT1 c...
June 20, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29930934/synthetic-and-non-synthetic-cannabinoid-drugs-and-their-adverse-effects-a-review-from-public-health-prospective
#4
REVIEW
Koby Cohen, Aviv M Weinstein
There is a growing use of novel psychoactive substances containing synthetic cannabinoids. Synthetic cannabinoid products have effects similar to those of natural cannabis, yet, these drugs are more potent and dangerous, and have been associated with dangerous adverse effects. Here, we review current literature on the epidemiology, acute, and chronic effects of synthetic and natural cannabinoid-based drugs. Synthetic drugs contain a mixture of psychoactive compounds that mostly bind cannabinoid receptors with high potency...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29929933/hospital-mortality-and-thirty-day-readmission-among-patients-with-non-acute-myocardial-infarction-related-cardiogenic-shock
#5
Mahek Shah, Brijesh Patel, Byomesh Tripathi, Manyoo Agarwal, Soumya Patnaik, Pradhum Ram, Shantanu Patil, Jooyoung Shin, Ulrich P Jorde
BACKGROUND: Cardiogenic shock (CS) in absence of acute myocardial infarction (AMI) has significant morbidity and mortality. This population of patients has been excluded from prior major randomized trials and observational studies. METHODS: We included patients with CS in absence of AMI from the 2013-14 HCUP's National Readmission Database. 30-day readmissions were studied and etiology for readmission was identified by using ICD-9CM codes in primary diagnosis field...
June 10, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29929165/high-throughput-label-free-microcontact-printing-graphene-based-biosensor-for-valley-fever
#6
Shih-Ming Tsai, Tyler Goshia, Yen-Chang Chen, Agnes Kagiri, Angelo Sibal, Meng-Hsuen Chiu, Anand Gadre, Vincent Tung, Wei-Chun Chin
The highly prevalent and virulent disease in the Western Hemisphere Coccidioidomycosis, also known as Valley Fever, can cause serious illness such as severe pneumonia with respiratory failure. It can also take on a disseminated form where the infection spreads throughout the body. Thus, a serious impetus exists to develop effective detection of the disease that can also operate in a rapid and high-throughput fashion. Here, we report the assembly of a highly sensitive biosensor using reduced graphene oxide (rGO) with Coccidioides(cocci) antibodies as the target analytes...
June 18, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29928523/muscle-atrophy-in-chronic-obstructive-pulmonary-disease-molecular-basis-and-potential-therapeutic-targets
#7
REVIEW
Esther Barreiro, Ariel Jaitovich
Patients with chronic obstructive pulmonary disease (COPD) experience several systemic manifestations such skeletal muscle dysfunction with and without muscle mass loss. Moreover, frequent comorbidities such as nutritional abnormalities, heart failure, and pulmonary hypertension, which are frequently associated with COPD may further contribute to skeletal muscle mass loss and dysfunction. Muscle dysfunction impairs the patients' exercise capacity and quality of life as daily life activities may be hampered by this problem...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29926563/-acute-heart-failure-and-acute-pulmonary-edema
#8
V D'orio, A Ancion, P Lancellotti
Acute heart failure is a common cause of admission in emergency department. Management requires rapid support when haemodynamic or respiratory parameters are altered. Identifying enabling factors and their specific treatment is an integral part of management. The most common clinical presentation is volume overload, whose treatment remains the combination of diuretics and vasodilators. In case of impaired perfusion, various inotropic supports may be considered, but also more and more circulatory assistance devices...
May 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29926549/predicting-mortality-in-patients-with-tuberculous-destroyed-lung-receiving-mechanical-ventilation
#9
Won Young Kim, Mi Hyun Kim, Eun Jung Jo, Jung Seop Eom, Jeongha Mok, Ki Uk Kim, Hye Kyung Park, Min Ki Lee, Kwangha Lee
BACKGROUND: Patients with acute respiratory failure secondary to tuberculous destroyed lung (TDL) have a poor prognosis. The aim of the present retrospective study was to develop a mortality prediction model for TDL patients who require mechanical ventilation. METHODS: Data from consecutive TDL patients who had received mechanical ventilation at a single university-affiliated tertiary care hospital in Korea were reviewed. Binary logistic regression was used to identify factors predicting intensive care unit (ICU) mortality...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29926546/effectiveness-and-safety-of-high-flow-nasal-cannula-oxygen-delivery-during-bronchoalveolar-lavage-in-acute-respiratory-failure-patients
#10
Eun Jin Kim, Chi Young Jung, Kyung Chan Kim
BACKGROUND: Bronchoalveolar lavage (BAL) is a necessary procedure for diagnosis of various lung diseases. High-flow nasal cannula (HFNC) oxygen delivery was recently introduced. This study aimed to investigate the safety and effectiveness of HFNC oxygen supply during BAL procedure in patients with acute respiratory failure (ARF). METHODS: Patients who underwent BAL while using HFNC at a partial pressure of oxygen in arterial blood/fraction of inspired oxygen (PaO₂/FiO₂; PF) ratio of 300 or below among patients who had been admitted from March 2013 to May 2017 were retrospectively investigated...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29926544/clinical-effectiveness-of-high-flow-nasal-cannula-in-hypoxaemic-patients-during-bronchoscopic-procedures
#11
Sang Mi Chung, Ju Whan Choi, Young Seok Lee, Jong Hyun Choi, Jee Youn Oh, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Kyung Ho Kang
BACKGROUND: Bronchoscopy is a useful diagnostic and therapeutic tool. However, the clinical use of high-flow nasal cannula (HFNC) in adults with acute respiratory failure for diagnostic and invasive procedures has not been well evaluated. We present our experiences of well-tolerated diagnostic bronchoscopy as well as cases of improved saturation in hypoxaemic patients after a therapeutic bronchoscopic procedure. METHODS: We retrospectively reviewed data of hypoxaemic patients who had undergone bronchoscopy for diagnostic or therapeutic purposes from October 2015 to February 2017...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29926359/breakthrough-infection-of-geotrichum-capitatum-during-empirical-caspofungin-therapy-after-umbilical-cord-blood-transplantation
#12
Shuki Oya, Tsuyoshi Muta
We experienced a breakthrough fungal infection caused by Geotrichum capitatum during empirical therapy with caspofungin. A 68-year-old male patient with refractory acute lymphoblastic leukemia had received umbilical cord blood transplantation after two courses of induction therapy. Empirical therapy with caspofungin was initiated 5 days before transplantation. Tacrolimus was continuously infused to prevent graft-versus-host disease. A minidose of methotrexate was intravenously administered on days 1 and 3 post-transplantation, which was changed to prednisolone from day 7 due to severe mucositis...
June 20, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29925726/methotrexate-associated-lymphoproliferative-disorder-complicated-by-severe-acute-respiratory-failure-and-ileal-perforation-a-case-report
#13
Eiji Suzuki, Takashi Kanno, Satoru Kimura, Takumi Irie, Hajime Odajima, Kiyoshi Migita
Lymphoproliferative disorder (LPD) is a potentially severe adverse effect of methotrexate (MTX) administration in patients with rheumatoid arthritis (RA). We report a case of MTX-associated LPD (MTX-LPD) in a patient with RA who developed severe pulmonary failure complicated by perforation of the terminal ileum. A 61-year-old woman with RA receiving MTX complained of dyspnea and abdominal pain. She was diagnosed with intestinal perforation and peritonitis, and underwent immediate abdominal surgery. Pathological examinations of the specimen obtained from the resected ileum and a bone marrow aspirate revealed diffuse large B-cell lymphoma...
June 19, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29925558/case-of-severe-acute-lupus-myocarditis-and-multiple-organ-failure
#14
Aaron M Hawkins, Lalith S B Jesuthasan, Deepak L Vardesh
We report a case of severe lupus myocarditis with rapid, acute deterioration to cardiogenic shock and multiorgan failure, highlighting the importance of early identification and treatment of acute presentations in patients with systemic lupus erythematosus. A 31-year-old woman with previously diagnosed subacute cutaneous lupus erythematosus initially presented with abdominal pain and frank per-rectal bleeding. She deteriorated rapidly with type 1 respiratory failure and acute kidney injury requiring dialysis secondary to acute cardiac failure with a prolonged intensive care unit admission, over a month...
June 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29925128/-comparative-study-on-deep-venous-thrombosis-onset-in-hospitalized-patients-with-different-underlying-diseases
#15
M L Sun, X H Wang, J Huang, J Wang, Y Wang
Objective: To improve the understanding of deep venous thrombosis (DVT), the present study was conducted to investigate the difference of DVT onset in hospitalized patients with different underlying diseases. Methods: This is a single-center retrospective study from Beijing Shijitan Hospital. Clinical data from hospital onset DVT patients from 2007 to 2016 were collected. DVT was confirmed with compression ultrasonography (CUS), color Doppler flow imaging (CDFI), CT venography (CTV), magnetic resonance venography (MRV), lower extremities radionuclide venography(RDV) or conventional venography (CV)...
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29924939/visualizing-heterogeneous-pulmonary-ventilation-respiratory-failure-due-to-an-anterior-mediastinal-mass
#16
Antoine Desîlets, Shaf Keshavjee, Ewan C Goligher
No abstract text is available yet for this article.
June 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29924358/blastomycosis-in-southern-saskatchewan-2000-2015-unique-presentations-and-disease-characteristics
#17
Sarah Lohrenz, Jessica Minion, Mamata Pandey, Kumudhini Karunakaran
In the literature, cases of blastomycosis in Canada have been documented in provinces bordering the Great Lakes, including Ontario and Quebec, as well as Manitoba. This is the first study to our knowledge reporting cases of mycosis seen in southern Saskatchewan suggesting a broader area of endemicity. We searched the Regina Qu'Appelle Health Region (RQHR) Microbiology Laboratory for all culture-confirmed cases of Blastomyces from January 2000 to December 2015 and identified 15 cases. Thirteen cases were reviewed, identifying common presenting symptoms, misdiagnosis, comorbidities, travel history, time from presentation to diagnosis, diagnostic specimen, treatment, and clinical outcome...
June 19, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29924026/management-of-adult-onset-methylmalonic-acidemia-with-hypotonia-and-acute-respiratory-failure-a-case-report
#18
Zhanqi Zhao, Chan-Ching Chu, Mei-Yun Chang, Hao-Tai Chang, Yeong-Long Hsu
RATIONALE: Methylmalonic acidemia (MMA) is an autosomal recessive disease of organic acidemia. PATIENT CONCERNS: We report a 26-year-old male who presented with metabolic acidosis, acute renal failure required hemodialysis and acute respiratory failure required mechanical ventilation support. Progressive hypotonia of muscles made weaning from mechanical ventilator difficult. DIAGNOSES: High level of serum methylmalonic acid and the mut genotype sequences confirmed the diagnosis of this adult-onset MMA...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923940/factors-associated-with-mechanical-ventilation-use-in-children-with-sickle-cell-disease-and-acute-chest-syndrome
#19
Takuto Takahashi, Yusuke Okubo, Maria A Pereda, Atsuhiko Handa, Scott Miller
OBJECTIVES: Acute chest syndrome is the leading cause of death in children with sickle cell disease and is generally due to respiratory failure. Epidemiologic factors for a need for mechanical ventilation in children with acute chest syndrome require further clarification. DESIGN: Retrospective observational study. SETTING: Nationally representative pediatric inpatient records in the United States by using the Kids' Inpatient Database for the years 2003, 2006, 2009, and 2012...
June 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29923937/pulmonary-functions-in-children-ventilated-for-acute-hypoxemic-respiratory-failure
#20
Stanzen Chakdour, Pankaj C Vaidya, Suresh Kumar Angurana, Jayashree Muralidharan, Meenu Singh, Sunit C Singhi
OBJECTIVE: To assess pulmonary functions of children who received mechanical ventilation for acute hypoxemic respiratory failure. DESIGN: Longitudinal study. SETTING: PICU and Pediatric Pulmonology Clinic of a tertiary care teaching hospital in North India. PATIENTS: All children, 5-12 years old, ventilated for acute hypoxemic respiratory failure in PICU from July 2012 to June 2013 and survived. INTERVENTIONS: The baseline admission variables recorded were as follows: age, sex, duration of illness, primary diagnosis at admission, Pediatric Risk of Mortality III score, lung injury score, mechanical ventilation parameters, oxygenation indices, and duration of PICU stay...
June 19, 2018: Pediatric Critical Care Medicine
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