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https://www.readbyqxmd.com/read/28817464/biologics-for-idiopathic-inflammatory-myopathies
#1
Siamak Moghadam-Kia, Rohit Aggarwal, Chester V Oddis
PURPOSE OF REVIEW: As treatment of refractory cases of idiopathic inflammatory myopathies (IIMs) has been challenging, there is growing interest in assessing novel biologics that target various pathways implicated in the pathogenesis of IIM. RECENT FINDINGS: In the largest clinical trial in adult and juvenile IIM assessing the effectiveness of rituximab, the primary outcome was not met but 83% of this refractory group of IIM patients met a predefined definition of improvement and rituximab demonstrated a significant glucocorticoid-sparing effect...
August 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28814833/markers-of-oxidative-nitrosative-stress-and-inflammation-in-lung-tissue-of-rats-exposed-to-different-intravenous-iron-compounds
#2
Jorge E Toblli, Gabriel Cao, Jorge F Giani, Fernando P Dominici, Margarita Angerosa
Iron deficiency anemia is a frequent complication in clinical conditions such as chronic kidney disease, chronic heart failure, inflammatory bowel disease, cancer, and excessive blood loss. Given the ability of iron to catalyze redox reactions, iron therapy can be associated with oxidative stress. The lung is uniquely susceptible to oxidative stress, and little is known about the effects of intravenous iron treatment in this organ. This study characterized changes in markers of oxidative/nitrosative stress and inflammation in the lung of non-iron deficient, non-anemic rats treated with five weekly doses (40 mg iron per kg body weight) of low molecular weight iron dextran (LMWID), iron sucrose (IS), ferric carboxymaltose (FCM), ferumoxytol (FMX), iron isomaltoside 1000 (IIM), or saline (control)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28814428/mortality-in-idiopathic-inflammatory-myopathy-results-from-a-swedish-nationwide-population-based-cohort-study
#3
Gerd Cecilie Dobloug, John Svensson, Ingrid E Lundberg, Marie Holmqvist
Patients with idiopathic inflammatory myopathies (IIMs) suffer an increased burden of comorbidities, but data on mortality in recently diagnosed IIM are conflicting. Also, little is known when, if ever, in relation to IIM diagnosis, mortality is increased. METHODS: A population-based IIM cohort of patients diagnosed between 2002 and 2011 and general population comparators were identified using healthcare registers. They were linked to the cause of death register for follow-up. RESULTS: 224 (31%) of the 716 patients with IIM and 870 (12%) of the 7100 general population died during follow-up...
August 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28796007/mri-scoring-methods-used-in-evaluation-of-muscle-involvement-in-patients-with-idiopathic-inflammatory-myopathies
#4
Kateřina Kubínová, Heřman Mann, Jiří Vencovský
PURPOSE OF REVIEW: MRI is a promising imaging method commonly used to assess muscle involvement in patients with idiopathic inflammatory myopathies (IIM). MRI enables evaluation of both activity and damage and is therefore an ideal noninvasive diagnostic and monitoring tool. Despite its widespread use, there is no universally accepted method for scoring and reporting of MRI findings. The aim of this review is to provide an overview of systems used in the evaluation of MR images in patients with IIM...
August 8, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28796006/novel-insights-of-disability-assessment-in-adult-myositis
#5
Hector Fabricio Espinosa-Ortega, Mariana Moreno-Ramirez, Helene Alexanderson
PURPOSE OF REVIEW: To review the novel development of standardized clinical outcome measures used in adult patients with idiopathic inflammatory myopathies (IIMs). A further aim was to determine what aspects of IIM are covered by these outcome measures according to the International Classification of Functioning, Disability and Health (ICF). RECENT FINDINGS: The sporadic inclusion body myositis functional assessment (sIFA) is the first diagnosis-specific patient-driven patient-reported outcome measure...
August 8, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28782262/relevance-of-ultrasonography-in-assessing-disease-activity-in-patients-with-idiopathic-inflammatory-myopathies
#6
Joana Sousa Neves, Daniela Santos Faria, Marcos Cerqueira, Maria Carmo Afonso, Filipa Teixeira
AIM: Idiopathic inflammatory myopathies (IIM) comprise a group of rare and heterogeneous diseases difficult to diagnose and follow up. Precise measures for assessing disease activity are not available at the moment. Our objective was to evaluate the usefulness of ultrasonography (US) as a monitoring tool in IIM. METHOD: The study evaluated IIM patients diagnosed and followed up from 2005 to 2015 in our department. Fifteen patients with a mean age of 52.2 ± 22...
August 7, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28765245/advancing-the-development-of-patient-reported-outcomes-for-adult-myositis-at-omeract-2016-an-international-delphi-study
#7
Jin Kyun Park, Christopher A Mecoli, Helene Alexanderson, Malin Regardt, Lisa Christopher-Stine, María Casal Domínguez, Ingrid de Groot, Catherine Sarver, Ingrid E Lundberg, Clifton O Bingham, Yeong Wook Song
OBJECTIVE: To define a set of core patient-reported domains and respective instruments for use in idiopathic inflammatory myopathies (IIM). Previously, we reported a systematic literature review on patient-reported outcomes (PRO) in IIM followed by conducting international focus groups to elicit patient perspectives of myositis symptoms and effects. METHODS: Based on qualitative content analysis of focus groups, an initial list of 26 candidate domains was constructed...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28763333/recent-clinical-trials-in-idiopathic-inflammatory-myopathies
#8
Valérie Leclair, Ingrid E Lundberg
PURPOSE OF REVIEW: Idiopathic inflammatory myopathies (IIMs) are complex multisystemic autoimmune diseases. Glucocorticoids remain the cornerstone of treatment in IIM, and the benefit of additional immunosuppressors is still debated. A limited number of controlled clinical trials have been available to support treatment guidelines, but in the last year, several clinical trials have been published. In this review, the highlights of recently published and on-going clinical trials in IIM will be summarized and discussed...
July 29, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28756161/ctpath-demixing-pathway-crosstalk-effect-from-transcriptomics-data-for-differential-pathway-identification
#9
Xin-Ping Xie, Bin Gan, Wulin Yang, Hong-Qiang Wang
Identifying differentially expressed pathways (DEPs) plays important roles in understanding tumor etiology and promoting clinical treatment of cancer or other diseases. By assuming gene expression to be a sparse non-negative linear combination of hidden pathway signals, we propose a pathway crosstalk-based transcriptomics data analysis method (ctPath) for identifying differentially expressed pathways. Biologically, pathways of different functions work in concert at the systematic level. The proposed method interrogates the crosstalks between pathways and discovers hidden pathway signals by mapping high-dimensional transcriptomics data into a low-dimensional pathway space...
July 26, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28733191/ethnomedicobotanical-study-of-indigenous-knowledge-on-medicinal-plants-used-for-the-treatment-of-reproductive-problems-in-nalbari-district-assam-india
#10
Simi Talukdar, Partha Pradip Adhikari, Ananta Borah
ETHNOPHARMACOLOGICAL RELEVANCE: Reproductive problems are evolving as most predominant health care problems in many countries, furthermore, WHO, 2012 exemplified maternal illnesses, birth asphyxia and post birth difficulties, are rising at an alarming rate.Not all abnormalities of the human reproductive system have the same origin; the effects on reproductive problems would likely be affected by both male and female. For easy accessibility and affordability medicinal plants play a key role in primary healthcare care services in India and their use is an integral part of the cultural heritage...
July 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28719832/expression-of-myhc-isoforms-mrna-transcripts-in-different-regions-of-the-masseter-and-medial-pterygoid-muscles-in-chimpanzees
#11
Neus Ciurana, Rosa Artells, Carmen Muñoz, Júlia Arias-Martorell, Gaëlle Bello-Hellegouarch, Alejandro Pérez-Pérez, Juan Francisco Pastor, Josep Maria Potau
OBJECTIVE: The aim of this study is to examine the expression pattern of the different myosin heavy chain (MyHC) isoforms in the masseter and medial pterygoid muscles by real time quantitative polymerase chain reaction (RT-qPCR) to obtain information at molecular level which can be related to the functional characteristics of these two muscles. DESIGN: The masseter, deep and superficial portion, and medial pterygoid muscles of five adult Pan troglodytes were dissected in order to obtain samples of the anterior and posterior regions of each portion of the masseter and of the medial pterygoid...
July 9, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28688028/novel-assessment-of-interstitial-lung-disease-using-the-computer-aided-lung-informatics-for-pathology-evaluation-and-rating-caliper-software-system-in-idiopathic-inflammatory-myopathies
#12
Patompong Ungprasert, Katelynn M Wilton, Floranne C Ernste, Sanjay Kalra, Cynthia S Crowson, Srinivasan Rajagopalan, Brian J Bartholmai
PURPOSE: To evaluate the correlation between measurements from quantitative thoracic high-resolution CT (HRCT) analysis with "Computer-Aided Lung Informatics for Pathology Evaluation and Rating" (CALIPER) software and measurements from pulmonary function tests (PFTs) in patients with idiopathic inflammatory myopathies (IIM)-associated interstitial lung disease (ILD). METHODS: A cohort of patients with IIM-associated ILD seen at Mayo Clinic was identified from medical record review...
July 7, 2017: Lung
https://www.readbyqxmd.com/read/28672937/is-it-cardiac-involvement-mimicking-acute-myocardial-infarction-in-idiopathic-inflammatory-myopathy
#13
Yizhi Xiao, Hui Luo, Shiqing Liu, Liping Duan, Yunhui You, Hongjun Zhao, Xiaoxia Zuo
Idiopathic inflammatory myopathy (IIM) comprises a group of rare systemic diseases characterized by progressive weakness of the symmetrical proximal limb muscles, elevated muscle enzymes, inflammation or necrosis on muscle biopsy. IIM may impair the function of multiple organs, particularly the heart. However, it rarely manifests as acute myocardial infarction (AMI) at initial presentation. The present study described the case of a 39-year-old woman with AMI, whose muscle biopsy on the left arm conformed to polymyositis...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28552479/biopharmaceutic-parameters-pharmacokinetics-transport-and-cyp-mediated-drug-interactions-of-iiim-017-a-novel-nitroimidazooxazole-analogue-with-anti-tuberculosis-activity
#14
Gurleen Kour, Parvinder Pal Singh, Asha Bhagat, Zabeer Ahmed
Nitroimidazoles are emerging as a new class of therapeutic agents with potent anti-tubercular activity. CSIR-IIIM has synthesized a novel nitrohydroimidazooxazole (NHIO) analogue, IIIM-017 with a MIC of 0.37μg/ml (against H37Rv). Here, we aim at further exploration of physicochemical properties and preclinical absorption, metabolism, disposition and pharmacokinetics of IIIM-017. In this study, in silico physicochemical parameters, lipophilicity, permeability, transport, hepatotoxicity, CYP mediated drug interactions and pharmacokinetics of IIIM-017 were investigated...
August 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28542733/the-pathogenesis-of-dermatomyositis
#15
REVIEW
C Thompson, V Piguet, E Choy
This review looks at the many different factors thought to play a role in idiopathic inflammatory myopathies (IIM), concentrating mainly on the dermatomyositis (DM) subtype. Subject areas addressed include looking at the different clinical features of IIM, paying particular attention to the skin manifestations. There is a discussion around investigations needed with their perceived value, followed by a description of the immunohistochemical findings of DM. This review goes on to address other attributing factors such as genetic associations with the different subtypes of IIM, and environmental factors including infections, ultraviolet radiation and vitamin D deficiency and drugs...
May 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28536758/serum-levels-of-adipokines-in-patients-with-idiopathic-inflammatory-myopathies-a-pilot-study
#16
Javier Loaiza-Félix, Mariana Moreno-Ramírez, F Luis Pérez-García, Valentín Jiménez-Rojas, Fausto Sánchez-Muñoz, M Luis Amezcua-Guerra
Adipokines are cytokines not only regulating metabolic and endocrine activities, but also modulating inflammatory and immune responses in several clinical settings, including autoimmunity. This study was aimed to evaluate whether serum adipokine levels may be useful as markers of disease activity in patients with idiopathic inflammatory myopathies (IIM). Adiponectin, leptin, chemokine C-C motif ligand-2 (CCL2), interleukin (IL)-6, and tumor necrosis factor (TNF) were measured in the serum of all participants...
August 2017: Rheumatology International
https://www.readbyqxmd.com/read/28524083/idiopathic-inflammatory-myopathies-a-review-of-the-classification-and-impact-of-pathogenesis
#17
REVIEW
Dana E Mandel, Charles J Malemud, Ali D Askari
Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune muscle diseases with significant morbidity and mortality. This review details and updates the pathogenesis and emerging importance of myositis-specific antibodies in the development of IIMs. An increase in the understanding of how these myositis-specific antibodies play a role in IIMs has led to the further categorization of IIMs from the traditional polymyositis versus dermatomyositis, to additional subcategories of IIMs such as necrotizing autoimmune myositis (NAM)...
May 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28499571/designing-an-internet-intervention-for-emerging-adults-who-experience-troubled-relationships
#18
Claire Burke Draucker, Donna S Martsolf, Stacey Crane, Lindsey Romero, Allison Leigh McCord
This article describes how the Internet Intervention Model (IIM) was used as an organizing framework to design a theoretically based Internet intervention for emerging adults who experience troubled intimate partner relationships. In the design process, the team addressed six fundamental questions related to the several components of the IIM. Decisions made regarding the design of the intervention based on the six questions are described. We focus in particular on how the intervention is based on the Theory of Emerging Adulthood and the Theory of Narrative Identity...
June 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28487494/the-varicella-vaccination-pattern-among-children-under-5-years-old-in-selected-areas-in-china
#19
Chenyan Yue, Yan Li, Yamin Wang, Yan Liu, Linsheng Cao, Xu Zhu, Kathryn Martin, Huaqing Wang, Zhijie An
BACKGROUND: Vaccine is the most effective way to protect susceptible children from varicella. Few published literature or reports on varicella vaccination of Chinese children exist. Thus, in order to obtain specific information on varicella vaccination of this population, we conducted this survey. METHODOLOGY: We first used purposive sampling methods to select 6 provinces 10 counties from eastern, middle and western parts of China with high quality of Immunization Information Management System (IIMS), and then randomly select children from population in the IIMS, then we checked vaccination certificate on-site...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28460448/anti-mda5-antibody-as-a-potential-diagnostic-and-prognostic-biomarker-in-patients-with-dermatomyositis
#20
Liubing Li, Qian Wang, Funing Yang, Chanyuan Wu, Si Chen, Xiaoting Wen, Chenxi Liu, Yongzhe Li
The presence of anti-MDA5 antibodies in serum represents an important biomarker in the diagnosis and prediction of prognosis for patients with idiopathic inflammatory myopathies (IIMs). Due to conflicting results that have been reported regarding the detection of anti-MDA5 antibodies, the goal of this study was to assess a potential association between the presence of anti-MDA5 antibodies and dermatomyositis/polymyositis (DM/PM), as well as the diagnostic and prognostic values of anti-MDA5 antibodies for DM/PM...
April 18, 2017: Oncotarget
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