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JOURNAL ARTICLE
Ocular Manifestations in Juvenile Behçet's Disease: A Registry-Based Analysis from the AIDA Network.
Carla Gaggiano, Abdurrahman Tufan, Silvana Guerriero, Gaafar Ragab, Jurgen Sota, Stefano Gentileschi, Stefania Costi, Ibrahim A Almaghlouth, Andrea Hinojosa-Azaola, Samar Tharwat, Petros P Sfikakis, Giuseppe Lopalco, Matteo Piga, Giovanni Conti, George Fragoulis, Angela Mauro, Ezgi D Batu, Seza Ozen, Maria Tarsia, Francesco La Torre, Perla A Kawakami-Campos, Antonio Vitale, Valeria Caggiano, Riza C Kardaş, Gian Marco Tosi, Bruno Frediani, Tadej Avčin, José Hernández-Rodríguez, Luca Cantarini, Claudia Fabiani
INTRODUCTION: This study aims to characterize ocular manifestations of juvenile Behçet's disease (jBD). METHODS: This was a registry-based observational prospective study. All subjects with jBD from the Autoinflammatory Diseases Alliance (AIDA) Network BD Registry showing ocular manifestations before 18 years were enrolled. RESULTS: We included 27 of 1000 subjects enrolled in the registry (66.7% male patients, 45 affected eyes). The median (interquartile range [IQR]) age at ocular involvement was 14...
March 30, 2024: Ophthalmology and Therapy
#2
JOURNAL ARTICLE
Mojca Zajc Avramovič, Nataša Toplak, Gašper Markelj, Nina Emeršič, Tadej Avčin
BACKGROUND: To evaluate long-term outcomes and prognostic factors in patients with juvenile idiopathic arthritis (JIA), presenting as oligoarthritis, who received IAC as the first treatment for their disease. METHODS: We conducted retrospective study at the University Children's Hospital Ljubljana, Slovenia, from January 2015 to May 2023 in children with JIA, clinically presenting as oligoarthritis receiving intra-articular corticosteroid injection (IAC) as the initial treatment...
March 14, 2024: Arthritis Research & Therapy
#3
JOURNAL ARTICLE
Karen Schreiber, Ian Giles, Nathalie Costedoat-Chalumeau, Catherine Nelson-Piercy, Radboud Jem Dolhain, Marta Mosca, Frauke Förger, Rebecca Fischer-Betz, Anna Molto, Angela Tincani, Elisabeth Pasquier, Benoit Marin, Elisabeth Elefant, Jane Salmon, Bonnie L Bermas, Lisa Sammaritano, Megan E B Clowse, Christina Chambers, Jill Buyon, Saori Abe Inoue, Nancy Agmon-Levin, Silvia Aguilera, Samar Al Emadi, Jeanette Andersen, Danieli Andrade, Aleksandra Antovic, Laurent Arnaud, Alice Ashouri Christiansen, Tadej Avcin, Sara Badreh-Wirström, George Bertsias, Ilaria Bini, Anca Bobirca, Ware Branch, Antonio Brucato, Irene Bultink, Susanna Capela, Irene Cecchi, Ricard Cervera, Cecilia Chighizola, Claudia Cobilinschi, Maria Jose Cuadrado, Dzifa Dey, Oseme Etomi, Gerard Espinosa, Julia Flint, João-Eurico Fonseca, Ruth Fritsch-Stork, Maria Gerosa, Bente Glintborg, Carina Gøtestam Skorpen, Bethan Goulden, Christine Graversgaard, Iva Gunnarsson, Latika Gupta, Merete Hetland, Ken Hodson, Beverley J Hunt, David Isenberg, Søren Jacobsen, Munther Khamashta, Roger Levy, Louise Linde, Jacob Lykke, Yvette Meissner, Louise Moore, Eric Morand, Sandra Navarra, Daniela Opris-Belinski, Monika Østensen, Hiroki Ozawa, Luis Fernando Perez-Garcia, Michelle Petri, Guillermo J Pons-Estel, Massimo Radin, Luigi Raio, Amihai Rottenstreich, Guillermo Ruiz-Irastorza, Slađana Rumpl Tunjić, Marite Rygg, Savino Sciascia, Anja Strangfeld, Elisabet Svenungsson, Maria Tektonidou, Anne Troldborg, Evelyne Vinet, Jelena Vojinovic, Anne Voss, Marianne Wallenius, Laura Andreoli
No abstract text is available yet for this article.
September 2023: Lancet Rheumatology
#4
EDITORIAL
Tadej Avčin, Angelo Ravelli
No abstract text is available yet for this article.
January 16, 2024: Pediatric Rheumatology Online Journal
#5
JOURNAL ARTICLE
Tomaž Poredoš, Tina Vesel Tajnšek, Anja Koren Jeverica, Mojca Zajc Avramovič, Gašper Markelj, Nina Emeršič, Tadej Avčin
BACKGROUND: Data suggest that food allergies greatly impact a child's health and growth due to inadequate nutrient intake. Our study aimed to establish the long-term outcome of children with food allergies compared to a control group. METHODS: This study was a retrospective cohort study with longitudinal follow-up with a mean period of 4.85 years from the diagnosis to the last study visit. The patients' nutritional intake was assessed using a three-day food diary and analysed by a dietitian...
December 22, 2023: Nutrients
#6
JOURNAL ARTICLE
Maria Tarsia, Mojca Zajc Avramovič, Ana Gazikalović, Damjana Ključevšek, Tadej Avčin
In recent years, imaging has become increasingly important to confirm diagnosis, monitor disease activity, and predict disease course and outcome in children with juvenile idiopathic arthritis (JIA). Over the past few decades, great efforts have been made to improve the quality of diagnostic imaging and to reach a consensus on which methods and scoring systems to use. However, there are still some critical issues, and the diagnosis, course, and management of JIA are closely related to clinical assessment. This review discusses the main indications for conventional radiography (XR), musculoskeletal ultrasound (US), and magnetic resonance imaging (MRI), while trying to maintain a clinical perspective...
November 28, 2023: Pediatric Radiology
#7
JOURNAL ARTICLE
Jens Klotsche, Kathryn S Torok, Ozgur Kasapcopur, Amra Adrovic, Maria Teresa Terreri, Ana Paula Sakamoto, Maria Katsicas, Flavio Sztajnbok, Edoardo Marrani, Alberto Sifuentes-Giraldo, Valda Stanevicha, Jordi Anton, Brian Feldmann, Mikhail Kostik, Dana Nemcova, Maria Jose Santos, Simone Appenzeller, Tadej Avcin, Cristina Battagliotti, Lillemor Berntson, Blanca Bica, Jürgen Brunner, Despina Eleftheriou, Liora Harel, Gerd Horneff, Tilmann Kallinich, Kirsten Minden, Susan Nielsen, Anjali Patwardhan, Nicola Helmus, Ivan Foeldvari
OBJECTIVES: Juvenile systemic sclerosis is a rare childhood disease. Three disease activity indices have been published for adult patients with systemic sclerosis: the European Scleroderma Study Group Index, a modified version of the European Scleroderma Study Group Index and the revised European Scleroderma Trials and Research index. The objective of this study was to determine the feasibility and performance of the three disease activity indices in a prospectively followed cohort of patients with juvenile systemic sclerosis...
October 2023: Journal of Scleroderma and related Disorders
#8
JOURNAL ARTICLE
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tatsuya Atsumi, Tadej Avcin, H Michael Belmont, Maria Laura Bertolaccini, D Ware Branch, Graziela Carvalheiras, Alessandro Casini, Ricard Cervera, Hannah Cohen, Nathalie Costedoat-Chalumeau, Mark Crowther, Guilherme de Jesús, Aurelien Delluc, Sheetal Desai, Maria De Sancho, Katrien M Devreese, Reyhan Diz-Kucukkaya, Ali Duarte-García, Camille Frances, David Garcia, Jean-Christophe Gris, Natasha Jordan, Rebecca K Leaf, Nina Kello, Jason S Knight, Carl Laskin, Alfred I Lee, Kimberly Legault, Steve R Levine, Roger A Levy, Maarten Limper, Michael D Lockshin, Karoline Mayer-Pickel, Jack Musial, Pier Luigi Meroni, Giovanni Orsolini, Thomas L Ortel, Vittorio Pengo, Michelle Petri, Guillermo Pons-Estel, Jose A Gomez-Puerta, Quentin Raimboug, Robert Roubey, Giovanni Sanna, Surya V Seshan, Savino Sciascia, Maria G Tektonidou, Angela Tincani, Denis Wahl, Rohan Willis, Cécile Yelnik, Catherine Zuily, Francis Guillemin, Karen Costenbader, Doruk Erkan
OBJECTIVE: To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) and EULAR. METHODS: This international multidisciplinary initiative included four phases: (1) Phase I, criteria generation by surveys and literature review; (2) Phase II, criteria reduction by modified Delphi and nominal group technique exercises; (3) Phase III, criteria definition, further reduction with the guidance of real-world patient scenarios, and weighting via consensus-based multicriteria decision analysis, and threshold identification; and (4) Phase IV, validation using independent adjudicators' consensus as the gold standard...
October 2023: Annals of the Rheumatic Diseases
#9
JOURNAL ARTICLE
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tatsuya Atsumi, Tadej Avcin, H Michael Belmont, Maria Laura Bertolaccini, D Ware Branch, Graziela Carvalheiras, Alessandro Casini, Ricard Cervera, Hannah Cohen, Nathalie Costedoat-Chalumeau, Mark Crowther, Guilherme de Jesus, Aurelien Delluc, Sheetal Desai, Maria De Sancho, Katrien M Devreese, Reyhan Diz-Kucukkaya, Ali Duarte-Garcia, Camille Frances, David Garcia, Jean-Christophe Gris, Natasha Jordan, Rebecca K Leaf, Nina Kello, Jason S Knight, Carl Laskin, Alfred I Lee, Kimberly Legault, Steve R Levine, Roger A Levy, Maarten Limper, Michael D Lockshin, Karoline Mayer-Pickel, Jack Musial, Pier Luigi Meroni, Giovanni Orsolini, Thomas L Ortel, Vittorio Pengo, Michelle Petri, Guillermo Pons-Estel, Jose A Gomez-Puerta, Quentin Raimboug, Robert Roubey, Giovanni Sanna, Surya V Seshan, Savino Sciascia, Maria G Tektonidou, Angela Tincani, Denis Wahl, Rohan Willis, Cecile Yelnik, Catherine Zuily, Francis Guillemin, Karen Costenbader, Doruk Erkan
OBJECTIVE: To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) and EULAR. METHODS: This international multidisciplinary initiative included 4 phases: 1) Phase I, criteria generation by surveys and literature review; 2) Phase II, criteria reduction by modified Delphi and nominal group technique exercises; 3) Phase III, criteria definition, further reduction with the guidance of real-world patient scenarios, and weighting via consensus-based multicriteria decision analysis, and threshold identification; and 4) Phase IV, validation using independent adjudicators' consensus as the gold standard...
October 2023: Arthritis & Rheumatology
#10
JOURNAL ARTICLE
Ivan Foeldvari, Jens Klotsche, Ozgur Kasapcopur, Amra Adrovic, Maria Teresa Terreri, Ana Paula Sakamoto, Valda Stanevicha, Jordi Anton, Brian M Feldman, Flavio Sztajnbok, Raju Khubchandani, Ekaterina Alexeeva, Maria Katsicas, Sujata Sawhney, Vanessa Smith, Simone Appenzeller, Tadej Avcin, Mikhail Kostik, Thomas Lehman, Edoardo Marrani, Dieneke Schonenberg-Meinema, Walter-Alberto Sifuentes-Giraldo, Natalia Vasquez-Canizares, Mahesh Janarthanan, Monika Moll, Dana Nemcova, Anjali Patwardhan, Maria Jose Santos, Cristina Battagliotti, Lillemor Berntson, Blanca Bica, Jürgen Brunner, Rolando Cimaz, Patricia Costa-Reis, Despina Eleftheriou, Liora Harel, Gerd Horneff, Sindhu R Johnson, Daniela Kaiser, Tilmann Kallinich, Dragana Lazarevic, Kirsten Minden, Susan Nielsen, Farzana Nuruzzaman, Siri Opsahl Hetlevik, Yosef Uziel, Nicola Helmus, Kathryn S Torok
OBJECTIVE: To compare organ involvement and disease severity between male and female patients with juvenile onset systemic sclerosis. METHODS: Demographics, organ involvement, laboratory evaluation, patient-reported outcomes and physician assessment variables were compared between male and female juvenile onset systemic sclerosis patients enrolled in the prospective international juvenile systemic sclerosis cohort at their baseline visit and after 12 months...
June 2023: Journal of Scleroderma and related Disorders
#11
JOURNAL ARTICLE
Tjaša Šinkovec Savšek, Mojca Zajc Avramovič, Tadej Avčin, Miša Korva, Tatjana Avšič Županc, Nataša Toplak
BACKGROUND: Paediatric patients with autoimmune rheumatic diseases (pARD) are often immunocompromised because of the disease and/or the therapy they receive. At the beginning of COVID-19 pandemic there was a great concern about the possibility of severe SARS-CoV-2 infection in these patients. The best method of protection is vaccination, so as soon as vaccine was licenced, we aimed to vaccinate them. Data on disease relapse rate after COVID-19 infection and vaccination are scarce, but they play important role in everyday clinical decisions...
May 19, 2023: Pediatric Rheumatology Online Journal
#12
JOURNAL ARTICLE
Alessia Alunno, Tadej Avcin, Catherine Haines, Sofia Ramiro, Francisca Sivera, Sara Badreh, Xenofon Baraliakos, Johannes W J Bijlsma, Frank Buttgereit, Kaushik Chaudhuri, Jose A P Da Silva, Jean Dudler, Ricardo J O Ferreira, Tania Gudu, Eric Hachulla, Mette Holland-Fischer, Annamaria Iagnocco, Tue Wenzel Kragstrup, György Nagy, Vasco C Romão, Simon R Stones, Marloes van Onna, Christopher J Edwards
BACKGROUND: Postgraduate rheumatology training programmes are already established at a national level in most European countries. However, previous work has highlighted a substantial level of heterogeneity in the organisation and, in part, content of programmes. OBJECTIVE: To define competences and standards of knowledge, skills and professional behaviours required for the training of rheumatologists. METHODS: A European Alliance of Associations for Rheumatology (EULAR) task force (TF) of 23 experts, including two members of the European Union of Medical Specialists (UEMS) section of rheumatology, was convened...
August 2023: Annals of the Rheumatic Diseases
#13
JOURNAL ARTICLE
Andreja Nataša Kopitar, Jernej Repas, Larisa Janžič, Maša Bizjak, Tina Tajnšek Vesel, Nina Emeršič, Mojca Zajc Avramovič, Alojz Ihan, Tadej Avčin, Mojca Pavlin
INTRODUCTION: Although children seem to be less susceptible to COVID-19, some of them develop a rare but serious hyperinflammatory condition called multisystem inflammatory syndrome in children (MIS-C). While several studies describe the clinical conditions of acute MIS-C, the status of convalescent patients in the months after acute MIS-C is still unclear, especially the question of persistence of changes in the specific subpopulations of immune cells in the convalescent phase of the disease...
2023: Frontiers in Immunology
#14
JOURNAL ARTICLE
Jelena Vojinović, Ivan Foeldvari, Joke Dehoorne, Violeta Panaviene, Gordana Susic, Gerd Horneff, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Jonathan Akikusa, Tadej Avcin, Cecilia Borlenghi, Edmund Arthur, Svitlana Y Tatulych, Chuanbo Zang, Vassilis Tsekouras, Bonnie Vlahos, Alberto Martini, Nicolino Ruperto
OBJECTIVES: CLIPPER2 was an 8-year, open-label extension of the phase 3 b, 2-year CLIPPER study on the safety and efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA), categorized as extended oligoarticular arthritis (eoJIA), enthesitis-related arthritis (ERA), or psoriatic arthritis (PsA). METHODS: Participants with eoJIA (2-17 years old), ERA, or PsA (each 12-17 years old) who received ≥1 etanercept dose (0.8 mg/kg weekly; maximum 50 mg) in CLIPPER could enter CLIPPER2...
May 4, 2023: Rheumatology
#15
Rosaria Talarico, Giuseppe Alvise Ramirez, Sofia C Barreira, Chiara Cardamone, Paola Triggianese, Silvia Aguilera, Jeanette Andersen, Tadej Avcin, Karelle Benistan, George Bertsias, Alessandra Bortoluzzi, Coralie Bouillot, Inita Bulina, Gerd R Burmester, Steven Callens, Patricia E Carreira, Ricard Cervera, Maurizio Cutolo, Laura Damian, Emanuel Della-Torre, Raquel Faria, João E Fonseca, Ilaria Galetti, Eric Hachulla, Luca Iaccarino, Søren Jacobsen, Nikita Khmelinskii, Maarten Limper, Diana Marinello, Alain Meyer, Gianluca Moroncini, Gyorgy Nagy, Marzena Olesinska, Cristina Pamfil, Margarita Pileckyte, Mauro Pistello, Simona Rednic, Christophe Richez, Vasco C Romão, Matthias Schneider, Savino Sciascia, Carlo Alberto Scirè, Gabriele Simonini, Vanessa Smith, Alberto Sulli, Chiara Tani, Sander W Tas, Angela Tincani, Madelon C Vonk, Maria Tektonidou, Marta Mosca
Recent studies have shown that people who are immunocompromised may inadvertently play a role in spurring the mutations of the virus that create new variants. This is because some immunocompromised individuals remain at risk of getting COVID-19 despite vaccination, experience more severe disease, are susceptible to being chronically infected and remain contagious for longer if they become infected and considering that immunocompromised individuals represent approximately 2% of the overall population, this aspect should be carefully considered...
March 14, 2023: Clinical and Experimental Rheumatology
#16
JOURNAL ARTICLE
Eve Mary Dorothy Smith, Amita Aggarwal, Jenny Ainsworth, Eslam Al-Abadi, Tadej Avcin, Lynette Bortey, Jon Burnham, Coziana Ciurtin, Christian M Hedrich, Sylvia Kamphuis, Deborah M Levy, Laura B Lewandowski, Naomi Maxwell, Eric F Morand, Seza Ozen, Clare E Pain, Angelo Ravelli, Claudia Saad Magalhaes, Clarissa A Pilkington, Dieneke Schonenberg-Meinema, Christiaan Scott, Kjell Tullus, Michael William Beresford
OBJECTIVES: Application of 'treat-to-target' (T2T) in childhood-onset systemic lupus erythematosus (cSLE) may improve care and health outcomes. This initiative aimed to harmonise existing evidence and expert opinion regarding T2T for cSLE. METHODS: An international T2T Task Force was formed of specialists in paediatric rheumatology, paediatric nephrology, adult rheumatology, patient and parent representatives. A steering committee formulated a set of draft overarching principles and points-to-consider, based on evidence from systematic literature review...
June 2023: Annals of the Rheumatic Diseases
#17
JOURNAL ARTICLE
Maša Bizjak, Nina Emeršič, Mojca Zajc Avramovič, Fabio Barbone, Federico Ronchese, Sara Della Paolera, Ester Conversano, Stefano Amoroso, Michael Vidoni, Tina Vesel Tajnšek, Gorazd Mlakar, Vojko Berce, Gašper Markelj, Tina Plankar Srovin, Tanja Golli, Damjan Osredkar, Anja Koren Jeverica, Nataša Toplak, Marko Pokorn, Tatjana Avšič Županc, Alojz Ihan, Mario Fafangel, Andrea Taddio, Tadej Avčin
OBJECTIVES: To estimate the incidence and describe the spectrum of inflammatory and autoimmune diseases linked to SARS-CoV-2 infection and COVID-19 vaccination in children from two neighbouring south central European countries. METHODS: We performed a multi-centre prospective cohort study of children under 18 years diagnosed with inflammatory/autoimmune diseases linked to SARS-CoV-2 infection or COVID-19 vaccination, who were admitted to the paediatric tertiary care hospitals in Slovenia and Friuli Venezia Giulia, Italy, from January 1, 2020, to December 31, 2021...
November 12, 2022: Clinical and Experimental Rheumatology
#18
Rosaria Talarico, Silvia Aguilera, Tobias Alexander, Zahir Amoura, Ana M Antunes, Laurent Arnaud, Tadej Avcin, Lorenzo Beretta, Stefano Bombardieri, Gerd R Burmester, Sara Cannizzo, Lorenzo Cavagna, Benjamin Chaigne, Alain Cornet, Nathalie Costedoat-Chalumeau, Andrea Doria, Alessandro Ferraris, Rebecca Fischer-Betz, João E Fonseca, Charissa Frank, Andrea Gaglioti, Ilaria Galetti, Jürgen Grunert, Vera Guimarães, Eric Hachulla, Frederic Houssiau, Luca Iaccarino, Thomas Krieg, Marteen Limper, Fransiska Malfait, Xavier Mariette, Diana Marinello, Thierry Martin, Lisa Matthews, Marco Matucci-Cerinic, Alain Meyer, Carlomaurizio Montecucco, Luc Mouthon, Ulf Müller-Ladner, Simona Rednic, Vasco C Romão, Matthias Schneider, Vanessa Smith, Alberto Sulli, Farah Tamirou, Domenica Taruscio, Anna V Taulaigo, Enrique Terol, Angela Tincani, Simone Ticciati, Giuseppe Turchetti, P Martin van Hagen, Jacob M van Laar, Ana Vieira, Jeska K de Vries-Bouwstra, Maurizio Cutolo, Marta Mosca
No abstract text is available yet for this article.
October 6, 2022: Nature Reviews. Rheumatology
#19
JOURNAL ARTICLE
Mark Kačar, Gašper Markelj, Tadej Avčin
PURPOSE OF REVIEW: Autoimmune and inflammatory complications have been shown to arise in all age groups and across the spectrum of inborn errors of immunity (IEI). This review aims to highlight recent ground-breaking research and its impact on our understanding of IEI. RECENT FINDINGS: Three registry-based studies of unprecedented size revealed the high prevalence of autoimmune, inflammatory and malignant complications in IEI. Two novel IEI were discovered: an autoinflammatory relopathy, cleavage-resistant RIPK1-induced autoinflammatory syndrome, as well as an inheritable phenocopy of PD-1 blockade-associated complication (as seen in cancer therapy) manifesting with multiorgan autoimmunity and Mycobacterium tuberculosis infection...
September 22, 2022: Current Opinion in Allergy and Clinical Immunology
#20
JOURNAL ARTICLE
Pavel V Ovseiko, Laure Gossec, Laura Andreoli, Uta Kiltz, Leonieke van Mens, Neelam Hassan, Marike van der Leeden, Heidi J Siddle, Alessia Alunno, Iain B McInnes, Nemanja S Damjanov, Florence Apparailly, Caroline Ospelt, Irene E van der Horst-Bruinsma, Elena Nikiphorou, Katie L Druce, Zoltán Szekanecz, Alexandre Sepriano, Tadej Avcin, George Bertsias, Georg Schett, Anne-Maree Keenan, Linda H Pololi, Laura C Coates
OBJECTIVES: Evidence on the current status of gender equity in academic rheumatology in Europe and potential for its improvement is limited. The EULAR convened a task force to obtain empirical evidence on the potential unmet need for support of female rheumatologists, health professionals and non-clinical scientists in academic rheumatology. METHODS: This cross-sectional study comprised three web-based surveys conducted in 2020 among: (1) EULAR scientific member society leaders, (2) EULAR and Emerging EULAR Network (EMEUNET) members and (3) EULAR Council members...
August 2022: RMD Open
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