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Bone scintigraphy

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https://www.readbyqxmd.com/read/29243019/evaluation-of-bone-metastatic-burden-by-bone-spect-ct-in-metastatic-prostate-cancer-patients-defining-threshold-value-for-total-bone-uptake-and-assessment-in-radium-223-treated-patients
#1
Takuro Umeda, Mitsuru Koizumi, Shohei Fukai, Noriaki Miyaji, Kazuki Motegi, Shuto Nakazawa, Tomohiro Takiguchi
OBJECTIVES: To establish a new three-dimensional quantitative evaluation method for bone metastasis, we applied bone single photon emission tomography with computed tomography (SPECT/CT). The total bone uptake (TBU), which measures active bone metastatic burden, was calculated as the sum of [mean uptake obtained as standardized uptake value (SUV) above a cut-off level] × (the volume of the lesion) in the trunk using bone SPECT/CT. We studied the threshold value and utility of TBU in prostate cancer patients treated with radium-223 (Ra-223) therapy...
December 14, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29242736/inguinal-herniation-of-urinary-bladder-on-f-18-sodium-fluoride-naf-pet-ct
#2
Sharjeel Usmani, Fahad Marafi, Najeeb Ahmed, Nafisah Kazem
Inguinal herniation of urinary bladder is uncommon and usually an incidental finding in asymptomatic patients. In some of these patients, residual urine volume and consequently, urinary tracer activity can be higher in the herniated bladder than the native bladder, in which case interpretation can be challenging on conventional planar imaging. We describe an interesting case of physiological activity in a herniated bladder simulating a "tear-drop". This case serves an important reminder that whilst F-18 NaF PET-CT has a similar spectrum of urinary activity to conventional bone scintigraphy; morphological correlation on hybrid imaging is invaluable in ensuring the physiological nature of uptake...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29241901/comparison-of-timed-automata-with-discrete-event-simulation-for-modeling-of-biomarker-based-treatment-decisions-an-illustration-for-metastatic-castration-resistant-prostate-cancer
#3
Koen Degeling, Stefano Schivo, Niven Mehra, Hendrik Koffijberg, Rom Langerak, Johann S de Bono, Maarten J IJzerman
BACKGROUND: With the advent of personalized medicine, the field of health economic modeling is being challenged and the use of patient-level dynamic modeling techniques might be required. OBJECTIVES: To illustrate the usability of two such techniques, timed automata (TA) and discrete event simulation (DES), for modeling personalized treatment decisions. METHODS: An early health technology assessment on the use of circulating tumor cells, compared with prostate-specific antigen and bone scintigraphy, to inform treatment decisions in metastatic castration-resistant prostate cancer was performed...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29221466/unusual-pathological-fracture-of-the-clavicle-revealing-primary-hyperparathyroidism-a-case-report
#4
Yassir Benameur, Hasnae Guerrouj, Imad Ghfir, Nouzha Ben Rais Aouad
BACKGROUND: Primary hyperparathyroidism revealed by a pathological fracture is very uncommon; in the majority of cases the discovery of lytic bone lesions on imaging examinations evokes in the clinician first a neoplastic etiology and a metabolic origin is often omitted. This case report adds to the existing literature as it describes an unusual presentation of primary hyperparathyroidism. CASE PRESENTATION: We report a case of a 50-year-old Moroccan man, without any known tumor, who presented a fracture of his left clavicle with multiple osteolytic lesions on computed tomography suggesting bone metastases...
December 9, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29204962/adult-leukoencephalopathies-with-prominent-infratentorial-involvement-can-be-caused-by-erdheim-chester-disease
#5
Luisa Chiapparini, Giulio Cavalli, Tiziana Langella, Anna Venerando, Giacomo De Luca, Sergio Raspante, Giorgio Marotta, Bianca Pollo, Giuseppe Lauria, Maria Giulia Cangi, Simonetta Gerevini, Andrea Botturi, Davide Pareyson, Lorenzo Dagna, Ettore Salsano
BACKGROUND: Leukoencephalopathies with prominent involvement of cerebellum and brainstem, henceforward called prominent infratentorial leukoencephalopathies (PILs), encompass a variety of inherited and acquired white matter diseases. Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis likely under-diagnosed as cause of adult PIL. METHODS: We reviewed the clinical and laboratory information of ten consecutive sporadic adult patients with PIL of unknown origin, who were investigated for ECD...
December 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29197346/radiographic-features-of-ollier-s-disease-two-case-reports
#6
Jamshid Sadiqi, Najibullah Rasouly, Hidayatullah Hamidi, Salahuddin Siraj
BACKGROUND: Ollier's disease is a non-hereditary, benign bone tumor which is usually characterized by presence of multiple radiolucent lesions (enchondromas) in the metaphysis of long bones with unilateral predominance. The disease is a rare clinical entity with 1/100000 occurrence in early childhood. Patients mostly present with multiple hard swellings and deformity of the tubular bones specially hands and feet with leg discrepancy and pathologic fractures. CASE PRESENTATION: We present two cases of Ollier's disease in a 13 years old female and 8 years old boy which had no specific symptoms...
December 2, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/29188431/cardiac-attr-amyloid-nuclear-imaging-not-all-bone-scintigraphy-radionuclide-tracers-are-created-equal
#7
Ji Can Yang, Josef Fox, Carol Chen, Anthony F Yu
No abstract text is available yet for this article.
November 29, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29181581/evaluation-of-femoral-head-viability-via-bone-scintigraphy-in-the-postoperative-pediatric-patient
#8
Ashishkumar K Parikh, Eleby R Washington, Adam J Bobbey, Stephanie E Spottswood
BACKGROUND: Evaluating postoperative patients with hardware is challenging following surgical intervention for hip maladies such as femoral neck fractures and slipped capital femoral epiphysis (SCFE). These children are at increased risk of developing avascular necrosis, and imaging may be requested to confirm or exclude this diagnosis. Children with Legg-Calvé-Perthes disease can be monitored for restoration of blood flow to the capital femoral epiphysis to guide management and help with prognosis...
November 27, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29181459/gallium-67-scintigraphy-in-differential-diagnosis-of-malignant-tumours-from-non-tumorous-lesions-of-the-maxilla
#9
Ichiro Ogura, Takaaki Oda, Mikiko Sue, Yoshihiko Sasaki, Kazuhide Hayama
OBJECTIVE: To assess the gallium-67 (67Ga) scintigraphy in differential diagnosis of malignant tumours from non-tumorous lesions of the maxilla. METHODS: Nineteen patients with malignant tumours (six cases of squamous cell carcinoma and one case of malignant melanoma) and non-tumorous lesions (seven cases of maxillary sinusitis and five cases of postoperative maxillary changes) in the maxilla underwent 67Ga and bone scintigraphy with CT and MRI. The statistical analysis with respect to comparison between imaging features of 67Ga and bone scintigraphy and maxillary lesions was performed with the Pearson's chi-squared test...
2017: Chinese Journal of Dental Research
https://www.readbyqxmd.com/read/29181269/diagnostic-test-accuracy-study-of-18f-sodium-fluoride-pet-ct-99mtc-labelled-diphosphonate-spect-ct-and-planar-bone-scintigraphy-for-diagnosis-of-bone-metastases-in-newly-diagnosed-high-risk-prostate-cancer
#10
Randi F Fonager, Helle D Zacho, Niels C Langkilde, Joan Fledelius, June A Ejlersen, Christian Haarmark, Helle W Hendel, Mine Benedicte Lange, Mads R Jochumsen, Jesper C Mortensen, Lars J Petersen
The aim of this study was to prospectively compare planar, bone scan (BS) versus SPECT/CT and NaF PET/CT in detecting bone metastases in prostate cancer. Thirty-seven consecutive, newly diagnosed, prostate cancer patients with prostate specific antigen (PSA) levels ≥ 50 ng/mL and who were considered eligible for androgen-deprivation therapy (ADT) were included in this study. BS, SPECT/CT, and NaF PET/CT, were performed prior to treatment and were repeated after six months of ADT. Baseline images from each index test were independently read by two experienced readers...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29175213/a-new-therapeutic-proposal-for-inoperable-osteosarcoma-photodynamic-therapy
#11
Guilherme Chohfi de Miguel, Ana Margarida Abrantes, Mafalda Laranjo, Ana Yoshie Kitagawa Grizotto, Bruno Camporeze, José Aires Pereira, Gonçalo Brites, Arménio Serra, Marta Pineiro, António Rocha-Gonsalves, Maria Filomena Botelho, Denise Gonçalves Priolli
BACKGROUND: Osteosarcoma, a malignant tumor characterized by bone or osteoid formation, is the second most common primary bone neoplasm. Clinical symptoms include local and surrounding pain, unrelieved by rest or anesthesia. Osteosarcoma has a poor chemotherapeutic response with prognosis dependent on complete tumor excision. Therefore, for inoperable osteosarcoma new therapeutic strategies are needed. The present study aimed to develop murine models of cranial and vertebral osteosarcoma that facilitate simple clinical monitoring and real-time imaging to evaluate the outcome of photodynamic therapy based on a previously developed photosensitizer...
November 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29163955/extra-osseous-99m-tc-methylene-diphosphonate-uptake-detected-enlargement-of-the-knee-joint-in-patient-with-polyarthritis
#12
Maria Grazia Caprio, Mariarosaria Manganelli, Simona Limone, Massimiliano Sorbillo, Mario Quarantelli, Alberto Cuocolo, Ciro Gabriele Mainolfi
Bone scintigraphy is a nuclear scanning test used to find abnormalities in the skeleton. Certain abnormal processes involving soft tissues can also cause skeletal accumulation of radiotracer during bone scintigraphy. We present a case of periarticular knee soft tissue (99m)Tc methylene diphosphonate uptake in a patient with asymmetric polyarthritis. A 33-year-old patient with asymmetric polyarthritis, skin lesions and joint pain underwent bone scintigraphy. Total body examination showed an extra-osseous uptake in periarticular soft tissue of knees joints...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29142364/bone-scan-in-evaluation-of-bone-viability-in-severe-frostbite-of-the-hand
#13
Ishan Garg, Maria J Baladron Zanetti, Ayse T Kendi
A 39-year-old male presented to the emergency department (ED) with frostbite to the fingers of both hands. In the ED, he received warm baths, acetylsalicylic acid, clopidogrel, and heparin. A three-phase bone scintigraphy with technetium-99m-methylene diphosphonate revealed absent radiotracer uptake in distal phalanges of both hands. The patient received acetylsalicylic acid, clopidogrel and wound care for the next 5 days and made an excellent recovery with satisfactory wound healing in both hands. Early rapid rewarming and reperfusion can improve the prognosis significantly and therefore bone scan done within first 1-2 days may give spurious results...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29142350/bone-scan-in-detection-of-biological-activity-in-nonhypertrophic-fracture-nonunion
#14
Sunny J Gandhi, Bhavdeep Rabadiya
Biological activity of the fracture site is very important factor in treatment planning of fracture nonunion. If no biological activity is detected, then an autologous bone graft can be supplemented or osteogenic supplementations, such as bone morphogenetic protein is given. If biological activity is present, then secure fixation is sufficient to achieve bony union. Biological activity of nonunions is usually assessed by conventional radiographs. The presence of callus formation is usually assessed as the presence of biological activity...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29127248/utility-of-111-in-cl3-scintigraphy-for-differentiating-bone-marrow-reconversion
#15
Shoji Okuda, Hironori Nishibori, Hiroaki Hoshi
Indium chloride ((111)In-Cl3) scintigraphy has been used to evaluate various hematological diseases for many years. However, there have been few reports on patients with bone marrow reconversion showing high uptake in (111)In-Cl3 scintigraphy. Herein, we report a case of a 68-year-old man with esophageal cancer who underwent (18)F-FDG PET/CT for staging of the disease. (18)F-FDG PET/CT demonstrated high uptake in the first lumbar vertebral body, which was difficult to distinguish bone metastasis and bone marrow reconversion...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29123415/impact-of-hypertrophic-pulmonary-osteoarthropathy-on-patients-with-lung-cancer
#16
Yu-Hung Fang, Chien-Chin Hsu, Meng-Jer Hsieh, Ming-Szu Hung, Ying-Huang Tsai, Yu-Ching Lin
Purpose: Hypertrophic pulmonary osteoarthropathy (HPOA) is a rare disease that most commonly occurs secondary to lung cancer. However, the clinical significance of HPOA remains unclear. The aim of this study was to evaluate the impact of HPOA on patients with lung cancer in Taiwan. Patients and methods: Data regarding lung cancer patients who demonstrated findings of HPOA on bone scintigraphy between 2010 and 2016 were retrospectively analyzed. Pathological confirmation of cases was conducted at Chiayi and Kaohsiung Chang Gang Memorial Hospital...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29105797/99m-tc-mip-1404-spect-ct-for-the-detection-of-psma-positive-lesions-in-225-patients-with-biochemical-recurrence-of-prostate-cancer
#17
Christian Schmidkonz, Claudia Hollweg, Michael Beck, Julia Reinfelder, Theresa I Goetz, James C Sanders, Daniela Schmidt, Olaf Prante, Tobias Bäuerle, Alexander Cavallaro, Michael Uder, Bernd Wullich, Peter Goebell, Torsten Kuwert, Philipp Ritt
BACKGROUND: 99m Tc-MIP-1404 (Progenics Pharmaceuticals, Inc., New York, NY) is a novel, SPECT-compatible 99m Tc-labeled PSMA inhibitor for the detection of prostate cancer. We present results of its clinical use in a cohort of 225 men with histologically confirmed prostate cancer referred for workup of biochemical relapse. METHODS: From April 2013 to April 2017, 99m Tc-MIP1404-scintigraphy was performed in 225 patients for workup of PSA biochemical relapse of prostate cancer...
January 2018: Prostate
https://www.readbyqxmd.com/read/29100167/early-identification-and-intervention-matters-a-comprehensive-review-of-current-evidence-and-recommendations-for-the-monitoring-of-bone-health-in-patients-with-cancer
#18
REVIEW
Thomas Brodowicz, Peyman Hadji, Daniela Niepel, Ingo Diel
Bone metastases are common in patients with advanced solid tumors, and many individuals experience debilitating skeletal-related events (SREs; e.g. pathologic fracture, hypercalcemia, radiotherapy or surgery to bone, and spinal cord compression). These events substantially affect disease outcomes, including survival and quality of life, and healthcare systems. Plain radiography is the most widely used imaging modality for the detection of bone metastases; skeletal scintigraphy, computed tomography, positron emission tomography and magnetic resonance imaging offer greater sensitivity but their use in routine practice is restricted by high costs and limited availability...
October 18, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29095277/acute-pancreatitis-as-an-initial-manifestation-of-parathyroid-carcinoma-a-case-report-and-literature-review
#19
REVIEW
Yuan Gao, Cheng Yu, Feixiang Xiang, Mingxing Xie, Lingyun Fang
RATIONALE: Parathyroid carcinoma is a rare endocrine malignancy. Acute pancreatitis as an initial manifestation of parathyroid carcinoma has been rarely reported. PATIENT CONCERNS: A 22-year-old woman was admitted to emergency room with a sudden attack of severe epigastric pain. DIAGNOSES: Acute pancreatitis was diagnosed as elevated levels of serum amylase. During the work-up for acute pancreatitis, patient's abnormally increased serum calcium and bones destruction revealed by abdominal computed tomography (CT) scan raised the suspicion of hyperparathyroidism or malignancy...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29093397/a-metastatic-gastric-tumor-from-ovarian-cancer
#20
Mitsuhiro Kono, Yasuaki Nagami, Masaki Ominami, Taishi Sakai, Takeshi Fukuda, Shusei Fukunaga, Fumio Tanaka, Satoshi Sugimori, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Kazunari Tominaga, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa
Gastric metastasis from ovarian cancer has rarely been reported. We herein report the case of a 64-year-old woman with gastric metastasis from ovarian cancer that was diagnosed as surgical stage IA. Diagnostic and staging laparotomy showed mucinous carcinoma of the right ovary. At one month after surgery, bone metastasis was detected via scintigraphy. On esophagogastroduodenoscopy, a 10-mm elevated lesion with ulceration on the top was seen in the stomach. The immunohistochemical analysis of biopsy specimens showed that these metastases arose from ovarian cancer...
November 1, 2017: Internal Medicine
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