Shima Ghasemi, Monika Shamsabadi, Axel Olesund, Andreas Erbs Hillers-Bendtsen, Francisco Najera, Fredrik Edhborg, Adil S Aslam, Wera Larsson, Zhihang Wang, Francoise M Amombo Noa, Rebecca J Salthouse, Lars Öhrström, Helen Hölzel, Ezequiel Perez-Inestrosa, Kurt V Mikkelsen, Jörg Hanrieder, Bo Albinsson, Ambra Dreos, Kasper Moth-Poulsen
This study presents the synthesis and characterization of two fluorescent norbornadiene (NBD) photoswitches, each incorporating two conjugated pyrene units. Expanding on the limited repertoire of reported photoswitchable fluorescent NBDs, we explore their properties with a focus on applications in bioimaging of amyloid beta (Aβ) plaques. While the fluorescence emission of the NBD decreases upon photoisomerization, aligning with what has been previously reported, for the first time we observed luminescence after irradiation of the quadricyclane (QC) isomer...
April 17, 2024: Chemistry: a European Journal