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N Almenara, L Ibarlucea, C Mendicute-Fierro, J M Seco, A Rodríguez-Diéguez, M A Garralda, M A Huertos
[RhCl(NCO)(nbyl)(PR3)] (nbyl = σ-norbornenyl; NCO = quinoline-8-acyl; R = p-F-C6H4) (1) has been synthesized by the reaction of [Rh(nbd)Cl]2 (nbd = norbornadiene) with 2 equivalents of NCHO (quinoline-8-carbaldehyde) and 2 equivalents of PR3. Compound 1 has been fully characterized in solution and also in the solid state by X-ray diffraction. Compound 1 shows low stability in solution and undergoes slow ring closure isomerization to [RhCl(NCO)(ntyl)(PR3)] (ntyl = σ-nortricyclyl) (2) after 12 hours. Reaction of 1 with an extra equivalent of aldehyde (NCHO) and PR3 led to the formation of [RhCl(H)(NCO)(PR3)2] (3) and an equivalent of ketone, which is a hydroacylation product...
October 24, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Fatma Nur Korkmaz, Gulsen Ozen, Ali Uğur Ünal, Pınar Kahraman Koytak, Nese Tuncer, Haner Direskeneli
Abstract/ Resumo Behcet's disease (BD) is a multisystem inflammatory disorder characterized by recurrent oral and genital ulcers, skin lesions and uveitis. The nervous system involvement of BD, neuro-Behcet's disease (NBD), is one of the important causes of mortality of the disease. Herein, we present a 29-year-old male with parenchymal NBD who has progressed rapidly and was managed with an uncommon aggressive immunosuppresive combination therapy. The patient first presented six years ago with vertigo and difficulty in talking and walking...
September 28, 2016: Acta Reumatológica Portuguesa
Stephen P Best, Feng Wang, Mohammed Tauhidul Islam, Shawkat Islam, Dominique Appadoo, Ryan Mcevey Trevorah, Christopher Thomas Chantler
Distortion of dynamic molecules is shown to give a clear signature in the vibrational spectra which can be modelled in terms of the energy barrier and sensitivity of the vibrational modes to the reaction coordinate. The reaction coordinate method (RCM) utilises ab initio-calculated spectra of the molecule in its ground and transition states together with their relative energies to predict the temperature dependence of the vibrational spectra. DFT-calculated spectra of the eclipsed (D5h) and staggered (D5d) forms of ferrocene (Fc), and its deuteriated analogue, within RCM explain the IR spectra of in gas (350 K), solution (300 K), solid solution (7-300 K) and solid (7-300 K) states...
October 13, 2016: Chemistry: a European Journal
M C R González, P Carro, L Vázquez, A H Creus
The morphology as well as the electric and electronic properties of aryl diazonium, in particular 4-nitrobenzene-diazonium (NBD), films on HOPG surfaces have been studied at the nanoscale level. By controlling the 2,2-diphenyl-1-picrylhydrazyl concentration during the NBD film growth, we have been able to control the thickness of the layer. The implications of NBD submonolayer adsorption on the electrical properties of this system have been analysed through Density Functional Theory (DFT) calculations, Atomic Force (AFM), Electric Force (EFM) and Kelvin Probe Force (KPFM) microscopies...
October 12, 2016: Physical Chemistry Chemical Physics: PCCP
Claudio D'Amore, Genny Orso, Fabio Fusi, Mario A Pagano, Giovanni Miotto, Alessia Forgiarini, Sara De Martin, Giulia Castellani, Giovanni Ribaudo, David Rennison, Margaret A Brimble, Brian Hopkins, Alessandro Ferrarese, Sergio Bova
Norbormide (NRB) is a unique compound that acts directly on rat vascular myocytes to trigger a contractile process, through an as yet unknown mechanism, which results in the selective contraction of rat peripheral arteries. To gain insight into the mechanisms involved in NRB rat-selective activity, we investigated the subcellular distribution of NRB-AF12, a nitrobenzoxadiazole (NBD)-derivative of NRB, in living NRB-sensitive and NRB-insensitive cells. In both cell types, NRB-AF12 localized to the endoplasmic reticulum (ER), Golgi apparatus, mitochondria, lysosomes, and endosomes; however, in NRB-sensitive cells, the fluorescence also extended to the plasma membrane...
2016: Frontiers in Pharmacology
Yaroslav Faletrov, Anna Brzostek, Renata Plocinska, Jarosław Dziadek, Elena Rudaya, Irina Edimecheva, Vladimir Shkumatov
Fluorescent steroids BODIPY-cholesterol (BPCh) and 7-nitrobenzoxadiazole-4-amino-(NBD)-labeled 22-NBD-chelesterol (22NC) as well as synthesized 20-(NBD)-pregn-5-en-3β-ol (20NP) were found to undergo bioconversions by Mycobacterium tuberculosis H37Rv and M. smegmatis mc(2) 155. The major fluorescent products were determined to be 4-en-3-one derivatives of the compounds. Degradation of NBD fluorophore was also detected in the cases of 22NC and 20NP, but neither NBD degradation nor steroidal part modification were observed for the synthesized 3-(NBD)-cholestane...
October 5, 2016: Steroids
Francesca Curreli, Dmitry S Belov, Ranjith R Ramesh, Naisargi Patel, Andrea Altieri, Alexander V Kurkin, Asim K Debnath
Since our first discovery of a CD4-mimic, NBD-556, which targets the Phe43 cavity of HIV-1 gp120, we and other groups made considerable progress in designing new CD4-mimics with viral entry-antagonist property. In our continued effort to make further progress we have synthesized twenty five new analogs based on our earlier reported viral entry antagonist, NBD-11021. These compounds were tested first in HIV-1 Env-pseudovirus based single-cycle infection assay as well as in a multi-cycle infection assay. Four of these new compounds showed much improved antiviral potency as well as cytotoxicity...
September 24, 2016: Bioorganic & Medicinal Chemistry
Melis Muz, Norbert Ost, Ralph Kühne, Gerrit Schüürmann, Werner Brack, Martin Krauss
The presence of aromatic amines in the environment has been in the focus of research, as many of these compounds are known or suspected mutagens and carcinogens. To facilitate the detection of aromatic amines in complex environmental samples by LC-high resolution mass spectrometry, an on-line-post-column and a pre-column derivatization method to label (in an ideal case) all aromatic amines was evaluated by applying different derivatization reagents. 4-Fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) was found to be the most promising labeling reagent due to its high reactivity with both primary and secondary amines and its low signal in positive mode electrospray ionization (ESI+)...
January 2017: Chemosphere
Emilia Wilmowicz, Kamil Frankowski, Agata Kućko, Michał Świdziński, Juan de Dios Alché, Anna Nowakowska, Jan Kopcewicz
Flower abscission is a highly regulated developmental process activated in response to exogenous (e.g. changing environmental conditions) and endogenous stimuli (e.g. phytohormones). Ethylene (ET) and abscisic acid (ABA) are very effective stimulators of flower abortion in Lupinus luteus, which is a widely cultivated species in Poland, Australia and Mediterranean countries. In this paper, we show that artificial activation of abscission by flower removal caused an accumulation of ABA in the abscission zone (AZ)...
September 21, 2016: Journal of Plant Physiology
Gaye Erten, Muhammed Kalkan, Sema Bilgiç Gazioğlu, Nilgun Akdeniz, Elif Ozkok, Burcak Vural
Objectives. In our study we aimed to determine VDR gene polymorphisms in patients with Behçet's disease (BD) and neuro-Behçet's disease (NBD) in Turkish population. Methods. PBL obtained from 37 patients with BD, 21 patients with NB, and 30 healthy controls were investigated. Genomic DNA was extracted from whole blood using the QIAamp Blood Kit. VDR ApaI (rs7975232), VDR FokI (rs2228570), and VDR TaqI (rs731236) genotyping was performed by real-time polymerase chain reaction with SimpleProbe melting-curve analysis...
2016: Disease Markers
Birgit Ploier, Anant K Menon
Scramblases translocate phospholipids across the membrane bilayer bidirectionally in an ATP-independent manner. The first scramblase to be identified and biochemically verified was opsin, the apoprotein of the photoreceptor rhodopsin. Rhodopsin is a G protein-coupled receptor localized in rod photoreceptor disc membranes of the retina where it is responsible for the perception of light. Rhodopsin's scramblase activity does not depend on its ligand 11-cis-retinal, i.e., the apoprotein opsin is also active as a scramblase...
2016: Journal of Visualized Experiments: JoVE
Toshihiko Hanai, Masae Sekine, Hiroshi Homma
The retention mechanisms of nitrobenzofurazan (NBD)-amino acids in reversed-phase ion-pair liquid chromatography were quantitatively analyzed in silico The most contributed interaction for the retention is the Lewis acid-base interaction between an aromatic ring of NBD-amino acids and hydroxyl-group hydrogen of tetra-butyl-ammonium hydroxide coated on the hydrophobic phase. Solvent effects significantly improved the relation between the calculated molecular interaction (MI) energy values using a molecular mechanics program and log k values measured in chromatography...
September 27, 2016: Journal of Chromatographic Science
Atika Mallek, Salma Jeribi, Sourour Yaiich, Habib Eleuch, Sameh Ghroubi
OBJECTIVE: To translate and linguistically validate in classical Arabic the French version of the neurogenic bowel dysfunction (NBD). MATERIAL/PATIENTS AND METHODS: The Arabic translation was obtained using the "forward translation/backward translation" method. Multiple sclerosis patients and spinal cord injury patients were included. Clinical measures involved the evaluation of the intestinal and anorectal dysfunction. Patients were asked to respond to a questionnaire twice within a 15-day interval...
September 2016: Annals of Physical and Rehabilitation Medicine
Philippe Gallien, Benoit Nicolas, Aurelie Durufle, Claire Le-Meur, Emilie Leblong, Lucie Chochina, Sandrine Robineau, Sabine Petrilli, Jephte Houedakor
OBJECTIVE: Transit disorders are frequent in multiple sclerosis with an impact on the health related quality of life. However, just a few studies have been published on this subject. Moreover, these studies often concern patients with high EDSS. To get a more accurate view, we conducted an epidemiological study including all patients seen in PRM consultation over a given period. MATERIALS/PATIENTS AND METHODS: All MS patients having been seen in PRM consultation over a 4-month period were questioned about the existence of constipation, its consequences and its management...
September 2016: Annals of Physical and Rehabilitation Medicine
Jean-Gabriel Previnaire, Jean-Marc Soler, Pierre-Eugène Mortier, Hemanou Bordji, Marie-Claude Fiolet, Marie-Agnès Navaux
OBJECTIVE: Bowel symptoms (constipation and incontinence) are frequent in patients with a neurologic disease. The prevalence of neurogenic bowel dysfunction (NBD) in rehabilitation centers is still largely unknown, their assessment difficult and the use of transanal irrigation non systematic even in presence of severe NBD. OBSERVATIONS: Prospective study by detailed questionnaire, with use of the Neurogenic Bowel Dysfunction Score (0-47) and the Patient Global Impression of Severity (PGI-S), a 1-item questionnaire (absent, mild, moderate, severe) for the severity of the bowel symptoms, and Bristol Stool Chart for stool consistency...
September 2016: Annals of Physical and Rehabilitation Medicine
Shinichi Hashimoto, Kei Ito, Shinsuke Koshida, Yoshihide Kanno, Takahisa Ogawa, Kaori Masu, Yuji Iwashita, Jun Horaguchi, Go Kobayashi, Yutaka Noda
Objective To retrospectively evaluate the risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and stent dysfunction after performing preoperative biliary drainage (BD) in patients with malignant biliary stricture. Methods Between January 2003 and February 2013, 105 consecutive patients who had undergone transpapillary BD before surgery were enrolled in this study. Procedure-related complications, stent dysfunction rates, and their respective risk factors were investigated...
2016: Internal Medicine
Qi Xiao, Jack D Rubien, Zhichun Wang, Ellen H Reed, Daniel A Hammer, Dipankar Sahoo, Paul A Heiney, Srujana S Yadavalli, Mark Goulian, Samantha E Wilner, Tobias Baumgart, Sergei A Vinogradov, Michael L Klein, Virgil Percec
The modular synthesis of a library containing seven self-assembling amphiphilic Janus dendrimers is reported. Three of these molecules contain environmentally friendly chiral-racemic fluorinated dendrons in their hydrophobic part (RF), one contains achiral hydrogenated dendrons (RH), while one denoted hybrid Janus dendrimer, contains a combination of chiral-racemic fluorinated and achiral hydrogenated dendrons (RHF) in its hydrophobic part. Two Janus dendrimers contain either chiral-racemic fluorinated dendrons and a green fluorescent dye conjugated to its hydrophilic part (RF-NBD) or achiral hydrogenated and a red fluorescent dye in its hydrophilic part (RH-RhB)...
September 28, 2016: Journal of the American Chemical Society
Seok Fang Oon, Meenakshii Nallappan, Nur Kartinee Kassim, Shamarina Shohaimi, Mohd Shazrul Fazry Sa'ariwijaya, Thiam Tsui Tee, Yew Hoong Cheah
Hyperlipidemia is defined as the presence of either hypertriglyceridemia or hypercholesterolemia, which could cause atherosclerosis. Although hyperlipidemia can be treated by hypolipidemic drugs, they are limited due to lack of effectiveness and safety. Previous studies demonstrated that xanthorrhizol (XNT) isolated from Curcuma xanthorrhizza Roxb. reduced the levels of free fatty acid and triglyceride in vivo. However, its ability to inhibit cholesterol uptake in HT29 colon cells and adipogenesis in 3T3-L1 cells are yet to be reported...
September 23, 2016: Biochemical and Biophysical Research Communications
Anton Emmanuel, Gayathri Kumar, Peter Christensen, Stuart Mealing, Zenia M Størling, Frederikke Andersen, Steven Kirshblum
BACKGROUND: People suffering from neurogenic bowel dysfunction (NBD) and an ineffective bowel regimen often suffer from fecal incontinence (FI) and related symptoms, which have a huge impact on their quality of life. In these situations, transanal irrigation (TAI) has been shown to reduce these symptoms and improve quality of life. AIM: To investigate the long-term cost-effectiveness of initiating TAI in patients with NBD who have failed standard bowel care (SBC)...
2016: PloS One
Naohiro Hashimoto, Ikiru Matsumoto, Hiromasa Takahashi, Hitomi Ashikawa, Hiroyuki Nakamura, Toshihiko Murayama
Sphingolipids such as sphingomyelin and glycosphingolipids (GSLs) derived from glucosylceramide (GlcCer), in addition to cholesterol, accumulate in cells/neurons in Niemann-Pick disease type C (NPC). The activities of acid sphingomyelinase and lysosomal glucocerebrosidase (GCase), which degrade sphingomyelin and GlcCer, respectively, are down-regulated in NPC cells, however, changes in GlcCer synthase activity have not yet been elucidated. We herein demonstrated for the first time that GlcCer synthase activity for the fluorescent ceramide, 4-nitrobenzo-2-oxa-1,3-diazole-labeled C6-ceramide (NBD-ceramide) increased in intact NPC1((-/-)) cells and cell lysates without affecting the protein levels...
November 2016: Neuropharmacology
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