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https://www.readbyqxmd.com/read/27917812/nasobiliary-drainage-for%C3%A2-benign-recurrent-intrahepatic-cholestasis%C3%A2-in-patients-refractory-to-standard-therapy
#1
Tolga Yakar, Mehmet Demir, Huseyin S Gokturk, Ayse G Unler Kanat, Alper G Parlakgumus, Birol Ozer, Ender Serin
PURPOSE: Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodic cholestasis and pruritus without anatomical obstruction. The aim of this study was to evaluate the safety and efficacy of nasobiliary drainage (NBD) in patients with BRIC refractory to medical therapy and to determine whether the use of NBD prolongs the episode duration. METHODS: This was a multicenter retrospective study consisting of 33 patients suffering from BRIC. All patients were administrated medical treatment and 16 patients who were refractory to standard medical therapies improved on treatment with temporary endoscopic NBD...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27914246/tract-based-analysis-of-white-matter-integrity-in-psychotic-and-nonpsychotic-bipolar-disorder
#2
Andrew Ji, Douglass Godwin, Jerrel Rutlin, Sridhar Kandala, Joshua S Shimony, Daniel Mamah
BACKGROUND: At least 50% of individuals with bipolar disorder (BD) present with psychosis during their lifetime. Psychotic symptoms have sometimes been linked to specific genetic and phenotypic markers. This study aims to explore potential differences between bipolar disorder subtypes by measuring white matter integrity of the brain and relationships with clinical measures. METHODS: Diffusion tensor imaging and clinical measures were acquired from 102 participants, grouped as psychotic bipolar disorder (PBD) (n=48), non-psychotic bipolar disorder (NBD) (n=24), and healthy controls (n=30)...
November 27, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27912062/atomic-structure-of-the-cystic-fibrosis-transmembrane-conductance-regulator
#3
Zhe Zhang, Jue Chen
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel evolved from the ATP-binding cassette (ABC) transporter family. In this study, we determined the structure of zebrafish CFTR in the absence of ATP by electron cryo-microscopy to 3.7 Å resolution. Human and zebrafish CFTR share 55% sequence identity, and 42 of the 46 cystic-fibrosis-causing missense mutational sites are identical. In CFTR, we observe a large anion conduction pathway lined by numerous positively charged residues...
December 1, 2016: Cell
https://www.readbyqxmd.com/read/27908240/new-fluorescent-macrolide-derivatives-for-studying-interactions-of-antibiotics-and-their-analogs-with-the-ribosomal-exit-tunnel
#4
A G Tereshchenkov, A V Shishkina, V V Karpenko, V A Chertkov, A L Konevega, P S Kasatsky, A A Bogdanov, N V Sumbatyan
Novel fluorescent derivatives of macrolide antibiotics related to tylosin bearing rhodamine, fluorescein, Alexa Fluor 488, BODIPY FL, and nitrobenzoxadiazole (NBD) residues were synthesized. The formation of complexes of these compounds with 70S E. coli ribosomes was studied by measuring the fluorescence polarization depending on the ribosome amount at constant concentration of the fluorescent substance. With the synthesized fluorescent tylosin derivatives, the dissociation constants for ribosome complexes with several known antibiotics and macrolide analogs previously obtained were determined...
October 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27897331/a-convenient-and-validated-enantiomer-separation-of-chiral-aliphatic-amines-as-nitrobenzoxadiazole-derivatives-on-polysaccharide-derived-chiral-stationary-phases-under-simultaneous-ultraviolet-and-fluorescence-detection
#5
Suraj Adhikari, Jong Seong Kang, Wonjae Lee
A convenient method using a fluorogenic agent, 4-chloro-7-nitro-1,2,3-benzoxadiazole (NBD-Cl), was developed for enantiomer separation of chiral aliphatic amines including amino alcohols by normal high-performance liquid chromatography. The enantiomer separation of chiral aliphatic amines as NBD derivatives was performed on six covalently bonded and four coated-type polysaccharide-derived chiral stationary phases (CSPs) under simultaneous ultraviolet (UV) and fluorescence detection (FLD). Among the covalently bonded CSPs, Chiralpak IE showed the best enantiomer separation for most analytes...
December 2016: Chirality
https://www.readbyqxmd.com/read/27879637/temperature-triggered-switchable-helix-helix-inversion-of-poly-phenylacetylene-bearing-l-valine-ethyl-ester-pendants-and-its-chiral-recognition-ability
#6
Yanli Zhou, Chunhong Zhang, Yuan Qiu, Lijia Liu, Taotao Yang, Hongxing Dong, Toshifumi Satoh, Yoshio Okamoto
A phenylacetylene containing the l-valine ethyl ester pendant (PAA-Val) was synthesized and polymerized by an organorhodium catalyst (Rh(nbd)BPh₄) to produce the corresponding one-handed helical cis-poly(phenylacetylene) (PPAA-Val). PPAA-Val showed a unique temperature-triggered switchable helix-sense in chloroform, while it was not observed in highly polar solvents, such as N,N'-dimethylformamide (DMF). By heating the solution of PPAA-Val in chloroform, the sign of the CD absorption became reversed, but recovered after cooling the solution to room temperature...
November 21, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27872481/imaging-cellular-dynamics-with-spectral-relaxation-imaging-microscopy-distinct-spectral-dynamics-in-golgi-membranes-of-living-cells
#7
Alireza Lajevardipour, James W M Chon, Amitabha Chattopadhyay, Andrew H A Clayton
Spectral relaxation from fluorescent probes is a useful technique for determining the dynamics of condensed phases. To this end, we have developed a method based on wide-field spectral fluorescence lifetime imaging microscopy to extract spectral relaxation correlation times of fluorescent probes in living cells. We show that measurement of the phase and modulation of fluorescence from two wavelengths permit the identification and determination of excited state lifetimes and spectral relaxation correlation times at a single modulation frequency...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27870912/atp-hydrolysis-induced-conformational-changes-in-the-vitamin-b12-transporter-btucd-revealed-by-md-simulations
#8
Chao Pan, Jingwei Weng, Wenning Wang
ATP binding cassette (ABC) transporters utilize the energy of ATP hydrolysis to uni-directionally transport substrates across cell membrane. ATP hydrolysis occurs at the nucleotide-binding domain (NBD) dimer interface of ABC transporters, whereas substrate translocation takes place at the translocation pathway between the transmembrane domains (TMDs), which is more than 30 angstroms away from the NBD dimer interface. This raises the question of how the hydrolysis energy released at NBDs is "transmitted" to trigger the conformational changes at TMDs...
2016: PloS One
https://www.readbyqxmd.com/read/27870528/catalytically-triggered-energy-release-from-strained-organic-molecules-the-surface-chemistry-of-quadricyclane-and-norbornadiene-on-pt-111
#9
Udo Bauer, Susanne Mohr, Tibor Döpper, Philipp Bachmann, Florian Späth, Fabian Düll, Matthias Schwarz, Olaf Brummel, Lukas Fromm, Ute Pinkert, Andreas Görling, Andreas Hirsch, Julien Bachmann, Hans-Peter Steinrück, Jörg Libuda, Christian Papp
We have investigated the surface chemistry of the polycyclic valence isomer pair norbornadiene (NBD) and quadricyclane (QC) on Pt(111). NBD/QC is considered a prototype system for energy storage in strained organic compounds. With our multimethod approach, including UV photoelectron spectroscopy, high resolution X-ray photoelectron spectroscopy, infrared reflec¬tion absorption spectroscopy and density functional theory calculations, we can unambiguously identify and differentiate between the two molecules in the multilayer phase which implies that the energy-loaded QC is stable in this state...
November 21, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27859900/reactive-conjugated-polymers-synthesis-modification-and-electrochemical-properties-of-polypentafluorophenylacetylene-co-polymers
#10
Mathamsanqa N Bhebhe, Eva Alvarez De Eulate, Yiwen Pei, Damien W M Arrigan, Peter J Roth, Andrew B Lowe
(Co)Polymers containing pentafluorophenylacetylene (F5 PA) have been prepared for the first time mediated by [Rh(nbd)Cl]2 /NEt3 to give materials with properties typical of poly(phenylacetylene)s prepared with this catalyst/co-catalyst combination. It is demonstrated that the F5 PA repeat units in these new (co)polymers serve as convenient reactive species for post-polymerization modification with thiols via para-fluoro aromatic nucleophilic substitution reactions to give an entirely new family of novel thioether-functional polyene materials accompanied by absorption maxima shifts of up to 130 nm...
November 18, 2016: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/27853796/investigation-of-thiolysis-of-nbd-amines-for-the-development-of-h2s-probes-and-evaluating-the-stability-of-nbd-dyes
#11
Fanbo Song, Zhifei Li, Jiayuan Li, Shuai Wu, Xianbo Qiu, Zhen Xi, Long Yi
In order to evaluate the thiolysis of NBD (7-nitro-1,2,3-benzoxadiazole) amines for development of H2S probes, herein we investigated the reactivity and selectivity of a series of NBD amines for the first time. The piperazinyl- and piperidyl-based NBD probes could react efficiently with micromolar H2S in buffer (pH 7.4), while such NBD(S) (nitrobenzothiadiazole) derivatives showed much slow thiolysis even in the presence of millimolar H2S. Low reactivity was also observed for thiolysis of these ethylamino-, ethanolamino- and anilino-based NBD probes...
November 17, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27853462/ethylene-potentiates-sulfur-mediated-reversal-of-cadmium-inhibited-photosynthetic-responses-in-mustard
#12
Nafees A Khan, Mohd Asgher, Tasir S Per, Asim Masood, Mehar Fatma, M I R Khan
The potential of exogenous ethylene and sulfur (S) in reversal of cadmium (Cd)-inhibited photosynthetic and growth responses in mustard (Brassica juncea L. cv. Pusa Jai Kisan) were studied. Plants grown with 50 μM Cd showed increased superoxide and H2O2 accumulation and lipid peroxidation together with increased activity of 1-aminocyclopropane carboxylic acid synthase (ACS) and ethylene production and inhibition of photosynthesis and growth. Application of 1 mM SO4(2-) or 200 μL L(-1) ethephon (ethylene source) influenced photosynthetic and growth performance equally in presence or absence of Cd...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27805808/fluorescent-probes-for-single-step-detection-and-proteomic-profiling-of-hdacs
#13
Yusheng Xie, Jingyan Ge, Haipeng Lei, Bo Peng, Huatang Zhang, Danyang Wang, Sijun Pan, Ganchao Chen, Lanfang Chen, Yi Wang, Quan Hao, Shao Q Yao, Hongyan Sun
HDACs play important roles in regulating various physiological and pathological processes. Developing fluorescent probes capable of detecting HDAC activity can help further elucidate the roles of HDACs in biology. In this study, we first developed a set of activity-based fluorescent probes by incorporating Kac residue and O-NBD group. Upon enzy-matic removal of the acetyl group in Kac residue, the released free amine reacted intramolecularly with the O-NBD moiety, resulting in turn-on of fluorescence. These designed probes are capable of detecting HDAC activity in a continuous fashion, thereby eliminating the extra step of fluorescence development...
November 2, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27794219/can-we-use-pca-to-detect-small-signals-in-noisy-data
#14
Jakob Spiegelberg, Ján Rusz
Principal component analysis (PCA) is among the most commonly applied dimension reduction techniques suitable to denoise data. Focusing on its limitations to detect low variance signals in noisy data, we discuss how statistical and systematical errors occur in PCA reconstructed data as a function of the size of the data set, which extends the work of Lichtert and Verbeeck, (2013) [16]. Particular attention is directed towards the estimation of bias introduced by PCA and its influence on experiment design. Aiming at the denoising of large matrices, nullspace based denoising (NBD) is introduced...
October 18, 2016: Ultramicroscopy
https://www.readbyqxmd.com/read/27792231/a-lipophilic-copper-ii-complex-as-an-optical-probe-for-intracellular-detection-of-no
#15
Neil Wilson, Lok Hang Mak, Agostino Cilibrizzi, Antony D Gee, Nicholas J Long, Rudiger Woscholski, Ramon Vilar
A new chemical sensor for cellular imaging of NO is presented. This cell-permeable probe is based on a complex where copper(ii) is coordinated to a tridentate ligand substituted with a fluorophore (NBD) and an octyl group. The fluorescence response of this complex towards a range of reactive species (namely NO, NO2(-), NO3(-), H2O2, ClO(-), O2(-) and ONOO(-)) has been studied in vitro showing that the probe is highly selective for NO. The probe is readily taken up by cells and is able to image the cellular concentrations of NO...
October 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27791341/a-synthetic-loop-replacement-peptide-that-blocks-canonical-nf-%C3%AE%C2%BAb-signaling
#16
Paul A Bruno, Alex Morriss-Andrews, Andrew R Henderson, Charles L Brooks, Anna K Mapp
Aberrant canonical NF-κB signaling is implicated in diseases from autoimmune disorders to cancer. A major therapeutic challenge is the need for selective inhibition of the canonical pathway without impacting the many non-canonical NF-κB functions. Here we show that a selective peptide-based inhibitor of canonical NF-κB signaling, in which a hydrogen bond in the NBD peptide is synthetically replaced by a non-labile bond, shows an about 10-fold increased potency relative to the original inhibitor. Not only is this molecule, NBD2, a powerful tool for dissection of canonical NF-κB signaling in disease models and healthy tissues, the success of the synthetic loop replacement suggests that the general strategy could be useful for discovering modulators of the many protein-protein interactions mediated by such structures...
October 28, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27785512/shining-new-light-on-ancient-drugs-preparation-and-subcellular-localisation-of-novel-fluorescent-analogues-of-cinchona-alkaloids-in-intraerythrocytic-plasmodium-falciparum
#17
John G Woodland, Roger Hunter, Peter J Smith, Timothy J Egan
Fluorescent derivatives of the archetypal antimalarial quinine and its diastereomer, quinidine, suitable for cellular imaging have been synthesised by attaching the small extrinsic fluorophore, NBD. Interactions of these derivatives with ferriprotoporphyrin IX were evaluated to verify that insights generated by live-cell imaging were relevant to the parent molecules. These analogues are shown by confocal and super-resolution microscopy to accumulate selectively in Plasmodium falciparum. Localisation to the region corresponding to the digestive vacuole supports the putative primary role of these alkaloids as haemozoin inhibitors...
October 27, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27783926/interactions-and-cooperativity-between-p-glycoprotein-structural-domains-determined-by-thermal-unfolding-provides-insights-into-its-solution-structure-and-function
#18
Zhengrong Yang, Qingxian Zhou, Leo Mok, Anukriti Singh, Douglas J Swartz, Ina L Urbatsch, Christie G Brouillette
Structural changes in mouse P-glycoprotein (Pgp) induced by thermal unfolding were studied by differential scanning calorimetry (DSC), circular dichroism and fluorescence spectroscopy to gain insight into the solution conformation(s) of this ABC transporter that may not be apparent from current crystal structures. DSC of reconstituted Pgp showed two thermal unfolding transitions in the absence of MgATP, suggesting that each transition involved the cooperative unfolding of two or more interacting structural domains...
October 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27774563/a-pentacoordinated-norbornenyl-acyl-rhodium-iii-complex-as-a-likely-intermediate-in-the-catalytic-hydroacylation-of-norbornadiene
#19
N Almenara, L Ibarlucea, C Mendicute-Fierro, J M Seco, A Rodríguez-Diéguez, M A Garralda, M A Huertos
[RhCl(NCO)(nbyl)(PR3)] (nbyl = σ-norbornenyl; NCO = quinoline-8-acyl; R = p-F-C6H4) (1) has been synthesized by the reaction of [Rh(nbd)Cl]2 (nbd = norbornadiene) with 2 equivalents of NCHO (quinoline-8-carbaldehyde) and 2 equivalents of PR3. Compound 1 has been fully characterized in solution and also in the solid state by X-ray diffraction. Compound 1 shows low stability in solution and undergoes slow ring closure isomerization to [RhCl(NCO)(ntyl)(PR3)] (ntyl = σ-nortricyclyl) (2) after 12 hours. Reaction of 1 with an extra equivalent of aldehyde (NCHO) and PR3 led to the formation of [RhCl(H)(NCO)(PR3)2] (3) and an equivalent of ketone, which is a hydroacylation product...
October 24, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27750273/a-case-report-of-severe-neuro-behcet-s-disease-treated-with-a-combination-of-immunosuppressives-and-a-tnf-inhibitor-a-difficult-therapeutic-choice
#20
Fatma Nur Korkmaz, Gulsen Ozen, Ali Uğur Ünal, Pınar Kahraman Koytak, Nese Tuncer, Haner Direskeneli
Abstract/ Resumo Behcet's disease (BD) is a multisystem inflammatory disorder characterized by recurrent oral and genital ulcers, skin lesions and uveitis. The nervous system involvement of BD, neuro-Behcet's disease (NBD), is one of the important causes of mortality of the disease. Herein, we present a 29-year-old male with parenchymal NBD who has progressed rapidly and was managed with an uncommon aggressive immunosuppresive combination therapy. The patient first presented six years ago with vertigo and difficulty in talking and walking...
September 28, 2016: Acta Reumatológica Portuguesa
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