Aditya Vikram Pachisia, Alka Kumari, Shubham Mehta, Anam Ahmed, Ashish Chauhan, Ankit Agarwal, Vignesh Dwarkanathan, Sachin Rajpoot, Shubham Prasad, Sanjay Kumar, Saroj Kant Sinha, Divya Sharma, Mahender Rajput, Prasenjit Das, Sushil Falodia, Rakesh Kochhar, B S Ramakrishna, Vineet Ahuja, Govind Makharia
BACKGROUND AND AIM: While European Society of Pediatric Gastroenterology Hepatology and Nutrition advocates a no-biopsy pathway for the diagnosis of celiac disease (CeD) in children if IgA anti-tissue transglutaminase antibody (anti-tTG ab) titer is ≥10-fold upper limit of normal (ULN) and have a positive IgA anti-endomysial antibody (EMA); the data for anti-tTG Ab titer-based diagnosis of CeD in adults is still emerging. We planned to validate if IgA anti-tTG Ab titer ≥10-fold predicts villous abnormalities of modified Marsh grade ≥2 in Asian adult patients with CeD...
December 14, 2023: Journal of Gastroenterology and Hepatology