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Muzamil Ashraf Makhdoomi, Deepti Singh, Ambili Nair Pananghat, Rakesh Lodha, Sushil Kumar Kabra, Kalpana Luthra
Anti-HIV-1 broadly neutralizing antibodies (bnAbs) have been extensively tested against pesudoviruses of diverse strains. We generated and characterized HIV-1 primary isolates from antiretroviral naïve infected Indian children, and determined their susceptibility to known NAbs. All the 8 isolates belonged to subtype-C and were R5 tropic. Majority of these viruses were resistant to neutralization by NAbs, suggesting that the bnAbs, known to efficiently neutralize pseudoviruses (adult and pediatric) of different strains, are less effective against pediatric primary isolates...
September 16, 2016: Virology
Pankaja Ravi Raghav, Dewesh Kumar, Pankaj Bhardwaj
INTRODUCTION: The Department of Community Medicine and Family Medicine (CMFM) has been started as a new model for imparting the components of family medicine and delivering health-care services at primary and secondary levels in all six newly established All India Institute of Medical Sciences (AIIMS), but there is no competency-based curriculum for it. The paper aims to share the experience of Delphi method in the process of developing consensus on core competencies of the new model of CMFM in AIIMS for undergraduate medical students in India...
July 2016: International Journal of Applied and Basic Medical Research
Himanshu Sekhar Behera, Gita Satpathy, Manjari Tripathi
BACKGROUND: Acanthamoeba spp. are free-living ubiquitous protozoans capable of causing Acanthamoeba meningitis/meningoencephalitis (AME) of the central nervous system in humans. Acanthamoeba spp. are divided into 20 different genotypes (T1-T20) on the basis of variation in nucleotide sequences of the 18S rRNA gene. The objective of this study was to identify the genotypes of Acanthamoeba spp. in patients of Acanthamoeba meningitis/meningoencephalitis (AME) using 18S rRNA gene-based PCR assay...
2016: Parasites & Vectors
Jeewan S Titiyal, Esha Agarwal, Dewang Angmo, Namrata Sharma, Atul Kumar
The purpose of this study is to comparatively evaluate the morphology of cataract, intraoperative and postoperative complications (IPC), and surgical outcomes of phacoemulsification in post 23G vitrectomized eyes in silicone oil versus air/gas group. This prospective interventional clinical study took place in the Dr. RP Centre for Ophthalmic Sciences, AIIMS, New Delhi, India. Eighty-nine eyes of 89 consecutive vitrectomized patients with cataract were included. All underwent phacoemulsification and evaluated for cataract morphology, surgical difficulties, IPC, visual acuity, and specular count...
August 2, 2016: International Ophthalmology
Naseem Shah, Vijay Prakash Mathur, Vartika Kathuria, Tanupriya Gupta
INTRODUCTION: Prevention of oral diseases can be achieved by preventive measures. There is an educational component associated to the preventive aspect. Health education is a cornerstone to the success of a preventive programme. Health education has always been regarded as a primary tool in imparting awareness, bringing changes in healthy behaviors and improved life. AIM: To assess the effectiveness of an Educational Video in improving oral health knowledge of subjects in a hospital setting...
April 2016: Indian Journal of Dentistry
Rajanikanta Swain, Chittaranjan Behera, Sudhir Kumar Gupta
The study presents a retrospective analysis of 64 cases of death resulting from ingestion of corrosive substances. The cases represented approximately 0.4% of all autopsies conducted and 13.6% of all fatal poisonings studied during the 10-year period from January 2005 to December 2014 at the Department of Forensic Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi. The data was analyzed with regard to age, sex, nature and source of corrosive substance used, survival period, cause and manner of death...
July 8, 2016: Medicine, Science, and the Law
Faraz A Farooqui, Surendra K Sharma, Atin Kumar, Manish Soneja, Kalaivani Mani, Ragesh Radhakrishnan, Nida Farooqui
PURPOSE: The objective of this study was to evaluate endothelial function and carotid intima media thickness (CIMT) in moderate to severe obstructive sleep apnea (OSA) without comorbidities. METHODS: It is an observational case control study in which endothelial function was assessed using flow-mediated dilatation (FMD) and peripheral arterial tonometry (PAT), and carotid artery ultrasound was used to measure CIMT in study group subjects that included 20 normotensive, non-diabetic, treatment naïve, and moderate to severe OSA patients, and 20 normotensive, non-diabetic, and non-OSA subjects served as a control group...
June 25, 2016: Sleep & Breathing, Schlaf & Atmung
Shreemanta Kumar Dash, Shailendra Patel, Krishnadutt Chavali
Sexual violence is a significant cause of physical and psychological harm and suffering for women and children. Although sexual violence mostly affects women and girls, boys are also subject to child sexual abuse. Nurse is the person who attends the victim first. In order to meet the rigid and ever-changing demands of providing care to the victim and complying with our confusing system of laws, the nursing should has been forced to expand into a Forensic nursing, specialty of its own. Nursing roles in the criminal justice service known by many names worldwide-Custody nursing, Prison/Correctional nursing, Immigration centre nursing, Sexual Assault Nurse Examiner (SANE) or Sexual Assault Forensic Examiner (SAFE), SARTs (Sexual assault response team), SARCs (Sexual assault referral centre) and FNDIs (Forensic nurse death investigator)...
August 2016: Journal of Forensic and Legal Medicine
K Kanabar, S K Sharma, V Sreenivas, A Biswas, M Soneja
PURPOSE: The Epworth Sleepiness Scale (ESS) is one of the most widely used questionnaire for the assessment of excessive daytime sleepiness (EDS) in sleep-disordered breathing (SDB). This study was conducted to assess the validity of ESS in the Hindi language. METHODS: The Hindi version was developed by translation and back translation by independent translators. The English and Hindi versions were administered to 115 bilingual subjects who presented with symptoms of SDB, of whom 98 underwent a polysomnography at a tertiary care hospital in North India...
May 18, 2016: Sleep & Breathing, Schlaf & Atmung
Shalimar, A Kumar, S Kedia, H Sharma, S R Gamanagatti, G S Gulati, B Nayak, B Thakur, S K Acharya
BACKGROUND: Results of endovascular interventions in hepatic venous outflow tract obstruction (HVOTO) have been reported from limited studies. Treatment outcomes and prognostic scores need further validation. AIM: To evaluate treatment outcomes and prognostic scores for hepatic venous outflow tract obstruction in an Indian population. METHODS: Consecutive patients with hepatic venous outflow tract obstruction diagnosed at a tertiary centre were included...
June 2016: Alimentary Pharmacology & Therapeutics
Surbhi Kashyap
This article is a case reflection of a personal encounter on the palliative care treatment required after the removal of a complicated case of a primary extra-gonadal retro-peritoneal endodermal sinus tumor (yolk sac tumor). This reflection is from the perspective of a recently graduated MD student who spent one month with an Indian pain management and palliative care team at the Institute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences (AIIMS), New Delhi.
January 2016: Indian Journal of Palliative Care
Sanjeev Bhoi, Nirmal Thakur, Pankaj Verma, Chhavi Sawhney, Sameer Vankar, Deepak Agrawal, Tejprakash Sinha
BACKGROUND: Due to lack of training in emergency care, basic emergency care in India is still in its infancy. We designed All India Institute of Medical Sciences basic emergency care course (AIIMS BECC) to address the issue. AIM: To improve the knowledge and skill of healthcare workers and laypersons in basic emergency care and to identify impact of the course. MATERIALS AND METHODS: Prospective study conducted over a period of 4 years. The target groups were medical and nonmedical personnel...
January 2016: Journal of Emergencies, Trauma, and Shock
V Prakash, Anu Thukral, M Jeeva Sankar, Ramesh K Agarwal, Vinod K Paul, Ashok K Deorari
BACKGROUND: There has been an increased emphasis on institutional births, and thus an increasing clinical work load for health care professionals in the recent past. Hence, continuing education, training, ongoing supervision, and mentorship of health care professionals working in these health facilities with easy access to guidelines in a cost effective manner has become a challenging task. With the increased emphasis on institutional births, and an increasing clinical work load, continuing education and training of health care professional managing these health facilities, their ongoing supervision, mentorship, with ready availability of guidelines in a cost effective manner becomes imperative and is a challenging task...
2016: BMC Medical Education
J B Sharma, Subhadra Sharma, B R Usha, Manisha Yadav, Sunesh Kumar, A K Mukhopadhyay
OBJECTIVES: To note the value of serum parathyroid hormone (PTH) levels in normal and high-risk pregnancies (HRP) in patients attending antenatal visits at All India Institute of Medical Sciences (AIIMS). MATERIALS AND METHODS: This is a cross-sectional study where a total of 282 patients attending Gynecology Outpatient Department at AIIMS, New Delhi were recruited. Among the 282 subjects, 251 were pregnant, and 31 were controls. The serum was tested for serum PTH levels using Beckman coulter access 2 immunoassay...
January 2016: Indian Journal of Endocrinology and Metabolism
Himansu Sekhar Behera, Anita Panda, Gita Satpathy, Pooja Bandivadekar, Murgesan Vanathi, Tushar Agarwal, Niranjan Nayak, Radhika Tandon
Free living amoeba of genus "Acanthamoeba" are the causative agents of severe sight threatening infection of cornea. This study was designed to characterise the genotype of 20 Acanthamoeba spp. isolates obtained from corneal scrapings of 183 suspected Acanthamoeba keratitis (AK) patients reporting to the outpatient department/ causuality services of Dr RP Centre for Ophthalmic Sciences, AIIMS, New Delhi, India in the past 5 years. Corneal scrapings were inoculated onto 2% non-nutrient agar plates overlaid with Escherichia coli...
February 16, 2016: Journal of Medical Microbiology
Subhash Soni, Peush Sahni, Samiran Nundy
s presented at scientific meetings are important for making ongoing research more widely known and may also reflect the quality of the parent institution's standard of patient care. We analyzed the abstracts presented at the annual meetings of IASG for the past 5 years for (i) medium of presentation (oral/poster/videos), (ii) subjects discussed, (iii) institution of origin, (iv) whether a prospective/ retrospective study or a case report, (v) changing trends, and (vi) awards received. Of the 1340 abstracts analyzed, there were 18...
December 2015: Indian Journal of Surgery
Varun Malhotra, Sarat P Chandra, Deepa Dash, Ajay Garg, Madhavi Tripathi, C S Bal, Manjari Tripathi
OBJECTIVES: Access to epilepsy surgery remains a considerable challenge in contemporary healthcare systems. Given the limitations in resources and demand for Epilepsy Monitoring Unit (EMU) assessments, information that can be used to expedite the process is of great value. The purpose of this study was to identify variables prior to EMU admission that may be associated with candidacy for prospective epilepsy surgery. METHODS: This was a prospective study conducted at the Department of Neurology, All India Institute of Medical Sciences, New Delhi, India...
March 2016: Epilepsy Research
R Rajalakshmi, Bridgitte Akila, Elizabeth Tharion
Heart rate variability (HRV) is a simple technique which helps to assess the alterations in cardiac autonomic activity in healthy and diseased individuals. It is performed in various research centers using different hardwares and softwares. Hence, HRV reports generated from these centers cannot be compared unless their HRV data acquisition systems and the HRV analysis softwares correlate or agree with each other. In this study, Intra-class correlation coefficient test was done to see the extent of correlation among three HRV analysis softwares used by researchers in India, namely, (1)...
January 2015: Indian Journal of Physiology and Pharmacology
Dablu Lal Gupta, Predeep Kumar Nagar, Vineet Kumar Kamal, Sanjeev Bhoi, D N Rao
INTRODUCTION: The susceptibility to adverse outcome from critical injury (occurrence of sepsis, septic shock, organ dysfunction/failure, and mortality) varies dramatically due to different degrees of inflammatory response. We assessed the relationship of the genotype distribution of various cytokine gene polymorphisms (CGP) with regard to the development of sepsis, organ dysfunction or mortality in severely injured patients. METHOD: Observational, hospital-based cohort study of 114 severely injured North Indian patients from New Delhi admitted to the Emergency Department (ED) of Trauma Centre, AIIMS...
2015: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
M Mahapatra, P K Singh, M Agarwal, M Prabhu, P Mishra, T Seth, S Tyagi, H P Patil, R Saxena
BACKGROUND: The incidence of aplastic anaemia (AA) is higher in Asia than in the West. The precise incidence of AA in India is not known due to lack of epidemiological study. 20-40% of pancytopenic patients in referral centres are of aplastic anaemia. PATIENTS AND METHODS: This was an analysis of 1501 patients diagnosed with aplastic anaemia over a period of seven and half years (January 2007- June 2014) attending the Aplastic clinic of department of haematology of All India Institute of Medical Sciences, New Delhi...
March 2015: Journal of the Association of Physicians of India
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