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capillary leak syndrome

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https://www.readbyqxmd.com/read/27913530/cytokine-release-syndrome-with-novel-therapeutics-for-acute-lymphoblastic-leukemia
#1
Noelle V Frey, David L Porter
T-cell-engaging immunotherapies are exciting new approaches to treat patients with acute lymphoblastic leukemia (ALL). These unique agents, which include blinatumomab, a CD3/CD19 bispecific antibody, and chimeric antigen receptor (CAR) modified T cells targeted to CD19 have shown unprecedented remission rates in the relapsed, refractory ALL setting. Cytokine release syndrome (CRS), resulting from the high magnitude of immune activation by these therapies, is the most significant treatment-related toxicity. CRS manifests with fever and malaise and can progress to life-threatening capillary leak with hypoxia and hypotension...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27806970/snake-bite-mortality-in-children-beyond-bite-to-needle-time
#2
M P Jayakrishnan, M G Geeta, P Krishnakumar, T V Rajesh, Biju George
OBJECTIVE: To study the clinical characteristics and predictors of mortality from snake bite envenomation in children. DESIGN: Prospective observational study with a one-group cohort design. SETTING: Paediatric intensive care unit of a tertiary care hospital in South India. SUBJECTS: The study cohort consisted of 145 children (55 girls and 90 boys) <12 years of age with snake bite envenomation. METHODS: Demographic and clinical details were recorded in a semistructured pro forma...
November 2, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27734564/epidemiology-risk-factors-and-prognosis-of-capillary-leak-syndrome-in-pediatric-recipients-of-stem-cell-transplants-a-retrospective-single-center-cohort-study
#3
Giovanna Lucchini, Andre Manfred Willasch, Julia Daniel, Jan Soerensen, Andrea Jarisch, Shahrzad Bakhtiar, Eva Rettinger, Joerg Brandt, Thomas Klingebiel, Peter Bader
CLS involves sudden loss of intravascular fluids into the interstitial spaces. CLS was described as a possible complication after SCT. Few studies report the incidence of CLS in pediatric populations. We aimed to assess CLS incidence, its risk factors, and impact on the survival. The clinical charts of patients <18 years of age transplanted at our institution between 2002 and 2012 were reviewed. CLS was defined by weight gain >3% in 24 hours and positive intake balance despite furosemide administration...
October 13, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27728427/scrub-typhus-presenting-as-capillary-leak-syndrome
#4
Viswanath Mv, Chaitanya Gb
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27688917/compartment-syndrome-as-a-result-of-systemic-capillary-leak-syndrome
#5
Kwadwo Kyeremanteng, Gianni D'Egidio, Cynthia Wan, Alan Baxter, Hans Rosenberg
Objective. To describe a single case of Systemic Capillary Leak Syndrome (SCLS) with a rare complication of compartment syndrome. Patient. Our patient is a 57-year-old male, referred to our hospital due to polycythemia (hemoglobin (Hgb) of 220 g/L), hypotension, acute renal failure, and bilateral calf pain. Measurements and Main Results. The patient required bilateral forearm, thigh, and calf fasciotomies during his ICU stay and continuous renal replacement therapy was instituted following onset of acute renal failure and oliguria...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/27680806/e5-lung-ultrasound-and-echocardiography-for-peripartum-haemodynamic-monitoring-of-patients-with-severe-preeclampsia
#6
J Ambrozic, K Prokselj, M Lucovnik
INTRODUCTION: The ability to judge intravascular volume is fundamental in the management of patients with severe preeclampsia. Insufficient intravascular volume can result in decreased oxygen delivery to tissues and exacerbates organ dysfunction. On the other hand, fluid excesses can lead to fluid extravasation and pulmonary edema. Outside of pregnancy, transthoracic echocardiography and lung ultrasonography have become important diagnostic and monitoring tools in critically ill patients...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27637319/systemic-capillary-leak-syndrome-and-autoimmune-diseases-a-case-series
#7
Aurélien Guffroy, Benjamin Dervieux, Simon Gravier, Camille Martinez, Joelle Deibener-Kaminsky, Eric Hachulla, Marc Michel, Jean-Christophe Weber, Anne-Sophie Korganow, Laurent Arnaud, Jacques-Eric Gottenberg, Jean Sibilia
OBJECTIVES: Systemic capillary leak syndrome (Clarkson's disease) is a rare entity characterized by recurrent and unpredictable attacks of capillary leakage of plasma fluid and proteins throughout the endothelium. Some cases are secondary. We describe the rare association between secondary capillary leak syndrome (SCLS) and autoimmune diseases. METHODS: We conducted a nationwide, retrospective, observational, and collaborative study throughout the hospital units of the Club des Rhumatismes et Inflammations network (CRI) between March and August 2015...
August 12, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27622772/microangiopathic-hemolytic-anemia-due-to-adamts-13-loss-in-idiopathic-systemic-capillary-leak-syndrome
#8
D C Moreira, C J Ng, R Quinones, X Liang, D W Chung, J Di Paola
: Essentials Idiopathic systemic capillary leak syndrome (SCLS) is characterized by episodes of vascular leakage. We present the case of a patient with SCLS who developed microangiopathic hemolytic anemia (MAHA). We propose that this anemia is the result of ADAMTS-13 loss in the third-space fluid. This suggests that MAHA can occur in patients with significant extravasation of proteins. SUMMARY: Idiopathic systemic capillary leak syndrome (SCLS) is a rare process characterized by acute and recurrent episodes of vascular leakage with severe hypotension, hypoalbuminemia, hemoconcentration and edema...
September 13, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27601291/a-possible-role-for-il-17-in-clarkson-s-disease
#9
Mathieu Simonin, Pierre Corbeau, Philippe Durand, Michelle Rosenzwajg, Anne Filleron, Tu-Anh Tran
INTRODUCTION: Systemic capillary leak syndrome (SCLS) is a rare disease characterized by recurrent episodes and a triad of "leak attacks": hypovolemic shock, generalized edema, hemoconcentration and paradoxical hypoalbuminemia. CASE STUDY AND DISCUSSION: Here we report a case of pediatric idiopathic SCLS with an episode of cough and fever followed two days later by myalgia, livedo, acrocyanosis, and five days later by edema, tachycardia, hypotension, and generalized tonic-clonic seizure...
December 0: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27473068/integrin-%C3%AE-d%C3%AE-2-cd11d-cd18-mediates-experimental-malaria-associated-acute-respiratory-distress-syndrome-ma-ards
#10
Isaclaudia G de Azevedo-Quintanilha, Adriana Vieira-de-Abreu, André Costa Ferreira, Daniele O Nascimento, Alessandra M Siqueira, Robert A Campbell, Tatiana P Teixeira Ferreira, Tatiana M Gutierrez, Gabriel M Ribeiro, Patricia M R E Silva, Alysson R Carvalho, Patricia T Bozza, Guy A Zimmerman, Hugo C Castro-Faria-Neto
BACKGROUND: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a potentially lethal complication of clinical malaria. Acute lung injury in MA-ARDS shares features with ARDS triggered by other causes, including alveolar inflammation and increased alveolar-capillary permeability, leading to leak of protein-rich pulmonary oedema fluid. Mechanisms and physiologic alterations in MA-ARDS can be examined in murine models of this syndrome. Integrin αDβ2 is a member of the leukocyte, or β2 (CD18), sub-family of integrins, and emerging observations indicate that it has important activities in leukocyte adhesion, accumulation and signalling...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27421574/high-resolution-ct-findings-of-idiopathic-pneumonia-syndrome-after-haematopoietic-stem-cell-transplantation-based-on-the-updated-concept-of-idiopathic-pneumonia-syndrome-by-the-american-thoracic-society-in-2011
#11
REVIEW
N Tanaka, Y Kunihiro, T Kobayashi, T Yujiri, S Kido, K Ueda, N Matsunaga
Idiopathic pneumonia syndrome (IPS) is an acute lung dysfunction of non-infectious aetiology and a severe complication following haematopoietic stem cell transplantation (HSCT). Recently, the American Thoracic Society (ATS) updated the concept of IPS and extended the concept to a wider range; it defined IPS as "an idiopathic syndrome of pneumopathy after HSCT, with evidence of widespread alveolar injury and in which infectious aetiologies and cardiac dysfunction, acute renal failure, or iatrogenic fluid overload have been excluded...
October 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27396981/raiders-of-the-lost-mark-endothelial-cells-and-their-role-in-transplantation-for-hematologic-malignancies
#12
Egil S Blix, Anne Husebekk
Endothelial cells (EC) are crucial for normal angiogenesis and important for patients with leukemia, myeloma, and lymphoma during and after hematopoietic stem cell transplantation (HSCT). Knowledge of endothelial dysfunction in hematologic malignancies is provided by translational studies analyzing soluble endothelial markers, morphologic and functional changes of EC cultured in patients' sera or enumeration of circulating EC or endothelial progenitor cells (EPC). EC are important for stem cell homing and maintenance...
July 10, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27386947/isoform-d-of-vascular-endothelial-growth-factor-in-systemic-capillary-leak-syndrome-a-case-report
#13
Soushi Ibata, Tsutomu Sato, Kohichi Takada, Ayumi Tatekoshi, Akari Hashimoto, Yusuke Kamihara, Wataru Jomen, Hiroto Horiguchi, Kaoru Ono, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato
BACKGROUND: Systemic capillary leak syndrome is a rare condition characterized by episodic attacks of hypovolemia due to systemic capillary hyperpermeability, which results in profound hypotension and edema. Although the implication of vascular endothelial growth factor, angiopoietin-2, and C-X-C motif chemokine 10 has been suggested, the pathogenesis of systemic capillary leak syndrome remains unclear. In this report, we describe a case of systemic capillary leak syndrome in which serum isoform D of vascular endothelial growth factor was elevated...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27338086/fulminant-capillary-leak-syndrome-in-a-patient-with-systemic-sclerosis-treated-with-imatinib-mesylate
#14
Monique E Hinchcliff, Jon Lomasney, Julie A Johnson, John Varga
No abstract text is available yet for this article.
October 2016: Rheumatology
https://www.readbyqxmd.com/read/27266048/-case-report-a-case-of-systemic-capillary-leak-syndrome
#15
Akiko Yamada, Kotomi Kurihara, Kiyohide Tachiki, Kazuaki Shigemitsu, Akihiro Fuke, Toshimasa Yamaguchi, Keiko Yamagami, Mieko Minami
No abstract text is available yet for this article.
January 10, 2016: Nihon Naika Gakkai Zasshi. the Journal of the Japanese Society of Internal Medicine
https://www.readbyqxmd.com/read/27195144/idiopathic-systemic-capillary-leak-syndrome-a-case-report
#16
Bulent Yardimci, Rumeyza Kazancioglu
INTRODUCTION: Idiopathic systemic capillary leak syndrome (ISCLS) is rarely seen, and presents with recurrent episodes of hypotension, shock, hemoconcentration, and hypoproteinemia. The main pathology is the dysfunction of the vascular endothelium, and it is characterized by an increase of capillary permeability that is accompanied by the loss of intravascular fluid and protein. CASE PRESENTATION: We present a 58-year-old female who presented with peripheral edema, leg pain, and syncope at the emergency department...
February 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27142601/fatal-primary-capillary-leak-syndrome-in-a-late-preterm-newborn
#17
Katarina Kulihova, Martina Prochazkova, Jana Semberova, Jan Janota
Primary capillary leak syndrome is a rare disease of unknown etiology, characterized by episodes of vascular collapse and plasma extravasation, which may lead to multiple organ failure. Primary capillary leak is extremely rare in children. The authors report a case of a late preterm newborn with fatal capillary leak syndrome of unknown etiology, manifesting as hypotension unresponsive to treatment, extravasation leading to generalised edema, disseminated intravascular coagulation and finally, multiple organ dysfunction syndrome...
October 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27132460/-the-value-of-picco-monitor-in-guiding-liquid-treatment-and-nursing-in-patients-with-post-trauma-capillary-leak-syndrome
#18
Cui Huijing, Yang Wanjie, Teng Hongyun, Sun Liping, Yu Kai
No abstract text is available yet for this article.
November 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/27099745/severe-cerebral-involvement-due-to-idiopathic-systemic-capillary-leak-syndrome
#19
Ali Riza Günes, Peter Berlit, Ralph Weber
The idiopathic systemic capillary leak syndrome (ISCLS) is a rare disorder, characterized by recurrent attacks of hypotension, hypoalbuminemia, and hemoconcentration, which is often misdiagnosed due to overlapping features with other diseases. Even though cerebral involvement is uncommon, a broad awareness is crucial, because of its life-threatening character.
April 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27069700/a-systemic-capillary-leak-syndrome-clarkson-syndrome-in-a-patient-with-chronic-lymphocytic-leukemia-a-case-report-in-an-out-of-hospital-setting
#20
Manon Durand Bechu, Antoine Rouget, Christian Recher, Elie Azoulay, Vincent Bounes
Systemic Capillary Leak Syndrome (SCLS) is a rare disease with poor prognosis, characterized by the occurrence of mucocutaneous and visceral edema with hypotension, hemoconcentration, and unexpected hypoalbuminemia. The disease can be idiopathic (Clarkson syndrome) or secondary to other diseases and treatments. We describe this syndrome in a prehospitalized, 63-year-old patient with chronic lymphocytic leukemia and an idiopathic form of SCLS manifesting as hypovolemic shock. Initial care is hospitalization in intensive care...
2016: Case Reports in Emergency Medicine
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