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Sentinel lymph node in cervical cancer

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https://www.readbyqxmd.com/read/29319395/initial-report-of-sentinel-lymph-node-identification-during-laparoscopic-radical-hysterectomy-using-a-new-gamma-probe-technology
#1
Shinichi Togami, Toshihiko Kawamura, Mika Fukuda, Shintaro Yanazume, Masaki Kamio, Hiroaki Kobayashi
BACKGROUND: The standard surgical procedure for early-stage cervical cancer is abdominal radical hysterectomy, including pelvic lymphadenectomy. Currently, minimally invasive surgical techniques for early cervical cancer are progressing; total laparoscopic radical hysterectomy (TLRH) is a possible alternative to abdominal surgery. In addition, sentinel node navigation surgery (SNNS), which can prevent lower limb edema, has been widely used for radical hysterectomy. MATERIALS AND METHODS: A radioisotope is injected into the uterine cervix 1 day preoperatively and surgeons carefully identify the correct sentinel lymph nodes (SLNs) to prevent picking up the cervical gamma rays during surgery...
January 10, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29273307/sentinel-lymph-node-biopsy-in-endometrial-cancer-feasibility-safety-and-lymphatic-complications
#2
Barbara Geppert, Céline Lönnerfors, Michele Bollino, Jan Persson
OBJECTIVE: To compare the rate of lymphatic complications in women with endometrial cancer undergoing sentinel lymph node biopsy versus a full pelvic and infrarenal paraaortic lymphadenectomy, and to examine the overall feasibility and safety of the former. METHODS: A prospective study of 188 patients with endometrial cancer planned for robotic surgery. Indocyanine green was used to identify the sentinel lymph nodes. In low-risk patients the lymphadenectomy was restricted to removal of sentinel lymph nodes whereas in high-risk patients also a full lymphadenectomy was performed...
December 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29223564/indocyanine-green-assisted-parametrial-dissection-during-type-c1-radical-hysterectomy-after-sentinel-lymph-node-biopsy-in-early-stage-cervical-cancer
#3
Nicolò Bizzarri, Valentina Ghirardi, Ali Kucukmetin
OBJECTIVES: The standard treatment for FIGO stage 1B1 cervical cancer is radical hysterectomy (RH) [1]. Indocyanine-green (ICG) is a drug injected within the cervical stroma to detect the sentinel lymph node (SLN) in cervical cancer [2,3]. ICG travels through the lymphatic channels in the lateral parametrium, which results enhanced with green, before reaching the SLNs. This could help identifying the surgical landmarks. The aim of this video is to propose a new approach to perform parametrial dissection as part of RH under the guidance of ICG...
December 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29214646/endoscopic-sentinel-lymph-node-biopsy-using-indocyanine-green-neomannosyl-human-serum-albumin
#4
Young Min Park, Yu Hua Quan, Ki Hyeok Kwon, Jae-Gu Cho, Jeong-Soo Woo, Beop-Min Kim, Yun-Sang Lee, Jae Min Jeong, Hyun Koo Kim, Jae-Jun Song
OBJECTIVE: The aim of this study was to determine the possibility of endoscopic sentinel lymph node biopsy of the head and neck region using indocyanine green-neomannosyl human serum albumin (ICG:MSA) and a custom-made intraoperative color-and-fluorescence-merged imaging system (ICFIS). METHODS: Using mouse and rabbit models of tongue cancer, we performed sentinel lymph node biopsy using an ICG:MSA tracer and custom imaging system equipped with an endoscope. RESULTS: ICG:MSA was localized to the cervical lymph node on the ipsilateral side for up to 30 minutes compared to ICG tracer (ICG n = 3, IGC:MSA n = 3)...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29213225/role-of-blue-dye-for-sentinel-lymph-node-detection-in-early-endometrial-cancer
#5
Stefano Restaino, Carlo Ronsini, Angelo Finelli, Emanuele Perrone, Giovanni Scambia, Francesco Fanfani
Background: Sentinel Lymphonode analysis has become a barely new and innovative way to treat early stages of endometrial cancer (Ballester et al., Lancet Oncol 469-476, 2011; Buda et al., Ann Surg Oncol 2975-81, 2016). Indocyanine green cervical injection is considered gold standard for mapping nodes' drainage. Blue dye is used as a valid alternative in many centers, due to the lower cost of execution. The objective of this video is to prove that methylene blue dye's cervical injection is a valid and "low-cost" method to obtain mapping of lymphatic drainage in patient with early endometrial cancer...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29194192/sentinel-node-biopsy-in-endometrial-cancer-with-dual-cervical-and-fundal-indocyanine-green-injection
#6
Ruben Ruiz, Mikel Gorostidi, Ibon Jaunarena, Constance Goiri, Justina Aguerre, Arantxa Lekuona
PURPOSE: The aim of this study was describe a novel sentinel lymph node (SLN) tracer injection procedure featuring dual cervical and fundal indocyanine green (ICG) injection for endometrial cancer and results of SLN biopsy. METHODS: Between June 26, 2014 and October 31, 2016, 111 patients underwent laparoscopic surgery for endometrial cancer at our institution. In all cases, we performed SLN biopsy with dual cervical and fundal ICG injection. All SLNs were processed with an ultrastaging technique...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29161240/rapid-nodal-staging-of-head-and-neck-cancer-surgical-specimens-with-flow-cytometric-analysis
#7
Valtteri Häyry, Åsa Kågedal, Eric Hjalmarsson, Pedro Farrajota Neves da Silva, Cecilia Drakskog, Gregori Margolin, Susanna Kumlien Georén, Eva Munck-Wikland, Ola Winqvist, Lars Olaf Cardell
BACKGROUND: Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. METHODS: We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC). Each lymph node was divided in two, one half processed for histopathology and the other half dissociated into single-cell suspension, stained for the carcinoma cell markers cytokeratin 5/8 (CK5/8), epithelial cell adhesion molecule (EpCAM) and epithelial mucin (MUC-1), and analysed with flow cytometry...
November 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29136624/value-of-intraoperative-cytological-and-pathological-sentinel-lymph-node-diagnosis-in-fertility-sparing-trachelectomy-for-early-stage-cervical-cancer
#8
Kenzo Sonoda, Hideaki Yahata, Kaoru Okugawa, Eisuke Kaneki, Tatsuhiro Ohgami, Masafumi Yasunaga, Shingo Baba, Yoshinao Oda, Hiroshi Honda, Kiyoko Kato
BACKGROUND AND OBJECTIVES: Trachelectomy, a fertility-sparing surgery for early-stage cervical cancer, can be performed only when there is no extrauterine extension present. Therefore, identifying the sentinel lymph nodes (SLNs) and using them to obtain an intraoperative pathologic diagnosis can provide information on the feasibility and safety of trachelectomy. Our aim was to assess the value of an intraoperative SLN diagnosis. METHODS: We retrospectively analyzed the accuracy of intraoperative imprint cytology and frozen-section examination in 201 patients at our institution in whom trachelectomy was planned...
November 15, 2017: Oncology
https://www.readbyqxmd.com/read/29121779/image-guided-surgery-in-gynecologic-oncology
#9
Henri Azaïs, Geoffroy Canlorbe, Yohan Kerbage, Anne Grabarz, Pierre Collinet, Serge Mordon
Image-guided surgery is a relevant way to reduce surgical morbidity and maximize cytoreductive surgery approach especially in ovarian cancer. Sentinel lymph node detection is a promising approach to avoid radical lymph node dissection and is slightly becoming standard in daily practice in endometrial and cervical cancer surgery even if it needs to be evaluated more precisely. Regarding carcinomatosis of ovarian origin, detection and treatment of microscopic disease could be appropriate to avoid local recurrences...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29032256/real-time-fluorescent-sentinel-lymph-node-mapping-with-indocyanine-green-in-women-with-previous-conization-undergoing-laparoscopic-surgery-for-early-invasive-cervical-cancer-comparison-with-radiotracer%C3%A2-%C3%A2-%C3%A2-blue-dye
#10
Alessandro Buda, Andrea Papadia, Giampaolo Di Martino, Sara Imboden, Beatrice Bussi, Luca Guerra, Elena De Ponti, Claudio Reato, Maria Luisa Gasparri, Cinzia Crivellaro, Michael Mueller
STUDY OBJECTIVE: To evaluate the added value of the fluorescence dye indocyanine green (ICG) for sentinel lymph node (SLN) mapping in women with cervical cancer who had undergone previous conization (stage 1A-1B1) by comparing ICG versus Tc99m radiotracer + blue dye (BD). DESIGN: Retrospective study (Canadian Task Force classification II-2). SETTING: Two European academic medical centers, San Gerardo Hospital, Italy and University of Berne, Switzerland...
October 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28969759/sentinel-lymph-node-biopsy-procedures
#11
REVIEW
Valeria M Moncayo, Adina L Alazraki, Naomi P Alazraki, John N Aarsvold
Accurate staging of many cancers with no clinical evidence of lymph node involvement is often a critical component of the management of such cancers and is generally and historically accomplished by accurate pathological assessment of multiple nodes. Unfortunately, such assessment usually involves excision of the multiple nodes and can result in significant morbidities. Over the past half century, and particularly over the last quarter century, investigators have defined and refined the "sentinel lymph node(s)" concept and have developed and investigated sentinel lymph node biopsy (SLNB) procedures...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28954449/-clinical-analysis-of-76-cases-of-sentinel-lymph-node-detection-in-cervical-cancer-and-endometrial-cancer
#12
S C Liang, Z Q Wang, J L Wang
Objective: To evaluate the feasibility and clinical value of identifying sentinel lymph node (SLN) and to assess possible factors associated with detection rate in both cervical cancer and endometrial cancer. Methods: Retrospective study of 76 cases (39 with cervical cancer and 37 with endometrial cancer) were conducted in Peking University People's Hospital. All patients underwent SLN biopsy with tracers of indocyanine green (ICG) and (or) carbon nanoparticles. All mapped SLN was resected and followed by procedures that systematic pelvic lymphadenectomy and hysterectomy according to National Comprehensive Cancer Network (NCCN) guidelines...
September 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28934992/breast-cancer-metastases-to-the-thyroid-gland-an-uncommon-sentinel-for-diffuse-metastatic-disease-a-case-report-and-review-of-the-literature
#13
Agata M Plonczak, Aimee N DiMarco, Roberto Dina, Dorothy M Gujral, Fausto F Palazzo
BACKGROUND: Metastases to the thyroid are rare. The most common primary cancer to metastasize to the thyroid is renal cell carcinoma, followed by malignancies of the gastrointestinal tract, lungs, and skin, with breast cancer metastases to the thyroid being rare. Overall, the outcomes in malignancies that have metastasized to the thyroid are poor. There are no prospective studies addressing the role of surgery in metastatic disease of the thyroid. Isolated thyroidectomy has been proposed as a local disease control option to palliate and prevent the potential morbidity of tumor extension related to the airway...
September 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28921419/sentinel-lymph-node-biopsy-in-endometrial-cancer-a-new-standard-of-care
#14
REVIEW
Stephanie A Sullivan, Emma C Rossi
Lymph node status is one of the most important factors in determining prognosis and the need for adjuvant treatment in endometrial cancer (EMCA). Unfortunately, full lymphadenectomy bears significant surgical and postoperative risks. The majority of patients with clinical stage I disease will not have metastatic disease; thus, a full lymphadenectomy only increases morbidity in this population of patients. The use of the sentinel lymph node (SLN) biopsy has emerged as an alternative to complete lymphadenectomy in EMCA...
September 18, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28911828/laparoscopic-sentinel-lymph-node-mapping-with-indocyanine-green-using-the-ispies-platform-initial-experience-argentina
#15
Julian Di Guilmi, Maria Cecilia Darin, Maria Toscano, Gustavo Maya
STUDY OBJECTIVE: To demonstrate the initial experience in Argentina using the iSpies indocyanine green (ICG) platform in sentinel lymph node mapping in patients with early-stage cervical cancer. DESIGN: Step-by-step demonstration of the technique using a video and pictures (educative video) (Canadian Task Force classification III). SETTING: Laparoscopic and robotic sentinel lymph node mapping using ICG has been shown to be safe and feasible; however, in developing countries, the opportunities to use fluorescent imaging through a minimally invasive approach are very limited, given the cost restrictions of acquiring the near-infrared technology and the fluorescent dyes...
September 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28873443/application-of-carbon-nanoparticles-in-laparoscopic-sentinel-lymph-node-detection-in-patients-with-early-stage-cervical-cancer
#16
Yan Lu, Jin-Ying Wei, De-Sheng Yao, Zhong-Mian Pan, Yao Yao
OBJECTIVE: To investigate the value of carbon nanoparticles in identifying sentinel lymph nodes in early-stage cervical cancer. METHODS: From January 2014 to January 2016, 40 patients with cervical cancer stage IA2-IIA, based on the International Federation of Gynecology and Obstetrics (FIGO) 2009 criteria, were included in this study. The normal cervix around the tumor was injected with a total of 1 mL of carbon nanoparticles (CNP)at 3 and 9 o'clock. All patients then underwent laparoscopic pelvic lymph node dissection and radical hysterectomy...
2017: PloS One
https://www.readbyqxmd.com/read/28861856/role-of-sentinel-node-in-differentiated-thyroid-cancer-a-prospective-study-comparing-patent-blue-injection-technique-lymphoscintigraphy-and-the-combined-technique
#17
R Gelmini, M Campanelli, F Cabry, A Franceschetto, G Ceresini, L Ruffini, A Zaccaroni, P Del Rio
PURPOSE: The purpose of the present study was to evaluate the feasibility and reproducibility of the sentinel lymph node (SLNs) biopsy in differentiated thyroid cancer using patent blue injection, lymphoscintigraphy and the combined techniques. METHODS: Between January 2011 and January 2013, 82 consecutive patients were enrolled in our prospective multicentre study. Inclusion criteria were 18 years of age, preoperative diagnosis of differentiated thyroid carcinoma, no evidence of lymph node enlargement and multifocal neoplasm...
August 31, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28807805/laparoscopic-sentinel-node-mapping-in-cervical-and-endometrial-malignancies-a-case-control-study-comparing-two-near-infrared-fluorescence-systems
#18
Alessandro Buda, Giampaolo Di Martino, Elena De Ponti, Paolo Passoni, Federica Sina, Claudio Reato, Francesca Vecchione, Daniela Giuliani
STUDY OBJECTIVE: The goal of this study was to evaluate the intraoperative and perioperative surgical outcomes of 2 different florescence systems commonly used for sentinel lymph node (SLN) mapping in women with early-stage cervical cancer or endometrial cancer. DESIGN: Case-control study (Canadian Task Force classification II-2). SETTING: The Gynecology Oncology Surgical Unit of the San Gerardo Hospital, Italy. PATIENTS: Thirty-four consecutive women with early stage-cervical cancer (stage IA-1B1) or apparent confined stage I endometrial cancer were included in the study...
August 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28751118/description-of-a-reproducible-anatomically-based-surgical-algorithm-for-detection-of-pelvic-sentinel-lymph-nodes-in-endometrial-cancer
#19
Jan Persson, Barbara Geppert, Céline Lönnerfors, Michele Bollino, Anna Måsbäck
OBJECTIVE: To describe and evaluate a reproducible, anatomically based surgical algorithm, including reinjection of tracer to enhance technical success rate, for detection of pelvic sentinel lymph nodes (SLNs) in endometrial cancer (EC). METHODS: A prospective study of 102 consecutive women with high risk EC scheduled for robotic surgery was conducted. Following cervical injection of a fluorescent dye, an algorithm for trans- and retroperitoneal identification of tracer display in the lower and upper paracervical pathways was strictly adhered to...
October 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28729099/implementing-a-cervical-sentinel-lymph-node-biopsy-program-quality-improvement-in-gynaecologic-oncology
#20
Maria C Cusimano, Rachel Walker, Marcus Q Bernardini, Geneviève Bouchard-Fortier, Stephane Laframboise, Taymaa May, Joan Murphy, Barry Rosen, Al Covens, Blaise Clarke, Patricia Shaw, Marjan Rouzbahman, Ravi Mohan, Sarah E Ferguson
OBJECTIVE: Sentinel lymph node (SLN) biopsy is becoming a reasonable alternative to pelvic lymphadenectomy in early-stage cervical cancer. It is therefore imperative that centres without prior experience are able to successfully implement the procedure. The objectives of the current study were to (1) describe the process of implementing an SLN biopsy program with a novel peer mentorship component and (2) assess post-program quality improvement metrics, including SLN detection rate (DR) and diagnostic parameters...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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