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Sentinel lymph node in cervical cancer

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https://www.readbyqxmd.com/read/27926501/abdominal-radical-trachelectomy-guided-by-sentinel-lymph-node-biopsy-for-stage-ib1-cervical-cancer-with-tumors-2-cm
#1
Xiangyun Deng, Ying Zhang, Dapeng Li, Xiaoling Zhang, Hui Guo, Fei Wang, Xiugui Sheng
Accuracy of prediction of pelvic lymph node status using sentinel lymph node biopsy (SLNB), and outcomes of SLNB-guided abdominal radical trachelectomy (ART) were assessed. Patients with stage IB1 (Figure 2009) cervical cancer and with tumors >2 cm were enrolled. Prior to fertility-sparing surgery 99mTc-labeled phytate was administered. SLNs were intraoperatively identified, excised, and assessed using fast-frozen sections. Systematic bilateral pelvic lymphadenectomy with or without para-aortic lymphadenectomy was subsequently undertaken...
December 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27894166/the-detection-of-sentinel-lymph-nodes-in-laparoscopic-surgery-for-uterine-cervical-cancer-using-99m-technetium-tin-colloid-indocyanine-green-and-blue-dye
#2
Tomohito Tanaka, Yoshito Terai, Keisuke Ashihara, Satoshi Tsunetoh, Hiroyuki Akagi, Takashi Yamada, Masahide Ohmichi
OBJECTIVE: Our objective was to determine the feasibility and detection rates and clarify the most effective combination of injected tracer types for sentinel lymph node (SLN) mapping in uterine cervical cancer in patients who have undergone laparoscopic surgery or neoadjuvant chemotherapy (NAC). METHODS: A total of 119 patients with cervical cancer underwent SLN biopsy at radical hysterectomy using three types of tracers. The various factors related to side-specific detection rate, sensitivity, and false negative (FN) rate were analyzed...
November 1, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27882757/-contribution-of-sentinel-lymph-node-biopsy-to-treatment-of-locally-advanced-stages-of-cervical-cancers
#3
J Sláma, M Zikán, D Fischerová, R Kocián, A Germanová, F Frühauf, D Cibula
OBJECTIVE: Usage of sentinel lymph-node (SLN) concept in locally advanced cervical cancers might help to individualise management. According to SLN status could be patients refered to neoadjuvant chemotherapy (NAC) with subsequent surgery or to primary chemoradiation. The aim of our study was to evaluate sensitivity of SLN detection in locally advanced cervical cancers and to assess the impact of NAC on frequency of their metastatic involvement. DESIGN: Retrospective clinical study...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27871836/sentinel-lymph-node-assessment-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#4
REVIEW
Anna Jo Bodurtha Smith, Amanda Nickles Fader, Edward J Tanner
BACKGROUND: In the staging of endometrial cancer, controversy remains regarding the role of sentinel lymph node mapping compared with other nodal assessment strategies. OBJECTIVE: We conducted a systematic review to evaluate the diagnostic accuracy and clinical impact of sentinel lymph node mapping in the management of endometrial cancer. DATA SOURCES: We searched Medline, Embase, and the Cochrane Central Registry of Controlled trials for studies published in English before March 25, 2016 (PROSPERO CRD42016036503)...
November 18, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27815812/sentinel-node-mapping-in-endometrial-cancer-patients-comparing-spect-ct-gamma-probe-and-dye
#5
Federica Elisei, Cinzia Crivellaro, Daniela Giuliani, Carlotta Dolci, Elena De Ponti, Luca Montanelli, Maria La Manna, Luca Guerra, Maurizio Arosio, Claudio Landoni, Alessandro Buda
OBJECTIVE: The aim of this study was to compare preoperative SPECT/CT with gamma-probe and methylene blue-dye (MBD) in the identification of sentinel lymph node (SLN) in early stage endometrial cancer. METHODS: 40 stage-I EC patients (66.7 ± 9.7 years) underwent preoperative lymphoscintigraphy. After about 3 h from Tc-99m-albumin nanocolloid cervical injection, all patients underwent SPECT/CT study. MBD was injected into the cervix just before surgery under general anesthesia...
November 4, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27815041/feasibility-of-robotic-assisted-laparoendoscopic-single-site-surgery-in-the-gynecologic-oncology-setting
#6
Lea A Moukarzel, Amanda N Fader, Edward J Tanner
STUDY OBJECTIVE: To assess the feasibility of incorporating robotic laparoendoscopic single-site (R-LESS) surgery into gynecologic oncology care. DESIGN: Retrospective study (Canadian Task Force classification II-3). SETTING: Academic university hospital. PATIENTS: Patients undergoing R-LESS hysterectomy for gynecologic malignancies, preinvasive disease, or risk reduction performed by a single gynecologic oncologist between 2014 and 2016...
November 1, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27792042/sentinel-lymph-nodes-mapping-in-cervical-cancer-a-comprehensive-review
#7
Yasser Diab
OBJECTIVE: A comprehensive literature search for more recent studies pertaining to sentinel lymph node mapping in the surveillance of cervical cancer to assess if sentinel lymph node mapping has sensitivity and specificity for evaluation of the disease; assessment of posttreatment response and disease recurrence in cervical cancer. MATERIALS AND METHODS: The literature review has been constructed on a step wise study design that includes 5 major steps. This includes search for relevant publications in various available databases, application of inclusion and exclusion criteria for the selection of relevant publications, assessment of quality of the studies included, extraction of the relevant data and coherent synthesis of the data...
October 27, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27776838/indocyanine-green-fluorescence-imaging-of-lymph-nodes-during-robotic-assisted-laparoscopic-operation-for-endometrial-cancer-a-prospective-validation-study-using-a-sentinel-lymph-node-surgical-algorithm
#8
Bjørn Hagen, Marit Valla, Guro Aune, Merethe Ravlo, Anne Britt Abusland, Elisabeth Araya, Marit Sundset, Solveig Tingulstad
OBJECTIVE: A sentinel lymph node (SLN) strategy may have particular value in endometrial cancer (EC) because a therapeutic effect of lymphadenectomy per se is unproven. The aim was to evaluate indocyanine green (ICG) and near-infrared (NIR) fluorescence mapping using a surgical algorithm. METHODS: From November 2012 through December 2015, women with apparently early stage EC underwent robot-assisted laparoscopic hysterectomy including ICG fluorescence SLN mapping following the Memorial Sloane Kettering Cancer Center (MSKCC) surgical algorithm...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27757531/-metastatic-mechanisms-of-uterine-malignancies-and-therapeutic-consequences
#9
S F Lax, K F Tamussino, P F Lang
Malignancies of the uterus metastasize by direct invasion of neighboring structures, lymphatically or hematogenously. Endometrial and cervical cancers lymphatically spread to the pelvic and para-aortic lymph nodes. For endometrial cancer the depth of myometrial invasion, lymphosvascular space involvement (LVSI) and a microcystic, elongated and fragmented (MELF) glandular invasion pattern are predictors for lymph node metastases. Metastases to the pelvic lymph nodes occur in approximately 10 % of endometrial cancer patients and in 30 % of these cases the para-aortic lymph nodes are also involved...
October 18, 2016: Der Pathologe
https://www.readbyqxmd.com/read/27750179/indocyanine-green-and-infrared-fluorescence-in-detection-of-sentinel-lymph-nodes-in-endometrial-and-cervical-cancer-staging-a-systematic-review
#10
Anabela Rocha, Ana Maria Domínguez, Fabrice Lécuru, Nicolas Bourdel
OBJECTIVE: Sentinel lymph node (SLN) mapping for endometrial (EC) and cervical cancers (CC) is a current technique that could provide benefits over traditional lymphadenectomy. Near-infrared (NIR) fluorescence imaging is a promising technique to perform this procedure. We conducted a systematic review of the evidence regarding the technique and the effectiveness of indocyanine green (ICG) during SLN biopsy, using robotic and laparoscopic assisted surgery and laparotomy. MATERIALS AND METHODS: We conducted a computer literature search for published English language studies in humans using PubMed since January 2010 up to May 2015...
September 30, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27742472/can-sentinel-lymph-node-biopsy-replace-pelvic-lymphadenectomy-for-early-cervical-cancer
#11
Genevieve K Lennox, Allan Covens
OBJECTIVE: Evaluate recurrence-free survival (RFS) and short-term morbidity in patients with early cervical cancer who undergo bilateral pelvic lymphadenectomy (BPLND) versus bilateral sentinel lymph node biopsy only (BSLNB) at primary surgery. METHODS: All patients with pathologically confirmed node negative stage IA/IB cervical cancer managed with BPLND or BSLNB were identified in the University of Toronto's prospective cervical cancer database from May 1984-June 2015...
October 11, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27738629/the-sentinel-node-approach-in-gynaecological-malignancies
#12
Angela Collarino, Sergi Vidal-Sicart, Germano Perotti, Renato A Valdés Olmos
This review discusses the state-of-the-art of sentinel lymph node mapping in gynaecological malignancies, including cervical cancer, endometrial cancer, and vulvar cancer, with an emphasis on new technological advances. For this objective, PubMed/MEDLINE was searched for relevant studies about the sentinel lymph node procedure in gynaecology. In particular, the use of preoperative lymphatic mapping with lymphoscintigraphy and single photon emission tomography/computed tomography (SPECT/CT) was identified in 18 studies...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27670732/near-infrared-fluorescence-guided-sentinel-node-mapping-of-the-ovary-with-indocyanine-green-in-a-minimally-invasive-setting-a-feasible-study
#13
Alessandro Buda, Paolo Passoni, Giacomo Corrado, Beatrice Bussi, Giuseppe Cutillo, Sonia Magni, Enrico Vizza
Sentinel lymph node (SLN) mapping has increased its feasibility in both early stage cervical and endometrial cancer. There are few SLN studies regarding the ovary, because of the risk of tumor dissemination and perhaps because the ovary represents an inconvenient site for injection. In this preliminary study, we have shown the feasibility of SLN mapping of the ovary with Indocyanine green (ICG) during laparoscopic retroperitoneal aortic surgical staging. The ten women who were included in this study underwent aortic with pelvic laparoscopic staging, which included SLN biopsy, extrafascial total hysterectomy and bilateral salpingo-oophorectomy in case of ovarian tumor...
September 23, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27668393/sensitivity-of-follow-up-methods-in-patients-after-fertility-sparing-surgery-for-cervical-cancers
#14
Jiri Slama, Daniela Fischerova, Michal Zikan, Roman Kocian, Anna Germanova, Filip Fruhauf, Ladislav Dusek, David Cibula
OBJECTIVE: The aim of our study was to compare the sensitivity of various methods and their combinations in the follow-up of patients with cervical cancer after fertility-sparing surgery (FSS). METHODS: Included were women with cervical cancer in stages IA2 to IB2 who underwent FSS, which includes pelvic lymphadenectomy, sentinel lymph node biopsy, abdominal radical trachelectomy, vaginal trachelectomy, or needle conization. Follow-up visits were scheduled at 3-month intervals and included symptom-oriented discussion, gynecological and physical examination, colposcopy, Papanicolaou test, human papillomavirus (HPV) DNA test, and ultrasound examination...
September 23, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27667001/-18-f-fdg-pet-ct-and-sentinel-lymph-node-biopsy-in-the-staging-of-patients-with-cervical-and-endometrial-cancer-role-of-dual-time-point-imaging
#15
M Mayoral, P Paredes, B Domènech, P Fusté, S Vidal-Sicart, A Tapias, A Torné, J Pahisa, J Ordi, F Pons, F Lomeña
OBJECTIVE: Definitive staging for cervical (CC) and endometrial cancer (EC) takes place once surgery is performed. The aim of this study was to evaluate the role of PET/CT in detecting lymphatic metastasis in patients with CC and EC using dual-time-point imaging (DPI), taking the histopathological results of sentinel lymph node (SLN) and lymphadenectomy as the reference. MATERIAL AND METHODS: A prospective study was conducted on 17 patients with early CC, and 13 patients with high-risk EC...
September 22, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27526991/sentinel-lymph-node-detection-rates-using-indocyanine-green-in-women-with-early-stage-cervical-cancer
#16
Anna L Beavis, Sergio Salazar-Marioni, Abdulrahman K Sinno, Rebecca L Stone, Amanda N Fader, Antonio Santillan-Gomez, Edward J Tanner
OBJECTIVE: Our study objective was to determine feasibility and mapping rates using indocyanine green (ICG) for sentinel lymph node (SLN) mapping in early-stage cervical cancer. METHODS: We performed a retrospective review of all women who underwent SLN mapping with ICG during primary surgical management of early-stage cervical cancer by robotic-assisted radical hysterectomy (RA-RH) or fertility-sparing surgery. Patients were treated at two high-volume centers from 10/2012 to 02/2016...
August 12, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27478163/potential-surgical-and-oncological-consequences-related-to-skin-tattoos-in-the-treatment-of-cervical-cancer
#17
Christhardt Köhler, Tariane Foiato, Simone Marnitz, Achim Schneider, Xin Le, Nasuh Utku Dogan, Tatiana Pfiffer, Anna Elena Jacob, Andrea Mölgg, Ingke Hagemann, Giovanni Favero
STUDY OBJECTIVE: To report the presence of tattoo ink affected pelvic lymph nodes in women with early cervical cancer and to discuss its potential oncological and surgical consequences. DESIGN CLASSIFICATION: Prospective observational study. SETTING: University Hospital in Hamburg, Germany. BACKGROUND: Skin tattoos on the feet, legs, and lower abdominal wall are progressively gaining popularity. Consequently, the number of tattooed women with cervical cancer has significantly increased in the last decade...
July 28, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27421753/risk-of-micrometastases-in-non-sentinel-pelvic-lymph-nodes-in-cervical-cancer
#18
D Cibula, M Zikan, J Slama, D Fischerova, R Kocian, A Germanova, A Burgetova, L Dusek, P Dundr, M Gregova, K Nemejcova
OBJECTIVE: A high sensitivity of sentinel lymph nodes (SLN) for pelvic lymph node (LN) staging has been repeatedly shown in patients with cervical cancer. However, since only SLN are evaluated by pathologic ultrastaging, the risk of small metastases, including small macrometastases (MAC) and micrometastases (MIC), in non-SLN is unknown. This can be a critical limitation for the oncological safety of abandoning a pelvic lymphadenectomy. METHODS: The patients selected for the study had cervical cancer and were at high risk for LN positivity (stage IB-IIA, biggest diameter≥3cm)...
October 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27396943/results-of-less-radical-fertility-sparing-procedures-with-omitted-parametrectomy-for-cervical-cancer-5years-of-experience
#19
Jiri Slama, Andrej Cerny, Ladislav Dusek, Daniela Fischerova, Michal Zikan, Roman Kocian, Anna Germanova, David Cibula
OBJECTIVE: The aim of our study was to describe oncological and obstetrical outcomes in patients who underwent less radical fertility-sparing surgical (FSS) procedures with omitted parametrectomy for cervical cancer. METHODS: Included were women with cervical cancer stages IA2-IB2 who were under the age of 40 and desired future pregnancy. Patients underwent pelvic lymphadenectomy and sentinel lymph node biopsy. Node-negative cases underwent subsequent cervical surgery and were further analyzed...
September 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27366869/the-role-of-spect-ct-lymphoscintigraphy-and-radioguided-sentinel-lymph-node-biopsy-in-managing-papillary-thyroid-cancer
#20
Raquel Novas Cabrera, Carlos T Chone, Denise E Zantut-Wittmann, Patrcia S Matos, Daniel M Ferreira, Pablo S Pereira, Mariana P Ribeiro, Allan O Santos, Celso D Ramos, Agrício N Crespo, Elba C Etchebehere
IMPORTANCE: Single-photon emission computed tomography/computed tomography (SPECT/CT) and radioguided sentinel lymph node biopsy (rSLNB) are techniques that could potentially benefit surgeons and pathologists in the identification of sentinel lymph node (SLN) metastases in patients with papillary thyroid carcinoma (PTC). Evidence suggests that these novel techniques lead to substantial changes in PTC management by reducing understaging and of occult lymph node (LN) metastases and optimizing neck surgery by increasing the necessity of lateral lymphadenectomy and decreasing central lymphadenectomy...
September 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
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