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https://www.readbyqxmd.com/read/29344569/endoscopic-full-thickness-resection-with-an-over-the-scope-clip-device-ftrd-in-the-colorectum-results-from-a-university-tertiary-referral-center
#1
Francesco Vitali, Andreas Naegel, Juergen Siebler, Markus F Neurath, Timo Rath
Background and study aims:  The full-thickness resection device (FTRD) represents a novel endoscopic treatment method for lesions unresectable with conventional endoscopic techniques. The overall aim of this study was to evaluate technical success and in toto resection rates, recurrence rates, as well as immediate or late complications in patients who underwent polyp removal with the FTRD. Patients and methods:  Data from a prospectively collected database of 12 patients who underwent 13 over-the-scope clip-based full-thickness resections between June 2015 and June 2017 were analyzed...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29339825/corallivory-and-the-microbial-debacle-in-two-branching-scleractinians
#2
Yvan Bettarel, Sébastien Halary, Jean-Christophe Auguet, Thanh Chi Mai, Ngoc Van Bui, Thierry Bouvier, Patrice Got, Corinne Bouvier, Sonia Monteil-Bouchard, Desnues Christelle
The grazing activity by specific marine organisms represents a growing threat to the survival of many scleractinian species. For example, the recent proliferation of the corallivorous gastropod Drupella now constitutes a critical case in all South-East Asian waters. If the damaging effects caused by this marine snail on coral polyps are relatively well known, the indirect incidence of predation on coral microbial associates is still obscure and might also potentially impair coral health. In this study, we compared the main ecological traits of coral-associated bacterial and viral communities living in the mucus layer of Acropora formosa and Acropora millepora, of healthy and predated individuals (i...
January 16, 2018: ISME Journal
https://www.readbyqxmd.com/read/29339485/elevated-d-2-hydroxyglutarate-during-colitis-drives-progression-to-colorectal-cancer
#3
Jie Han, Dakota Jackson, Janette Holm, Kevin Turner, Paula Ashcraft, Xuan Wang, Beth Cook, Erland Arning, Robert M Genta, K Venuprasad, Rhonda F Souza, Lawrence Sweetman, Arianne L Theiss
d-2-hydroxyglutarate (D2HG) is produced in the tricarboxylic acid cycle and is quickly converted to α-ketoglutarate by d-2-hydroxyglutarate dehydrogenase (D2HGDH). In a mouse model of colitis-associated colon cancer (CAC), urine level of D2HG during colitis correlates positively with subsequent polyp counts and severity of dysplasia. The i.p. injection of D2HG results in delayed recovery from colitis and severe tumorigenesis. The colonic expression of D2HGDH is decreased in ulcerative colitis (UC) patients at baseline who progress to cancer...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29337039/the-presence-of-small-and-diminutive-proximal-hyperplastic-polyps-is-associated-with-higher-rates-of-synchronous-advanced-neoplasia-compared-with-patients-without-serrated-lesions
#4
Hamoudah Thayer, Ma Karen, Esteban Marcus, Hayat Waqas, Mahon Brett, Jakate Shriram, Melson Joshua
BACKGROUND: The association of proximal small and diminutive hyperplastic polyps (HPs) with synchronous neoplasia (AN) is not well defined. However, sessile serrated polyps, even when small, are known to portend synchronous neoplastic risk. Currently, when proximal small hyperplastic polyps are detected, the USMTF does not recommend a change in surveillance interval. We aimed to compare the rates of synchronous AN in a screening colonoscopy cohort of patients with small and then diminutive proximal HPs in comparison, first to a cohort absent any serrated or proximal hyperplastic polyps, and then in comparison with a cohort with small proximal sessile serrated polyps (SSPs)...
January 11, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29333424/anatomical-distribution-and-detection-rate-of-colorectal-neoplasms-according-to-age-in-the-colonoscopic-screening-of-a-korean-population
#5
Suk-Young Lee, Wan Hee Song, Sang Cheul Oh, Byung-Wook Min, Sun Il Lee
Purpose: Because data as a basis for the determination of proper age and modality for screening of colorectal neoplasms is lacking, we evaluated detection rates and anatomical distribution of colorectal neoplasms according to age in healthy individuals who underwent total colonoscopy for health checkup. Methods: A total of 16,100 cases that had received the colonoscopic examination from January to December in 2014 were analyzed. The total number of individuals who received total colonoscopy were divided by the number of individuals harboring colorectal adenoma to calculate the detection rate of colorectal adenoma...
January 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29332745/a-critical-overview-of-the-current-myofascial-pain-literature-january-2018
#6
REVIEW
Jan Dommerholt, Todd Hooks, Li-Wei Chou, Michelle Finnegan
The majority of papers included in the quarterly review discuss various aspects of dry needling (DN), which continues to be of interest to researchers and clinicians. A study by Liu et al. is the first paper to examine the effects of DN of acetylcholine, esterase and receptors. The study provides support for the integrated trigger point hypothesis and for DN. A paper by Hightower and colleagues found an intriguing link between low magnesium levels in the drink water supply, vitamin D, and myofascial pain, cancer, tendon ruptures, and colon polyps...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29324674/calcitriol-supplementation-causes-decreases-in-tumorigenic-proteins-and-different-proteomic-and-metabolomic-signatures-in-right-versus-left-sided-colon-cancer
#7
Monica M Schroll, Katelyn R Ludwig, Kerry M Bauer, Amanda B Hummon
Vitamin D deficiency is a common problem worldwide. In particular, it is an issue in the Northern Hemisphere where UVB radiation does not penetrate the atmosphere as readily. There is a correlation between vitamin D deficiency and colorectal cancer incidence and mortality. Furthermore, there is strong evidence that cancer of the ascending (right side) colon is different from cancer of the descending (left side) colon in terms of prognosis, tumor differentiation, and polyp type, as well as at the molecular level...
January 11, 2018: Metabolites
https://www.readbyqxmd.com/read/29320750/the-many-faces-of-intestinal-tract-gastric-heterotopia-a-series-of-four-cases-highlighting-clinical-and-pathological-heterogeneity
#8
Aqsa Nasir, Stuart K Amateau, Sabina Khan, Ross W Simpson, Dale C Snover, Khalid Amin
Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 year, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual clinical presentation was iron deficiency anemia, seen in three cases, while one patient presented with abdominal pain. Endoscopically two cases were visualized as pedunculated polyps and two as sessile/plaques like lesions...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29317721/sex-differences-in-risk-factors-of-uncomplicated-colonic-diverticulosis-in-a-metropolitan-area-from-northern-china
#9
Fang Yang, Yanmin Zheng, Xihui Jiang, Zhengyan Su, Ya Wang, Lin Lin, Houning Lv, Jie Zhang, Jingwen Zhao, Bangmao Wang, Kui Jiang, Chao Sun
As the world's most populated and rapidly aging country, there is limited information on sex-related differences in factors regarding uncomplicated colonic diverticulosis in China. We aimed to investigate sex differences in individual risk factor in a northern metropolis. Patients with colonic diverticulosis who underwent indicated colonoscopy were queried with respect to medical history and demographic features. Demographic information, life style factors and co-morbidities were retrieved from a prospective dataset...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29290324/-mucosal-schwann-cells-hamartoma-review-of-a-recently-described-entity
#10
Francisco García-Molina, José Antonio Ruíz-Macia, Joaquin Sola
Neural lesions of the colon may be masses (schwannomas and neurofibromas) or, more frequently, small polyps including perineuromas, ganglioneuromas and granular cell tumors. Some neural lesions are associated with congenital syndromes (neurofibromatosis-1, multiple endocrine neoplasia-2B). Recently, a new entity has been described named mucosal Schwann cell hamartoma, consisting of an intramucosal neural proliferation; to date, less than forty cases have been reported. We report a further case in a patient from whom a polyp was extirpated during colonoscopy screening...
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29284484/platform-independent-gene-expression-signature-differentiates-sessile-serrated-adenomas-polyps-and-hyperplastic-polyps-of-the-colon
#11
Yasir Rahmatallah, Magomed Khaidakov, Keith K Lai, Hannah E Goyne, Laura W Lamps, Curt H Hagedorn, Galina Glazko
BACKGROUND: Sessile serrated adenomas/polyps are distinguished from hyperplastic colonic polyps subjectively by their endoscopic appearance and histological morphology. However, hyperplastic and sessile serrated polyps can have overlapping morphological features resulting in sessile serrated polyps diagnosed as hyperplastic. While sessile serrated polyps can progress into colon cancer, hyperplastic polyps have virtually no risk for colon cancer. Objective measures, differentiating these types of polyps would improve cancer prevention and treatment outcome...
December 28, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29283904/role-of-full-spectrum-endoscopy-in-colorectal-cancer-screening-randomized-trial
#12
Henar Núñez-Rodríguez, Pilar Diez-Redondo, Manuel Pérez-Miranda, Manuel Gonzalez Sagrado, Rosa Conde, Carlos De la Serna
GOALS: The aim of this study was to compare a new, full-spectrum endoscope (Fuse; EndoChoice, Alpharetta, GA) to standard forward-viewing colonoscopy in the detection of colorectal neoplasms. BACKGROUND: Colonoscopy, the gold standard for the detection of colorectal cancer, fails to detect 22% to 28% of polyps, increasing the risk of interval cancer. Endoscopic improvement of the adenoma detection rate decrease interval carcinomas. Full-spectrum endoscopy (FUSE) (330-degree field of view), in a tandem study, has been shown to reduce the adenoma miss rate...
December 27, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29282496/management-of-complex-polyps-of-the-colon-and-rectum
#13
REVIEW
Fernando A Angarita, Adina E Feinberg, Stanley M Feinberg, Robert H Riddell, J Andrea McCart
PUPRPOSE: Benign polyps that are technically challenging and unsafe to remove via polypectomy are known as complex polyps. Concerns regarding safety and completeness of resection dictate they undergo advanced endoscopic techniques, such as endoscopic mucosal resection or surgery. We provide a comprehensive overview of complex polyps and current treatment options. METHODS: A review of the English literature was conducted to identifyarticles describing the management of complex polyps of the colon and rectum...
December 28, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29282495/detection-rate-and-proximal-shift-tendency-of-adenomas-and-serrated-polyps-a-retrospective-study-of-62-560-colonoscopies
#14
Shuling Chen, Kaiyu Sun, Kang Chao, Yuli Sun, Liru Hong, Zijin Weng, Yi Cui, Minhu Chen, Shenghong Zhang
PURPOSE: The purpose of this study is to estimate the detection rates of adenomas and serrated polyps and to identify proximalization and associate risk factors in patients from Southern China. METHODS: Consecutive patients undergoing colonoscopy from 2004 to 2013 in Guangzhou were included. The proportions of proximal adenomas to advanced adenomas and serrated polyps were compared and potential predictors were evaluated. RESULTS: Colonoscopies (n = 62,560) were performed, and 11,427 patients were diagnosed with polyps...
December 27, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29280125/-pediatric-colonoscopy-in-south-china-a-single-center-experience-from-229-cases
#15
Jinhua Chen, Huichuan Yu, Weijie Zhong, Honglei Chen, Xianhe Kong, Jiachen Sun, Xiaolin Wang, Chujun Li
OBJECTIVE: To investigate the safety, feasibility, clinical value, indication, and distribution of diagnostic diseases in different age groups of colonoscopy in pediatric patients. METHODS: A retrospective analysis was performed on the data of pediatric patients receiving colonoscopy from April 2013 to June 2016 at The Sixth Affiliated Hospital of Sun Yat-sen University. Pediatric patients were divided into 0-6 years group (n=57) and 7-14 years group (n=172). Indication for colonoscopy, detective events and diagnostic diseases distribution were compared between two groups...
December 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29277562/evaluating-the-expression-level-of-co-stimulatory-molecules-cd-80-and-cd-86-in-different-types-of-colon-polyps
#16
N Peyravian, E Gharib, A Moradi, M Mobahat, P Tarban, P Azimzadeh, E Nazemalhosseini-Mojarad, H Asadzadeh Aghdaei
PURPOSE OF THE STUDY: Co-stimulatory molecules CD80 and CD86 are the members of B7 family, which stimulate the T lymphocytes in response to the malignant colon polyps. However, the expression of these molecules is depressed in cancers. In the present study, the transcription levels of CD80 and CD86 genes in the colon polyps (Precancerous lesions) and its association with the clinical features were examined. PATIENTS AND METHODS: Forty-nine biopsies samples from patients with the colorectal polyps and 10 healthy subjects were collected by the colonoscopy...
December 22, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29261351/clinical-value-of-ct-colonography-versus-preoperative-colonoscopy-in-the-surgical-management-of-occlusive-colorectal-cancer
#17
Natally Horvat, Aradhna Raj, John M Ward, J Joshua Smith, Arnold J Markowitz, Marc J Gollub
OBJECTIVE: CT colonography (CTC) has been recognized as a complementary approach to evaluating the entire colon after incomplete colonoscopy (IC) in patients with occlusive colorectal cancer (CRC). The objective of this study is to evaluate changes in preoperative surgical planning after CTC is performed for patients with occlusive CRC and IC in an oncologic hospital. MATERIALS AND METHODS: This retrospective study included 65 consecutive patients with occlusive CRC who underwent CTC after IC at our institution from February 2000 to April 2016...
December 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29259861/inflammatory-fibroid-polyp-of-the-gastric-antrum-presenting-as-hypovolemic-shock-case-report-and-literature-review
#18
Kyle D Klingbeil, Alexandra Balaban, Raymond M Fertig, A Caresse Gamret, Yuna Gong, Carolyn Torres, Shevonne S Satahoo
Inflammatory fibroid polyps (IFP) are an extremely rare entity that arise within the submucosa of the gastrointestinal tract, and represent less than 0.1% of all gastric polyps. They are most commonly localized to the gastric antrum, small intestines and recto-sigmoid colon. IFPs are most commonly found incidentally upon endoscopic evaluation in the absence of symptoms. Presenting symptoms depend on the location of the tumor, although polyps located in the stomach most commonly present with epigastric pain and early satiety...
November 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29250683/hemorrhagic-polypoid-gastric-and-colonic-metastases-nine-years-after-uterine-leiomyosarcoma-case-report
#19
Nicoleta Puie, Lavinia Patricia Trică, Georgiana Anca Nagy, Ioana Rusu, Alina Simona Şovrea, Carmen Georgiu
INTRODUCTION: Uterine leiomyosarcoma (ULMS) is a rare tumor, representing 1-2% of all uterine malignancies. It is highly aggressive, with high metastatic rate, especially in lungs, peritoneal cavity, retroperitoneum, bones and liver, usually during the first years after diagnosis. CASE PRESENTATION: A 58-year-old woman, with subtotal hysterectomy and bilateral adnexectomy, followed by radiochemotherapy for spindle-type ULMS nine years ago, presented with gastrointestinal bleeding and severe anemia...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29247803/staphylococcus-aureus-controls-interleukin-5-release-in-upper-airway-inflammation
#20
C Bachert, G Holtappels, M Merabishvili, T Meyer, A Murr, N Zhang, K Van Crombruggen, E Gevaert, U Völker, B M Bröker, M Vaneechoutte, F Schmidt
Staphylococcus aureus is a frequent colonizer of the upper airways in chronic rhinosinusitis with nasal polyps, but also resides intramucosally; it has been shown that secreted staphylococcal proteins such as enterotoxins and serine proteases induce the release of cytokines such as IL-5. We have analyzed nasal polyp tissue freshly obtained during routine surgery, which did or did not contain cultivatable S. aureus, to study spontaneous IL-5 production by nasal polyp tissue over 24 and 72h in tissue culture...
December 13, 2017: Journal of Proteomics
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