Alexander J Najibi, Ryan S Lane, Miguel C Sobral, Giovanni Bovone, Shawn Kang, Benjamin R Freedman, Joel Gutierrez Estupinan, Alberto Elosegui-Artola, Christina M Tringides, Maxence O Dellacherie, Katherine Williams, Hamza Ijaz, Sören Müller, Shannon J Turley, David J Mooney
Following immunization, lymph nodes dynamically expand and contract. The mechanical and cellular changes enabling the early-stage expansion of lymph nodes have been characterized, yet the durability of such responses and their implications for adaptive immunity and vaccine efficacy are unknown. Here, by leveraging high-frequency ultrasound imaging of the lymph nodes of mice, we report more potent and persistent lymph-node expansion for animals immunized with a mesoporous silica vaccine incorporating a model antigen than for animals given bolus immunization or standard vaccine formulations such as alum, and that durable and robust lymph-node expansion was associated with vaccine efficacy and adaptive immunity for 100 days post-vaccination in a mouse model of melanoma...
May 6, 2024: Nature Biomedical Engineering