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Hongjuan Zhao, Li Li, Cuixia Zheng, Yongwei Hao, Mengya Niu, Yujie Hu, Junbiao Chang, Zhenzhong Zhang, Lei Wang
The effects of photodynamic therapy (PDT) are limited by the hypoxic tumor microenvironment (TME). In this paper, a new type of biocompatible multifunctional photosensitizer delivery system was fabricated to relieve tumor hypoxia and improve the efficacy of PDT. The photosensitizer hematoporphyrin monomethyl ether (HMME) and catalase (CAT) were encapsulated in the pores of mesoporous graphitic-phase carbon nitride nanosheets (mpg-C3 N4 ). Next, hyaluronic (HA) was coated on the surface of the mpg-C3 N4 via an amide linkage to construct the tumor-targeting HAase/CAT dual activatable and mpg-C3 N4 /HMME response photosensitizer delivery system (HA@mpg-C3 N4 -HMME/CAT)...
April 10, 2018: Colloids and Surfaces. B, Biointerfaces
Chaoyu Liang, Heping Wang, Min Zhang, Wei Cheng, Zihuang Li, Junpeng Nie, Gan Liu, Daizheng Lian, Zhenhua Xie, Laiqiang Huang, Xiaowei Zeng
Oxaliplatin is a promising antitumor drug, but its effectiveness is limited by its side effects in vivo. In this study, we introduced an Oxaliplatin prodrug (Oxa(IV)) self-controlled release strategy, in which Oxa(IV) is encapsulated by TPGS functionalized mesoporous silica nanoparticles (MSNs), and its release is controlled by biological stimuli, such as acidic environments in tumor tissue and high concentrations of reductants in cancer cells. Despite the lack of auxiliary "gatekeepers" to MSNs, this simplified model of Oxa(IV)-MSNs-TPGS could fine-tune the movements of the drug release...
April 16, 2018: Journal of Colloid and Interface Science
Nele-Johanna Hempel, Katharina Brede, Niels Erik Olesen, Natalja Genina, Matthias Manne Knopp, Korbinian Löbmann
The aim of this study was to introduce a fast and reliable differential scanning calorimetry (DSC)-based method to determine the monomolecular loading capacity of drugs with good glass-forming ability in mesoporous silica (MS). The proposed method is based on a solvent-free melting/fusion of drug into the MS during a heat-cool-heat cycle in the DSC. Overloaded drug-MS systems were analyzed in the DSC at different drug ratios (50, 60, 70, 80 and 90% w/w) to quantify the excess drug in the (the fraction not adsorbed to the MS surface)...
April 18, 2018: International Journal of Pharmaceutics
Seyyed Pouya Hadipour Moghaddam, Mostafa Yazdimamaghani, Hamidreza Ghandehari
Tunable glutathione (GSH)-sensitive hollow mesoporous silica nanoparticles (HMSiO2 NPs) were developed using a structural difference-based selective etching strategy. These organosilica hollow nanoparticles contained disulfide linkages (S-S) in the outer shell which were degraded by GSH. The particles were compared with their nonGSH-sensitive tetraethyl orthosilicate (TEOS) HMSiO2 counterparts in terms of their synthesis method, characterization, DOX release profile, and in vitro cytotoxicity in MCF-7 breast cancer cells...
April 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Simon Krause, Volodymyr Bon, Irena Senkovska, Daniel M Többens, Dirk Wallacher, Renjith S Pillai, Guillaume Maurin, Stefan Kaskel
Negative gas adsorption (NGA) in ordered mesoporous solids is associated with giant contractive structural transitions traversing through metastable states. Here, by systematically downsizing the crystal dimensions of a mesoporous MOF (DUT-49) from several micrometers to less than 200 nm, counterintuitive NGA phenomena are demonstrated to critically depend on the primary crystallite size. Adsorbing probe molecules, such as n-butane or nitrogen, gives insights into size-dependent activation barriers and thermodynamics associated with guest-induced network contraction...
April 20, 2018: Nature Communications
M Usman Munir, Ayesha Ihsan, Yasra Sarwar, Sadia Zafar Bajwa, Khizra Bano, Bushra Tehseen, Neelam Zeb, Irshad Hussain, M Tayyab Ansari, Madiha Saeed, Juan Li, M Zubair Iqbal, Aiguo Wu, Waheed S Khan
We report the development of effective drug loaded nanocarriers to combat multidrug resistant infection especially in case of osteomyelitis. The hollow mesoporous hydroxyapatite nanoparticles (hmHANPs) and solid/non-hollow hydroxyapatite nanoparticles (sHANPs) were synthesized by core-shell and co-precipitation techniques respectively. High encapsulation of the drug (ciprofloxacin) was observed in hmHANPs as compared to sHANPs, which may be due to the hollow porous structure of hmHANPs. These nanoparticles were characterized by scanning electron microscope (FESEM), N2 adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Thermogravimetric analysis (TGA)...
April 17, 2018: International Journal of Pharmaceutics
Yulei Yin, Yuan Gao, Aimin Li
Biochar samples with controllable specific surface area and mesopore ratio were self-activated from furfural residues by recycled pyrolysis gas. The objective of this study was to develop a new cyclic utilization method for the gas produced by pyrolysis. The influences of preparation parameters on the resulting biochar were studied by varying the pyrolysis-gas flow rate, activation time and temperature. Structural characterization of the produced biochar was performed by analysis of nitrogen adsorption isotherms at 77 K and scanning electron microscope (SEM)...
April 17, 2018: Waste Management
Youngsoo Ro, Min Yeoung Gim, Jong Won Lee, Eo Jin Lee, In Kyu Song
A serious of mesoporous La-zeolite X catalysts (La-x-Zeol X (x = 0, 0.25, 0.5, 0.75, 1.0, and 2.0)) were prepared by a hydrothermal method with a variation of carbon template content (x, wt%). The prepared catalysts were applied to the isobutane/2-butene alkylation. Mesopore volume of the catalysts increased with increasing carbon template content, while acidity of the catalysts decreased with increasing carbon template content. In the catalytic reaction, productivity of C8 alkylate (C8 alkylate g/g-catalyst) and selectivity for C8 alkylate showed volcano-shaped trends with respect to carbon template content...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Jungwon Heo, Ying Liu, Anupriya K Haridas, Jinwoo Jeon, Xiaohui Zhao, Kwon-Koo Cho, Hyo-Jun Ahn, Younki Lee, Jou-Hyeon Ahn
Recently, tin oxide (SnO2) has received significant attention for use as an anode material for next generation lithium-ion batteries (LIBs) owing to its high theoretical capacity (782 mAh g-1), which is more than twice of that of the commercialized graphite (372 mAh g-1). Several additional advantages, such as low cost, environmental friendliness, easy fabrication and natural abundance improve its promise. Although the theoretical capacity of SnO2 is high, volume expansion during cycling causes issue with cycling stability...
September 1, 2018: Journal of Nanoscience and Nanotechnology
No-Kuk Park, Yong Han Jeong, Misook Kang, Tae Jin Lee
The catalytic activity of a macro-mesoporous catalyst coated on a metal foam plate in the reforming of bio-ethanol to synthesis gas was investigated. The catalysts were prepared by coating a support with a noble metal and transition metal. The catalytic activity for the production of synthetic gas by the reforming of bio-ethanol was compared according to the support material, reaction temperature, and steam/carbon ratio. The catalysts coated on the metal foams were prepared using a template method, in which macro-pores and meso-pores were formed by mixing polymer beads...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Young-Min Kim, Gwang Hoon Rhee, Chang Hyun Ko, Ki Hoon Kim, Kyeong Youl Jung, Ji Man Kim, Young-Kwon Park
The thermal and catalytic pyrolysis of Pinus densiflora (P. densiflora) were performed to test the catalytic cracking efficiency of two mesoporous Al2O3 catalysts with different surface areas. Thermogravimetric analysis (TGA) of P. densiflora showed that the differential TG (DTG) peak heights obtained from catalytic pyrolysis were smaller than those of non-catalytic pyrolysis due to the conversion of the reaction intermediates to coke. Pyrolyzer-gas chromatography/mass spectrometry analysis/flame ionization detection (Py-GC/MS/FID) suggested that using the Al2O3 catalysts, the yields of phenols and levoglucosan decreased with a concomitant increase in the yields of aldehydes, alcohol, ketones, and furans...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Chencheng Hu, Zhengran Yi, Wanxin She, Juan Wang, Junwu Xiao, Shuai Wang
We successfully design and construct urchin-like non-precious-metal bifunctional oxygen electrocatalysts via a two-step pyrolysis process, where nitrogen, sulfur co-doped carbon nanotube frameworks are grafted onto mesoporous cobalt sulfide/nitrogen, sulfur co-doped carbon spheres. The urchin-like structure grants large electrochemically active area, good electron and mass transfer capability, as well as excellent structural stability. Nitrogen, sulfur co-doped carbon can synergistically enhance the catalytic activity of cobalt sulfide sites, and also contribute to the exposure of heteroatom-induced active sites, such as, pyridinic N, graphitic N, and C-S-C...
April 13, 2018: Journal of Colloid and Interface Science
Manik Mandal, George Farid, Michal Kruk
Bridged-organosilica nanotubes with a variety of bridging groups (methylene, ethylene, ethenylene, phenylene and p-xylylene) were synthesized using swollen mixtures of Pluronic triblock copolymer surfactants as micellar templates. The mixtures consisted of Pluronic F127 surfactant (EO106 PO70 EO106 ) with long poly(ethylene oxide), PEO, blocks, which help prevent the formation of consolidated structures, and another Pluronic with shorter PEO blocks and higher poly(propylene oxide) content, which promote swelling and the cylindrical micelle morphology...
April 4, 2018: Journal of Colloid and Interface Science
Jinsuo Gao, Shouchun Wu, Yanling Han, Feng Tan, Yong Shi, Mengyao Liu, Xinyong Li
Increasing the amount of surface active sites of the material may be a feasible way to improve the efficiency ofthe generation of Fe2+ in the photo-Fenton process. In this work, a simple synthesis method was adopted to synthesize 3D ordered mesoporous CuFe2 O4 with large specific surface areaby using ferric nitrate and copper nitrate as the precursor and KIT-6 as the template. The synthesized materials were characterized by nitrogen adsorption-desorption, XRD, TEM, FT-IR and UV-vis DRS. The catalytic properties of the mesoporous material were thoroughly evaluated by activating hydrogen peroxide to remove sulfonamides in near neutral water...
April 1, 2018: Journal of Colloid and Interface Science
Xin Li, Xiaoguo Ma, Renfeng Huang, Xiaowen Xie, Lihui Guo, Menyuan Zhang
Atrazine contamination of water is of considerable concern because of the potential hazard to human health. In this study, a magnetic molecularly imprinted polymer for atrazine was prepared by the surface imprinting technique using Fe3 O4 as the core, mesoporous silica as the carrier, atrazine as the template and itaconic acid as the functional monomer. The magnetic molecularly imprinted polymer was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction and vibration sample magnetometry...
April 20, 2018: Journal of Separation Science
Lixiao Wang, Yiling Lou, Hong Zhu, Qian Huang, Lingdan Yao, Liping Lou, Qi Lin
The application of carbonized materials (CMs) from solid wastes for the control of hydrophobic organic contaminants is a promising way to treat wastes. In this paper, the physicochemical properties of CMs prepared from industry (fly ash and sewage sludge), plant (rice straw and bamboo fragments), and livestock (chicken manure) were analyzed, their adsorption capacities for nonylphenol were studied, and the relationship between the adsorption capacity and the physicochemical properties of different types of CMs was investigated...
April 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Gui-Bing Hu, Cheng-Yi Xiong, Wen-Bin Liang, Xiao-Shan Zeng, Hui-Ling Xu, Yang Yang, Li-Ying Yao, Ruo Yuan, Dong-Rong Xiao
In this work, a novel mesoporous luminescence-functionalized metal-organic framework (Ru-PCN-777) with high stability and excellent electrochemiluminescence (ECL) performance was synthesized by immobilizing Ru(bpy)2(mcpbpy)2+ on the Zr6 cluster of PCN-777 via a strong coordination bond between Zr4+ and -COO-. Consequently, the Ru(bpy)2(mcpbpy)2+ could not only cover the surface of PCN-777, but also grafted into the interior of PCN-777, which greatly increased the loading amount of Ru(bpy)2(mcpbpy)2+ and effectively prevented the leaching of the Ru(bpy)2(mcpbpy)2+ resulting in a stable and high ECL response...
April 20, 2018: ACS Applied Materials & Interfaces
Wei-Qi Wang, Xiu-Li Wang, Xin-Hui Xia, Zhu-Jun Yao, Yu Zhong, Jiang-Ping Tu
Construction of multifunctional photoelectrochemical energy devices is of great importance to energy saving. In this study, we have successfully prepared a mesoporous WO3 film on FTO glass via a facile dip-coating sol-gel method; the designed mesoporous WO3 film exhibited advantages including high transparency, good adhesion and high porosity. Also, multifunctional integrated energy storage and optical modulation ability are simultaneously achieved by the mesoporous WO3 film. Impressively, the mesoporous WO3 film exhibits a noticeable electrochromic energy storage performance with a large optical modulation up to 75...
April 20, 2018: Nanoscale
Jixin Yao, Kang Zhang, Wen Wang, Xueqin Zuo, Qun Yang, Huaibao Tang, Mingzai Wu, Guang Li
Excellent corrosion resistance is crucial for photovoltaic devices to acquire high and stable performance under high corrosive complicated environments. Creative inspiration comes from sandwich construction, whereby Fe3O4 nanoparticles were anchored onto hollow core-shell carbon mesoporous microspheres and wrapped by N-graphene nanosheets (HCCMS/Fe3O4@N-RGO) to obtain integrated high corrosive resistance and stability. The as-prepared multiple composite material possesses outstanding performance as a result of structure optimization, performance improvement, and interface synergy...
April 20, 2018: Nanoscale
Ruijun Pan, Xingxing Xu, Rui Sun, Zhaohui Wang, Jonas Lindh, Kristina Edström, Maria Strømme, Leif Nyholm
Poor cycling stability and safety concerns regarding lithium (Li) metal anodes are two major issues preventing the commercialization of high-energy density Li metal-based batteries. Herein, a novel tri-layer separator design that significantly enhances the cycling stability and safety of Li metal-based batteries is presented. A thin, thermally stable, flexible, and hydrophilic cellulose nanofiber layer, produced using a straightforward paper-making process, is directly laminated on each side of a plasma-treated polyethylene (PE) separator...
April 19, 2018: Small
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