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https://www.readbyqxmd.com/read/28636572/mood-symptoms-in-stabilized-patients-with-schizophrenia-a-bipolar-type-with-predominant-psychotic-features
#1
Konstantinos N Fountoulakis, Dina Popovic, Mariela Mosheva, Melina Siamouli, Katerina Moutou, Xenia Gonda
BACKGROUND: Schizophrenia (SZ) and bipolar disorder (BD) are traditionally distinguished on the basis of progressive deterioration and long-term outcome, but a more dimensional approach is warranted. There are limited data on the occurrence of manic symptoms in patients with schizophrenia. The aim of the current study was to search for patterns in the clinical symptomatology, which may suggest the presence of one or several mood disorders under the label of schizophrenia. SUBJECTS AND METHODS: Hundred-seventy-five patients diagnosed with schizophrenia according to DSM-5 were included in the study...
June 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28630926/vasculogenic-hydrogel-enhances-islet-survival-engraftment-and-function-in-leading-extrahepatic-sites
#2
Jessica D Weaver, Devon M Headen, Jahizreal Aquart, Christopher T Johnson, Lonnie D Shea, Haval Shirwan, Andrés J García
Islet transplantation is a promising alternative therapy for insulin-dependent patients, with the potential to eliminate life-threatening hypoglycemic episodes and secondary complications of long-term diabetes. However, widespread application of this therapy has been limited by inadequate graft function and longevity, in part due to the loss of up to 60% of the graft in the hostile intrahepatic transplant site. We report a proteolytically degradable synthetic hydrogel, functionalized with vasculogenic factors for localized delivery, engineered to deliver islet grafts to extrahepatic transplant sites via in situ gelation under physiological conditions...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28629762/targeting-the-tumor-and-its-associated-stroma-one-and-one-can-make-three-in-adoptive-t-cell-therapy-of-solid-tumors
#3
Anna Mondino, Gerlanda Vella, Laura Icardi
Adoptive T cell therapy (ACT) has become a promising immunotherapeutic option for cancer patients. The proof for ACT therapeutic efficacy was first obtained with allogenic T cells and then reproduced with T cells isolated from patients' tumor samples (i.e. tumor-infiltrating lymphocytes). It is now clear that specificity of ACT products can be educated by genetically engineering T cells with classical T Cell Receptors (TCR) or chimeric antigen receptors (CAR). To date a poor accessibility of the tumor mass and a hostile microenvironment, influenced by genetic and epigenetic instability, mainly limit ACT therapeutic efficacy in the case of solid tumors...
June 15, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28629470/policy-lessons-from-health-taxes-a-systematic-review-of-empirical-studies
#4
Alexandra Wright, Katherine E Smith, Mark Hellowell
BACKGROUND: Taxes on alcohol and tobacco have long been an important means of raising revenues for public spending in many countries but there is increasing interest in using taxes on these, and other unhealthy products, to achieve public health goals. We present a systematic review of the research on health taxes, and aim to generate insights into how such taxes can: (i) reduce consumption of targeted products and related harms; (ii) generate revenues for health objectives and distribute the tax burden across income groups in an efficient and equitable manner; and (iii) be made politically sustainable...
June 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28622045/age-related-characteristics-of-outpatients-with-anxiety-disorders-the-leiden-routine-outcome-monitoring-study
#5
Anke Schat, Martijn S van Noorden, Therese van Amelsvoort, Erik J Giltay, Nic J A van der Wee, Marc J Noom, Robert R J M Vermeiren, Frans G Zitman
OBJECTIVE: It has been hypothesised that clinically important age-related differences between adults with anxiety disorders exist; this study aims to elucidate these differences. METHODS: We analysed data from 1950 outpatients diagnosed with DSM-IV-TR anxiety disorders treated at a Dutch hospital or affiliated mental healthcare centres. Three age-groups (young- (18-25; n = 435), mid- (26-40; n = 788) and older adult (41-65; n = 727)) were compared with regard to social demographic characteristics, diagnostic characteristics, anxiety symptom profile, general psychiatric symptom profile and generic health status, in addition, linear analyses were carried out with age as a continuous variable...
June 16, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28615674/meta-analysis-of-genome-wide-snp-and-pathway-based-associations-for-facets-of-neuroticism
#6
Song E Kim, Han-Na Kim, Yeo-Jun Yun, Seong Gu Heo, Juhee Cho, Min-Jung Kwon, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Chol Shin, Nam H Cho, Yeon Ah Sung, Hyung-Lae Kim
Neuroticism is a heritable personality trait that is comprised of distinct sub-factors, or facets. Sub-factors of neuroticism are linked to different emotional states or psychiatric symptoms and studying the genetic variants associated with these facets may help reveal the biological mechanisms underlying psychiatric disorders. In the present study, a meta-analysis of genome-wide association studies for six facets of neuroticism was performed in 5584 participants from three cohorts. Additionally, a Gene Set Enrichment Analysis was conducted to find biological pathways associated with each facet...
June 15, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28614535/should-azoospermic-patients-with-varicocele-disease-undergo-surgery-to-recover-fertility
#7
Leonardo de Souza Alves, Francisco Batista de Oliveira
Introduction: Varicocele disease is well-known cause of infertility in men. The presence of spermatic varices veins create a hostile environment to spermatogenesis. It results in reduced quality of the sperm production and in some cases can determine a total absence of sperm. The varicocelectomy procedure in patients with non-obstructive azoospermia (NOA) can raise the rates of sperm in the semen analysis. A positive rate for sperm, even if very low, may be sufficient to enable the capture of sperm intended for in-vitro fertilization without the use of donor sperm...
April 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28612145/transanal-hartmann-s-colostomy-reversal-assisted-by-laparoscopy-outcomes-of-the-first-10-patients
#8
Jean-Sébastien Trépanier, María Clara Arroyave, Raquel Bravo, Marta Jiménez-Toscano, Francisco B DeLacy, María Fernandez-Hevia, Antonio M Lacy
INTRODUCTION: Restoration of intestinal continuity after Hartmann's procedure is a technically difficult surgery associated with significant morbidity and mortality. This study presents the short-term results of a new approach: a transanal Hartmann's colostomy reversal assisted by laparoscopy. METHOD: This is a retrospective analysis of data collected in one tertiary hospital, from October 2013 to November 2015. RESULTS: During the study period, there were ten cases of transanal Hartmann's reversal...
June 13, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28609625/conformational-dynamics-of-the-lipopolysaccharide-from-escherichia-coli-o91-revealed-by-nmr-spectroscopy-and-molecular-simulations
#9
Pilar Blasco, Dhilon S Patel, Olof Engström, Wonpil Im, Göran Widmalm
The outer leaflet of the outer membrane in gram-negative bacteria contains lipopolysaccharides (LPS) as a major component, and the outer membrane provides a physical barrier and protection against hostile environments. The enterohemorrhagic E. coli of serogroup O91 has an O-antigen polysaccharide (PS) with five sugar residues in the repeating unit (RU) and the herein studied O-antigen PS contains ~10 RUs. 1H,13C-HSQC-NOESY experiments on a [1-13C]-labeled PS were employed to deduce 1H,1H cross-relaxation rates and transglycosidic 3JCH related to the  torsional angles...
June 13, 2017: Biochemistry
https://www.readbyqxmd.com/read/28604800/characterising-variation-in-wheat-traits-under-hostile-soil-conditions-in-india
#10
Jaswant S Khokhar, Sindhu Sareen, Bhudeva S Tyagi, Gyanendra Singh, Apurba K Chowdhury, Tapamay Dhar, Vinod Singh, Ian P King, Scott D Young, Martin R Broadley
Intensive crop breeding has increased wheat yields and production in India. Wheat improvement in India typically involves selecting yield and component traits under non-hostile soil conditions at regional scales. The aim of this study is to quantify G*E interactions on yield and component traits to further explore site-specific trait selection for hostile soils. Field experiments were conducted at six sites (pH range 4.5-9.5) in 2013-14 and 2014-15, in three agro-climatic regions of India. At each site, yield and component traits were measured on 36 genotypes, representing elite varieties from a wide genetic background developed for different regions...
2017: PloS One
https://www.readbyqxmd.com/read/28604632/experimental-autoimmune-encephalomyelitis-eae-induced-elevated-expression-of-the-e1-isoform-of-methyl-cpg-binding-protein-2-mecp2e1-implications-in-multiple-sclerosis-ms-induced-neurological-disability-and-associated-myelin-damage
#11
Tina Khorshid Ahmad, Ting Zhou, Khaled AlTaweel, Claudia Cortes, Ryan Lillico, Ted Martin Lakowski, Kiana Gozda, Michael Peter Namaka
Multiple sclerosis (MS) is a chronic neurological disease characterized by the destruction of central nervous system (CNS) myelin. At present, there is no cure for MS due to the inability to repair damaged myelin. Although the neurotrophin brain derived neurotrophic factor (BDNF) has a beneficial role in myelin repair, these effects may be hampered by the over-expression of a transcriptional repressor isoform of methyl CpG binding protein 2 (MeCP2) called MeCP2E1. We hypothesize that following experimental autoimmune encephalomyelitis (EAE)-induced myelin damage, the immune system induction of the pathogenic MeCP2E1 isoform hampers the myelin repair process by repressing BDNF expression...
June 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28604105/the-relations-of-child-adiposity-with-parent-to-child-and-parent-to-parent-hostility
#12
Michael F Lorber, Mandi L White-Ajmani, Denise Dixon, Amy M S Slep, Richard E Heyman
OBJECTIVE: Investigate (1) the association of child adiposity with parent-to-child and parent-to-parent hostility, (2) the mediation of these associations by dietary behaviours and (3) moderation by gender. DESIGN: One hundred thirty-five couples with 6- to 14-year-old children completed measures of emotional and physical aggression, overreactive discipline and child diet. Parent-to-parent hostility was also coded from laboratory observations. MAIN OUTCOME MEASURE: Child adiposity was a combination of body mass index and waist-to-hip ratio...
June 11, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28596180/the-non-combatant-status-importance-and-implications-for-medical-personnel
#13
EDITORIAL
Daniel Wilkins, C Dieppe
Under the laws of armed conflict military medics are deemed non-combatants, and as such are subject to certain protections and limitations. The non-combatant status is defined in the famous Geneva Conventions, which form the basis of the international law of armed conflict. The protections afforded to medical personnel in armed conflict are a result of the need to protect and treat the sick and injured during times of hostility. This paper describes the history and legal development of the non-combatant status, and summarises the importance and implications of the contents of the Geneva Conventions that are relevant to medical personnel as non-combatants...
June 8, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28594372/purine-acquisition-and-synthesis-by-human-fungal-pathogens
#14
REVIEW
Jessica L Chitty, James A Fraser
While members of the Kingdom Fungi are found across many of the world's most hostile environments, only a limited number of species can thrive within the human host. The causative agents of the most common invasive fungal infections are Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans. During the infection process, these fungi must not only combat the host immune system while adapting to dramatic changes in temperature and pH, but also acquire sufficient nutrients to enable growth and dissemination in the host...
June 8, 2017: Microorganisms
https://www.readbyqxmd.com/read/28592908/-how-do-polish-workers-respond-to-the-information-concerning-health-oriented-lifestyle
#15
Elżbieta Korzeniowska, Krzysztof Puchalski
BACKGROUND: Information overload, including commercial ones, about healthy lifestyle, is a challenge for perception of health education. MATERIAL AND METHODS: The empirical data gathered from 100 employees in 2010 by means of free interviews with a standardized list of required information, aimed at analyzing a feeling of pressure to lead a healthy lifestyle, including reactions to meassages provided by the media. RESULTS: Respondents feel pressure associated with a healthy lifestyle from doctors, the state, relatives, friends and themselves...
June 8, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28589674/differences-in-the-early-stages-of-social-information-processing-for-adolescents-involved-in-bullying
#16
Alexa Guy, Kirsty Lee, Dieter Wolke
Bullying victimization has commonly been associated with deficiencies in social information processing (SIP). In contrast, findings regarding bullying perpetration are mixed, with some researchers claiming that bullies may have superior SIP abilities than victimized or uninvolved youth. This study investigated the effects of bullying and victimization on early SIP; specifically the recognition and interpretation of social information. In stage 1, 2,782 adolescents (11-16 years) were screened for bullying involvement, and in stage 2, 723 of these participants (mean age = 13...
June 7, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28588894/aetiological-pathways-to-borderline-personality-disorder-symptoms-in-early-adolescence-childhood-dysregulated-behaviour-maladaptive-parenting-and-bully-victimisation
#17
Catherine Winsper, James Hall, Vicky Y Strauss, Dieter Wolke
BACKGROUND: Developmental theories for the aetiology of Borderline Personality Disorder (BPD) suggest that both individual features (e.g., childhood dysregulated behaviour) and negative environmental experiences (e.g., maladaptive parenting, peer victimisation) may lead to the development of BPD symptoms during adolescence. Few prospective studies have examined potential aetiological pathways involving these two factors. METHOD: We addressed this gap in the literature using data from the Avon Longitudinal Study of Parents and Children (ALSPAC)...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28587285/study-on-an-indoor-positioning-system-for-harsh-environments-based-on-wi-fi-and-bluetooth-low-energy
#18
Gabriel de Blasio, Alexis Quesada-Arencibia, Carmelo R García, Jezabel Miriam Molina-Gil, Cándido Caballero-Gil
This paper presents a study of positioning system that provides advanced information services based on Wi-Fi and Bluetooth Low Energy (BLE) technologies. It uses Wi-Fi for rough positioning and BLE for fine positioning. It is designed for use in public transportation system stations and terminals where the conditions are "hostile" or unfavourable due to signal noise produced by the continuous movement of passengers and buses, data collection conducted in the constant presence thereof, multipath fading, non-line of sight (NLOS) conditions, the fact that part of the wireless communication infrastructure has already been deployed and positioned in a way that may not be optimal for positioning purposes, variable humidity conditions, etc...
June 6, 2017: Sensors
https://www.readbyqxmd.com/read/28586715/hostility-predicts-alcohol-consumption-over-a-21-year-follow-up-in-the-gazel-cohort
#19
Guillaume Airagnes, Cédric Lemogne, Alice Gueguen, Nicolas Hoertel, Marcel Goldberg, Frédéric Limosin, Marie Zins
BACKGROUND: Hostility has been found to be positively associated with alcohol intake in cross-sectional studies. Our aim was to examine prospectively the long-lasting association of hostility with alcohol consumption. METHODS: We included 10,612 men and 3834 women from the French Gazel cohort with mean ages in 1993 of 48.6 (SD=2.9) and 45.7(SD=4.2), respectively. Hostility (i.e., total, cognitive and behavioral) was assessed in 1993 with the Buss and Durkee Hostility Inventory...
May 30, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28585591/current-status-of-helicobacter-pylori-association-with-haematological-and-cardiovascular-diseases-a-mini-review
#20
Jibran Sualeh Muhammad, Syed Faisal Zaidi, Sheikh Abdul Saeed, Muhammad Ishaq
Helicobacter pylori infection is considered the most commonly prevalent gastrointestinal pathogen where it manages to survive despite the hostile environment of human stomach, leading to various gastric diseases including gastric cancer. Due to the chronic inflammatory state induced by H. pylori and its interaction with host immune system have diverted researchers to investigate its correlation with systemic diseases outside of the gastrointestinal tract. This literature review was done to explore the association of H...
June 2017: JPMA. the Journal of the Pakistan Medical Association
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