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https://www.readbyqxmd.com/read/28449098/insights-on-persistent-airway-infection-by-nontypeable-haemophilus-influenzae-in-chronic-obstructive-pulmonary-disease
#1
Christian P Ahearn, Mary C Gallo, Timothy F Murphy
Nontypeable Haemophilus influenzae (NTHi) is the most common bacterial cause of infection of the lower airways in adults with chronic obstructive pulmonary disease (COPD). Infection of the COPD airways causes acute exacerbations, resulting in substantial morbidity and mortality. NTHi has evolved multiple mechanisms to establish infection in the hostile environment of the COPD airways, allowing the pathogen to persist in the airways for months to years. Persistent infection of the COPD airways contributes to chronic airway inflammation that increases symptoms and accelerates the progressive loss of pulmonary function, which is a hallmark of the disease...
April 25, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28445142/potential-biomarkers-of-dna-replication-stress-in-cancer
#2
Liqun Ren, Long Chen, Wei Wu, Lorenza Garribba, Huanna Tian, Zihui Liu, Ivan Vogel, Chunhui Li, Ian D Hickson, Ying Liu
Oncogene activation is an established driver of tumorigenesis. An apparently inevitable consequence of oncogene activation is the generation of DNA replication stress (RS), a feature common to most cancer cells. RS, in turn, is a causal factor in the development of chromosome instability (CIN), a near universal feature of solid tumors. It is likely that CIN and RS are mutually reinforcing drivers that not only accelerate tumorigenesis, but also permit cancer cells to adapt to diverse and hostile environments...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28444004/relation-between-hiv-status-risky-sexual-behavior-and-mental-health-in-an-msm-sample-from-three-chilean-cities
#3
Fabiola Gómez, Jaime Barrientos, Manuel Cárdenas
Objective: To explore the association among HIV status; negative psychological symptoms (anxiety, depression, and hostility); and risky sexual behaviors (multiple sexual partners and unprotected sexual intercourse) in a Chilean sample of men who have sex with men (MSM). Methods: This study had a cross-sectional design and a sample of 325 MSM whose ages ranged from 18 to 64 years (mean: 30.8; standard deviation: 9.8). Association tests (chi-squared) and group mean comparisons (Student's t-tests and F-tests) were performed...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28442849/operative-management-of-enteroatmospheric-fistula-in-bj%C3%A3-rck-4-open-abdomen-patients-by-the-help-of-laparoscopic-lateral-approach
#4
Fahri Yetişir, A Ebru Sarer
As the open abdomen (OA) management increases, the number of fistula formation has also been increasing during the last two decades. These fistulas in OA have been defined as enteroatmospheric fistula (EAF). EAF occurring in a frozen OA is classified as Björck 4 OA. Management of Björck 4 OA patient is not easy and mortality of these patients is very high in spite of the presence of modern treatment modalities. There are a few surgical approaches for treatment of Björck 4 OA patients. One of them is excising the hostile segment by lateral abdominal approach from the healthy side or entering from lateral border of OA wound after enough time intervals for subsiding of the edematous intestine in acute inflammatory reaction in the hostile environment...
April 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28442248/social-environments-and-interpersonal-distance-regulation-in-psychosis-a-virtual-reality-study
#5
Chris N W Geraets, Marije van Beilen, Roos Pot-Kolder, Jacqueline Counotte, Mark van der Gaag, Wim Veling
BACKGROUND: Experimentally studying the influence of social environments on mental health and behavior is challenging, as social context is difficult to standardize in laboratory settings. Virtual Reality (VR) enables studying social interaction in terms of interpersonal distance in a more ecologically valid manner. Regulation of interpersonal distance may be abnormal in patients with psychotic disorders and influenced by environmental stress, symptoms or distress. AIMS: To investigate interpersonal distance in people with a psychotic disorder and at ultrahigh risk for psychosis (UHR) compared to siblings and controls in virtual social environments, and explore the relationship between clinical characteristics and interpersonal distance...
April 22, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28441722/experimental-demonstration-and-circuitry-for-a-very-compact-coil-only-pulse-echo-emat
#6
Dirk Rueter
This experimental study demonstrates for the first time a solid-state circuitry and design for a simple compact copper coil (without an additional bulky permanent magnet or bulky electromagnet) as a contactless electromagnetic acoustic transducer (EMAT) for pulse echo operation at MHz frequencies. A pulsed ultrasound emission into a metallic test object is electromagnetically excited by an intense MHz burst at up to 500 A through the 0.15 mm filaments of the transducer. Immediately thereafter, a smoother and quasi "DC-like" current of 100 A is applied for about 1 ms and allows an echo detection...
April 22, 2017: Sensors
https://www.readbyqxmd.com/read/28441642/first-in-man-percutaneous-transaxillary-artery-placement-and-removal-of-the-impella-5-0-mechanical-circulatory-support-device
#7
Kenta Nakamura, Sandeep Krishnan, Claudius Mahr, James M McCabe
We report on the fully percutaneous insertion and removal of the Impella 5.0 microaxial flow device via the axillary artery in a patient with cardiogenic shock and peripheral artery disease. Due to inadequate iliofemoral vasculature and desire for mobility, the axillary artery was felt to be the most appropriate access approach for temporary mechanical circulatory support. The procedure was well tolerated and the patient was supported for 17 days, at which time the device was safely removed in a fully percutaneous manner at the time of permanent left ventricular assist device placement...
May 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28441328/a-gradient-field-pulsed-eddy-current-probe-for-evaluation-of-hidden-material-degradation-in-conductive-structures-based-on-lift-off-invariance
#8
Yong Li, Haoqing Jing, Ilham Mukriz Zainal Abidin, Bei Yan
Coated conductive structures are widely adopted in such engineering fields as aerospace, nuclear energy, etc. The hostile and corrosive environment leaves in-service coated conductive structures vulnerable to Hidden Material Degradation (HMD) occurring under the protection coating. It is highly demanded that HMD can be non-intrusively assessed using non-destructive evaluation techniques. In light of the advantages of Gradient-field Pulsed Eddy Current technique (GPEC) over other non-destructive evaluation methods in corrosion evaluation, in this paper the GPEC probe for quantitative evaluation of HMD is intensively investigated...
April 25, 2017: Sensors
https://www.readbyqxmd.com/read/28440973/histochemical-and-immunohistochemical-study-of-%C3%AE-sma-collagen-and-pcna-in-epithelial-ovarian-neoplasm
#9
Nungki Anggorowati, Chatarina Ratna Kurniasari, Karina Damayanti, Titik Cahyanti, Irianiwati Widodo, Ahmad Ghozali, Muhammad Mansyur Romi, Dwi Cahyani Ratna Sari, Nur Arfian
Background: Alpha-smooth muscle actin (α-SMA) is an isoform of actin, positive in myofibroblasts and is an epithelial to mesenchymal transition (EMT) marker. EMT is a process by which tumor cells develop to be more hostile and able to metastasize. Progression of tumor cells is always followed by cell composition and extracellular matrix component alteration. Increased α-SMA expression and collagen alteration may predict the progressivity of ovarian neoplasms. Objective: The aim of this research was to analyse the characteristic of α-SMA and collagen in tumor cells and stroma of ovarian neoplasms...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28438250/new-validity-evidence-of-the-parent-parq-control-scale-of-parental-educational-styles
#10
Omar García-Pérez, Mercedes Inda-Caro, Susana Torío-López
BACKGROUND: The Parent PARQ/Control (short version) for mothers and fathers is an inventory of 29 items where parents record their acceptance-rejection and control behaviors towards their children. Despite vast research on IPARQTheory, it has yet to be vali-dated for a Spanish population. The goal of this study is to analyze the psychometric properties of the instrument and its factorial structure. METHOD: Participants were 4,168 parents from the Principality of Asturias (2,166 mothers and 2,002 fathers)...
May 2017: Psicothema
https://www.readbyqxmd.com/read/28436272/moderation-of-the-effects-of-discrimination-induced-affective-responses-on-health-outcomes
#11
Meg Gerrard, Frederick X Gibbons, Mary E Fleischli, Carolyn E Cutrona, Michelle L Stock
OBJECTIVE: The goal of the study was to examine differential mediation of long-term effects of discrimination on health behaviour and health status by internalising (anxiety and depression) and externalising (hostility and anger), and to explore moderation of these effects, specifically, by the presence of support networks and coping tendencies. DESIGN: The current analyses employed structural equation modelling of five waves of data from Black female participants of the Family and Community Health Study over 11 years (M age 37-48)...
April 23, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28431107/double-fixation-for-abdominal-aortic-aneurysm-repair-using-afx-body-and-endurant-proximal-aortic-cuff-mid-term-results
#12
Miltiadis I Matsagkas, George Kouvelos, Konstantinos Spanos, Athanasios Athanasoulas, Athanasios Giannoukas
Our goal was to evaluate the use of an AFX main body combined with an Endurant proximal aortic cuff to treat selected patients with an abdominal aortic aneurysm (AAA) associated with anatomical challenges, such as a small distal aortic diameter and a hostile aortic neck. A retrospective analysis of prospectively collected data from 2 vascular institutions identified 14 elective patients with an AAA (all men, 73.5 ± 5.1 years) treated with the AFX main body combined with an Endurant proximal aortic cuff...
April 17, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28427482/a-genetic-variant-brain-dervied-neurotrophic-factor-bdnf-polymorphism-interacts-with-hostile-parenting-to-predict-error-related-brain-activity-and-thereby-risk-for-internalizing-disorders-in-children
#13
Alexandria Meyer, Greg Hajcak, Elizabeth Hayden, Haroon I Sheikh, Shiva M Singh, Daniel N Klein
The error-related negativity (ERN) is a negative deflection in the event-related potential occurring when individuals make mistakes, and is increased in children with internalizing psychopathology. We recently found that harsh parenting predicts a larger ERN in children, and recent work has suggested that variation in the brain-derived neurotrophic factor (BDNF) gene may moderate the impact of early life adversity. Parents and children completed measures of parenting when children were 3 years old (N = 201); 3 years later, the ERN was measured and diagnostic interviews as well as dimensional symptom measures were completed...
April 21, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28423356/knockdown-of-mir-27a-sensitizes-colorectal-cancer-stem-cells-to-trail-by-promoting-the-formation-of-apaf-1-caspase-9-complex
#14
Rui Zhang, Jian Xu, Jian Zhao, Jinghui Bai
MicroRNAs have been proved to participate in multiple biological processes in cancers. For developing resistance to cytotoxic drug, cancer cells, especially the cancer stem cells, usually change their microRNA expression profile to survive in hostile environments. In the present study, we found that expression of microRNA-27a was increased in colorectal cancer stem cells. High level of microRNA-27a was indicated to induce the resistance to TNF-related apoptosis-inducing ligand (TRAIL). Knockdown of microRNA-27a resensitized colorectal cancer stem cells to TRAIL-induced cell death...
April 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422297/piecing-together-the-aggression-puzzle-testing-the-mediating-variables-linking-early-to-later-aggression
#15
Christopher P Barlett, Kaitlyn M Helmstetter, Douglas A Kowalewski, Logan Pezzillo
Results from several studies show that early aggression predicts later aggression; however, few studies have examined the mediating mechanisms in these relations. The paucity of research that has tested mediation found that aggressive motives and hostile attributions are important causal processes. This past work is limited by not measuring aggression multiple times throughout the study to test aggression change over time and the variables that mediate such change. The current study had participants (N = 90) interact with a same-sex confederate on a modified version of the Tangram Task-our measure of aggressive behavior-for three trials...
April 19, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28421682/predicting-abstinence-from-methamphetamine-use-after-residential-rehabilitation-findings-from-the-methamphetamine-treatment-evaluation-study
#16
Rebecca McKetin, Astrid Kothe, Amanda L Baker, Nicole K Lee, Joanne Ross, Dan I Lubman
INTRODUCTION AND AIMS: We previously found that residential rehabilitation increased continuous abstinence from methamphetamine use 1 year after treatment. We examine what client and treatment characteristics predict this outcome. DESIGN AND METHODS: Participants (n = 176) were dependent on methamphetamine and entering residential rehabilitation for methamphetamine use. Simultaneous logistic regression was used to identify independent predictors of continuous abstinence from methamphetamine use at 1 year follow-up...
April 18, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28421401/liquid-marbles-as-bioreactors-for-the-study-of-three-dimensional-cell-interactions
#17
Raja K Vadivelu, Harshad Kamble, Ahmed Munaz, Nam-Trung Nguyen
Liquid marble as a bioreactor platform for cell-based studies has received significant attention, especially for developing 3D cell-based assays. This platform is particularly suitable for 3D in-vitro modeling of cell-cell interactions. For the first time, we demonstrated the interaction of olfactory ensheathing cells (OECs) with nerve debris and meningeal fibroblast using liquid marbles. As the transplantation of OECs can be used for repairing nerve injury, degenerating cell debris within the transplantation site can adversely affect the survival of transplanted OECs...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28421074/immunometabolic-phenotype-alterations-associated-with-the-induction-of-disease-tolerance-and-persistent-asymptomatic-infection-of-salmonella-in-the-chicken-intestine
#18
REVIEW
Michael H Kogut, Ryan J Arsenault
The adaptation of Salmonella enterica to the eukaryotic host is a key process that enables the bacterium to survive in a hostile environment. Salmonella have evolved an intimate relationship with its host that extends to their cellular and molecular levels. Colonization, invasion, and replication of the bacteria in an appropriate host suggest that modification of host functions is central to pathogenesis. Intuitively, this subversion of the cell must be a complex process, since hosts are not inherently programmed to provide an environment conducive to pathogens...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28420411/characterization-of-a-novel-aspartyl-protease-inhibitor-from-haemonchus-contortus
#19
Baojie Li, Javaid Ali Gadahi, Wenxiang Gao, Zhenchao Zhang, Muhammad Ehsan, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan
BACKGROUND: Aspartyl protease inhibitor (API) was thought to protect intestinal parasitic nematodes from their hostile proteolytic environment. Studies on Ostertagia ostertagi, Ascaris suum and Brugia malayi indicated that aspins might play roles in nematode infection. In a recent study, proteins differentially expressed between free-living third-stage larvae (L3) and activated L3 (xL3) of Haemonchus contortus were identified by 2D-DIGE. API was found downregulated in xL3 when compared with L3...
April 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28419362/obesity-as-a-presentation-of-munchausen-syndrome-by-proxy
#20
Carlos Alberto Nogueira-de-Almeida, Carla Cristina J N de Almeida, Natália Inocêncio Pereira, Nilton Antonio de Souza Filho, Valmir Aparecido de Oliveira
Objective: To describe a case of an obese child whose weight gain was related to the Munchausen Syndrome by proxy (MSP). Methods: This is a case report including information regarding the child's clinical history and the mother's behavior. The common features of the syndrome are confronted with the description of the case, seeking to demonstrate the similarities. Results: The description ratifies the diagnosis based on the signs and symptoms presented by the child (<5 years old, frequent contacts with health system, symptoms witnessed only by the mother, confusing findings, not helped by treatments, emotionally distant father) and the attitude of the mother (concerned, interested in procedures, comfortable in the medical setting, higher medical knowledge, hostile when thwarted)...
April 17, 2017: Journal of Tropical Pediatrics
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