keyword
MENU ▼
Read by QxMD icon Read
search

Hostile

keyword
https://www.readbyqxmd.com/read/29776354/sleep-disturbance-and-psychological-distress-are-associated-with-functional-dyspepsia-based-on-rome-iii-criteria
#1
Yong Li, Yaoyao Gong, Yinghui Li, Danjun He, Yuqin Wu, Haofei Wang, Xiaoyin Cong, Muxin Wei, Lin Lin
BACKGROUND: Functional dyspepsia (FD) is considered a bio-psychosocial disorder. The role of psychosocial factors in FD pathogenesis remains unclear. METHODS: This study evaluated sleep quality and mood symptoms in patients with FD, assessing the associations of FD severity, disordered sleep, and psychological symptoms. One-hundred-and-fifteen adult patients with typical FD symptoms were enrolled alongside 61 healthy volunteers. Rome III criteria were used to evaluate FD symptoms; sleep disorder was assessed with the Pittsburgh Sleep Quality Index (PSQI), and Symptom Checklist-90-Revised (SCL-90R) was utilized to determine the status of depression, anxiety and other psychological symptoms...
May 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29775042/bioinspired-synergy-sensor-chip-of-photonic-crystals-graphene-oxide-for-multi-amines-recognition
#2
Wanjie Ren, Meng Qin, Xiaotian Hu, Fengyu Li, Yuanfeng Wang, Yu Huang, Meng Su, Wenbo Li, Xin Qian, Kang-Lai Tang, Yanlin Song
Benefiting from the integrated functions of cilia and glomeruli in the olfactory system, animals can discriminate various odours even in hostile environments. Inspired by this synergetic system of response and signal processing units, a sensor chip of gra-phene oxide (GO) and photonic crystals (PCs) is fabricated. The GO aerogel functions like the olfactory cilia, which effectively captures the analytes and generates abundant sensing signals for recognition; and the PCs act as the olfactory glomeruli, whose periodic structure enables selective enhancement of the fluorescent signals to realize further signal processing...
May 18, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29773890/intraperitoneal-administration-of-the-anti-il-23-antibody-prevents-the-establishment-of-intestinal-nematodes-in-mice
#3
M Gomez-Samblas, D Bernal, A Bolado-Ortiz, S Vilchez, F Bolás-Fernández, A M Espino, M Trelis, A Osuna
Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with anti-IL-23 antibodies would reduce the establishment and development of parasitic intestinal nematodes. In this study, we show that animals treated with anti-IL-23 monoclonal antibodies showed a drastic reduction in the number of mouse pinworms (Aspiculuris tetraptera) recovered from the intestine (p < 0...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773445/transcatheter-aortic-valve-insertion-in-patients-with-hostile-ascending-aorta-calcification
#4
Akio Nakasu, Kevin L Greason, Vuyisile T Nkomo, Mackram F Eleid, Alberto Pochettino, Katherine S King, Gurpreet S Sandhu, Eric E Williamson, David R Holmes
OBJECTIVE: Calcification of the ascending aorta complicates aortic valve replacement. Transcatheter aortic valve replacement is an alternative procedure in this situation, but it requires manipulation through the hostile area in the ascending aorta. We reviewed our transcatheter aortic valve insertion experience to better understand the surgical mortality risk of valve insertion in patients with extensive calcification of the ascending aorta. METHODS: We retrospectively reviewed the records of 665 consecutive patients who received transcatheter aortic valve insertion from November 2008 through December 2015...
April 7, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29772307/family-environment-interacts-with-crhr1-rs17689918-to-predict-mental-health-and-behavioral-outcomes
#5
Arunima Roy, Kariina Laas, Triin Kurrikoff, Andreas Reif, Toomas Veidebaum, Klaus-Peter Lesch, Jaanus Harro
BACKGROUND: Corticotrophin-releasing hormone receptor-1 gene (CRHR1) variants have been implicated in mental health. However, little is known of the effects of CRHR1 on long-term mental health and behavior in presence of environmental stressors. We assess the effects of CRHR1 variant (rs17689918)-by-environment interactions on emotionality and behavioral traits, including anxiety, depression, aggression and antisocial behaviors. We also determine effects of rs17689918-by-environment-by-sex interactions on the above-mentioned outcomes...
May 14, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29771386/immunotherapy-in-cns-cancers-the-role-of-immune-cell-trafficking
#6
Nivedita M Ratnam, Mark R Gilbert, Amber J Giles
Glioblastoma (GBM) is a highly malignant CNS tumor with very poor survival despite intervention with conventional therapeutic strategies. Although the CNS is separated from the immune system by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB), emerging evidence of immune surveillance and the selective infiltration of GBMs by immune suppressive cells indicates that there is breakdown or compromise of these physical barriers. This in turn offers hope that immunotherapy can be applied to specifically target and reduce tumor burden...
May 15, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29771143/cell-envelope-lipids-in-the-pathophysiology-of-mycobacterium-tuberculosis
#7
Parul Singh, Nagender Rao Rameshwaram, Sudip Ghosh, Sangita Mukhopadhyay
Mycobacterium tuberculosis is an intracellular bacterium that persists and replicates inside macrophages. The bacterium possesses an unusual lipid-rich cell envelope that provides a hydrophobic impermeable barrier against many environmental stressors and allows it to survive extremely hostile intracellular surroundings. Since the lipid-rich envelope is crucial for M. tuberculosis virulence, the components of the cell wall lipid biogenesis pathways constitute an attractive target for the development of vaccines and antimycobacterial chemotherapeutics...
May 17, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29768994/anhedonia-and-the-relationship-between-other-depressive-symptoms-and-aggressive-behavior
#8
Taban Salem, E Samuel Winer, D Gage Jordan, Michael R Nadorff, Jennifer R Fanning, Jessica Bryant, Mitchell E Berman, Jennifer C Veilleux
Depression has been linked to multiple forms of aggressive behavior in college students; however, it is unclear which aspects of depression explain this connection. Anhedonia, defined as the loss of interest and/or pleasure in previously enjoyed activities, may provide unique information about relationships between depression and aggression. Using cross-sectional data from two independent samples of college students ( N = 747 and N = 736 for Study 1 and Study 2, respectively), we examined whether anhedonia helped explain the relationship between broader depressive symptoms and different forms of aggressive and antisocial behavior...
May 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29767235/inhibition-of-microrna%C3%A2-16-protects-mesenchymal-stem-cells-against-apoptosis
#9
Jiang Rui, Shaohong Fang, Yongchen Wang, Bo Lv, Bo Yu, Shufeng Li
Bone marrow‑derived mesenchymal stem cells (BM‑MSCs) have been used in experimental research and clinical trials for heart function restoration and cardiomyocyte regeneration. However, due to a hostile microenvironment created by ischemia, hypoxia and pro‑inflammatory factors, the survival rate of implanted BM‑MSCs remains low. Therefore, strategies that can promote BM‑MSC survival and prevent apoptosis are required. Previous studies have reported that microRNA‑16 (miR‑16) can inhibit cell proliferation by targeting several proteins and signal pathway, not only by inducing apoptosis...
May 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29767141/weaning-stress-and-gastrointestinal-barrier-development-implications-for-lifelong-gut-health-in-pigs
#10
REVIEW
Adam J Moeser, Calvin S Pohl, Mrigendra Rajput
The gastrointestinal (GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions (e.g., digestion, absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs...
December 2017: Animal nutrition
https://www.readbyqxmd.com/read/29765693/homophily-heterophily-and-the-diversity-of-messages-among-decision-making-individuals
#11
Pouria Ramazi, James Riehl, Ming Cao
To better understand the intriguing mechanisms behind cooperation among decision-making individuals, we study the simple yet appealing use of preplay communication or cheap talk in evolutionary games, when players are able to choose strategies based on whether an opponent sends the same message as they do. So when playing games, in addition to pure cooperation and defection, players have two new strategies in this setting: homophilic (respectively, heterophilic) cooperation which is to cooperate (respectively, defect) only with those who send the same message as they do...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29763647/a-simple-cell-based-high-throughput-screening-hts-assay-for-inhibitors-of-salmonella-enterica-rna-polymerase-containing-the-general-stress-response-regulator-rpos-%C3%AF-s
#12
Javier Campos-Gomez, Jorge A Benitez
RNA polymerase containing the stress response regulator σS subunit (RpoS) plays a key role in bacterial survival in hostile environments in nature and during infection. Here we devise and validate a simple cell-based high throughput luminescence assay for this holoenzyme suitable for screening large chemical libraries in a robotic platform.
May 12, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29763438/phasome-analysis-of-pathogenic-and-commensal-neisseria-species-expands-the-known-repertoire-of-phase-variable-genes-and-highlights-common-adaptive-strategies
#13
Joseph J Wanford, Luke R Green, Jack Aidley, Christopher D Bayliss
Pathogenic Neisseria are responsible for significantly higher levels of morbidity and mortality than their commensal relatives despite having similar genetic contents. Neisseria possess a disparate arsenal of surface determinants that facilitate host colonisation and evasion of the immune response during persistent carriage. Adaptation to rapid changes in these hostile host environments is enabled by phase variation (PV) involving high frequency, stochastic switches in expression of surface determinants. In this study, we analysed 89 complete and 79 partial genomes, from the NCBI and Neisseria PubMLST databases, representative of multiple pathogenic and commensal species of Neisseria using PhasomeIt, a new program that identifies putatively phase-variable genes and homology groups by the presence of simple sequence repeats (SSR)...
2018: PloS One
https://www.readbyqxmd.com/read/29756560/sexual-coercion-perpetration-and-victimization-gender-similarities-and-differences-in-adolescence
#14
Andrés A Fernández-Fuertes, Rodrigo J Carcedo, Begoña Orgaz, Antonio Fuertes
Sexual coercion is a worldwide health problem that endangers the well-being of those involved. In the same line of the most recent and comprehensive studies, this study sought to investigate the extent of sexual coercion, both perpetration and victimization, among male and female adolescents. Moreover, it jointly analyzed the predictive power of different variables that have been considered as useful to design preventive programs. For this purpose, a cross-sectional study, using proportional stratified cluster sampling, was performed and 1,242 Spanish adolescents (15-19 years old) were surveyed...
May 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29755295/patterns-of-emotional-availability-between-mothers-and-young-children-associations-with-risk-factors-for-borderline-personality-disorder
#15
Rebecca D Trupe, Jenny Macfie, Rebecca M Skadberg, Gretchen Kurdziel
Emotional availability (EA) characterizes a warm, close relationship between caregiver and child. We compared patterns (clusters) of EA on risk factors, including those for borderline personality disorder (BPD). We sampled 70 children aged 4 to 7 years from low-socioeconomic backgrounds, 51% of whose mothers had BPD. We coded filmed interactions for EA: mothers' sensitivity, structuring, non-intrusiveness, non-hostility, and children's responsiveness to, and involvement of, mothers. We additionally coded children's over -responsiveness and over -involvement...
January 2018: Infant and Child Development
https://www.readbyqxmd.com/read/29753694/physiological-adaptation-of-the-growth-restricted-fetus
#16
REVIEW
Karel Maršál
The growth-restricted fetus in utero is exposed to a hostile environment and suffers undernutrition and hypoxia. To cope with the stress, the fetus changes its physiological functions. These adaptive changes aid intrauterine survival; however, they can lead to permanent functional and structural changes that can contribute to the development of serious chronic diseases later in life. Epigenetic mechanisms are an important part of the pathophysiological processes behind this "developmental origin of adult diseases...
February 24, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29753254/posttraumatic-stress-disorder-depression-and-suicidal-ideation-in-veterans-results-from-the-mind-your-heart-study
#17
Melanie B Arenson, Mary A Whooley, Thomas C Neylan, Shira Maguen, Thomas J Metzler, Beth E Cohen
Veterans with PTSD or depression are at increased risk for suicidal ideation. However, few studies have examined that risk in those with comorbid PTSD and depression, instead focusing on these disorders individually. This study investigates the association of suicidal ideation with comorbid PTSD and depression and examines the role of military and psychosocial covariates. We evaluated 746 veterans using the CAPS to assess PTSD and the PHQ-9 to measure depression and suicidal ideation. Covariates were assessed via validated self-report measures...
April 22, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29749368/effect-of-inherited-red-cell-defects-on-growth-of-plasmodium-falciparum-an-in-vitro-study
#18
Vrushali Pathak, Roshan Colah, Kanjaksha Ghosh
Background & objectives: High prevalence of certain polymorphic alleles of erythrocytes in malaria endemic area has been linked to the resistance provided by these alleles against parasitic infestations. Numerous studies undertaken to demonstrate this correlation have generated conflicting results. This study was undertaken to investigate the abilities of various polymorphic erythrocytes to support in vitro growth of Plasmodium falciparum parasites. Methods: In this study under in vitro condition the ability of P...
January 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29748581/leptin-increases-mitochondrial-opa1-via-gsk3-mediated-oma1-ubiquitination-to-enhance-therapeutic-effects-of-mesenchymal-stem-cell-transplantation
#19
Fan Yang, Rongrong Wu, Zhi Jiang, Jinghai Chen, Jinliang Nan, Sheng'an Su, Na Zhang, Chen Wang, Jing Zhao, Cheng Ni, Yingchao Wang, Wangxing Hu, Zhiru Zeng, Keyang Zhu, Xianbao Liu, Xinyang Hu, Wei Zhu, Hong Yu, Jinyu Huang, Jian'an Wang
Accumulating evidence revealed that mesenchymal stem cells (MSCs) confer cardioprotection against myocardial infarction (MI). However, the poor survival and engraftment rate of the transplanted cells limited their therapeutic efficacy in the heart. The enhanced leptin production associated with hypoxia preconditioning contributed to the improved MSCs survival. Mitochondrial integrity determines the cellular fate. Thus, we aimed to investigate whether leptin can enhance mitochondrial integrity of human MSCs (hMSCs) to protect against various stress...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29747589/additional-oxidative-stress-reroutes-the-global-response-of-aspergillus-fumigatus-to-iron-depletion
#20
Vivien Kurucz, Thomas Krüger, Károly Antal, Anna-Maria Dietl, Hubertus Haas, István Pócsi, Olaf Kniemeyer, Tamás Emri
BACKGROUND: Aspergillus fumigatus has to cope with a combination of several stress types while colonizing the human body. A functional interplay between these different stress responses can increase the chances of survival for this opportunistic human pathogen during the invasion of its host. In this study, we shed light on how the H2 O2 -induced oxidative stress response depends on the iron available to this filamentous fungus, using transcriptomic analysis, proteomic profiles, and growth assays...
May 10, 2018: BMC Genomics
keyword
keyword
50666
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"