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Matthew Stephens

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https://www.readbyqxmd.com/read/27936454/white-matter-volumes-in-youth-offspring-of-bipolar-parents
#1
Fabiano G Nery, Matthew Norris, James C Eliassen, Wade A Weber, Thomas J Blom, Jeffrey A Welge, Drew A Barzman, Jeffrey R Strawn, Caleb M Adler, Stephen M Strakowski, Melissa P DelBello
BACKGROUND: Studying youth at high risk of developing bipolar disorder may clarify neurobiological factors associated with vulnerability to this illness. We present here a baseline characterization of brain structure in youth at-risk for bipolar disorder. METHODS: Magnetic resonance images were obtained from 115 child and adolescent offspring of bipolar disorder type I subjects and 57 healthy child and adolescent offspring of healthy parents (healthy control offspring)...
November 25, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27936365/how-much-is-too-much-patterns-of-drinking-during-alcohol-treatment-and-associations-with-post-treatment-outcomes-across-three-alcohol-clinical-trials
#2
Katie Witkiewitz, Corey R Roos, Matthew R Pearson, Kevin A Hallgren, Stephen A Maisto, Megan Kirouac, Alyssa A Forcehimes, Adam D Wilson, Charles S Robinson, Elizabeth McCallion, J Scott Tonigan, Nick Heather
OBJECTIVE: This secondary data analysis examined patterns of drinking during alcohol treatment and associated drinking outcomes during the first year following treatment. The goal was to provide clinicians with guidance on which patients may be most at risk for negative long-term outcomes based on drinking patterns during treatment. METHOD: This study was an analysis of existing data (N = 3,851) from three randomized clinical trials for alcohol use disorder: the COMBINE Study (n = 1,383), Project MATCH (n = 1,726), and the United Kingdom Alcohol Treatment Trial (n = 742)...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27935956/correction-chromosomal-level-assembly-of-the-asian-seabass-genome-using-long-sequence-reads-and-multi-layered-scaffolding
#3
Shubha Vij, Heiner Kuhl, Inna S Kuznetsova, Aleksey Komissarov, Andrey A Yurchenko, Peter Van Heusden, Siddharth Singh, Natascha M Thevasagayam, Sai Rama Sridatta Prakki, Kathiresan Purushothaman, Jolly M Saju, Junhui Jiang, Stanley Kimbung Mbandi, Mario Jonas, Amy Hin Yan Tong, Sarah Mwangi, Doreen Lau, Si Yan Ngoh, Woei Chang Liew, Xueyan Shen, Lawrence S Hon, James P Drake, Matthew Boitano, Richard Hall, Chen-Shan Chin, Ramkumar Lachumanan, Jonas Korlach, Vladimir Trifonov, Marsel Kabilov, Alexey Tupikin, Darrell Green, Simon Moxon, Tyler Garvin, Fritz J Sedlazeck, Gregory W Vurture, Gopikrishna Gopalapillai, Vinaya Kumar Katneni, Tansyn H Noble, Vinod Scaria, Sridhar Sivasubbu, Dean R Jerry, Stephen J O'Brien, Michael C Schatz, Tamás Dalmay, Stephen W Turner, Si Lok, Alan Christoffels, László Orbán
[This corrects the article DOI: 10.1371/journal.pgen.1005954.].
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27935335/pediatric-chondromyxoid-fibroma-like-osteosarcoma
#4
Matthew Stark, Stephen D Heinrich, Raju Sivashanmugam, Dane Mackey, Ewa Wasilewska, Randall Craver
Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is a low-grade osteosarcoma, often misdiagnosed on initial biopsy as a benign lesion, with five cases previously described. We report a 13-year-old male with an intramedullary lytic CMF-OS of the right tibial proximal metaphysis with cortical destruction and soft tissue extension. Diagnosis was based on malignant new bone formation, increased mitotic figures, lamellar bone permeation with bony destruction, and correlation with imaging studies. There were no metastasis at presentation and the tumor showed good response to standard chemotherapy with >95% necrosis...
December 9, 2016: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/27931134/constitutive-activation-of-alternative-nuclear-factor-kappa-b-pathway-in-canine-diffuse-large-b-cell-lymphoma-contributes-to-tumor-cell-survival-and-is-a-target-of-new-adjuvant-therapies
#5
Davis M Seelig, Daisuke Ito, Colleen L Forster, Una A Yoon, Matthew Breen, Linda J Burns, Veronika Bachanova, Kerstin Lindblad-Toh, Timothy D O'Brien, Stephen C Schmechel, Anthony E Rizzardi, Jaime F Modiano, Michael A Linden
Activation of the classical nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway is a common molecular event observed in both human and canine diffuse large B-cell lymphoma (DLBCL). Although the oncogenic potential of the alternative NFκB pathway (ANFκBP) has also been recently identified in DLBCL, its precise role in tumor pathogenesis and potential as a treatment target is understudied. We hypothesized that up-regulation of the ANFκBP plays an important role in the proliferation and survival of canine DLBCL cells, and we demonstrate that the ANFκBP is constitutively active in primary canine DLBCL samples and a cell line (CLBL1)...
December 8, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27929605/nasopharyngeal-airway-to-prevent-tension-pneumocephalus-after-open-resection-of-anterior-skull-base-tumors
#6
Matthew E Spector, Jon-Paul Pepper, Stephen Sullivan, Lawrence Marentette, Erin McKean
We conducted a retrospective study to assess the efficacy of using a nasopharyngeal airway in lieu of a tracheotomy or prolonged intubation for the diversion of airflow to prevent tension pneumocephalus after an open resection of anterior skull base tumors. Our study population was made up of 120 patients-74 males and 46 females, aged 12 to 84 years (mean: 48.7)-who had undergone an anterior skull base resection with documented nasopharyngeal airway placement from 1996 through 2009. Our main outcome measure was the presence of tension pneumocephalus while controlling for the placement of a lumbar drain, the development of a cerebrospinal fluid (CSF) leak, and the type of reconstruction...
December 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27928041/biodiversity-as-a-multidimensional-construct-a-review-framework-and-case-study-of-herbivory-s-impact-on-plant-biodiversity
#7
S Naeem, Case Prager, Brian Weeks, Alex Varga, Dan F B Flynn, Kevin Griffin, Robert Muscarella, Matthew Palmer, Stephen Wood, William Schuster
Biodiversity is inherently multidimensional, encompassing taxonomic, functional, phylogenetic, genetic, landscape and many other elements of variability of life on the Earth. However, this fundamental principle of multidimensionality is rarely applied in research aimed at understanding biodiversity's value to ecosystem functions and the services they provide. This oversight means that our current understanding of the ecological and environmental consequences of biodiversity loss is limited primarily to what unidimensional studies have revealed...
December 14, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27927919/clinical-evaluation-and-cost-analysis-of-the-great-basin-shiga-toxin-direct-molecular-assay-for-the-detection-of-shiga-toxin-producing-escherichia-coli-stec-in-diarrheal-stool-specimens
#8
Matthew L Faron, Nathan A Ledeboer, Jessica Connolly, Paul A Granato, Brenda R Alkins, Jennifer Dien Bard, Judy A Daly, Stephen Young, Blake W Buchan
The Shiga Toxin Direct molecular assay (ST Direct) relies on nucleic acid amplification and solid array-based amplicon detection to identify Shiga toxin-encoding E. coli (STEC) in preserved stool specimens. Genes encoding Shiga toxin (stx1, stx2), as well as the E. coli serotype O:157-specific marker rfbE, are simultaneously detected within 2 hours. ST Direct was evaluated using 1,084 prospectively collected preserved stool specimens across five clinical centers. An additional 55 retrospectively collected, frozen specimens were included to increase the number of positive specimens evaluated...
December 7, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27927638/assessment-of-shoulder-pain-for-non-specialists
#9
Matthew Gray, Alasdair Wallace, Stephen Aldridge
No abstract text is available yet for this article.
December 7, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27926671/of-20-376-lumbar-discectomies-2-6-of-patients-readmitted-within-30-days-surgical-site-infection-pain-and-thromboembolic-events-are-the-most-common-reasons-for-readmission
#10
Matthew L Webb, Stephen J Nelson, Ameya Save, Jonathan Cui, Adam M Lukasiewicz, Andre M Samuel, Pablo J Diaz-Collado, Daniel D Bohl, Nathaniel T Ondeck, Ryan P McLynn, Jonathan N Grauer
STUDY DESIGN: A retrospective cohort study of prospectively collected data. OBJECTIVE: As an initial effort to address readmissions after lumbar discectomy, reasons for hospital readmission are identified and discussed. SUMMARY OF BACKGROUND DATA: Lumbar discectomy is a commonly performed procedure. The Affordable Care Act codifies penalties for hospital readmissions. New quality-based reimbursements tied to readmissions call for a better understanding of the causes of readmission after procedures such as lumbar discectomy...
December 6, 2016: Spine
https://www.readbyqxmd.com/read/27926646/treatment-of-a-pregnant-patient-in-a-persistent-vegetative-state
#11
Matthew P Romagano, William E Scorza, Stephen E Lammers, Carole Dorr, John C Smulian
BACKGROUND: Brain injury leading to a persistent vegetative state during pregnancy involves difficult medical and ethical decisions. CASE: A 21-year-old multigravid woman entered a persistent vegetative state at 20 1/7 weeks of gestation after cardiac arrest with postanoxic brain injury from a suspected drug overdose. The clinical disciplines responsible for her case formed a collaborative care plan involving ventilator, nutrition, and medication support of the mother and regular fetal monitoring and ultrasound testing...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27925641/simvastatin-exposure-and-rotator-cuff-repair-in-a-rat-model
#12
Matthew E Deren, John R Ehteshami, Joshua S Dines, Mark C Drakos, Steve B Behrens, Stephen Doty, Struan H Coleman
Simvastatin is a common medication prescribed for hypercholesterolemia that accelerates local bone formation. It is unclear whether simvastatin can accelerate healing at the tendon-bone interface after rotator cuff repair. This study was conducted to investigate whether local and systemic administration of simvastatin increased tendon-bone healing of the rotator cuff as detected by maximum load to failure in a controlled animal-based model. Supraspinatus tendon repair was performed on 120 Sprague-Dawley rats...
December 7, 2016: Orthopedics
https://www.readbyqxmd.com/read/27925281/effect-of-natural-organic-matter-on-the-photo-induced-toxicity-of-titanium-dioxide-tio2-nanoparticles
#13
Alexis M Wormington, Jason Coral, Matthew M Alloy, Carmen L Damare, Charles M Mansfield, Stephen J Klaine, Joseph H Bisesi, Aaron P Roberts
Nano-TiO2 is the most widely used form of nanoparticles in commercial industry, and come in two main configurations: rutile and anatase. Rutile TiO2 is used in UV screening applications, while anatase TiO2 crystals have a surface defect that makes them photoreactive. There are numerous reports in the literature of photo-induced toxicity to aquatic organisms following co-exposure to anatase nano-TiO2 and UV. All natural freshwater contains varying amounts of natural organic matter (NOM), which can drive UV attenuation and quench ROS in aquatic ecosystems...
December 7, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27920123/selective-enhancement-of-insulin-sensitivity-in-the-endothelium-in-vivo-reveals-a-novel-proatherosclerotic-signalling-loop
#14
Hema Viswambharan, Nadira Y Yuldasheva, Anshuman Sengupta, Helen Imrie, Matthew C Gage, Natalie J Haywood, Andrew M Walker, Anna Skromna, Natalia Makova, Stacey L Galloway, Pooja Shah, Piruthivi Sukumar, Karen E Porter, Peter J Grant, Ajay M Shah, Celio X Santos, Jing Li, David J Beech, Stephen Wheatcroft, Richard M Cubbon, Mark T Kearney
RATIONALE: In the endothelium, insulin stimulates endothelial nitric oxide synthase (eNOS) to generate the anti-atherosclerotic signalling radical NO. Insulin resistant type 2 diabetes is associated with reduced NO availability and accelerated atherosclerosis. The effect of enhancing endothelial insulin sensitivity on NO availability is unclear. OBJECTIVE: To answer this question we generated a mouse with endothelial cell (EC)-specific over-expression of the human insulin receptor (hIRECO) using the Tie2 promoter-enhancer...
December 5, 2016: Circulation Research
https://www.readbyqxmd.com/read/27919677/an-individual-differences-approach-to-multiple-target-visual-search-errors-how-search-errors-relate-to-different-characteristics-of-attention
#15
Stephen H Adamo, Matthew S Cain, Stephen R Mitroff
Multiple-target visual searches, where more than one target can be present within a single search array, are especially error-prone such that a second target is more likely to be missed after a first target has been detected. Increasingly, evidence supports a resource depletion account of these errors-a first target consumes attentional resources leaving fewer available to process a second target. However, "attention" is broadly defined and is composed of many different characteristics, leaving considerable uncertainty about how attention affects second-target detection...
December 2, 2016: Vision Research
https://www.readbyqxmd.com/read/27917837/purification-crystallization-and-characterization-of-the-pseudomonas-outer-membrane-protein-fapf-a-functional-amyloid-transporter
#16
Sarah L Rouse, Wlliam J Hawthorne, Sebastian Lambert, Marc L Morgan, Stephen A Hare, Stephen Matthews
Bacteria often produce extracellular amyloid fibres via a multi-component secretion system. Aggregation-prone, unstructured subunits cross the periplasm and are secreted through the outer membrane, after which they self-assemble. Here, significant progress is presented towards solving the high-resolution crystal structure of the novel amyloid transporter FapF from Pseudomonas, which facilitates the secretion of the amyloid-forming polypeptide FapC across the bacterial outer membrane. This represents the first step towards obtaining structural insight into the products of the Pseudomonas fap operon...
December 1, 2016: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/27915116/7t-mr-of-intracranial-pathology-preliminary-observations-and-comparisons-to-3t-and-1-5t
#17
Emmanuel C Obusez, Mark Lowe, Se-Hong Oh, Irene Wang, M S Jennifer Bullen, Paul Ruggieri, Virginia Hill, Daniel Lockwood, Todd Emch, Doksu Moon, Gareth Loy, Jonathan Lee, Matthew Kiczek, D O Manoj Massand, Volodymyr Statsevych, Todd Stultz, Stephen E Jones
PURPOSE: There have been an increasing number of studies involving ultra-high-field 7T of intracranial pathology, however, comprehensive clinical studies of neuropathology at 7T still remain limited. 7T has the advantage of a higher signal-to-noise ratio and a higher contrast-to-noise ratio, compared to current low field clinical MR scanners. We hypothesized 7T applied clinically, may improve detection and characterization of intracranial pathology. MATERIALS AND METHODS: We performed an IRB-approved 7T prospective study of patients with neurological disease who previously had lower field 3T and 1...
November 30, 2016: NeuroImage
https://www.readbyqxmd.com/read/27914982/nanotopography-controls-cell-cycle-changes-involved-with-skeletal-stem-cell-self-renewal-and-multipotency
#18
Louisa C Y Lee, Nikolaj Gadegaard, María C de Andrés, Lesley-Anne Turner, Karl V Burgess, Stephen J Yarwood, Julia Wells, Manuel Salmeron-Sanchez, Dominic Meek, Richard O C Oreffo, Matthew J Dalby
In culture isolated bone marrow mesenchymal stem cells (more precisely termed skeletal stem cells, SSCs) spontaneously differentiate into fibroblasts, preventing the growth of large numbers of multipotent SSCs for use in regenerative medicine. However, the mechanisms that regulate the expansion of SSCs, while maintaining multipotency and preventing fibroblastic differentiation are poorly understood. Major hurdles to understanding how the maintenance of SSCs is regulated are (a) SSCs isolated from bone marrow are heterogeneous populations with different proliferative characteristics and (b) a lack of tools to investigate SSC number expansion and multipotency...
November 24, 2016: Biomaterials
https://www.readbyqxmd.com/read/27913673/structural-insights-into-functional-amyloid-inhibition-in-gram-ve-bacteria
#19
REVIEW
William Hawthorne, Sarah Rouse, Lee Sewell, Stephen J Matthews
Amyloids are proteinaceous aggregates known for their role in debilitating degenerative diseases involving protein dysfunction. Many forms of functional amyloid are also produced in nature and often these systems require careful control of their assembly to avoid the potentially toxic effects. The best-characterised functional amyloid system is the bacterial curli system. Three natural inhibitors of bacterial curli amyloid have been identified and recently characterised structurally. Here, we compare common structural features of CsgC, CsgE and CsgH and discuss the potential implications for general inhibition of amyloid...
December 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27911759/neurotransmitter-release-can-be-stabilized-by-a-mechanism-that-prevents-voltage-changes-near-the-end-of-action-potentials-from-affecting-calcium-currents
#20
Stephen G Clarke, Matthew S Scarnati, Kenneth G Paradiso
: At chemical synapses, presynaptic action potentials (APs) activate voltage-gated calcium channels, allowing calcium to enter and trigger neurotransmitter release. The duration, peak amplitude, and shape of the AP falling phase alter calcium entry, which can affect neurotransmitter release significantly. In many neurons, APs do not immediately return to the resting potential, but instead exhibit a period of depolarization or hyperpolarization referred to as an afterpotential. We hypothesized that presynaptic afterpotentials should alter neurotransmitter release by affecting the electrical driving force for calcium entry and calcium channel gating...
November 9, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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