keyword
MENU ▼
Read by QxMD icon Read
search

Matthew Stephens

keyword
https://www.readbyqxmd.com/read/28541469/clinical-and-molecular-evidence-of-atovaquone-and-azithromycin-resistance-in-relapsed-babesia-microti-infection-associated-with-rituximab-and-chronic-lymphocytic-leukemia
#1
Matthew S Simon, Lars F Westblade, Alexis Dziedziech, Joseph E Visone, Richard R Furman, Stephen G Jenkins, Audrey N Schuetz, Laura A Kirkman
Babesiosis treatment failures with standard therapy have been reported, but the molecular mechanisms are not well understood. We describe the emergence of atovaquone and azithromycin resistance associated with mutations in the binding regions of the target proteins of both drugs during treatment of an immunosuppressed patient with relapsing babesiosis.
May 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28539449/anti-hiv-1-adcc-antibodies-following-latency-reversal-and-treatment-interruption
#2
Wen Shi Lee, Anne B Kristensen, Thomas A Rasmussen, Martin Tolstrup, Lars Østergaard, Ole S Søgaard, Bruce D Wines, P Mark Hogarth, Arnold Reynaldi, Miles P Davenport, Sean Emery, Janaki Amin, David A Cooper, Virginia L Kan, Julie Fox, Henning Gruell, Matthew S Parsons, Stephen J Kent
There is growing interest in utilizing antibody-dependent cellular cytotoxicity (ADCC) to eliminate infected cells following reactivation from HIV-1 latency. A potential barrier is that HIV-1-specific ADCC antibodies decline in patients on long-term antiretroviral therapy (ART) and may not be sufficient to eliminate reactivated latently infected cells. It is not known whether reactivation from latency with latency-reversing agents (LRA) could provide sufficient antigenic stimulus to boost HIV-1-specific ADCC...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28539260/phylogenetic-relationships-of-the-tribe-toxotrypanini-diptera-tephritidae-based-on-molecular-characters
#3
Ximo Mengual, Peter Kerr, Allen L Norrbom, Norman B Barr, Matthew L Lewis, Anna M Stapelfeldt, Sonja J Scheffer, Patrick Woods, Md-Sajedul Islam, Cheslavo A Korytkowski, Keiko Uramoto, Erick J Rodriguez, Bruce D Sutton, Norma Nolazco, Gary J Steck, Stephen Gaimari
Current hypotheses of relationship among the species of the fruit fly genera Anastrepha and Toxotrypana are tested using sequence data from six DNA regions: the mitochondrial regions 16S, CAD, and COI, and the nuclear regions EF1a, PER, and PGD. DNA sequences were obtained from 146 species of Anastrepha, representing 19 of the 21 species groups as well as five of the six clades of the robusta group, and four species of Toxotrypana in addition to species of Hexachaeta, Pseudophorellia, Alujamyia, and 13 other tephritid genera used as outgroups...
May 21, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28539084/creating-safer-health-systems-lessons-from-other-sectors-and-an-account-of-an-application-in-the-safer-clinical-systems-programme
#4
Peter Spurgeon, Hugh Flanagan, Matthew Cooke, Mark Sujan, Stephen Cross, Rose Jarvis
Despite well meaning initiatives over decades, the percentage of inpatients suffering adverse events remains constant in most advanced health systems. The notion of incident reporting as used in other safety critical industries has proved far less effective in healthcare. This article describes a new patient safety paradigm in the search for improved patient safety in healthcare. Underpinned by a holistic use of human factors the Safer Clinical Systems programme involves a proactive, risk-based approach seeking to eliminate or control risk before it is converted to patient harm...
May 2017: Health Services Management Research
https://www.readbyqxmd.com/read/28537878/biological-characterization-of-sn32976-a-selective-inhibitor-of-pi3k-and-mtor-with-preferential-activity-to-pi3k%C3%AE-in-comparison-to-established-pan-pi3k-inhibitors
#5
Gordon W Rewcastle, Sharada Kolekar, Christina M Buchanan, Swarna A Gamage, Anna C Giddens, Kit Y Tsang, Jackie D Kendall, Ripudaman Singh, Woo-Jeong Lee, Greg C Smith, Weiping Han, David J Matthews, William A Denny, Peter R Shepherd, Stephen M F Jamieson
Multiple therapeutic agents have been developed to target the phosphatidylinositol 3-kinase (PI3K) signaling pathway, which is frequently dysregulated in cancer promoting tumor growth and survival. These include pan PI3K inhibitors, which target class Ia PI3K isoforms and have largely shown limited single agent activity with narrow therapeutic windows in clinical trials. Here, we characterize SN32976, a novel pan PI3K inhibitor, for its biochemical potency against PI3K isoforms and mTOR, kinase selectivity, cellular activity, pharmacokinetics, pharmacodynamics and antitumor efficacy relative to five clinically-evaluated pan PI3K inhibitors: buparlisib, dactolisib, pictilisib, omipalisib and ZSTK474...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28536960/predictors-of-inpatient-psychiatric-hospitalization-for-children-and-adolescents-with-autism-spectrum-disorder
#6
Giulia Righi, Jill Benevides, Carla Mazefsky, Matthew Siegel, Stephen J Sheinkopf, Eric M Morrow
Autism Spectrum Disorder (ASD) is associated with significant healthcare expenditures and a greater utilization of psychiatric health services. High utilization may not be evenly distributed across individuals with ASD. The objective of this study was to identify individual and family characteristics that increase the risk of psychiatric hospitalization. Naturalistic study of two age- and gender-matched ASD cohorts, inpatients enrolled in the Autism Inpatient Collection (AIC) and outpatients enrolled in the Rhode Island Consortium of Autism Research and Treatment (RI-CART), revealed a number of factors associated with hospitalization...
May 23, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28536307/gene-expression-profiling-in-braf-mutated-melanoma-reveals-patient-subgroups-with-poor-outcomes-to-vemurafenib-that-may-be-overcome-by-cobimetinib-plus-vemurafenib
#7
Matthew J Wongchenko, Grant A McArthur, Brigitte Dréno, James Larkin, Paolo A Ascierto, Jeffrey Sosman, Luc Andries, Mark Kockx, Stephen D Hurst, Ivor Caro, Isabelle Rooney, Priti S Hegde, Luciana Molinero, Huibin Yue, Ilsung Chang, Lukas C Amler, Yibing Yan, Antoni Ribas
The association of tumor gene expression profiles with progression-free survival (PFS) outcomes in patients with BRAF(V600)-mutated melanoma treated with vemurafenib or cobimetinib combined with vemurafenib was evaluated. <br /><br />Experimental Design: Gene expression of archival tumor samples from patients in four trials (BRIM-2, BRIM-3, BRIM-7, and coBRIM) was evaluated. Genes significantly associated with PFS (P<0 .05) were identified by univariate Cox proportional hazards modeling, then subjected to unsupervised hierarchical clustering, principal component analysis, and recursive partitioning to develop optimized gene signatures...
May 23, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28527929/new-predictors-of-complications-in-carotid-body-tumor-resection
#8
Gloria Y Kim, Peter F Lawrence, Rameen S Moridzadeh, Kate Zimmerman, Alberto Munoz, Kuauhyama Luna-Ortiz, Gustavo S Oderich, Juan de Francisco, Jorge Ospina, Santiago Huertas, Leonardo R de Souza, Thomas C Bower, Steven Farley, Hugh A Gelabert, Marcus R Kret, E John Harris, Giovanni De Caridi, Francesco Spinelli, Matthew R Smeds, Christos D Liapis, John Kakisis, Anastasios P Papapetrou, Eike S Debus, Christian-A Behrendt, Edgar Kleinspehn, Joshua D Horton, Firas F Mussa, Stephen W K Cheng, Mark D Morasch, Khurram Rasheed, Matthew E Bennett, Jean Bismuth, Alan B Lumsden, Christopher J Abularrage, Alik Farber
OBJECTIVE: This study examined the relationship between two new variables, tumor distance to base of skull (DTBOS) and tumor volume, with complications of carotid body tumor (CBT) resection, including bleeding and cranial nerve injury. METHODS: Patients who underwent CBT resection between 2004 and 2014 were studied using a standardized, multi-institutional database. Demographic, perioperative, and outcomes data were collected. CBT measurements were determined from computed tomography, magnetic resonance imaging, and ultrasound examination...
June 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28523850/n-aryl-groups-are-ubiquitous-in-cross-dehydrogenative-couplings-because-they-stabilize-reactive-intermediates
#9
Althea S-K Tsang, A Stephen K Hashmi, Peter Comba, Marion Kerscher, Bun Chan, Matthew Todd
The mechanism of cross-dehydrogenative coupling (CDC) reactions has been examined by experimental and computational means. We have provided a rationale for the ubiquity of the N-aryl group in these reactions. The aryl substituent stabilizes two intermediates and the high-energy transition state that connects them, which together represent the rate-determining step. This knowledge has enabled us to predict new CDC substrates that react either well or poorly.
May 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28520615/increased-risk-of-myocardial-infarction-in-hiv-infected-individuals-in-north-america-compared-to-the-general-population
#10
Daniel R Drozd, Mari M Kitahata, Keri N Althoff, Jinbing Zhang, Stephen J Gange, Sonia Napravnik, Greer A Burkholder, William C Mathews, Michael J Silverberg, Timothy R Sterling, Susan R Heckbert, Matthew J Budoff, Stephen Van Rompaey, Joseph A C Delaney, Cherise Wong, Weiqun Tong, Frank J Palella, Richard A Elion, Jeffrey N Martin, John T Brooks, Lisa P Jacobson, Joseph J Eron, Amy C Justice, Matthew S Freiberg, Daniel B Klein, Wendy S Post, Michael S Saag, Richard D Moore, Heidi M Crane
BACKGROUND: Previous studies of cardiovascular disease (CVD) among HIV-infected individuals have been limited by the inability to validate and differentiate atherosclerotic type 1 myocardial infarctions (T1MIs) from other events. We sought to define the incidence of T1MIs and risk attributable to traditional and HIV-specific factors among participants in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), and compare adjusted incidence rates to the general population Atherosclerosis Risk in Communities (ARIC) cohort...
May 17, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28515126/radiomanganese-pet-detects-changes-in-functional-%C3%AE-cell-mass-in-mouse-models-of-diabetes
#11
Reinier Hernandez, Stephen A Graves, Trillian Gregg, Halena R VanDeusen, Rachel J Fenske, Haley N Wienkes, Christopher G England, Hector F Valdovinos, Justin J Jeffery, Todd E Barnhart, Gregory W Severin, Robert J Nickles, Michelle E Kimple, Matthew J Merrins, Weibo Cai
The noninvasive measurement of functional β-cell mass would be clinically valuable for monitoring the progression of type 1 and type 2 diabetes, as well as the viability of transplanted insulin-producing cells. Although previous work employing magnetic resonance imaging has shown promise for functional β-cell mass determination through voltage-dependent Ca(2+) channel (VDCC)-mediated internalization of Mn(2+), the clinical utility of this technique is limited by the cytotoxic levels of Mn(2+) contrast agent...
May 17, 2017: Diabetes
https://www.readbyqxmd.com/read/28513074/%C3%AE-myrtoxin-mp1a-is-a-helical-heterodimer-from-the-venom-of-the-jack-jumper-ant-with-antimicrobial-membrane-disrupting-and-nociceptive-activities
#12
Zoltan Dekan, Stephen J Heady, Martin Scanlon, Brian A Baldo, Tzong-Hsien Lee, Marie-Isabel Aguilar, Jennifer R Deuis, Irina Vetter, Alysha G Elliott, Maite Amado, Matthew A Cooper, Dianne Alewood, Paul Francis Alewood
Δ-Myrtoxin-Mp1a (Mp1a), a 49-residue heterodimeric peptide from the venom of Myrmecia pilosula is comprised of a 26-mer A chain and a 23-mer B chain connected by two disulfide bonds in an antiparallel arrangement. Combination of the individual synthetic chains via aerial oxidation remarkably resulted in the self-assembly of Mp1a as a homogenous product without the need for directed disulfide bond formation. NMR analysis revealed a well-defined, unique structure containing a pair of antiparallel α-helices...
May 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28511286/who-achieves-low-risk-drinking-during-alcohol-treatment-an-analysis-of-patients-in-three-alcohol-clinical-trials
#13
Katie Witkiewitz, Matthew R Pearson, Kevin A Hallgren, Stephen A Maisto, Corey R Roos, Megan Kirouac, Adam D Wilson, Kevin A Montes, Nick Heather
BACKGROUND AND AIMS: There is evidence that low risk drinking is possible during the course of alcohol treatment and can be maintained following treatment. Our aim was to identify characteristics associated with low risk drinking during treatment in a large sample of individuals as they received treatment for alcohol dependence. DESIGN: Integrated analysis of data from the COMBINE study, Project MATCH, and the United Kingdom Alcohol Treatment Trial using repeated measures latent class analysis to identify patterns of drinking and predictors of low risk drinking patterns during treatment...
May 16, 2017: Addiction
https://www.readbyqxmd.com/read/28508523/the-effect-of-sodium-hypochlorite-concentration-and-irrigation-needle-extension-on-biofilm-removal-from-a-simulated-root-canal-model
#14
Saifalarab A Mohmmed, Morgana E Vianna, Matthew R Penny, Stephen T Hilton, Jonathan C Knowles
To investigate the effect of sodium hypochlorite concentration and needle extension on removal of Enterococcus faecalis biofilm, sixty root canal models were 3D printed. Biofilms were grown on the apical 3 mm of the canal for 10 days. Irrigation for 60s with 9 mL of either 5.25% or 2.5% NaOCl or water was performed using a needle inserted either 3 or 2 mm from the canal terminus and imaged using fluorescence microscopy and residual biofilm percentages were calculated using imaging software. The data were analysed using analysis of covariance and two-sample t-tests...
May 16, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/28507160/emergent-magnetism-at-transition-metal-nanocarbon-interfaces
#15
Fatma Al Ma'Mari, Matthew Rogers, Shoug Alghamdi, Timothy Moorsom, Stephen Lee, Thomas Prokscha, Hubertus Luetkens, Manuel Valvidares, Gilberto Teobaldi, Machiel Flokstra, Rhea Stewart, Pierluigi Gargiani, Mannan Ali, Gavin Burnell, B J Hickey, Oscar Cespedes
Charge transfer at metallo-molecular interfaces may be used to design multifunctional hybrids with an emergent magnetization that may offer an eco-friendly and tunable alternative to conventional magnets and devices. Here, we investigate the origin of the magnetism arising at these interfaces by using different techniques to probe 3d and 5d metal films such as Sc, Mn, Cu, and Pt in contact with fullerenes and rf-sputtered carbon layers. These systems exhibit small anisotropy and coercivity together with a high Curie point...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28505220/multicenter-evaluation-of-the-bruker-maldi-biotyper-ca-system-for-the-identification-of-clinically-important-bacteria-and-yeasts
#16
Deborah A Wilson, Stephen Young, Karen Timm, Susan Novak-Weekley, Elizabeth M Marlowe, Neil Madisen, Jennifer L Lillie, Nathan A Ledeboer, Rebecca Smith, Josh Hyke, Christen Griego-Fullbright, Patricia Jim, Paul A Granato, Matthew L Faron, Joven Cumpio, Blake W Buchan, Gary W Procop
Objectives: A report on the multicenter evaluation of the Bruker MALDI Biotyper CA System (MBT-CA; Bruker Daltonics, Billerica, MA) for the identification of clinically important bacteria and yeasts. Methods: In total, 4,399 isolates of medically important bacteria and yeasts were assessed in the MBT-CA. These included 2,262 aerobic gram-positive (AGP) bacteria, 792 aerobic gram-negative (AGN) bacteria 530 anaerobic (AnA) bacteria, and 815 yeasts (YSTs). Three processing methods were assesed...
May 13, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28504420/use-of-supramolecular-assemblies-as-lithographic-resists
#17
Scott M Lewis, Antonio Fernandez, Guy A DeRose, Matthew S Hunt, George F S Whitehead, Agnese Lagzda, Hayden R Alty, Jesus Ferrando-Soria, Sarah Varey, Andreas K Kostopoulos, Fredrik Schedin, Christopher A Muryn, Grigore A Timco, Axel Scherer, Stephen G Yeates, Richard E P Winpenny
A new resist material for electron beam lithography has been created that is based on a supramolecular assembly. Initial studies revealed that with this supramolecular approach, high-resolution structures can be written that show unprecedented selectivity when exposed to etching conditions involving plasmas.
May 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28498146/first-line-antiretroviral-treatment-outcomes-and-durability-in-hiv-infected-children-treated-through-the-universal-coverage-health-program-in-thailand
#18
Sirinya Teeraananchai, Torsak Bunupuradah, Thanyawee Puthanakit, Stephen J Kerr, Kiat Ruxrungtham, Suchada Chaivooth, Sorakij Bhakeecheep, Matthew G Law, Kulkanya Chokephaibulkit
BACKGROUND: We assessed the treatment outcomes on first-line antiretroviral therapy (ART), and factors associated with switching regimen in HIV-infected children treated through the universal coverage health program (UC) in Thailand. METHODS: Children aged <15 years at ART initiation who had been receiving ART for at least 6 months between 2008 and 2014 through UC were included in the analysis. The Kaplan-Meier method was used to estimate immunological recovery (IMR), immunological failure, and virological failure (VF)...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28494073/associations-of-luminal-and-basal-subtyping-of-prostate-cancer-with-prognosis-and-response-to-androgen-deprivation-therapy
#19
Shuang G Zhao, S Laura Chang, Nicholas Erho, Menggang Yu, Jonathan Lehrer, Mohammed Alshalalfa, Corey Speers, Matthew R Cooperberg, Won Kim, Charles J Ryan, Robert B Den, Stephen J Freedland, Edwin Posadas, Howard Sandler, Eric A Klein, Peter Black, Roland Seiler, Scott A Tomlins, Arul M Chinnaiyan, Robert B Jenkins, Elai Davicioni, Ashley E Ross, Edward M Schaeffer, Paul L Nguyen, Peter R Carroll, R Jeffrey Karnes, Daniel E Spratt, Felix Y Feng
Importance: There is a clear need for a molecular subtyping approach in prostate cancer to identify clinically distinct subgroups that benefit from specific therapies. Objectives: To identify prostate cancer subtypes based on luminal and basal lineage and to determine associations with clinical outcomes and response to treatment. Design, Setting, and Participants: The PAM50 classifier was used to subtype 1567 retrospectively collected (median follow-up, 10 years) and 2215 prospectively collected prostate cancer samples into luminal- and basal-like subtypes...
May 11, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28493789/idiopathic-pulmonary-fibrosis-data-driven-textural-analysis-of-extent-of-fibrosis-at-baseline-and-15-month-follow-up
#20
Stephen M Humphries, Kunihiro Yagihashi, Jason Huckleberry, Byung-Hak Rho, Joyce D Schroeder, Matthew Strand, Marvin I Schwarz, Kevin R Flaherty, Ella A Kazerooni, Edwin J R van Beek, David A Lynch
Purpose To evaluate associations between pulmonary function and both quantitative analysis and visual assessment of thin-section computed tomography (CT) images at baseline and at 15-month follow-up in subjects with idiopathic pulmonary fibrosis (IPF). Materials and Methods This retrospective analysis of preexisting anonymized data, collected prospectively between 2007 and 2013 in a HIPAA-compliant study, was exempt from additional institutional review board approval. The extent of lung fibrosis at baseline inspiratory chest CT in 280 subjects enrolled in the IPF Network was evaluated...
May 10, 2017: Radiology
keyword
keyword
50664
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"