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https://www.readbyqxmd.com/read/27859886/collateral-blood-flow-in-different-cerebrovascular-hierarchy-provides-endogenous-protection-in-cerebral-ischemia
#1
Chuanming Luo, Fengyin Liang, Huixia Ren, Xiaoli Yao, Qiang Liu, Mingyue Li, Dajiang Qin, Ti-Fei Yuan, Zhong Pei, Huanxing Su
Collateral blood flow as vascular adaptions to focal cerebral ischemia is well recognized. However, few studies directly investigate the dynamics of collateral vessel recruitment in vivo and little is known about the effect of collateral blood flow in different cerebrovascular hierarchy on the neuropathology after focal ischemic stroke. Here, we report that collateral blood flow is critically involved in blood vessel compensations following regional ischemia. We occluded a pial arteriole using femtosecond laser ablating under the intact thinned skull and documented the changes of collateral flow around the surface communication network and between the surface communication network and subsurface microcirculation network using in vivo two photon microscopy imaging...
November 15, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27717122/genetic-variants-in-cetp-increase-risk-of-intracerebral-hemorrhage
#2
Christopher D Anderson, Guido J Falcone, Chia-Ling Phuah, Farid Radmanesh, H Bart Brouwers, Thomas W K Battey, Alessandro Biffi, Gina M Peloso, Dajiang J Liu, Alison M Ayres, Joshua N Goldstein, Anand Viswanathan, Steven M Greenberg, Magdy Selim, James F Meschia, Devin L Brown, Bradford B Worrall, Scott L Silliman, David L Tirschwell, Matthew L Flaherty, Peter Kraft, Jeremiasz M Jagiella, Helena Schmidt, Björn M Hansen, Jordi Jimenez-Conde, Eva Giralt-Steinhauer, Roberto Elosua, Elisa Cuadrado-Godia, Carolina Soriano, Koen M van Nieuwenhuizen, Catharina J M Klijn, Kristiina Rannikmae, Neshika Samarasekera, Rustam Al-Shahi Salman, Catherine L Sudlow, Ian J Deary, Andrea Morotti, Alessandro Pezzini, Joanna Pera, Andrzej Urbanik, Alexander Pichler, Christian Enzinger, Bo Norrving, Joan Montaner, Israel Fernandez-Cadenas, Pilar Delgado, Jaume Roquer, Arne Lindgren, Agnieszka Slowik, Reinhold Schmidt, Chelsea S Kidwell, Steven J Kittner, Salina P Waddy, Carl D Langefeld, Goncalo Abecasis, Cristen J Willer, Sekar Kathiresan, Daniel Woo, Jonathan Rosand
OBJECTIVE: In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. Here, we test the hypothesis that CETP DNA sequence variants associated with higher HDL-C also increase risk for ICH...
November 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27702986/gadd45a-is-a-heterochromatin-relaxer-that-enhances-ips-cell-generation
#3
Keshi Chen, Qi Long, Tao Wang, Danyun Zhao, Yanshuang Zhou, Juntao Qi, Yi Wu, Shengbiao Li, Chunlan Chen, Xiaoming Zeng, Jianguo Yang, Zisong Zhou, Weiwen Qin, Xiyin Liu, Yuxing Li, Yingying Li, Xiaofen Huang, Dajiang Qin, Jiekai Chen, Guangjin Pan, Hans R Schöler, Guoliang Xu, Xingguo Liu, Duanqing Pei
Reprogramming of somatic cells to induced pluripotent stem cells rewrites the code of cell fate at the chromatin level. Yet, little is known about this process physically. Here, we describe a fluorescence recovery after photobleaching method to assess the dynamics of heterochromatin/euchromatin and show significant heterochromatin loosening at the initial stage of reprogramming. We identify growth arrest and DNA damage-inducible protein a (Gadd45a) as a chromatin relaxer in mouse embryonic fibroblasts, which also enhances somatic cell reprogramming efficiency...
October 4, 2016: EMBO Reports
https://www.readbyqxmd.com/read/27392709/lp-pla2-silencing-protects-against-ox-ldl-induced-oxidative-stress-and-cell-apoptosis-via-akt-mtor-signaling-pathway-in-human-thp1-macrophages
#4
HuaDong Zheng, DaJiang Cui, XiaoJuan Quan, WeiLin Yang, YingNa Li, Lin Zhang, EnQi Liu
Atherosclerosis is a disease of the large- and medium-size arteries that is characterized by the formation of atherosclerotic plaques, in which foam cells are the characteristic pathological cells. However, the key underlying pathomechanisms are still not fully elucidated. In this study, we investigated the role of lipoprotein-associated phospholipase A2 (Lp-PLA2) in ox-LDL-induced oxidative stress and cell apoptosis, and further, elucidated the potential machanisms in human THP1 macrophages. Flow cytometry and western blot analyses showed that both cell apoptosis and Lp-PLA2 expression were dose-dependently elevated after ox-LDL treatment for 24 h and also time-dependently increased after 50 mg/L ox-LDL incubation in THP1 macrophages...
September 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27346686/platelet-related-variants-identified-by-exomechip-meta-analysis-in-157-293-individuals
#5
John D Eicher, Nathalie Chami, Tim Kacprowski, Akihiro Nomura, Ming-Huei Chen, Lisa R Yanek, Salman M Tajuddin, Ursula M Schick, Andrew J Slater, Nathan Pankratz, Linda Polfus, Claudia Schurmann, Ayush Giri, Jennifer A Brody, Leslie A Lange, Ani Manichaikul, W David Hill, Raha Pazoki, Paul Elliot, Evangelos Evangelou, Ioanna Tzoulaki, He Gao, Anne-Claire Vergnaud, Rasika A Mathias, Diane M Becker, Lewis C Becker, Amber Burt, David R Crosslin, Leo-Pekka Lyytikäinen, Kjell Nikus, Jussi Hernesniemi, Mika Kähönen, Emma Raitoharju, Nina Mononen, Olli T Raitakari, Terho Lehtimäki, Mary Cushman, Neil A Zakai, Deborah A Nickerson, Laura M Raffield, Rakale Quarells, Cristen J Willer, Gina M Peloso, Goncalo R Abecasis, Dajiang J Liu, Panos Deloukas, Nilesh J Samani, Heribert Schunkert, Jeanette Erdmann, Myriam Fornage, Melissa Richard, Jean-Claude Tardif, John D Rioux, Marie-Pierre Dube, Simon de Denus, Yingchang Lu, Erwin P Bottinger, Ruth J F Loos, Albert Vernon Smith, Tamara B Harris, Lenore J Launer, Vilmundur Gudnason, Digna R Velez Edwards, Eric S Torstenson, Yongmei Liu, Russell P Tracy, Jerome I Rotter, Stephen S Rich, Heather M Highland, Eric Boerwinkle, Jin Li, Ethan Lange, James G Wilson, Evelin Mihailov, Reedik Mägi, Joel Hirschhorn, Andres Metspalu, Tõnu Esko, Caterina Vacchi-Suzzi, Mike A Nalls, Alan B Zonderman, Michele K Evans, Gunnar Engström, Marju Orho-Melander, Olle Melander, Michelle L O'Donoghue, Dawn M Waterworth, Lars Wallentin, Harvey D White, James S Floyd, Traci M Bartz, Kenneth M Rice, Bruce M Psaty, J M Starr, David C M Liewald, Caroline Hayward, Ian J Deary, Andreas Greinacher, Uwe Völker, Thomas Thiele, Henry Völzke, Frank J A van Rooij, André G Uitterlinden, Oscar H Franco, Abbas Dehghan, Todd L Edwards, Santhi K Ganesh, Sekar Kathiresan, Nauder Faraday, Paul L Auer, Alex P Reiner, Guillaume Lettre, Andrew D Johnson
Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monitored clinically by complete blood counts, specifically with measurements of platelet count (PLT) and mean platelet volume (MPV). Identifying genetic effects on PLT and MPV can provide mechanistic insights into platelet biology and their role in disease. Therefore, we formed the Blood Cell Consortium (BCX) to perform a large-scale meta-analysis of Exomechip association results for PLT and MPV in 157,293 and 57,617 individuals, respectively...
July 7, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27153000/rvtests-an-efficient-and-comprehensive-tool-for-rare-variant-association-analysis-using-sequence-data
#6
Xiaowei Zhan, Youna Hu, Bingshan Li, Goncalo R Abecasis, Dajiang J Liu
MOTIVATION: Next-generation sequencing technologies have enabled the large-scale assessment of the impact of rare and low-frequency genetic variants for complex human diseases. Gene-level association tests are often performed to analyze rare variants, where multiple rare variants in a gene region are analyzed jointly. Applying gene-level association tests to analyze sequence data often requires integrating multiple heterogeneous sources of information (e.g. annotations, functional prediction scores, allele frequencies, genotypes and phenotypes) to determine the optimal analysis unit and prioritize causal variants...
May 1, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27054276/group-wise-consistent-cortical-parcellation-based-on-connectional-profiles
#7
Tuo Zhang, Dajiang Zhu, Xi Jiang, Shu Zhang, Zhifeng Kou, Lei Guo, Tianming Liu
For decades, seeking common, consistent and corresponding anatomical/functional regions across individual brains via cortical parcellation has been a longstanding challenging problem. In our opinion, two major barriers to solve this problem are determining meaningful cortical boundaries that segregate homogeneous regions and establishing correspondences among parcellated regions of multiple brains. To establish a corresponding system across subjects, we recently developed the Dense Individualized and Common Connectivity-based Cortical Landmarks (DICCCOL) system which possesses group-wise consistent white matter fiber connection patterns across individuals and thus provides a dense map of corresponding cortical landmarks...
August 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27011505/modified-innervated-radial-collateral-artery-perforator-flap-for-repairing-digital-defects
#8
Dajiang Song, Jinsong Li, Kuangwen Li, Jun Liu, Jian Xu
The authors presented their clinical experience and demonstrated surgical methods to reconstruct soft-tissue defects in the digit by using modified innervated radial collateral artery perforator flap. Surgical procedures that involved 12 modified innervated radial collateral artery perforator flaps were performed in 12 patients. Among the patients, two had defects in the thumbs, six had defects in the index fingers, whereas two had defects in the middle fingers, two had defects in the little fingers. The flaps ranged in size from 5...
December 2015: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27011476/use-of-free-modified-innervated-posterior-interosseous-artery-perforator-flap-to-repair-digital-skin-and-soft-tissue-defects
#9
Jun Liu, Dajiang Song, Jian Xu, Jinsong Li, Kuangwen Li, Hongbin Lv
Current techniques to reconstruct soft tissue of the fingers result in scarring and functional deficits. Perforator flaps raised on the posterior interosseous artery are thin and well vascularised, and cause minimal donor site scarring. Using a flap with sensory nerves was hoped to contribute to the desired postoperative sensory recovery of fingers. We used modified innervated posterior interosseous perforator flaps to repair digital defects in 18 patients. Injuries included digit amputations and palmar soft tissue defects...
December 2015: Indian Journal of Surgery
https://www.readbyqxmd.com/read/26965621/rare-variant-in-scavenger-receptor-bi-raises-hdl-cholesterol-and-increases-risk-of-coronary-heart-disease
#10
Paolo Zanoni, Sumeet A Khetarpal, Daniel B Larach, William F Hancock-Cerutti, John S Millar, Marina Cuchel, Stephanie DerOhannessian, Anatol Kontush, Praveen Surendran, Danish Saleheen, Stella Trompet, J Wouter Jukema, Anton De Craen, Panos Deloukas, Naveed Sattar, Ian Ford, Chris Packard, Abdullah al Shafi Majumder, Dewan S Alam, Emanuele Di Angelantonio, Goncalo Abecasis, Rajiv Chowdhury, Jeanette Erdmann, Børge G Nordestgaard, Sune F Nielsen, Anne Tybjærg-Hansen, Ruth Frikke Schmidt, Kari Kuulasmaa, Dajiang J Liu, Markus Perola, Stefan Blankenberg, Veikko Salomaa, Satu Männistö, Philippe Amouyel, Dominique Arveiler, Jean Ferrieres, Martina Müller-Nurasyid, Marco Ferrario, Frank Kee, Cristen J Willer, Nilesh Samani, Heribert Schunkert, Adam S Butterworth, Joanna M M Howson, Gina M Peloso, Nathan O Stitziel, John Danesh, Sekar Kathiresan, Daniel J Rader
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C levels but, paradoxically, increased atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans remains unclear. Through targeted sequencing of coding regions of lipid-modifying genes in 328 individuals with extremely high plasma HDL-C levels, we identified a homozygote for a loss-of-function variant, in which leucine replaces proline 376 (P376L), in SCARB1, the gene encoding SR-BI...
March 11, 2016: Science
https://www.readbyqxmd.com/read/26711822/-comparison-of-minimally-invasive-using-a-tubular-retraction-system-versus-open-transforaminal-lumbar-interbody-fusion-for-the-treatment-of-lumbar-degenerative-diseases
#11
RANDOMIZED CONTROLLED TRIAL
Zhiping Luo, Haiqun Rao, Dajiang Huang, Guoyong Li, Chao Liu, Shuanghai Dong, Jiwei Tian
OBJECTIVE: To compare the clinical effect of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) using a tubular retraction system with traditional transforaminal lumbar interbody fusion (TLIF) for the treatment of lumbar degenerative diseases. METHOD: From June 2009 to June 2013, a total of 96 patients in Department of Orthopaedics, Armed Police Jiangxi Corps Hospital, suffering from lumbar degenerative diseases were divided into 2 groups randomly...
September 1, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26559266/surgical-versus-conservative-intervention-for-acute-achilles-tendon-rupture-a-prisma-compliant-systematic-review-of-overlapping-meta-analyses
#12
REVIEW
Hao Zhang, Hao Tang, Qianyun He, Qiang Wei, Dake Tong, Chuangfeng Wang, Dajiang Wu, Guangchao Wang, Xin Zhang, Wenbin Ding, Di Li, Chen Ding, Kang Liu, Fang Ji
Although many meta-analyses comparing surgical intervention with conservative treatment have been conducted for acute Achilles tendon rupture, discordant conclusions are shown. This study systematically reviewed the overlapping meta-analyses relating to surgical versus conservative intervention of acute Achilles tendon rupture to assist decision makers select among conflicting meta-analyses, and to offer intervention recommendations based on the currently best evidence.Multiple databases were comprehensively searched for meta-analyses comparing surgical with conservative treatment of acute Achilles tendon rupture...
November 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26544530/complete-mitochondrial-genome-of-stummer-s-racerunner-eremias-stummeri-from-kazakhstan
#13
Tianhe Zhou, Dajiang Li, Tatjana N Dujsebayeva, Jinlong Liu, Xianguang Guo
The whole mitochondrial genome was determined from a viviparous racerunner, Eremias stummeri, which was collected from southeast Kazakhstan. The mitogenome sequence was 19 602 bp in size, containing 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes and a control region, which is similar to the typical mtDNA of vertebrates. Mitochondrial genomes analyses using maximum parsimony and Bayesian analyses yielded identical phylogenetic trees, indicating a close phylogenetic affinity of the sampled taxa in genus Eremias...
November 6, 2015: Mitochondrial DNA
https://www.readbyqxmd.com/read/26195294/assessing-effects-of-prenatal-alcohol-exposure-using-group-wise-sparse-representation-of-fmri-data
#14
COMPARATIVE STUDY
Jinglei Lv, Xi Jiang, Xiang Li, Dajiang Zhu, Shijie Zhao, Tuo Zhang, Xintao Hu, Junwei Han, Lei Guo, Zhihao Li, Claire Coles, Xiaoping Hu, Tianming Liu
Task-based fMRI activation mapping has been widely used in clinical neuroscience in order to assess different functional activity patterns in conditions such as prenatal alcohol exposure (PAE) affected brains and healthy controls. In this paper, we propose a novel, alternative approach of group-wise sparse representation of the fMRI data of multiple groups of subjects (healthy control, exposed non-dysmorphic PAE and exposed dysmorphic PAE) and assess the systematic functional activity differences among these three populations...
August 30, 2015: Psychiatry Research
https://www.readbyqxmd.com/read/26082632/mesoporous-bioactive-glass-surface-modified-poly-lactic-co-glycolic-acid-electrospun-fibrous-scaffold-for-bone-regeneration
#15
Shijie Chen, Zhiyuan Jian, Linsheng Huang, Wei Xu, Shaohua Liu, Dajiang Song, Zongmiao Wan, Amanda Vaughn, Ruisen Zhan, Chaoyue Zhang, Song Wu, Minghua Hu, Jinsong Li
A mesoporous bioactive glass (MBG) surface modified with poly(lactic-co-glycolic acid) (PLGA) electrospun fibrous scaffold for bone regeneration was prepared by dip-coating a PLGA electrospun fibrous scaffold into MBG precursor solution. Different surface structures and properties were acquired by different coating times. Surface morphology, chemical composition, microstructure, pore size distribution, and hydrophilicity of the PLGA-MBG scaffold were characterized. Results of scanning electron microscopy indicated that MBG surface coating made the scaffold rougher with the increase of MBG content...
2015: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/26039791/correction-construction-of-multi-scale-consistent-brain-networks-methods-and-applications
#16
Bao Ge, Yin Tian, Xintao Hu, Hanbo Chen, Dajiang Zhu, Tuo Zhang, Junwei Han, Lei Guo, Tianming Liu
No abstract text is available yet for this article.
2015: PloS One
https://www.readbyqxmd.com/read/25951620/quantitative-three-dimensional-analysis-of-poly-lactic-co-glycolic-acid-microsphere-using-hard-x-ray-nano-tomography-revealed-correlation-between-structural-parameters-and-drug-burst-release
#17
Xiaozhou Huang, Na Li, Dajiang Wang, Yuyan Luo, Ziyu Wu, Zhefei Guo, Qixing Jin, Zhuying Liu, Yafei Huang, Yongming Zhang, Chuanbin Wu
The objective of this study was to investigate the use of transmission hard X-ray nano-computed-tomography (nano-CT) for characterization of the pore structure and drug distribution in poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating bovine serum albumin and to study the correlation between drug distribution and burst release. The PLGA microspheres were fabricated using a double-emulsion method. The results of pore structure analysis accessed with nano-CT were compared with those acquired by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM)...
August 10, 2015: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/25876038/construction-of-multi-scale-consistent-brain-networks-methods-and-applications
#18
Bao Ge, Yin Tian, Xintao Hu, Hanbo Chen, Dajiang Zhu, Tuo Zhang, Junwei Han, Lei Guo, Tianming Liu
Mapping human brain networks provides a basis for studying brain function and dysfunction, and thus has gained significant interest in recent years. However, modeling human brain networks still faces several challenges including constructing networks at multiple spatial scales and finding common corresponding networks across individuals. As a consequence, many previous methods were designed for a single resolution or scale of brain network, though the brain networks are multi-scale in nature. To address this problem, this paper presents a novel approach to constructing multi-scale common structural brain networks from DTI data via an improved multi-scale spectral clustering applied on our recently developed and validated DICCCOLs (Dense Individualized and Common Connectivity-based Cortical Landmarks)...
2015: PloS One
https://www.readbyqxmd.com/read/25740221/methods-for-association-analysis-and-meta-analysis-of-rare-variants-in-families
#19
Shuang Feng, Giorgio Pistis, He Zhang, Matthew Zawistowski, Antonella Mulas, Magdalena Zoledziewska, Oddgeir L Holmen, Fabio Busonero, Serena Sanna, Kristian Hveem, Cristen Willer, Francesco Cucca, Dajiang J Liu, Gonçalo R Abecasis
Advances in exome sequencing and the development of exome genotyping arrays are enabling explorations of association between rare coding variants and complex traits. To ensure power for these rare variant analyses, a variety of association tests that group variants by gene or functional unit have been proposed. Here, we extend these tests to family-based studies. We develop family-based burden tests, variable frequency threshold tests and sequence kernel association tests. Through simulations, we compare the performance of different tests...
May 2015: Genetic Epidemiology
https://www.readbyqxmd.com/read/25708700/mitochondrial-fusion-provides-an-initial-metabolic-complementation-controlled-by-mtdna
#20
Liang Yang, Qi Long, Jinglei Liu, Haite Tang, Yuxing Li, Feixiang Bao, Dajiang Qin, Duanqing Pei, Xingguo Liu
Heteroplasmic cells, harboring both mutant and normal mitochondrial DNAs (mtDNAs), must accumulate mutations to a threshold level before respiratory activity is affected. This phenomenon has led to the hypothesis of mtDNA complementation by inter-mitochondrial content mixing. The precise mechanisms of heteroplasmic complementation are unknown, but it depends both on the mtDNA nucleoid dynamics among mitochondria as well as the mitochondrial dynamics as influenced by mtDNA. We tracked nucleoids among the mitochondria in real time to show that they are shared after complete fusion but not 'kiss-and-run'...
July 2015: Cellular and Molecular Life Sciences: CMLS
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