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https://www.readbyqxmd.com/read/28212266/individual-patterns-in-blood-borne-indicators-of-fatigue-trait-or-chance
#1
Ross Julian, Tim Meyer, Hugh H K Fullagar, Sabrina Skorski, Mark Pfeiffer, Michael Kellmann, Alexander Ferrauti, Anne Hecksteden
Julian, R, Meyer, T, Fullagar, HHK, Skorski, S, Pfeiffer, M, Kellmann, M, Ferrauti, A, and Hecksteden, A. Individual patterns in blood-borne indicators of fatigue-trait or chance. J Strength Cond Res 31(3): 608-619, 2017-Blood-borne markers of fatigue such as creatine kinase (CK) and urea (U) are widely used to fine-tune training recommendations. However, predictive accuracy is low. A possible explanation for this dissatisfactory characteristic is the propensity of athletes to react to different patterns of fatigue indicators (e...
March 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28211610/fibroid-vascularisation-assessed-with-three-dimensional-power-doppler-ultrasound-is-a-predictor-for-uterine-fibroid-growth-a-prospective-cohort-study
#2
L L Nieuwenhuis, A L Keizer, B Stoelinga, J W R Twisk, W J K Hehenkamp, H A M Brölmann, J A F Huirne
OBJECTIVE: To analyse fibroid vascularisation measured with 3D Power Doppler in relation to absolute fibroid volume change during 12 months follow up and in relation to fibroid growth rate per year DESIGN: A prospective cohort study was performed between March 2012 and March 2014. SETTING: Outpatient clinic of the VU medical centre, Amsterdam. POPULATION OR SAMPLE: All premenopausal women diagnosed with a maximum of 2 fibroids with expectative management were consecutively included...
February 17, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28211134/effect-of-age-on-the-performance-of-bispectral-and-entropy-indices-during-sevoflurane-pediatric-anesthesia-a-pharmacometric-study
#3
Alberto Sciusco, Joseph F Standing, Yucheng Sheng, Pasquale Raimondo, Gilda Cinnella, Michele Dambrosio
BACKGROUND: Bispectral index (BIS) and entropy monitors have been proposed for use in children, but research has not supported their validity for infants. However, effective monitoring of young children may be even more important than for adults, to aid appropriate anesthetic dosing and reduce the chance of adverse consequences. This prospective study aimed to investigate the relationships between age and the predictive performance of BIS and entropy monitors in measuring the anesthetic drug effects within a pediatric surgery setting...
February 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28209405/insights-of-pb-isotopic-signature-into-the-historical-evolution-and-sources-of-pb-contamination-in-a-sediment-core-of-the-southwestern-iberian-atlantic-shelf
#4
Mário Mil-Homens, Carlos Vale, Pedro Brito, Filipa Naughton, Teresa Drago, Joana Raimundo, Bárbara Anes, Sabine Schmidt, Miguel Caetano
Stable Pb isotopic ratios and concentrations of Al, Cu and Pb were measured in a 5m long sediment core (VC2B) retrieved at 96m water depth in the southwestern Iberian Atlantic shelf. Five phases during the last 9.5kyrs were identified, two of them (Roman Period and modern mining) marked by a decrease of (206)Pb/(207)Pb ratios reflecting additional inputs of Pb derived from mining activities. The Roman Period was also characterized by high (208)Pb/(206)Pb ratios suggesting the exploitation of the outcropping portion of the orebody intensely weathered when compared with the other formations later mined...
February 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28208802/the-effect-of-mitochondrial-supplements-on-mitochondrial-activity-in-children-with-autism-spectrum-disorder
#5
Leanna M Delhey, Ekim Nur Kilinc, Li Yin, John C Slattery, Marie L Tippett, Shannon Rose, Sirish C Bennuri, Stephen G Kahler, Shirish Damle, Agustin Legido, Michael J Goldenthal, Richard E Frye
Treatment for mitochondrial dysfunction is typically guided by expert opinion with a paucity of empirical evidence of the effect of treatment on mitochondrial activity. We examined citrate synthase and Complex I and IV activities using a validated buccal swab method in 127 children with autism spectrum disorder with and without mitochondrial disease, a portion of which were on common mitochondrial supplements. Mixed-model linear regression determined whether specific supplements altered the absolute mitochondrial activity as well as the relationship between the activities of mitochondrial components...
February 13, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28207751/flavor-pleasantness-processing-in-the-ventral-emotion-network
#6
Jelle R Dalenberg, Liselore Weitkamp, Remco J Renken, Luca Nanetti, Gert J Ter Horst
The ventral emotion network-encompassing the amygdala, insula, ventral striatum, and ventral regions of the prefrontal cortex-has been associated with the identification of emotional significance of perceived external stimuli and the production of affective states. Functional magnetic resonance imaging (fMRI) studies investigating chemosensory stimuli have associated parts of this network with pleasantness coding. In the current study, we independently analyzed two datasets in which we measured brain responses to flavor stimuli in young adult men...
2017: PloS One
https://www.readbyqxmd.com/read/28207596/a-role-for-adrenergic-receptors-in-the-uterotonic-effects-of-ergometrine-in-isolated-human-term-nonlaboring-myometrium
#7
Rebecca A Fanning, Florike Sheehan, Claire Leyden, Niamh Duffy, Luis F Iglesias-Martinez, Michael F Carey, Deirdre P Campion, John J O'Connor
BACKGROUND: Ergometrine is a uterotonic agent that is recommended in the prevention and management of postpartum hemorrhage. Despite its long-standing use, the mechanism by which it acts in humans has never been elucidated fully. The objective of this study was to investigate the role of adrenoreceptors in ergometrine's mechanism of action in human myometrium. The study examined the hypothesis that α-adrenoreceptor antagonism would result in the reversal of the uterotonic effects of ergometrine...
February 15, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28207476/faecal-calprotectin-in-cystic-fibrosis-and-it-s-relation-to-disease-parameters-a-longitudinal-analysis-over-12-years
#8
Helmut Ellemunter, Alexander Engelhardt, Katharina Schüller, Gratiana Steinkamp
OBJECTIVES: Faecal calprotectin (FC) is a marker of inflammation in the intestinal tract. We assessed FC levels longitudinally in patients with cystic fibrosis (CF) and evaluated the relation between FC results and relevant markers of disease. METHODS: Calprotectin was measured in faecal samples starting in 2003 and values were stored in the centre's patient database. In this retrospective analysis we searched for associations of FC concentrations with disease severity and progression...
February 15, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28207178/dental-development-in-down-syndrome-and-healthy-children-a-comparative-study-using-the-demirjian-method
#9
M S van der Linden, S Vucic, D J F van Marrewijk, E M Ongkosuwito
OBJECTIVE: In children with Down syndrome, the timing of dental eruption is important for orthodontics treatment planning. Aim of this study was to determine whether tooth eruption and development of the dentition in children with Down syndrome are impaired. MATERIAL AND METHODS: Dental development was scored on orthopantomograms (OPTs) of 95 children with Down syndrome. The dental age was determined at the left mandibular side according to the Demirjian method and by converting the assigned scores to the dental maturity score...
February 16, 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28205533/a-data-driven-approach-for-evaluating-multi-modal-therapy-in-traumatic-brain-injury
#10
Jenny Haefeli, Adam R Ferguson, Deborah Bingham, Adrienne Orr, Seok Joon Won, Tina I Lam, Jian Shi, Sarah Hawley, Jialing Liu, Raymond A Swanson, Stephen M Massa
Combination therapies targeting multiple recovery mechanisms have the potential for additive or synergistic effects, but experimental design and analyses of multimodal therapeutic trials are challenging. To address this problem, we developed a data-driven approach to integrate and analyze raw source data from separate pre-clinical studies and evaluated interactions between four treatments following traumatic brain injury. Histologic and behavioral outcomes were measured in 202 rats treated with combinations of an anti-inflammatory agent (minocycline), a neurotrophic agent (LM11A-31), and physical therapy consisting of assisted exercise with or without botulinum toxin-induced limb constraint...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28203384/venous-haemodynamics-of-jet-impulse-technology-within-a-lower-limb-fibreglass-cast-a-randomized-controlled-trial
#11
Irene Braithwaite, Stephen Mackintosh, Samantha Buchanan, Kerstin Schwarzenlander, Bernadette De Ruyter
OBJECTIVES: We investigated popliteal venous haemodynamics of the VenaJet Jet Impulse Technology system within a below-knee fibreglass cast. DESIGN: Randomized controlled trial. PARTICIPANTS: Twenty-four healthy participants aged 18-54 had both feet placed within the Jet Impulse Technology system and were randomised for one or other leg to be within a below-knee fibreglass cast. SETTING: Pacific Radiology, Lower Hutt, Wellington...
February 2017: JRSM Open
https://www.readbyqxmd.com/read/28202088/what-influences-the-home-range-size-of-free-roaming-domestic-dogs
#12
S Dürr, N K Dhand, C Bombara, S Molloy, M P Ward
In many regions of the world domestic dogs are free roaming and live in close relationship with humans. These free-roaming domestic dogs (FRDD) can cause public health problems such as dog bites and transmission of infectious diseases. To effectively control diseases transmitted by FRDD, knowledge on the dogs' behaviour is required. To identify predictors of home range (HR) size, we collected global positioning system data from 135 FRDD living in eight Aboriginal and Torres Strait Islander communities in Northern Australia...
February 16, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28202011/a-comparison-of-analytic-approaches-for-individual-patient-data-meta-analyses-with-binary-outcomes
#13
Doneal Thomas, Robert Platt, Andrea Benedetti
BACKGROUND: Individual patient data meta-analyses (IPD-MA) are often performed using a one-stage approach-- a form of generalized linear mixed model (GLMM) for binary outcomes. We compare (i) one-stage to two-stage approaches (ii) the performance of two estimation procedures (Penalized Quasi-likelihood-PQL and Adaptive Gaussian Hermite Quadrature-AGHQ) for GLMMs with binary outcomes within the one-stage approach and (iii) using stratified study-effect or random study-effects. METHODS: We compare the different approaches via a simulation study, in terms of bias, mean-squared error (MSE), coverage and numerical convergence, of the pooled treatment effect (β 1) and between-study heterogeneity of the treatment effect (τ 1(2) )...
February 16, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28201910/mode-specific-excited-state-dynamics-study-of-bis-phenylethynyl-benzene-from-ultrafast-raman-loss-spectroscopy
#14
Khokan Roy, Surajit Kayal, Freek Ariese, Andrew Beeby, Siva Umapathy
Femtosecond transient absorption (fs-TA) and Ultrafast Raman Loss Spectroscopy (URLS) have been applied to reveal the excited state dynamics of bis(phenylethynyl)benzene (BPEB), a model system for one-dimensional molecular wires that have numerous applications in opto-electronics. It is known from the literature that in the ground state BPEB has a low torsional barrier, resulting in a mixed population of rotamers in solution at room temperature. For the excited state this torsional barrier had been calculated to be much higher...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28199954/effects-of-single-family-rooms-on-nurse-parent-and-nurse-infant-interaction-in-neonatal-intensive-care-unit
#15
Mirka Toivonen, Liisa Lehtonen, Eliisa Löyttyniemi, Anna Axelin
BACKGROUND: Single-family rooms in neonatal intensive care unit can provide longer interaction between family and staff. On the other hand, separation in private rooms has been shown detrimental to child development if parents are not present. AIMS: To examine the effects of single-family rooms on nurse-family, nurse-parent and nurse-infant interaction time in neonatal intensive care unit. STUDY DESIGN: A quantitative, comparative, observational study was conducted before and after a move to a neonatal intensive care unit with single-family rooms...
February 12, 2017: Early Human Development
https://www.readbyqxmd.com/read/28199381/impact-of-the-anti-aquaporin-4-autoantibody-on-inner-retinal-structure-function-and-structure-function-associations-in-japanese-patients-with-optic-neuritis
#16
Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Ichiro Nakashima, Makoto Nakamura
PURPOSE: An autoantibody against aquaporin-4 (AQP4 Ab) is highly specific for neuromyelitis optica spectrum disorder and plays a pathogenic role in this disease. The purpose of this study was to investigate the impact of AQP4 Ab on inner retinal structure, function, and the structure-function relationships in eyes with optic neuritis. METHODS: Thirty five eyes from 25 cases who had received visual function tests and RTVue optical coherence tomography (OCT) measurement at least six months after the latest episode of optic neuritis were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28198773/early-post-operative-results-of-percutaneous-needle-fasciotomy-in-451-patients-with-dupuytren-disease
#17
Sanne Molenkamp, Tanneke A M Schouten, Dieuwke C Broekstra, Paul M N Werker, J Daniel Moolenburgh
BACKGROUND: Percutaneous needle fasciotomy (PNF) is a minimally invasive treatment modality for Dupuytren disease (DD). In this study we analyzed the efficacy and complication-rate of PNF using a statistical method that takes the multi-level structure of data, regarding multiple measurements from the same patients, into account. METHODS: The data of 470 treated rays from 451 patients with Dupuytren disease that underwent percutaneous needle fasciotomy (PNF) were analyzed retrospectively...
February 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28197773/change-in-tongue-pressure-in-patients-with-head-and-neck-cancer-after-surgical-resection
#18
Yoko Hasegawa, Kazuma Sugahara, Tatsuyuki Fukuoka, Shota Saito, Ayumi Sakuramoto, Nobuhide Horii, Saori Sano, Kana Hasegawa, Yuta Nakao, Tomoki Nanto, Kanenori Kadoi, Kuniyasu Moridera, Kazuma Noguchi, Kazuhisa Domen, Hiromitsu Kishimoto
Tongue pressure is reportedly associated with dysphagia. This study investigated relationships among characteristics of head and neck cancer, tongue pressure and dysphagia screening tests performed in patients with head and neck cancer during the acute phase after surgical resection. Fifty-seven patients (36 men, 21 women; age range 26-95 years) underwent surgical resection and dysphagia screening tests (Repetitive Saliva Swallowing Test, Water Swallowing Test, Modified Water Swallowing Test and Food Test) and pre- and postoperative measurement of tongue pressure at 5 time points (preoperatively, and 1-2 weeks and 1, 2, and 3 months postoperatively)...
February 14, 2017: Odontology
https://www.readbyqxmd.com/read/28196874/prospective-evaluation-of-sunitinib-induced-cardiotoxicity-in-patients-with-metastatic-renal-cell-carcinoma
#19
Vivek Narayan, Stephen M Keefe, Naomi Haas, Le Wang, Igor Puzanov, Mary E Putt, Anna Catino, James Fang, Neeraj Agarwal, David Hyman, Amanda M Smith, Brian S Finkelman, Hari K Narayan, Steven Ewer, Chantal ElAmm, Daniel J Lenihan, Bonnie Ky
PURPOSE: To prospectively evaluate cardiotoxicity risk with sunitinib in metastatic renal cell carcinoma (mRCC) routine clinical practice using comprehensive echocardiography and biomarker phenotyping. PATIENTS AND METHODS: In a multi-center prospective study of 90 mRCC patients, echocardiography and biomarkers of cardiovascular injury and stress were quantified at baseline, 3.5, 15, and 33 weeks following sunitinib initiation. These "on-drug" visits corresponded to cycles 1, 3, and 6, respectively...
February 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28196848/gps-based-exposure-to-greenness-and-walkability-and-accelerometry-based-physical-activity
#20
Peter James, Jaime E Hart, J Aaron Hipp, Jonathan Mitchell, Jacqueline Kerr, Philip M Hurvitz, Karen Glanz, Francine Laden
BACKGROUND: Physical inactivity is a risk factor for cancer that may be influenced by environmental factors. Indeed, dense and well-connected built environments and environments with natural vegetation may create opportunities for higher routine physical activity. However, studies have focused primarily on residential environments to define exposure and self-reported methods to estimate physical activity. The current study explores the momentary association between minute-level global positioning systems (GPS)-based greenness exposure and time-matched objectively measured physical activity...
February 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
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