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Wheezy in children

Elizabeth L Degabriele, Kara L Holloway, Julie A Pasco, Natalie K Hyde, Peter J Vuillermin, Lana J Williams, Sharon L Brennan-Olsen
AIM: World-wide, approximately 14% of children have prevalent asthma. As most bone accrual occurs in childhood, and data suggest a detrimental role in bone from asthma and/or medications, we investigated whether asthma was associated with radiologically confirmed fractures in a large cohort of children. METHODS: Data from the Barwon Asthma Study (2005), a population-based, cross-sectional survey of all children attending 91 primary schools in the Barwon Statistical Division, were linked to the Geelong Osteoporosis Study Fracture Grid (2006-2007), a fracture register encompassing the Barwon Statistical Division (n = 16 438; 50...
April 3, 2018: Journal of Paediatrics and Child Health
Hikmet Tekin Nacaroglu, Demet Can, Ilker Gunay, Canan Sule Unsal Karkıner, Turkan Gunay, Dilek Cimrin, Tugba Nalcabasmaz
INTRODUCTION: Environmental tobacco smoke (ETS) is thought to increase the severity and number of attacks in wheezy children. Objective assessments are needed to change the behavior of families to reduce the exposure of wheezy children to ETS. AIM: To determine whether informing families about their children's urinary cotinine levels curtailed the exposure of children to ETS. MATERIAL AND METHODS: A survey was used to determine the ETS exposure level, and the urinary cotinine level of each patient was tested...
August 2017: Postȩpy Dermatologii i Alergologii
Ozge Yilmaz, Ahmet Turkeli, Ece Onur, Sema Bilge, Hasan Yuksel
OBJECTIVES: Prenatal and postnatal smoke exposures are associated with many lung diseases in children due to impaired lung function, increased inflammation, and oxidative stress. We aimed to determine the influence of secondhand tobacco smoke exposure on the levels of nasal glutathione, IL-8, IL-17, MMP-9, and TIMP-1, as well as serum surfactant protein-D (SP-D) in wheezy children. METHODS: We enrolled 150 children with recurrent wheezing and recorded wheezing characteristics at enrollment...
May 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Iram Haq, Caroline Harris, Jake Taylor, Michael C McKean, Malcolm Brodlie
No abstract text is available yet for this article.
August 5, 2017: Archives of Disease in Childhood
Christina G Kwong, Leonard B Bacharier
PURPOSE OF REVIEW: Antibiotics are commonly used to treat wheezy lower respiratory tract illnesses in preschoolers, although these infections have been traditionally thought to be predominantly of viral origin. Our purpose is to review recent research pertaining to the role of antibiotics in lower respiratory tract illnesses and on subsequent asthma development, as well as the possible mechanisms of their effects. RECENT FINDINGS: Increasing evidence suggests that asthma pathogenesis is associated with events during infancy and early childhood, particularly respiratory tract infections...
May 2017: Current Allergy and Asthma Reports
Katherine Harris, Gioia Mosler, Samson A Williams, Abigail Whitehouse, Rosalind Raine, Jonathan Grigg
OBJECTIVE: The asthma control test (ACT) is a validated tool for assessing control in asthmatic children aged 12 years and older. Using the ACT, we sought to assess asthma control and knowledge in London secondary school children. METHODS: Secondary schools in London, UK, participated in this study. Children with doctor-diagnosed asthma were invited to complete an online questionnaire that included the ACT and questions about asthma. Suboptimal asthma control was defined as an ACT score of ≤ 19 out of a maximum score of 25...
December 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
J de Blic, J Brouard, A Vabret, A Deschildre
The spectrum of respiratory viruses is expanding and emerging diseases have been described regularly over the last fifteen years. The origin of these emerging respiratory viruses may be zoonotic (by crossing species barrier, after changes to RNA viruses such as avian influenza virus type A or coronaviruses), or related to the use of new identification techniques (metapneumovirus, bocavirus). The relationship between bronchiolitis and asthma is now better understood thanks to prospective follow up of birth cohorts...
February 2017: Revue des Maladies Respiratoires
Linan Zeng, Die Hu, Imti Choonara, Dezhi Mu, Lingli Zhang, Xihong Li, Zuojie Zhang, Zhiqiang Hu, Shuyan Quan
BACKGROUND: Antibiotics are one of the most widely misused group of medicines. The aim of this study was to investigate the use of antibiotics in one of the paediatric emergency departments in China. METHODS: We performed a prospective, cross-sectional study of antibiotic use in the paediatric emergency room of West China Second University Hospital. A total of 500 consecutive patients from March 25 to April 3 2013 were included. Clinical details of the patients were also collected in order to analyse antibiotic use...
February 2017: International Journal of Pharmacy Practice
Somnath Mukhopadhyay, Paul Seddon, Gemma Earl, Emma Wileman, Liz Symes, Cathy Olden, Corinne Alberti, Stephen Bremner, Alison Lansley, Colin N A Palmer, Nicole Beydon
BACKGROUND: Asthma is a common problem in children and, if inadequately controlled, may seriously diminish their quality of life. Inhaled short-acting beta2 agonists such as salbutamol are usually prescribed as 'reliever' medication to help control day-to-day symptoms such as wheeze. As with many medications currently prescribed for younger children (defined as those aged 2 years 6 months to 6 years 11 months), there has been no pre-licensing age-specific pharmacological testing; consequently, the doses currently prescribed (200-1000 μg) may be ineffective or likely to induce unnecessary side effects...
November 11, 2016: Trials
Fernando Maria de Benedictis, Andrew Bush
Wheeze is a common symptom in young children and is usually associated with viral illnesses. It is a major source of morbidity and is responsible for a high consumption of healthcare and economic resources worldwide. A few children have a condition resembling classical asthma. Rarer specific conditions may have a wheezy component and should be considered in the differential diagnosis. Over the last half century, there have been many circular discussions about the best way of managing preschool wheeze. In general, intermittent wheezing should be treated with intermittent bronchodilator therapy, and a controller therapy should be prescribed for a young child with recurrent wheezing only if positively indicated, and only then if carefully monitored for efficacy...
April 2017: Archives of Disease in Childhood
Grace Li, Ofran Almossawi, Hasna Dulfeker, Vicky Jones, Felicity Taylor
AIM: To compare the palatability of oral non-soluble and oral soluble prednisolone tablets in paediatric patients admitted to the general paediatric wards in an acute London Trust. METHOD: As part of ongoing quality improvement initiatives, the Paediatric and Pharmacy departments compared tolerability of soluble versus non-soluble prednisolone in a group of 27 patients. Using a modified 5 point hedonic scale with 'smiley' faces we measured palatability and tolerance (swallowed versus refusal or vomiting) over two three week periods: the first period whilst soluble prednisolone was dispensed (n=17) and the second period after the switch to non-soluble prednisolone had been made (n=10)...
September 2016: Archives of Disease in Childhood
Wenjing Gu, Yuqing Wang, Chuangli Hao, Xinxing Zhang, Yongdong Yan, Zhengrong Chen, Wujun Jiang, Xuejun Shao, Wei Ji
Our aim was to study the epidemiology and clinical manifestations of human metapneumovirus (hMPV) infection in children in the Suzhou area, China, and to investigate the effect of thymic stromal lymphopoietin (TSLP) on wheezing in hMPV-infected children. The study included 13,533 children with respiratory tract infections who were admitted to the Children's Hospital of Soochow University between January 2009 and December 2014. Clinical data were recorded. Plasma levels of TSLP, interleukin (IL)-4, and IL-2 were compared among 35 wheezing children with single hMPV infection, 15 non-wheezing children with hMPV infection, and 35 wheezing children with other viral infections...
March 24, 2017: Japanese Journal of Infectious Diseases
Véronique Nève, Sébastien Hulo, Jean-Louis Edmé, Sophie Boileau, Georges Baquet, Guillaume Pouessel, Caroline Thumerelle, Antoine Deschildre, Régis Matran
Uncontrolled wheezing disorder is common in preschoolers and disease control assessment is challenging as parents frequently overestimate the extent to which their child's disease is controlled. This is the first study of forced expiratory volume in t s (FEVt)/forced vital capacity (FVC) ratio measurements (i.e. FEV1/FVC, FEV0.75/FVC and FEV0.5/FVC) in wheezy preschoolers in relation to disease control. Our objective was to evaluate whether FEVt/FVC ratios less than the lower limit of normal (LLN; z-score <-1...
August 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Selda Hançerli-Törün, Deniz Özçeker, Metin Uysalol, Zeynep Tamay, Güntülü Şık, Ayper Somer, Meral Çıplak, Agop Çıtak, Nuran Salman, Nermin Güler
The aim of study was to evaluate various risk in patients who were hospitalized with moderate to severe virus-induced wheezing. Infants hospitalized with virus-induced wheezing were enrolled in the study. Respiratory viruses were detected in nasopharyngeal swab and total IgE levels and skin prick tests were performed in all patients. The mean age of the patients was 11.2±9 months. The most common detected viral agents were Respiratory Syncytial Virus, (33.6%), Influenza virus (16.3.%). Children with positive family history of atopy had their first virus-induced wheezing at an earlier age (9...
July 2015: Turkish Journal of Pediatrics
Qing Fan, Tingting Gu, Peijie Li, Ping Yan, Dehong Chen, Bingchao Han
BACKGROUND: The study aimed to explore possible factors influencing wheezing in children with Mycoplasma pneumoniae pneumonia (MPP). METHODS: The study included 84 children with MPP, who were divided into two groups: wheezy group (n=40) and non-wheezy group (n=44), along with 30 age-matched healthy controls. T-cell immunoglobulin and mucin domain gene (Tim) 1, 3 and Toll-like receptor (TLR) 2, 4 were evaluated using RT-PCR. Serum IL-10, TNF-α, IFN-γ and IgE were assessed by enzyme-linked immunosorbent assay...
December 2016: Heart, Lung & Circulation
Dorottya Czövek, Claire Shackleton, Zoltán Hantos, Kate Taylor, Anushma Kumar, Archana Chacko, Robert S Ware, Gergely Makan, Bence Radics, Zoltán Gingl, Peter D Sly
RATIONALE: Individual assessment of airway obstruction in preschool-age children requires sensitive and specific lung function methods with low demand of cooperation. Although the forced oscillation technique (FOT) is feasible in young children, conventional measurements of respiratory impedance (Zrs) have limited diagnostic power in individuals. OBJECTIVE: To find descriptors of within-breath Zrs that are sensitive indicators of airway obstruction during tidal breathing in children...
October 2016: Thorax
Victoria MacBean, Caroline J Jolley, Timothy G Sutton, Akash Deep, Anne Greenough, John Moxham, Gerrard F Rafferty
BACKGROUND: Parasternal intercostal muscle electromyography (EMGpara) represents a novel tool to assess respiratory load when volitional techniques are not possible. This study examined the application of EMGpara in healthy, wheezy, and critically ill children. METHODS: Surface EMGpara was measured during tidal breathing in 92 healthy children, 20 wheezy preschool children (with measurements repeated following bronchodilator), and 25 mechanically ventilated children during supported ventilation and on continuous positive airways pressure...
September 2016: Pediatric Research
C C Grant, J Crane, E A Mitchell, J Sinclair, A Stewart, T Milne, J Knight, C Gilchrist, C A Camargo
BACKGROUND: Vitamin D has immune-modulating effects. We determined whether vitamin D supplementation during pregnancy and infancy prevents aeroallergen sensitization and primary care respiratory illness presentations. METHODS: A randomized, double-blind, placebo-controlled parallel-group trial. We assigned pregnant women, from 27-week gestation to birth, and then their infants, from birth to 6 months, to placebo or one of two dosages of daily oral vitamin D. Woman/infant pairs were randomized to: placebo/placebo, 1000 IU/400 IU or 2000 IU/800 IU...
September 2016: Allergy
Solomon Shavit, Shlomo Cohen, Aliza Goldman, Lior Ben-Dov, Avraham Avital, Chaim Springer, Avigdor Hevroni
OBJECTIVE: Spirometry including bronchodilator responsiveness is considered routine in the workup of asthma in older children. However, in wheezy infants the existence of bronchodilator responsiveness and its prognostic significance remain unclear. METHODS: Infants (< 2 years) with chronic or recurrent wheezing or coughing were evaluated by infant pulmonary function testing (PFT). Maximal expiratory flow at the point of functional residual capacity (V̇maxFRC) was measured before and 20 minutes after salbutamol administration...
September 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Ilknur Bostanci, Serap Ozmen, Hilal Susam Sen, Emine Misirlioglu Dibek, Pelin Zorlu
No abstract text is available yet for this article.
November 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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