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JOURNAL ARTICLE
Deni Tressová, Elien De Caluwé, Stefan Bogaerts
Since the publication of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) , identity impairment has become a diagnostic criterion for all personality disorders. The current study examined the occurrence of identity dimensions, clinically relevant identity impairments and personality pathology, and associations between these constructs in 92 forensic patients and 139 healthy controls. Patients showed higher levels of almost all identity dimensions, identity impairments, personality disorders, and almost all maladaptive personality traits than controls...
April 23, 2024: International Journal of Offender Therapy and Comparative Criminology
#2
JOURNAL ARTICLE
Saadia Ilyas, Imran Khan, Zaland A Yousafzai, Qazi Kamran Amin, Zainab Rahman, Muhammad Bilal
BACKGROUND: Corynebacterium diphtheriae infection, causing diphtheria, is a public health concern, particularly in developing nations like Pakistan. Despite immunization efforts, recent outbreaks since 2022 have emphasized the continuing threat. This study focuses on describing the clinical characteristics of children with diphtheria-induced myocarditis and exploring the association between early cardiac abnormalities, future fatality rates, and contributing factors. METHODS: A one-year cross-sectional study was undertaken at Lady Reading Hospital MTI Peshawar, encompassing 73 pediatric patients diagnosed with diphtheria-associated myocarditis...
March 2024: Curēus
#3
JOURNAL ARTICLE
Yuzhen Jiang, Lei Xiang, Da He, Wei Tian
OBJECTIVE: To assess the feasibility of the robot-assisted retractor. To compare the muscle injury of the two operation modes, intermittent retraction mode and continuous retraction mode in the robot-assisted retractor to find a better robot operation mode. METHODS: A new robot-assisted retractor experimental platform was developed. Three incisions were made on the backs of three beagles. The robot-assisted retractor was used to retract the muscle on both sides of the incisions in intermittent retraction mode and continuous retraction mode, and the operation of the robot system was observed...
2024: Journal of Orthopaedic Surgery
#4
JOURNAL ARTICLE
Fahad A Al Dihan, Mohannad A Alghamdi, Faisal A Aldihan, Nawaf M Alamer, Faisal A Alshahrani, Ayyob Alqarni
Introduction The use of robotic-assisted surgeries (RAS) has been growing in surgical specialties. It allows surgeons to perform higher-quality operations with fewer complications, mortality, and morbidity. However, there are a lot of misconceptions about RAS among patients. Therefore, our study aimed to assess the knowledge, attitude, awareness, and future expectations of RAS in patients attending surgical clinics. Methods A cross-sectional study was conducted in King Abdulaziz Medical City (KAMC) surgical clinics in Riyadh, Saudi Arabia...
March 2024: Curēus
#5
JOURNAL ARTICLE
Marlon Luca Machal
OBJECTIVES: This research aims to present and assess the Primary Functions of autoinjectors introduced in ISO 11608-1:2022. Investigate the risks in current autoinjector technology, identify and assess risks and benefits associated with Artificial Intelligence (AI) powered autoinjectors, and propose a framework for mitigating these risks. ISO 11608-1:2022 is a standard that specifies requirements and test methods for needle-based injection systems intended to deliver drugs, focusing on design and function to ensure patient safety and product effectiveness...
2024: Frontiers in medical technology
#6
JOURNAL ARTICLE
Namiko Nishida, Nanae Nagata, Keigo Shimoji, Naoto Jingami, Kengo Uemura, Akihiko Ozaki, Makio Takahashi, Yoshihiro Urade, Sadayuki Matsumoto, Koichi Iwasaki, Ryosuke Okumura, Masatsune Ishikawa, Hiroki Toda
Idiopathic normal pressure hydrocephalus in elderly people is considered a form of glymphopathy caused by malfunction of the waste clearance pathway, called the glymphatic system. Tau is a representative waste material similar to amyloid-β. During neurodegeneration, lipocalin-type prostaglandin D synthase (L-PGDS), a major cerebrospinal fluid (CSF) protein, is reported to act as a chaperone that prevents the neurotoxic aggregation of amyloid-β. L-PGDS is also a CSF biomarker in idiopathic normal pressure hydrocephalus and significantly correlates with tau concentration, age, and age-related brain white matter changes detected by magnetic resonance imaging...
2024: Frontiers in Aging Neuroscience
#7
REVIEW
Léo Pio-Lopez, Michael Levin
Maintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to cancer and an accumulation of molecular and cellular disorders. Perhaps, the most consistent and pervasive result of these failures is aging, which is characterized by the progressive loss of function and decline in the ability to maintain anatomical homeostasis and reproduce. This leads to organ malfunction, diseases, and ultimately death. The traditional understanding of aging is that it is caused by the accumulation of molecular and cellular damage...
April 16, 2024: Ageing Research Reviews
#8
JOURNAL ARTICLE
Yongrong Zhou, Yan Zhao, Zhaoxing Ma
With the increasing demand for electricity, microgrid systems are facing issues such as insufficient backup capacity, frequent load switching, and frequent malfunctions, making research on microgrid resilience crucial, especially to improve system power supply reliability. This paper proposes a method for analyzing the resilience metric of new energy grid-connected microgrid system, and proposes optimization strategies to improve resilience. Firstly, a measurement method for the resilience of the microgrid system is established based on the operating characteristics of the system components...
2024: PloS One
#9
JOURNAL ARTICLE
Huicheng Chen, Zhimao Wu, Ziwei Yan, Chuan Chen, Yingying Zhang, Qiaoling Wang, Yuqing Gao, Kun Ling, Jinghua Hu, Qing Wei
Serving as the cell's sensory antennae, primary cilia are linked to numerous human genetic diseases when they malfunction. DZIP1L, identified as one of the genetic causes of human autosomal recessive polycystic kidney disease (ARPKD), is an evolutionarily conserved ciliary basal body protein. Although it has been reported that DZIP1L is involved in the ciliary entry of PKD proteins, the underlying mechanism remains elusive. Here, an uncharacterized role of DZIP1L is reported in modulating the architecture and function of transition fibers (TFs), striking ciliary base structures essential for selective cilia gating...
April 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#10
JOURNAL ARTICLE
Leo Meriranta, Selma Sorri, Kanutte Huse, Xiaonan Liu, Ivana Spasevska, Sadia Zafar, Iftekhar Chowdhury, Olli Dufva, Eerika Sahlberg, Luka Tandaric, Marja-Liisa Karjalainen-Lindsberg, Marko Hyytiainen, Markku Varjosalo, June H Myklebust, Sirpa Leppa
Pathomechanisms that activate oncogenic B-cell receptor (BCR) signaling in diffuse large B-cell lymphoma (DLBCL), are largely unknown. Kelch-like family member 6 (KLHL6) encoding a substrate-adapter for Cullin-3-RING E3 ubiquitin-ligase (CRL) with poorly established targets is recurrently mutated in DLBCL. By applying high-throughput protein interactome screens and functional characterization, we discovered that KLHL6 regulates BCR by targeting its signaling subunits CD79A and CD79B. Loss of physiological KLHL6 expression pattern was frequent among the MCD/C5-like activated B-cell DLBCLs and was associated with higher CD79B levels and dismal outcome...
April 17, 2024: Blood cancer discovery
#11
JOURNAL ARTICLE
Liang Ning, Dongfeng Pei
With the rapid development of the national economy, power security is very important for the security of the country and people's happiness. Electricity is an important energy source for a country. Even if the power system malfunctions for a short period of time, it would cause incalculable losses to social production and people's lives. Among them, one of the most important reasons for power system faults is the occurrence of power line faults, so diagnosing faulty lines has great research significance. On the basis of analyzing the structure and working principle of the deep learning model convolutional neural network (CNN), this article used the CNN model to diagnose faults in power lines and analyzed the simulation results...
April 30, 2024: Heliyon
#12
JOURNAL ARTICLE
Jiangshan Xu, Pengcheng Guo, Shijie Hao, Shuncheng Shangguan, Quan Shi, Giacomo Volpe, Keke Huang, Jing Zuo, Juan An, Yue Yuan, Mengnan Cheng, Qiuting Deng, Xiao Zhang, Guangyao Lai, Haitao Nan, Baihua Wu, Xinyi Shentu, Liang Wu, Xiaoyu Wei, Yujia Jiang, Xin Huang, Fengyu Pan, Yumo Song, Ronghai Li, Zhifeng Wang, Chuanyu Liu, Shiping Liu, Yuxiang Li, Tao Yang, Zhicheng Xu, Wensi Du, Ling Li, Tanveer Ahmed, Kai You, Zhen Dai, Li Li, Baoming Qin, Yinxiong Li, Liangxue Lai, Dajiang Qin, Junling Chen, Rong Fan, Yongyin Li, Jinlin Hou, Michael Ott, Amar Deep Sharma, Tobias Cantz, Axel Schambach, Karsten Kristiansen, Andrew P Hutchins, Berthold Göttgens, Patrick H Maxwell, Lijian Hui, Xun Xu, Longqi Liu, Ao Chen, Yiwei Lai, Miguel A Esteban
The mechanism by which mammalian liver cell responses are coordinated during tissue homeostasis and perturbation is poorly understood, representing a major obstacle in our understanding of many diseases. This knowledge gap is caused by the difficulty involved with studying multiple cell types in different states and locations, particularly when these are transient. We have combined Stereo-seq (spatiotemporal enhanced resolution omics-sequencing) with single-cell transcriptomic profiling of 473,290 cells to generate a high-definition spatiotemporal atlas of mouse liver homeostasis and regeneration at the whole-lobe scale...
April 16, 2024: Nature Genetics
#13
JOURNAL ARTICLE
Roxana Apostol, Paul Rodrigue
After therapeutic pelvic radiation for malignancy such as prostate cancer, patients are at greater risk for spontaneous ureteral rupture. Bladder outlet obstruction and other more proximal causes of obstruction also exacerbate this vulnerability. Here we present a case of spontaneous ureteral rupture during a 99m Tc-mercaptoacetyltriglycine nuclear renal scan secondary to Foley catheter obstruction in a 73-y-old man with a prior ureteral reimplantation procedure. Prompt detection of Foley catheter malfunction could potentially prevent such adverse events...
April 16, 2024: Journal of Nuclear Medicine Technology
#14
JOURNAL ARTICLE
Eliza M Greiner, Gorica D Petrovich
It is adaptive to restrict eating under uncertainty, such as during habituation to novel foods and unfamiliar environments. However, sustained restrictive eating can become maladaptive. Currently, the neural substrates of restrictive eating are poorly understood. Using a model of feeding avoidance under novelty, our recent study identified forebrain activation patterns and found evidence that the central nucleus of the amygdala (CEA) is a core integrating node. The current study analyzed the activity of CEA inputs in male and female rats to determine if specific pathways are recruited during feeding under novelty...
April 16, 2024: Brain Structure & Function
#15
JOURNAL ARTICLE
Adil Illi, Khadija Bouzaachane, Salah El Hadaj, El Mahdi El Guarmah
Detecting emergency aircraft landing sites is crucial for ensuring passenger and crew safety during unexpected forced landings caused by factors like engine malfunctions, adverse weather, or other aviation emergencies. In this article, we present a dataset consisting of Google Maps images with their corresponding masks, specifically crafted with manual annotations of emergency aircraft landing sites, distinguishing between safe areas with suitable conditions for emergency landings and unsafe areas presenting hazardous conditions...
June 2024: Data in Brief
#16
JOURNAL ARTICLE
Razan M Alajoleen, Liwu Li, Xin M Luo
Regulatory B (Breg) cells have been demonstrated to play an important role in the inhibition of a wide range of immunological responses, and they are absent or malfunction in autoimmune diseases like lupus. Breg cells can control immunological responses and keep the immune system in a balanced state by releasing immunosuppressive cytokines such as transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10), which in turn promote regulatory T (Treg) cells and reduce effector T cell responses. Breg cells have also been linked to the modulation of cancer immunity...
2024: Methods in Molecular Biology
#17
REVIEW
Svyatoslav S Sokolov, Fedor F Severin
For most of their lifespan, the probability of death for many animal species increases with age. Gompertz law states that this increase is exponential. In this work, we have compared previously published data on the survival kinetics of different lines of progeric mice. Visual analysis showed that in six lines of these rapidly aging mutants, the probability of death did not strictly depend on age. In contrast, ten lines of progeric mice have survival curves similar to those of the control animals, that is, in agreement with Gompertz law, similar to the shape of an exponential curve upside down...
February 2024: Biochemistry. Biokhimii︠a︡
#18
Andrew Takla, Fahad Eid, Mostafa Elbanna, Mohamed Magdi Eid, Akshay Joshi, Abdallah Bitar, Ryan Lydon, Scott Feitell
Left ventricular assist devices serve as a salvage therapy for patients with advanced heart failure. Complications such as thrombosis and obstruction can lead to acute device malfunction, posing significant clinical risks. A multidisciplinary approach is crucial for management. Few cases in the literature have demonstrated the safety and efficacy of percutaneous intervention, which holds significant value due to its less invasive nature and minimal risk of morbidity, especially in high-risk surgical patients...
2024: Methodist DeBakey Cardiovascular Journal
#19
Johnathan N O'Neil, Kai Lauren Yung, Gaetano Difini, Pankaj Rohilla, M Saad Bhamla
The air-water of the planet's water bodies, such as ponds, lakes and streams, presents an uncertain ecological niche with predatory threats from above and below. As Microvelia move across the water surface in small ponds, they face potential injury from attacks by birds, fish, and underwater invertebrates. Thus, our study investigates the effects of losing individual or pairs of tarsi on the Microvelia's ability to walk on water. Removal of both hind tarsi causes Microvelia spp . to rock their bodies (yaw) while running across the water surface at ±19°, compared to ±7° in non-ablated specimens...
April 2, 2024: bioRxiv
#20
JOURNAL ARTICLE
Xinxiao Liu, Chuanjiang Li, Dongyu Li
Resilience is to appraise the ability of disturbed systems to recover cooperative performance after suffering from failures or disturbances. In this paper, the improvement on the exponential tracking resilience for disturbed Euler-Lagrange systems is explored by settling the unknown time-variant faults imposed on the communication interaction between agents. First, we transform the resilient exponential tracking problem into designing the trajectory and velocity observers for leaders, and showcase that the proposed observers are resilient to communication interaction malfunctions...
April 2, 2024: ISA Transactions
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