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https://www.readbyqxmd.com/read/29682057/silent-migration-of-ventriculoperitoneal-shunt-per-anus-in-a-child-management-and-review-of-literature
#1
Sachin Parshuram Guthe, Survashe Pravin, Poonam Darade, Vernon Velho
The aim of this paper is to report a case of ventriculoperitoneal (VP) shunt tube coming out through the anus in a 6-year-old boy, who had undergone shunt revision surgery for the malfunctioning of the peritoneal end 6 months back. Among the complications of VP shunt surgery, such unusual migration of peritoneal end of the VP shunt is very rare. The possible factors responsible for this complication, in our case, were abdominal adhesions and thin bowel wall in the children. Although this complication has been previously reported, it remains an exceedingly rare case...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681798/the-lili-motif-of-m3-s2-linkers-is-a-component-of-the-nmda-receptor-channel-gate
#2
Marek Ladislav, Jiri Cerny, Jan Krusek, Martin Horak, Ales Balik, Ladislav Vyklicky
N-methyl-D-aspartate receptors (NMDARs) mediate excitatory synaptic transmission in the central nervous system, underlie the induction of synaptic plasticity, and their malfunction is associated with human diseases. Native NMDARs are tetramers composed of two obligatory GluN1 subunits and various combinations of GluN2A-D or, more rarely, GluN3A-B subunits. Each subunit consists of an amino-terminal, ligand-binding, transmembrane and carboxyl-terminal domain. The ligand-binding and transmembrane domains are interconnected via polypeptide chains (linkers)...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29679372/paraneoplastic-cerebellar-degeneration-yo-antibody-alters-mitochondrial-calcium-buffering-capacity
#3
Debabrata Panja, Christian A Vedeler, Manja Schubert
AIM: Neurodegeneration is associated with dysfunction of calcium buffering capacity and thereby sustained cellular and mitochondrial calcium overload. Paraneoplastic cerebellar degeneration (PCD), characterized by progressive Purkinje neuron degeneration following paraneoplastic Yo antibody internalisation and binding to cerebellar degeneration-related protein CDR2 and CDR2L, has been linked to intracellular calcium homeostasis imbalance due to calbindin D28k malfunction. Therefore, we hypothesized that Yo antibody internalisation affects not only calbindin calcium binding capacity but also calcium-sensitive mitochondrial-associated signalling, causing mitochondrial calcium overload and thereby Purkinje neuron death...
April 21, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29675822/the-field-experiments-and-model-of-the-natural-dust-deposition-effects-on-photovoltaic-module-efficiency
#4
Marek Jaszczur, Janusz Teneta, Katarzyna Styszko, Qusay Hassan, Paulina Burzyńska, Ewelina Marcinek, Natalia Łopian
The maximisation of the efficiency of the photovoltaic system is crucial in order to increase the competitiveness of this technology. Unfortunately, several environmental factors in addition to many alterable and unalterable factors can significantly influence the performance of the PV system. Some of the environmental factors that depend on the site have to do with dust, soiling and pollutants. In this study conducted in the city centre of Kraków, Poland, characterised by high pollution and low wind speed, the focus is on the evaluation of the degradation of efficiency of polycrystalline photovoltaic modules due to natural dust deposition...
April 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29675239/a-luminescent-aluminium-salen-complex-allows-for-monitoring-dynamic-vesicle-trafficking-from-the-golgi-apparatus-to-lysosomes-in-living-cells
#5
Juan Tang, Hao-Yan Yin, Jun-Long Zhang
The Golgi apparatus is well-known as the center of vesicle trafficking whose malfunction might cause the breakdown of overall cellular architecture and ultimately cell death. The development of fluorescent probes to not only precisely stain the Golgi apparatus but also monitor dynamic vesicle trafficking is of great significance. While fluorescent proteins and fluorescent lipid analogs have been reported, they are sometime limited by either overexpression and toxicity or lack of high selectivity, respectively...
February 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29673555/structure-and-mechanism-of-mitochondrial-electron-transport-chain
#6
REVIEW
Runyu Guo, Jinke Gu, Shuai Zong, Meng Wu, Maojun Yang
Respiration is one of the most vital and basic features of living organisms. In mammals, respiration is accomplished by respiratory chain complexes located on the mitochondrial inner membrane. In the past century, scientists put tremendous efforts in understanding these complexes, but failed to solve the high resolution structure until recently. In 2016, three research groups reported the structure of respiratory chain supercomplex from different species, and fortunately the structure solved by our group has the highest resolution...
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29673298/initial-clinical-experience-using-the-low-profile-altura-endograft-system-with-double-d-shaped-proximal-stents-for-endovascular-aneurysm-repair
#7
Dainis Krievins, Albrecht Krämer, Janis Savlovskis, Georgij Oszkinis, E Sebastian Debus, Alexander Oberhuber, Christopher K Zarins
PURPOSE: To report the initial clinical results of endovascular aneurysm repair (EVAR) using the low-profile (14-F) Altura Endograft System, which features a double "D-shaped" stent design with suprarenal fixation and modular iliac components that are deployed from distal to proximal. METHODS: From 2011 to 2015, 90 patients (mean age 72.8±8.3 years; 79 men) with abdominal aortic aneurysm (AAA; mean diameter 53.8±5.7 mm) were treated at 10 clinical sites in 2 prospective, controlled clinical studies using the Altura endograft...
April 1, 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29672695/new-onset-of-phrenic-nerve-palsy-after-laser-assisted-transvenous-lead-extraction-a-single-centre-experience
#8
Tardu Özkartal, François Regoli, Giulio Conte, Maria Luce Caputo, Catherine Klersy, Tiziano Moccetti, Angelo Auricchio
Aims: Phrenic nerve palsy (PNP) after mechanical transvenous lead extraction (TLE) was recently described for the first time. We aimed to analyse our TLE database for the presence of PNP. Methods and results: All consecutive patients referred to our institution were included in this study. Every available post-procedural chest X-ray was compared to the routinely performed pre-procedural radiographs. A newly elevated hemidiaphragm ipsilateral to TLE was considered indicative of PNP...
April 16, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29670379/assessment-of-an-accessorized-pre-filled-syringe-for-home-administered-benralizumab-in-severe-asthma
#9
Gary T Ferguson, Adel H Mansur, Joshua S Jacobs, Jacques Hebert, Corbin Clawson, Wenli Tao, Yanping Wu, Mitchell Goldman
Background: Patients prefer at-home subcutaneous administration of biologics across different diseases, yet no biologic is approved for at-home use for severe, uncontrolled asthma. Objective: We assessed at-home functionality, reliability, and performance of an accessorized pre-filled syringe (APFS) for subcutaneous benralizumab administration, an anti-eosinophil monoclonal antibody indicated for add-on maintenance treatment of patients with severe eosinophilic asthma...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29667250/a-new-2d-echocardiographic-approach-to-evaluate-the-membrane-and-valve-movement-of-the-berlin-heart-excor-vad-chamber-in-pediatric-vad-patients
#10
Arianna Di Molfetta, Roberta Iacobelli, Gianfranco Ferrari, Sergio Filippelli, Gianluigi Perri, Alessandra Toscano, Rachele Adorisio, Paolo Guccione, Antonio Amodeo
The use of Berlin Heart EXCOR VAD (BH) is a validated therapy to bridge pediatric patients to heart transplant. Serial echocardiographic (ECHO) assessment of VAD patients is necessary to support patients' management. This work aims at developing an innovative strategy to evaluate the BH device functioning by ECHO and its interaction with the native heart in a pediatric population. ECHO evaluation of BH membrane movement, and inflow and outflow valves was performed in 2D, 2D-color Doppler, M-mode, and M-mode color Doppler to assess the functioning of the device by direct positioning of the ECHO probe on the BH cannulas and membranes...
April 2018: Artificial Organs
https://www.readbyqxmd.com/read/29667046/radiotherapy-in-patients-with-cardiac-implantable-electronic-devices-clinical-and-dosimetric-aspects
#11
Giulia Riva, Ombretta Alessandro, Ruggero Spoto, Annamaria Ferrari, Cristina Garibaldi, Federica Cattani, Rosa Luraschi, Elena Rondi, Nicola Colombo, Fulvio Lorenzo Francesco Giovenzana, Carlo Maria Cipolla, Mikolaj Winnicki, Martina Persiani, Fabiana Castelluccia, Massimo Sarra Fiore, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
As a result of aging, the number of patients with cardiac implantable electronic device (CIED) requiring radiotherapy (RT) continues to rise. The aim of this work was to evaluate RT-related malfunctions of CIED in a cohort of patients who underwent RT in our clinic from June 2010 to December 2016. We retrospectively analyzed 93 RT treatments in 63 patients with CIEDs. Patients were treated with 3D conformal RT, intensity-modulated RT and stereotactic RT. We collected clinical characteristics of cancer, models of CIEDs, total RT dose to tumor and radiation energy...
April 17, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29666294/laryngeal-responses-to-mechanically-assisted-cough-in-progressing-amyotrophic-lateral-sclerosis
#12
Tiina M Andersen, Astrid Sandnes, Ove Fondenes, Roy M Nilsen, Ole-Bjørn Tysnes, John-Helge Heimdal, Hege H Clemm, Thomas Halvorsen, Maria Vollsœter, Ola D Røksund
BACKGROUND: Respiratory complications represent the major cause of death in amyotrophic lateral sclerosis (ALS). Noninvasive respiratory support is the mainstay therapy, but treatment becomes challenging as the disease progresses, possibly due to a malfunctioning larynx, which is the entrance to the airways. We studied laryngeal response patterns to mechanically assisted cough (mechanical insufflation-exsufflation) as ALS progresses. METHODS: This prospective longitudinal study of 13 consecutively included subjects with ALS were followed up during 2011-2016 with repeated tests of lung function, neurological status, and laryngeal responses to mechanical insufflation-exsufflation using video-recorded flexible transnasal fiberoptic laryngoscopy...
April 17, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29664956/you-pray-to-your-god-a-qualitative-analysis-of-challenges-in-the-provision-of-safe-timely-and-affordable-surgical-care-in-uganda
#13
Katherine Albutt, Rachel R Yorlets, Maria Punchak, Peter Kayima, Didacus B Namanya, Geoffrey A Anderson, Mark G Shrime
BACKGROUND: Five billion people lack access to safe, affordable, and timely surgical and anesthesia care. Significant challenges remain in the provision of surgical care in low-resource settings. Uganda is no exception. METHODS: From September to November 2016, we conducted a mixed-methods countrywide surgical capacity assessment at 17 randomly selected public hospitals in Uganda. Researchers conducted 35 semi-structured interviews with key stakeholders to understand factors related to the provision of surgical care...
2018: PloS One
https://www.readbyqxmd.com/read/29660409/chronic-intestinal-pseudo-obstruction-syndrome-and-gastrointestinal-malrotation-in-an-infantwith-schaaf-yang-syndrome-expanding-the-phenotypic-spectrum
#14
Allan Bayat, Michael Bayat, Ricardo Lozoya, Christian P Schaaf
We report a novel patient with the phenotypic characteristics of Schaaf-Yang syndrome. In addition, the patient has a severe chronic digestive malfunction, rendering him dependent on intermittent enteral supplementation. To our knowledge, this is the first report of Schaaf-Yang syndrome associated with severe chronic digestive malfunction manifesting with both a malrotation and signs of a chronic intestinal pseudo-obstruction.
April 13, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29660140/time-course-of-the-photochemical-reflectance-index-pri-during-photosynthetic-induction-its-relationship-with-the-photochemical-yield-of-photosystem-ii
#15
Keach Murakami, Yasuomi Ibaraki
Time courses of photochemical reflectance index (PRI) of an attached cucumber leaf during a dark-light transition were compared to those of photochemical yields of photosystem II (YII ) to discuss the feasibility of PRI imaging for estimating the efficiency of photosynthetic light use. YII and PRI were simultaneously evaluated with a pulse-amplitude modulation chlorophyll fluorometer and a low-cost imaging system consisted of digital cameras and band-pass filters, respectively. YII decreased immediately after the transition and then increased under various photon flux densities...
April 16, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29656283/economic-and-political-innovation-for-nutritional-improvement
#16
Joachim von Braun
Large shares of the world population are still affected by nutrition deficiencies and undernutrition. However, the current global agriculture and food system and its international governance shows signs of serious malfunctioning, and is not equipped to cope with the current and future challenges it is facing. In view of the complex and multi-dimensional nature of nutrition problems, a framework is put forward here to improve the understanding of underlying causalities, and to identify priorities for action...
April 13, 2018: World Review of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29655999/ovarian-hyperstimulation-syndrome-leading-to-ventriculoperitoneal-shunt-malfunction-case-report
#17
Amit Azriel, Benjamin Fleming, Uri P Dior, Samuel Moscovici, Yuval Sufaro, Mohammed Awad, Kate Drummond
Ventriculoperitoneal shunt (VPS) insertion is a common neurosurgical procedure for hydrocephalus. Unfortunately, VPS malfunction is not uncommon, with an estimated cumulative rate of 32% at 5 years. As flow through the shunt is influenced by the pressure gradient between the ventricles and the peritoneal cavity, malfunction may be caused by elevated intra-abdominal pressure. We present a rare patient with ascites following ovarian hyperstimulation syndrome (OHSS) leading to shunt malfunction. OHSS is a potentially life-threatening complication of controlled ovarian stimulation caused by the administration of exogenous gonadotropins...
April 11, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29655550/proteomic-investigating-the-cooperative-lethal-effect-of-egfr-and-mdm2-inhibitors-on-ovarian-carcinoma
#18
Shing-Jyh Chang, En-Chi Liao, Hsin-Yueh Yeo, Wen-Hong Kuo, Hsin-Yi Chen, Yi-Ting Tsai, Yu-Shan Wei, Ying-Jen Chen, Yi-Shiuan Wang, Ji-Min Li, Chuan-Chi Shih, Chia-Hao Chan, Hsiu-Chuan Chou, Yung-Jen Chuang, Hong-Lin Chan
With the concept of precision medicine, combining multiple molecular-targeting therapies has brought new approaches to current cancer treatments. Malfunction of the tumor suppressor protein, p53 is a universal hallmark in human cancers. Under normal conditions, p53 is degraded through an ubiquitin-proteosome pathway regulated by its negative regulator, MDM2. In contrast, cellular stress such as DNA damage will activate p53 to carry out DNA repair, cell cycle arrest, and apoptosis. In this study, we focused on ovarian carcinoma with high EGFR and MDM2 overexpression rate...
April 12, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29653261/assessment-of-obstetric-and-gynecologic-fda-device-approvals-and-recalls
#19
Sheena Galhotra, Joseph Maurice
STUDY OBJECTIVE: To evaluate and compare the recall rates of Obstetric and Gynecologic devices approved via the Food and Drug Administration's (FDA) 510(k) and Premarket Approval (PMA) processes DESIGN: Retrospective Observational Study (Canadian Task Force Classification II-2) SETTING: Clinical settings in the United States of America that use Obstetric and Gynecologic devices SUBJECTS: 2,249 FDA approved Obstetric and Gynecologic Devices that were recalled between November 1, 2002 and December 31, 2017...
April 10, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29652244/deriving-fuel-based-emission-factor-thresholds-to-interpret-heavy-duty-vehicle-roadside-plume-measurements
#20
David C Quiros, Jeremy D Smith, Walter A Ham, William H Robertson, Tao Huai, Alberto Ayala, Shaohua Hu
Remote sensing devices have been used for decades to measure gaseous emissions from individual vehicles at the roadside. Systems have also been developed that entrain diluted exhaust and can also measure particulate matter (PM) emissions. In 2015, the California Air Resources Board (CARB) reported that 8% of in-field diesel particulate filters (DPF) on heavy-duty (HD) vehicles were malfunctioning and emitted about 70% of total diesel PM emissions from the DPF-equipped fleet. A new high-emitter problem in the heavy-duty vehicle fleet had emerged...
April 13, 2018: Journal of the Air & Waste Management Association
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